SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3luf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKE_A_HSMA190_1
(NITROPHORIN 4)		 3luf TWO-COMPONENT SYSTEM
RESPONSE
REGULATOR/GGDEF
DOMAIN PROTEIN
(Aeromonas
salmonicida) 		3 / 3 ASP A  10
LEU A  54
LEU A  56
 MG  A 301 (-2.6A)
None
None
 0.63A 1ikeA-3lufA:
undetectable		 1ikeA-3lufA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NP1_B_HSMB304_1
(NITROPHORIN 1)		 3luf TWO-COMPONENT SYSTEM
RESPONSE
REGULATOR/GGDEF
DOMAIN PROTEIN
(Aeromonas
salmonicida) 		3 / 3 ASP A  10
LEU A  54
LEU A  56
 MG  A 301 (-2.6A)
None
None
 0.73A 1np1B-3lufA:
undetectable		 1np1B-3lufA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RLB_F_REAF177_1
(RETINOL BINDING
PROTEIN)		 3luf TWO-COMPONENT SYSTEM
RESPONSE
REGULATOR/GGDEF
DOMAIN PROTEIN
(Aeromonas
salmonicida) 		5 / 11 LEU A  51
ALA A  23
VAL A  76
LEU A  96
LEU A 117
 None
 1.01A 1rlbF-3lufA:
undetectable		 1rlbF-3lufA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WOP_A_FFOA2887_1
(AMINOMETHYLTRANSFERA
SE)		 3luf TWO-COMPONENT SYSTEM
RESPONSE
REGULATOR/GGDEF
DOMAIN PROTEIN
(Aeromonas
salmonicida) 		3 / 3 ASP A  10
GLU A  63
ARG A  71
 MG  A 301 (-2.6A)
None
None
 0.70A 1wopA-3lufA:
undetectable		 1wopA-3lufA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAQ_A_2GMA2001_2
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 1B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 3luf TWO-COMPONENT SYSTEM
RESPONSE
REGULATOR/GGDEF
DOMAIN PROTEIN
(Aeromonas
salmonicida) 		4 / 6 ILE A  77
THR A  79
VAL A  67
ASP A  58
 None
 1.09A 4iaqA-3lufA:
undetectable		 4iaqA-3lufA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDA_A_RLTA403_1
(MARINER MOS1
TRANSPOSASE)		 3luf TWO-COMPONENT SYSTEM
RESPONSE
REGULATOR/GGDEF
DOMAIN PROTEIN
(Aeromonas
salmonicida) 		4 / 6 ASP A 222
ASN A 221
ALA A 220
TYR A 215
 None
 1.20A 4mdaA-3lufA:
undetectable		 4mdaA-3lufA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0X_B_SAMB501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 3luf TWO-COMPONENT SYSTEM
RESPONSE
REGULATOR/GGDEF
DOMAIN PROTEIN
(Aeromonas
salmonicida) 		3 / 3 SER A 153
ALA A 152
THR A 161
 None
 0.70A 5n0xB-3lufA:
2.5		 5n0xB-3lufA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YVN_A_ACTA305_0
(GLUTATHIONE
S-TRANSFERASE
OMEGA-1)		 3luf TWO-COMPONENT SYSTEM
RESPONSE
REGULATOR/GGDEF
DOMAIN PROTEIN
(Aeromonas
salmonicida) 		4 / 6 GLU A   9
LYS A 101
LEU A 107
LEU A  18
 MG  A 301 ( 4.3A)
MG  A 301 ( 4.3A)
None
None
 1.18A 5yvnA-3lufA:
2.8		 5yvnA-3lufA:
21.53