SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3lu2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ITU_A_CILA451_1
(RENAL DIPEPTIDASE)		 3lu2 LMO2462 PROTEIN
(Listeria
monocytogenes) 		7 / 12 ASP A   9
GLU A 105
HIS A 172
HIS A 192
ARG A 203
ASP A 261
PRO A 266
 ZN  A 310 (-2.7A)
ZN  A 310 ( 4.0A)
ZN  A 309 (-4.3A)
ZN  A 309 (-4.6A)
None
ZN  A 309 (-3.7A)
None
 0.62A 1ituA-3lu2A:
42.7		 1ituA-3lu2A:
26.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ITU_B_CILB452_1
(RENAL DIPEPTIDASE)		 3lu2 LMO2462 PROTEIN
(Listeria
monocytogenes) 		7 / 12 ASP A   9
GLU A 105
HIS A 172
HIS A 192
ARG A 203
ASP A 261
PRO A 266
 ZN  A 310 (-2.7A)
ZN  A 310 ( 4.0A)
ZN  A 309 (-4.3A)
ZN  A 309 (-4.6A)
None
ZN  A 309 (-3.7A)
None
 0.62A 1ituB-3lu2A:
42.8		 1ituB-3lu2A:
26.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_D_THAD4_1
(LIVER
CARBOXYLESTERASE I)		 3lu2 LMO2462 PROTEIN
(Listeria
monocytogenes) 		6 / 12 LEU A  43
GLY A  45
LEU A  11
LEU A 102
ILE A  81
PHE A  23
 None
 1.43A 1mx1D-3lu2A:
undetectable		 1mx1D-3lu2A:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SBR_A_VIBA502_1
(YKOF)		 3lu2 LMO2462 PROTEIN
(Listeria
monocytogenes) 		4 / 6 ALA A 195
LEU A 205
ILE A 220
CYH A 248
 None
 0.89A 1sbrA-3lu2A:
undetectable
1sbrB-3lu2A:
undetectable		 1sbrA-3lu2A:
20.06
1sbrB-3lu2A:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8G_B_017B401_2
(POL POLYPROTEIN)		 3lu2 LMO2462 PROTEIN
(Listeria
monocytogenes) 		6 / 12 GLY A 154
ALA A 138
ASP A 140
GLY A 129
VAL A 128
PRO A 109
 None
 1.17A 2f8gB-3lu2A:
undetectable		 2f8gB-3lu2A:
14.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		 3lu2 LMO2462 PROTEIN
(Listeria
monocytogenes) 		4 / 6 LEU A 272
ASN A  32
ILE A 265
PHE A 224
 None
 1.14A 2jn3A-3lu2A:
undetectable		 2jn3A-3lu2A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AVP_A_MV2A313_1
(PANTOTHENATE KINASE)		 3lu2 LMO2462 PROTEIN
(Listeria
monocytogenes) 		4 / 7 ASP A   9
HIS A   7
ILE A 142
ASN A 133
 ZN  A 310 (-2.7A)
ZN  A 310 (-4.5A)
None
None
 1.04A 3avpA-3lu2A:
undetectable		 3avpA-3lu2A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BEX_A_PAUA248_0
(TYPE III
PANTOTHENATE KINASE)		 3lu2 LMO2462 PROTEIN
(Listeria
monocytogenes) 		5 / 10 ASN A 136
GLY A 154
THR A 131
LEU A 173
THR A 181
 None
 1.50A 3bexA-3lu2A:
undetectable
3bexB-3lu2A:
undetectable		 3bexA-3lu2A:
20.81
3bexB-3lu2A:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DFR_A_MTXA164_1
(DIHYDROFOLATE
REDUCTASE)		 3lu2 LMO2462 PROTEIN
(Listeria
monocytogenes) 		5 / 12 LEU A 130
LEU A 121
LEU A 160
HIS A 159
THR A 168
 None
 0.96A 3dfrA-3lu2A:
undetectable		 3dfrA-3lu2A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LB3_A_4CHA191_0
(DEHALOPEROXIDASE A)		 3lu2 LMO2462 PROTEIN
(Listeria
monocytogenes) 		4 / 6 PHE A 224
PHE A 281
TYR A 278
VAL A 222
 None
 1.04A 3lb3A-3lu2A:
undetectable		 3lb3A-3lu2A:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LB3_B_4CHB192_0
(DEHALOPEROXIDASE A)		 3lu2 LMO2462 PROTEIN
(Listeria
monocytogenes) 		4 / 6 PHE A 224
PHE A 281
TYR A 278
VAL A 222
 None
 1.09A 3lb3B-3lu2A:
undetectable		 3lb3B-3lu2A:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDT_B_VORB506_1
(CHOLESTEROL
24-HYDROXYLASE)		 3lu2 LMO2462 PROTEIN
(Listeria
monocytogenes) 		5 / 11 VAL A 170
SER A 171
ILE A 247
ALA A 218
ALA A 212
 None
 1.03A 3mdtB-3lu2A:
undetectable		 3mdtB-3lu2A:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0V_A_MIXA1301_1
(DNA TOPOISOMERASE
2-BETA)		 3lu2 LMO2462 PROTEIN
(Listeria
monocytogenes) 		4 / 7 GLY A 129
ILE A 107
ASN A 136
MET A 213
 None
 1.08A 4g0vA-3lu2A:
undetectable		 4g0vA-3lu2A:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_A_TMQA202_1
(DIHYDROFOLATE
REDUCTASE)		 3lu2 LMO2462 PROTEIN
(Listeria
monocytogenes) 		5 / 12 ILE A 189
LEU A 306
PRO A 307
LEU A  90
ILE A   4
 None
 0.91A 4m2xA-3lu2A:
undetectable		 4m2xA-3lu2A:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_E_TMQE202_1
(DIHYDROFOLATE
REDUCTASE)		 3lu2 LMO2462 PROTEIN
(Listeria
monocytogenes) 		5 / 12 ILE A 189
LEU A 306
PRO A 307
LEU A  90
ILE A   4
 None
 0.92A 4m2xE-3lu2A:
undetectable		 4m2xE-3lu2A:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODO_B_FK5B203_2
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD)		 3lu2 LMO2462 PROTEIN
(Listeria
monocytogenes) 		3 / 3 ALA A  26
GLN A  44
GLY A  45
 None
 0.63A 4odoC-3lu2A:
undetectable		 4odoC-3lu2A:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNU_A_QDNA602_1
(CYTOCHROME P450 2D6)		 3lu2 LMO2462 PROTEIN
(Listeria
monocytogenes) 		5 / 11 LEU A 104
GLY A 111
GLU A 108
LEU A 120
ALA A  63
 None
 1.03A 4wnuA-3lu2A:
undetectable		 4wnuA-3lu2A:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBQ_A_DIFA601_1
(SERUM ALBUMIN)		 3lu2 LMO2462 PROTEIN
(Listeria
monocytogenes) 		5 / 11 LEU A 104
PHE A 153
LEU A 114
GLY A 154
LEU A 161
 None
 1.34A 4zbqA-3lu2A:
undetectable		 4zbqA-3lu2A:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DSG_A_0HKA1201_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M4,ENDOLYSIN,ENDOLYS
IN,MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4)		 3lu2 LMO2462 PROTEIN
(Listeria
monocytogenes) 		3 / 3 ASN A 162
LEU A 117
PHE A 167
 None
 0.76A 5dsgA-3lu2A:
undetectable		 5dsgA-3lu2A:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H8T_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 3lu2 LMO2462 PROTEIN
(Listeria
monocytogenes) 		5 / 12 LEU A  36
ALA A 275
ILE A 256
SER A 260
LEU A 285
 None
 1.15A 5h8tA-3lu2A:
undetectable		 5h8tA-3lu2A:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3lu2 LMO2462 PROTEIN
(Listeria
monocytogenes) 		5 / 12 VAL A  31
LEU A  75
LEU A  93
GLY A  99
LEU A  36
 None
 1.32A 5iktB-3lu2A:
undetectable		 5iktB-3lu2A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3lu2 LMO2462 PROTEIN
(Listeria
monocytogenes) 		5 / 12 VAL A  74
LEU A  75
LEU A  93
GLY A  99
LEU A  36
 None
 1.32A 5iktB-3lu2A:
undetectable		 5iktB-3lu2A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_D_ADND502_1
(ADENOSYLHOMOCYSTEINA
SE)		 3lu2 LMO2462 PROTEIN
(Listeria
monocytogenes) 		3 / 3 LEU A 161
ASN A 136
LEU A 150
 None
 0.76A 6exiD-3lu2A:
undetectable		 6exiD-3lu2A:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GB9_A_ACTA508_0
(MOLYBDOPTERIN
BIOSYNTHESIS PROTEIN
CNX1)		 3lu2 LMO2462 PROTEIN
(Listeria
monocytogenes) 		3 / 3 VAL A  31
ALA A 275
GLN A  44
 None
 0.63A 6gb9A-3lu2A:
undetectable		 6gb9A-3lu2A:
21.22