SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3lto'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FK6_A_LNLA1201_1
(NON-SPECIFIC LIPID
TRANSFER PROTEIN)		 3lto MEVALONATE
DIPHOSPHATE
DECARBOXYLASE
(Legionella
pneumophila) 		5 / 12 ARG A 219
ALA A 222
LEU A 226
ALA A 230
ILE A 242
 None
 0.90A 1fk6A-3ltoA:
undetectable		 1fk6A-3ltoA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM9_A_9CRA201_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3lto MEVALONATE
DIPHOSPHATE
DECARBOXYLASE
(Legionella
pneumophila) 		3 / 3 GLN A 241
ILE A  19
HIS A 297
 None
 0.74A 1fm9A-3ltoA:
undetectable		 1fm9A-3ltoA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JZS_A_MRCA1301_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 3lto MEVALONATE
DIPHOSPHATE
DECARBOXYLASE
(Legionella
pneumophila) 		5 / 11 GLY A 293
PRO A 294
HIS A 186
HIS A 297
SER A 193
 None
 1.20A 1jzsA-3ltoA:
undetectable		 1jzsA-3ltoA:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K74_A_9CRA463_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3lto MEVALONATE
DIPHOSPHATE
DECARBOXYLASE
(Legionella
pneumophila) 		3 / 3 GLN A 241
ILE A  19
HIS A 297
 None
 0.74A 1k74A-3ltoA:
undetectable		 1k74A-3ltoA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNI_A_MTKA501_1
(CYTOCHROME P450 2C8)		 3lto MEVALONATE
DIPHOSPHATE
DECARBOXYLASE
(Legionella
pneumophila) 		5 / 12 SER A  49
SER A 161
ASN A 107
ALA A  20
THR A 289
 None
None
None
SO4  A 400 (-3.3A)
None
 1.03A 2nniA-3ltoA:
undetectable		 2nniA-3ltoA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RK8_A_PPFA3969_1
(PHOSPHOENOLPYRUVATE
CARBOXYKINASE,
CYTOSOLIC [GTP])		 3lto MEVALONATE
DIPHOSPHATE
DECARBOXYLASE
(Legionella
pneumophila) 		4 / 8 LYS A  23
SER A 200
ASP A 291
ALA A 203
 SO4  A 400 (-4.7A)
None
SO4  A 400 (-4.2A)
None
 1.42A 2rk8A-3ltoA:
undetectable		 2rk8A-3ltoA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K5V_B_STIB2_2
(TYROSINE-PROTEIN
KINASE ABL1)		 3lto MEVALONATE
DIPHOSPHATE
DECARBOXYLASE
(Legionella
pneumophila) 		4 / 6 LEU A 179
VAL A 188
VAL A 287
ILE A  19
 None
 1.24A 3k5vB-3ltoA:
undetectable		 3k5vB-3ltoA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFG_B_LEUB289_0
(GLYCYL-TRNA
SYNTHETASE ALPHA
SUBUNIT)		 3lto MEVALONATE
DIPHOSPHATE
DECARBOXYLASE
(Legionella
pneumophila) 		3 / 3 PHE A 109
SER A 120
SER A 117
 None
 0.97A 3ufgB-3ltoA:
undetectable		 3ufgB-3ltoA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KXI_A_NCTA402_1
(NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA-4
NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
BETA-2)		 3lto MEVALONATE
DIPHOSPHATE
DECARBOXYLASE
(Legionella
pneumophila) 		4 / 8 TYR A 181
TRP A 236
THR A 237
CYH A 243
 None
 1.25A 5kxiA-3ltoA:
undetectable
5kxiB-3ltoA:
undetectable		 5kxiA-3ltoA:
21.36
5kxiB-3ltoA:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KXI_D_NCTD402_1
(NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA-4
NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
BETA-2)		 3lto MEVALONATE
DIPHOSPHATE
DECARBOXYLASE
(Legionella
pneumophila) 		4 / 8 TYR A 181
TRP A 236
THR A 237
CYH A 243
 None
 1.24A 5kxiD-3ltoA:
undetectable
5kxiE-3ltoA:
undetectable		 5kxiD-3ltoA:
21.36
5kxiE-3ltoA:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CNJ_D_NCTD402_1
(NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA-4
NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
BETA-2)		 3lto MEVALONATE
DIPHOSPHATE
DECARBOXYLASE
(Legionella
pneumophila) 		4 / 8 TYR A 181
TRP A 236
THR A 237
CYH A 243
 None
 1.24A 6cnjD-3ltoA:
undetectable
6cnjE-3ltoA:
undetectable		 6cnjD-3ltoA:
12.30
6cnjE-3ltoA:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EF6_A_ACTA405_0
(AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 3lto MEVALONATE
DIPHOSPHATE
DECARBOXYLASE
(Legionella
pneumophila) 		4 / 6 THR A 215
ARG A 219
PRO A 211
GLN A 252
 None
 1.39A 6ef6A-3ltoA:
undetectable		 6ef6A-3ltoA:
21.12