SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3lua'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLC_A_CHDA332_0
(CHOLOYLGLYCINE
HYDROLASE)		 3lua RESPONSE REGULATOR
RECEIVER PROTEIN
(Ruminiclostridiu
m
thermocellum) 		5 / 12 PHE A  43
THR A  77
ALA A  70
ILE A  49
ILE A  31
 None
 1.11A 2rlcA-3luaA:
undetectable		 2rlcA-3luaA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XYT_H_TC9H1206_2
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3lua RESPONSE REGULATOR
RECEIVER PROTEIN
(Ruminiclostridiu
m
thermocellum) 		4 / 7 THR A  86
TYR A 105
ASP A  55
SER A  88
 None
 1.22A 2xytI-3luaA:
undetectable		 2xytI-3luaA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EIG_A_MTXA200_2
(DIHYDROFOLATE
REDUCTASE)		 3lua RESPONSE REGULATOR
RECEIVER PROTEIN
(Ruminiclostridiu
m
thermocellum) 		4 / 5 ASP A   2
ILE A  25
VAL A 122
THR A  80
 None
 1.24A 3eigA-3luaA:
undetectable		 3eigA-3luaA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_H_CLMH221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3lua RESPONSE REGULATOR
RECEIVER PROTEIN
(Ruminiclostridiu
m
thermocellum) 		5 / 12 SER A 103
LEU A  51
VAL A   5
PHE A  22
VAL A 119
 None
 1.40A 3u9fH-3luaA:
undetectable
3u9fI-3luaA:
undetectable		 3u9fH-3luaA:
17.81
3u9fI-3luaA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR1_B_017B101_1
(PROTEASE PR5-DRV)		 3lua RESPONSE REGULATOR
RECEIVER PROTEIN
(Ruminiclostridiu
m
thermocellum) 		5 / 10 LEU A  51
ALA A  85
ASP A  55
VAL A   5
ILE A  53
 None
 1.02A 5kr1A-3luaA:
undetectable		 5kr1A-3luaA:
24.78