SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3lue'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FLC_C_RAPC999_1
(SERINE/THREONINE-PRO
TEIN KINASE MTOR
FKBP)		 3lue ALPHA-ACTININ-3
(Homo
sapiens) 		4 / 8 PHE K  73
GLY K  76
THR K  52
PHE K 148
 None
 1.00A 5flcB-3lueK:
undetectable		 5flcB-3lueK:
6.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FLC_G_RAPG999_1
(SERINE/THREONINE-PRO
TEIN KINASE MTOR
FKBP)		 3lue ALPHA-ACTININ-3
(Homo
sapiens) 		4 / 8 PHE K  73
GLY K  76
THR K  52
PHE K 148
 None
 0.99A 5flcF-3lueK:
undetectable		 5flcF-3lueK:
6.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1803_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 3lue ALPHA-ACTININ-3
(Homo
sapiens) 		5 / 10 ILE K 141
ILE K 145
LEU K 146
ILE K 129
ASN K 133
 None
 1.34A 5vkqA-3lueK:
undetectable
5vkqD-3lueK:
undetectable		 5vkqA-3lueK:
5.24
5vkqD-3lueK:
5.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1808_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 3lue ALPHA-ACTININ-3
(Homo
sapiens) 		5 / 10 ILE K 129
ASN K 133
ILE K 141
ILE K 145
LEU K 146
 None
 1.35A 5vkqA-3lueK:
undetectable
5vkqB-3lueK:
undetectable		 5vkqA-3lueK:
5.24
5vkqB-3lueK:
5.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1801_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 3lue ALPHA-ACTININ-3
(Homo
sapiens) 		5 / 10 ILE K 129
ASN K 133
ILE K 141
ILE K 145
LEU K 146
 None
 1.34A 5vkqC-3lueK:
undetectable
5vkqD-3lueK:
undetectable		 5vkqC-3lueK:
5.24
5vkqD-3lueK:
5.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X5Q_D_D16D402_1
(THYMIDYLATE SYNTHASE)		 3lue ALPHA-ACTININ-3
(Homo
sapiens) 		4 / 8 LYS K 103
PHE K  73
ILE K  69
GLY K 132
 None
 0.84A 5x5qD-3lueK:
undetectable		 5x5qD-3lueK:
16.22