SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ltw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_A_1FLA2001_1
(SERUM ALBUMIN)		 3ltw ARYLAMINE
N-ACETYLTRANSFERASE
NAT
(Mycobacterium
marinum) 		5 / 11 LEU A 266
ILE A 270
GLY A 223
CYH A 274
LEU A 249
 None
 1.14A 2bxeA-3ltwA:
undetectable		 2bxeA-3ltwA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_B_1FLB2001_1
(SERUM ALBUMIN)		 3ltw ARYLAMINE
N-ACETYLTRANSFERASE
NAT
(Mycobacterium
marinum) 		5 / 12 LEU A 266
ILE A 270
GLY A 223
CYH A 274
LEU A 249
 None
 1.16A 2bxeB-3ltwA:
undetectable		 2bxeB-3ltwA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_A_ACTA141_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		 3ltw ARYLAMINE
N-ACETYLTRANSFERASE
NAT
(Mycobacterium
marinum) 		3 / 3 VAL A 246
ASP A 247
GLU A 267
 None
 0.68A 2qeuA-3ltwA:
undetectable		 2qeuA-3ltwA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_C_ACTC141_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		 3ltw ARYLAMINE
N-ACETYLTRANSFERASE
NAT
(Mycobacterium
marinum) 		3 / 3 VAL A 246
ASP A 247
GLU A 267
 None
 0.66A 2qeuC-3ltwA:
undetectable		 2qeuC-3ltwA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ROX_B_T44B128_1
(TRANSTHYRETIN)		 3ltw ARYLAMINE
N-ACETYLTRANSFERASE
NAT
(Mycobacterium
marinum) 		4 / 6 LEU A 226
GLU A 235
LEU A 221
THR A 212
 None
 0.90A 2roxB-3ltwA:
undetectable		 2roxB-3ltwA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LM8_C_VIBC223_1
(THIAMINE
PYROPHOSPHOKINASE)		 3ltw ARYLAMINE
N-ACETYLTRANSFERASE
NAT
(Mycobacterium
marinum) 		4 / 8 ASP A 127
TYR A 154
LEU A 156
LEU A 125
 None
 0.98A 3lm8A-3ltwA:
undetectable
3lm8C-3ltwA:
undetectable		 3lm8A-3ltwA:
21.81
3lm8C-3ltwA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I00_A_ZMRA509_2
(NEURAMINIDASE)		 3ltw ARYLAMINE
N-ACETYLTRANSFERASE
NAT
(Mycobacterium
marinum) 		4 / 5 LEU A  41
ARG A  66
ILE A  36
ASN A  74
 None
 1.00A 4i00A-3ltwA:
undetectable		 4i00A-3ltwA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OJ4_A_DIFA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3ltw ARYLAMINE
N-ACETYLTRANSFERASE
NAT
(Mycobacterium
marinum) 		4 / 8 LEU A  25
LEU A  28
VAL A  29
ILE A  77
 None
 0.89A 4oj4A-3ltwA:
undetectable		 4oj4A-3ltwA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_B_SAMB301_0
(UNCHARACTERIZED
PROTEIN MJ0489)		 3ltw ARYLAMINE
N-ACETYLTRANSFERASE
NAT
(Mycobacterium
marinum) 		6 / 12 GLY A 129
TYR A  69
LEU A 176
GLY A 132
GLY A  67
PHE A 204
 None
HLZ  A 300 (-4.1A)
None
None
None
HLZ  A 300 (-4.4A)
 1.34A 5d4uB-3ltwA:
undetectable		 5d4uB-3ltwA:
24.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_E_CVIE301_0
(REGULATORY PROTEIN
TETR)		 3ltw ARYLAMINE
N-ACETYLTRANSFERASE
NAT
(Mycobacterium
marinum) 		5 / 12 MET A 222
ALA A 210
LEU A 226
ILE A 228
ARG A 230
 None
 1.33A 5vlmE-3ltwA:
undetectable		 5vlmE-3ltwA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X2T_I_PEMI202_1
(HEMOGLOBIN SUBUNIT
ALPHA
HEMOGLOBIN SUBUNIT
BETA)		 3ltw ARYLAMINE
N-ACETYLTRANSFERASE
NAT
(Mycobacterium
marinum) 		4 / 8 ALA A 150
THR A 136
ALA A 211
TRP A  97
 None
 0.93A 5x2tI-3ltwA:
undetectable
5x2tJ-3ltwA:
undetectable
5x2tK-3ltwA:
undetectable
5x2tL-3ltwA:
undetectable		 5x2tI-3ltwA:
20.57
5x2tJ-3ltwA:
18.84
5x2tK-3ltwA:
20.57
5x2tL-3ltwA:
18.84