SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3lun'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BDW_B_DVAB8_0
(GRAMICIDIN A)		 3lun ULILYSIN
(Methanosarcina
acetivorans) 		3 / 3 VAL A  74
VAL A 145
TRP A  75
 None
 0.97A 1bdwA-3lunA:
undetectable
1bdwB-3lunA:
undetectable		 1bdwA-3lunA:
5.65
1bdwB-3lunA:
5.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C6Z_B_ROCB505_1
(PROTEIN (PROTEASE))		 3lun ULILYSIN
(Methanosarcina
acetivorans) 		5 / 12 ALA A 209
ASP A 207
VAL A 175
ILE A  82
ILE A 205
 None
 0.92A 1c6zA-3lunA:
undetectable		 1c6zA-3lunA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C6Z_B_ROCB505_1
(PROTEIN (PROTEASE))		 3lun ULILYSIN
(Methanosarcina
acetivorans) 		5 / 12 ALA A 209
ASP A 207
VAL A 175
ILE A  93
ILE A 205
 None
 1.02A 1c6zA-3lunA:
undetectable		 1c6zA-3lunA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DF7_A_MTXA501_1
(DIHYDROFOLATE
REDUCTASE)		 3lun ULILYSIN
(Methanosarcina
acetivorans) 		5 / 12 ILE A  64
LEU A 313
VAL A 309
LEU A 234
ILE A  67
 None
 0.88A 1df7A-3lunA:
undetectable		 1df7A-3lunA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HPV_B_478B200_2
(HIV-1 PROTEASE)		 3lun ULILYSIN
(Methanosarcina
acetivorans) 		6 / 9 ALA A 209
ASP A 207
VAL A 175
ILE A  93
VAL A 203
ILE A 205
 None
 1.17A 1hpvB-3lunA:
undetectable		 1hpvB-3lunA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXB_A_ROCA100_1
(HIV-1 PROTEASE)		 3lun ULILYSIN
(Methanosarcina
acetivorans) 		5 / 12 ALA A 209
ASP A 207
VAL A 175
ILE A  82
ILE A 205
 None
 0.81A 1hxbA-3lunA:
undetectable		 1hxbA-3lunA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXB_A_ROCA100_3
(HIV-1 PROTEASE)		 3lun ULILYSIN
(Methanosarcina
acetivorans) 		5 / 12 ALA A 209
ASP A 207
VAL A 175
ILE A  82
ILE A 205
 None
 0.87A 1hxbB-3lunA:
undetectable		 1hxbB-3lunA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXB_A_ROCA100_3
(HIV-1 PROTEASE)		 3lun ULILYSIN
(Methanosarcina
acetivorans) 		5 / 12 ALA A 209
ASP A 207
VAL A 175
ILE A  93
ILE A 205
 None
 0.97A 1hxbB-3lunA:
undetectable		 1hxbB-3lunA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KF6_B_ACTB704_0
(FUMARATE REDUCTASE
FLAVOPROTEIN
FUMARATE REDUCTASE
IRON-SULFUR PROTEIN)		 3lun ULILYSIN
(Methanosarcina
acetivorans) 		3 / 3 ARG A 317
GLY A 202
ASP A 201
 None
 0.59A 1kf6A-3lunA:
undetectable
1kf6B-3lunA:
undetectable		 1kf6A-3lunA:
17.13
1kf6B-3lunA:
25.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXD_A_ACRA734_1
(ALPHA AMYLASE)		 3lun ULILYSIN
(Methanosarcina
acetivorans) 		4 / 6 ASN A 266
TRP A 240
TYR A 292
GLY A 268
 None
None
ZN  A 999 ( 4.9A)
None
 1.41A 1mxdA-3lunA:
undetectable		 1mxdA-3lunA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N49_D_RITD401_1
(PROTEASE)		 3lun ULILYSIN
(Methanosarcina
acetivorans) 		5 / 11 ALA A 209
ASP A 207
VAL A 175
ILE A  93
ILE A 205
 None
 0.94A 1n49C-3lunA:
undetectable		 1n49C-3lunA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OHR_A_1UNA201_2
(ASPARTYLPROTEASE)		 3lun ULILYSIN
(Methanosarcina
acetivorans) 		5 / 9 LEU A 171
GLY A 211
ILE A  93
VAL A  69
ILE A 173
 None
 0.98A 1ohrB-3lunA:
undetectable		 1ohrB-3lunA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OS2_A_HAEA874_1
(MACROPHAGE
METALLOELASTASE)		 3lun ULILYSIN
(Methanosarcina
acetivorans) 		4 / 5 HIS A 228
GLU A 229
HIS A 232
HIS A 238
 ZN  A 999 (-3.1A)
ZN  A 999 ( 3.8A)
ZN  A 999 (-3.1A)
ZN  A 999 (-3.0A)
 0.34A 1os2A-3lunA:
8.5		 1os2A-3lunA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OS2_D_HAED574_1
(MACROPHAGE
METALLOELASTASE)		 3lun ULILYSIN
(Methanosarcina
acetivorans) 		4 / 4 HIS A 228
GLU A 229
HIS A 232
HIS A 238
 ZN  A 999 (-3.1A)
ZN  A 999 ( 3.8A)
ZN  A 999 (-3.1A)
ZN  A 999 (-3.0A)
 0.36A 1os2D-3lunA:
8.5		 1os2D-3lunA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R55_A_097A518_1
(ADAM 33)		 3lun ULILYSIN
(Methanosarcina
acetivorans) 		5 / 10 THR A 225
HIS A 228
GLU A 229
HIS A 232
HIS A 238
 None
ZN  A 999 (-3.1A)
ZN  A 999 ( 3.8A)
ZN  A 999 (-3.1A)
ZN  A 999 (-3.0A)
 0.56A 1r55A-3lunA:
13.5		 1r55A-3lunA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TMX_B_BEZB882_0
(HYDROXYQUINOL
1,2-DIOXYGENASE)		 3lun ULILYSIN
(Methanosarcina
acetivorans) 		5 / 12 LEU A 179
TYR A 292
ILE A 187
HIS A 238
HIS A 232
 None
ZN  A 999 ( 4.9A)
None
ZN  A 999 (-3.0A)
ZN  A 999 (-3.1A)
 1.39A 1tmxB-3lunA:
undetectable		 1tmxB-3lunA:
24.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTT_A_HAEA1265_1
(MACROPHAGE
METALLOELASTASE)		 3lun ULILYSIN
(Methanosarcina
acetivorans) 		4 / 4 HIS A 228
GLU A 229
HIS A 232
HIS A 238
 ZN  A 999 (-3.1A)
ZN  A 999 ( 3.8A)
ZN  A 999 (-3.1A)
ZN  A 999 (-3.0A)
 0.44A 1uttA-3lunA:
8.6		 1uttA-3lunA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTZ_A_HAEA1267_1
(MACROPHAGE
METALLOELASTASE)		 3lun ULILYSIN
(Methanosarcina
acetivorans) 		4 / 4 HIS A 228
GLU A 229
HIS A 232
HIS A 238
 ZN  A 999 (-3.1A)
ZN  A 999 ( 3.8A)
ZN  A 999 (-3.1A)
ZN  A 999 (-3.0A)
 0.34A 1utzA-3lunA:
8.6		 1utzA-3lunA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTZ_B_HAEB1266_1
(MACROPHAGE
METALLOELASTASE)		 3lun ULILYSIN
(Methanosarcina
acetivorans) 		4 / 4 HIS A 228
GLU A 229
HIS A 232
HIS A 238
 ZN  A 999 (-3.1A)
ZN  A 999 ( 3.8A)
ZN  A 999 (-3.1A)
ZN  A 999 (-3.0A)
 0.37A 1utzB-3lunA:
8.6		 1utzB-3lunA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y93_A_HAEA301_1
(MACROPHAGE
METALLOELASTASE)		 3lun ULILYSIN
(Methanosarcina
acetivorans) 		5 / 6 ILE A 187
HIS A 228
GLU A 229
HIS A 232
HIS A 238
 None
ZN  A 999 (-3.1A)
ZN  A 999 ( 3.8A)
ZN  A 999 (-3.1A)
ZN  A 999 (-3.0A)
 0.56A 1y93A-3lunA:
8.6		 1y93A-3lunA:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1H_B_GBNB501_1
(BRANCHED CHAIN
AMINOTRANSFERASE)		 3lun ULILYSIN
(Methanosarcina
acetivorans) 		4 / 8 VAL A  71
GLY A 223
THR A 225
ALA A 226
 None
 0.82A 2a1hA-3lunA:
undetectable
2a1hB-3lunA:
undetectable		 2a1hA-3lunA:
19.68
2a1hB-3lunA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVO_B_MK1B902_1
(POL POLYPROTEIN)		 3lun ULILYSIN
(Methanosarcina
acetivorans) 		5 / 9 LEU A 171
GLY A 211
ILE A  93
VAL A  69
ILE A 173
 None
 1.02A 2avoA-3lunA:
undetectable		 2avoA-3lunA:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_A_MK1A901_2
(POL POLYPROTEIN)		 3lun ULILYSIN
(Methanosarcina
acetivorans) 		3 / 3 ASP A 294
VAL A 299
PRO A 109
 None
 0.65A 2avvA-3lunA:
undetectable		 2avvA-3lunA:
16.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BPX_B_MK1B902_2
(HIV-1 PROTEASE)		 3lun ULILYSIN
(Methanosarcina
acetivorans) 		6 / 12 ALA A 209
ASP A 207
VAL A 175
ILE A  82
VAL A 203
ILE A 205
 None
 1.13A 2bpxB-3lunA:
undetectable		 2bpxB-3lunA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E7F_A_C2FA3000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 3lun ULILYSIN
(Methanosarcina
acetivorans) 		5 / 12 GLU A 229
ILE A 121
LEU A 313
GLY A 231
ILE A 230
 ZN  A 999 ( 3.8A)
None
None
None
None
 1.19A 2e7fA-3lunA:
undetectable		 2e7fA-3lunA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F81_A_017A302_1
(POL POLYPROTEIN)		 3lun ULILYSIN
(Methanosarcina
acetivorans) 		5 / 12 ALA A 209
ASP A 207
VAL A 175
ILE A  93
ILE A 205
 None
 1.01A 2f81A-3lunA:
undetectable		 2f81A-3lunA:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F81_A_017A302_2
(POL POLYPROTEIN)		 3lun ULILYSIN
(Methanosarcina
acetivorans) 		5 / 12 ALA A 209
ASP A 207
VAL A 175
ILE A  93
ILE A 205
 None
 0.97A 2f81B-3lunA:
undetectable		 2f81B-3lunA:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HU6_A_HAEA269_1
(MACROPHAGE
METALLOELASTASE)		 3lun ULILYSIN
(Methanosarcina
acetivorans) 		4 / 4 HIS A 228
GLU A 229
HIS A 232
HIS A 238
 ZN  A 999 (-3.1A)
ZN  A 999 ( 3.8A)
ZN  A 999 (-3.1A)
ZN  A 999 (-3.0A)
 0.38A 2hu6A-3lunA:
8.5		 2hu6A-3lunA:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IDW_B_017B401_1
(PROTEASE)		 3lun ULILYSIN
(Methanosarcina
acetivorans) 		5 / 11 ALA A 209
ASP A 207
VAL A 175
ILE A  93
ILE A 205
 None
 0.93A 2idwA-3lunA:
undetectable		 2idwA-3lunA:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JIH_A_097A1001_1
(ADAMTS-1)		 3lun ULILYSIN
(Methanosarcina
acetivorans) 		5 / 9 ASP A 186
LEU A 188
HIS A 228
GLU A 229
HIS A 232
 None
None
ZN  A 999 (-3.1A)
ZN  A 999 ( 3.8A)
ZN  A 999 (-3.1A)
 1.30A 2jihA-3lunA:
14.2		 2jihA-3lunA:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JIH_A_097A1001_1
(ADAMTS-1)		 3lun ULILYSIN
(Methanosarcina
acetivorans) 		6 / 9 LEU A 188
THR A 225
HIS A 228
GLU A 229
HIS A 232
HIS A 238
 None
None
ZN  A 999 (-3.1A)
ZN  A 999 ( 3.8A)
ZN  A 999 (-3.1A)
ZN  A 999 (-3.0A)
 0.46A 2jihA-3lunA:
14.2		 2jihA-3lunA:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JIH_B_097B1001_1
(ADAMTS-1)		 3lun ULILYSIN
(Methanosarcina
acetivorans) 		6 / 8 LEU A 188
THR A 225
HIS A 228
GLU A 229
HIS A 232
HIS A 238
 None
None
ZN  A 999 (-3.1A)
ZN  A 999 ( 3.8A)
ZN  A 999 (-3.1A)
ZN  A 999 (-3.0A)
 0.43A 2jihB-3lunA:
14.1		 2jihB-3lunA:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4L_A_TPVA403_2
(PROTEASE)		 3lun ULILYSIN
(Methanosarcina
acetivorans) 		6 / 12 ALA A 209
VAL A 175
ILE A  82
GLY A 211
VAL A 203
ILE A 205
 None
 1.35A 2o4lB-3lunA:
undetectable		 2o4lB-3lunA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OGY_A_C2FA3000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 3lun ULILYSIN
(Methanosarcina
acetivorans) 		5 / 12 GLU A 229
ILE A 121
LEU A 313
GLY A 231
ILE A 230
 ZN  A 999 ( 3.8A)
None
None
None
None
 1.17A 2ogyA-3lunA:
undetectable		 2ogyA-3lunA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OGY_B_C2FB4000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 3lun ULILYSIN
(Methanosarcina
acetivorans) 		5 / 12 GLU A 229
ILE A 121
LEU A 313
GLY A 231
ILE A 230
 ZN  A 999 ( 3.8A)
None
None
None
None
 1.21A 2ogyB-3lunA:
undetectable		 2ogyB-3lunA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OW9_A_HAEA502_1
(COLLAGENASE 3)		 3lun ULILYSIN
(Methanosarcina
acetivorans) 		4 / 6 HIS A 228
GLU A 229
HIS A 232
HIS A 238
 ZN  A 999 (-3.1A)
ZN  A 999 ( 3.8A)
ZN  A 999 (-3.1A)
ZN  A 999 (-3.0A)
 0.26A 2ow9A-3lunA:
8.0		 2ow9A-3lunA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OW9_B_HAEB502_1
(COLLAGENASE 3)		 3lun ULILYSIN
(Methanosarcina
acetivorans) 		4 / 4 HIS A 228
GLU A 229
HIS A 232
HIS A 238
 ZN  A 999 (-3.1A)
ZN  A 999 ( 3.8A)
ZN  A 999 (-3.1A)
ZN  A 999 (-3.0A)
 0.30A 2ow9B-3lunA:
7.9		 2ow9B-3lunA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZR_C_HAEC3001_1
(COLLAGENASE 3)		 3lun ULILYSIN
(Methanosarcina
acetivorans) 		4 / 4 HIS A 228
GLU A 229
HIS A 232
HIS A 238
 ZN  A 999 (-3.1A)
ZN  A 999 ( 3.8A)
ZN  A 999 (-3.1A)
ZN  A 999 (-3.0A)
 0.28A 2ozrC-3lunA:
7.9		 2ozrC-3lunA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZR_D_HAED3002_1
(COLLAGENASE 3)		 3lun ULILYSIN
(Methanosarcina
acetivorans) 		4 / 4 HIS A 228
GLU A 229
HIS A 232
HIS A 238
 ZN  A 999 (-3.1A)
ZN  A 999 ( 3.8A)
ZN  A 999 (-3.1A)
ZN  A 999 (-3.0A)
 0.29A 2ozrD-3lunA:
7.9		 2ozrD-3lunA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZR_E_HAEE3003_1
(COLLAGENASE 3)		 3lun ULILYSIN
(Methanosarcina
acetivorans) 		4 / 4 HIS A 228
GLU A 229
HIS A 232
HIS A 238
 ZN  A 999 (-3.1A)
ZN  A 999 ( 3.8A)
ZN  A 999 (-3.1A)
ZN  A 999 (-3.0A)
 0.45A 2ozrE-3lunA:
8.0		 2ozrE-3lunA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZR_F_HAEF3004_1
(COLLAGENASE 3)		 3lun ULILYSIN
(Methanosarcina
acetivorans) 		3 / 3 HIS A 228
HIS A 232
HIS A 238
 ZN  A 999 (-3.1A)
ZN  A 999 (-3.1A)
ZN  A 999 (-3.0A)
 0.36A 2ozrF-3lunA:
7.8		 2ozrF-3lunA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYN_A_1UNA1001_1
(PROTEASE RETROPEPSIN)		 3lun ULILYSIN
(Methanosarcina
acetivorans) 		5 / 12 ALA A 209
VAL A 175
ILE A  93
VAL A 203
ILE A 205
 None
 0.96A 2pynA-3lunA:
undetectable		 2pynA-3lunA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYN_A_1UNA1001_2
(PROTEASE RETROPEPSIN)		 3lun ULILYSIN
(Methanosarcina
acetivorans) 		5 / 12 ALA A 209
VAL A 175
ILE A  93
VAL A 203
ILE A 205
 None
 0.96A 2pynB-3lunA:
undetectable		 2pynB-3lunA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q5K_A_AB1A201_1
(PROTEASE)		 3lun ULILYSIN
(Methanosarcina
acetivorans) 		5 / 9 ALA A 209
VAL A 175
ILE A  93
VAL A 203
ILE A 205
 None
 1.07A 2q5kA-3lunA:
undetectable		 2q5kA-3lunA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q63_A_1UNA1001_3
(PROTEASE RETROPEPSIN)		 3lun ULILYSIN
(Methanosarcina
acetivorans) 		5 / 12 ALA A 209
VAL A 175
ILE A  93
VAL A 203
ILE A 205
 None
 0.96A 2q63B-3lunA:
undetectable		 2q63B-3lunA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QAK_A_1UNA1001_3
(PROTEASE RETROPEPSIN)		 3lun ULILYSIN
(Methanosarcina
acetivorans) 		5 / 12 ALA A 209
VAL A 175
ILE A  93
VAL A 203
ILE A 205
 None
 0.96A 2qakB-3lunA:
undetectable		 2qakB-3lunA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHC_B_AB1B9001_1
(PROTEASE RETROPEPSIN)		 3lun ULILYSIN
(Methanosarcina
acetivorans) 		6 / 11 ALA A 209
ASP A 207
VAL A 175
ILE A  93
VAL A 203
ILE A 205
 None
 1.08A 2qhcA-3lunA:
undetectable		 2qhcA-3lunA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHC_B_AB1B9001_2
(PROTEASE RETROPEPSIN)		 3lun ULILYSIN
(Methanosarcina
acetivorans) 		5 / 12 ALA A 209
ASP A 207
VAL A 175
ILE A  93
ILE A 205
 None
 0.84A 2qhcB-3lunA:
undetectable		 2qhcB-3lunA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X0P_A_ADNA1607_1
(ALCALIGIN
BIOSYNTHESIS PROTEIN)		 3lun ULILYSIN
(Methanosarcina
acetivorans) 		4 / 8 GLY A 231
ILE A 239
ASN A 288
ALA A 191
 None
 0.87A 2x0pA-3lunA:
undetectable		 2x0pA-3lunA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKW_B_P1BB1475_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3lun ULILYSIN
(Methanosarcina
acetivorans) 		5 / 6 LEU A 171
ARG A 317
ILE A 230
ILE A 116
LEU A 101
 None
 1.29A 2xkwB-3lunA:
undetectable		 2xkwB-3lunA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z54_A_AB1A200_1
(HIV-1 PROTEASE)		 3lun ULILYSIN
(Methanosarcina
acetivorans) 		5 / 12 ALA A 209
ASP A 207
VAL A 175
ILE A  93
ILE A 205
 None
 0.96A 2z54A-3lunA:
undetectable		 2z54A-3lunA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z54_A_AB1A200_2
(HIV-1 PROTEASE)		 3lun ULILYSIN
(Methanosarcina
acetivorans) 		6 / 12 ALA A 209
ASP A 207
VAL A 175
ILE A  93
VAL A 203
ILE A 205
 None
 1.10A 2z54B-3lunA:
undetectable		 2z54B-3lunA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BVB_B_017B401_2
(PROTEASE
(RETROPEPSIN))		 3lun ULILYSIN
(Methanosarcina
acetivorans) 		6 / 12 ALA A 209
ASP A 207
VAL A 175
ILE A  93
VAL A 203
ILE A 205
 None
 1.16A 3bvbB-3lunA:
undetectable		 3bvbB-3lunA:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BVD_A_CUA803_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3lun ULILYSIN
(Methanosarcina
acetivorans) 		3 / 3 HIS A 238
HIS A 232
HIS A 228
 ZN  A 999 (-3.0A)
ZN  A 999 (-3.1A)
ZN  A 999 (-3.1A)
 0.75A 3bvdA-3lunA:
undetectable		 3bvdA-3lunA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYW_A_017A201_2
(HIV-1 PROTEASE)		 3lun ULILYSIN
(Methanosarcina
acetivorans) 		5 / 12 ALA A 209
ASP A 207
VAL A 175
ILE A  93
ILE A 205
 None
 0.96A 3cywB-3lunA:
undetectable		 3cywB-3lunA:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D1Y_A_ROCA201_2
(HIV-1 PROTEASE)		 3lun ULILYSIN
(Methanosarcina
acetivorans) 		5 / 9 LEU A 171
GLY A 211
ILE A  93
VAL A  69
ILE A 173
 None
 1.10A 3d1yB-3lunA:
undetectable		 3d1yB-3lunA:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D1Z_B_017B201_2
(HIV-1 PROTEASE)		 3lun ULILYSIN
(Methanosarcina
acetivorans) 		5 / 12 ALA A 209
ASP A 207
VAL A 175
ILE A  93
ILE A 205
 None
 0.95A 3d1zB-3lunA:
undetectable		 3d1zB-3lunA:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D20_A_017A201_1
(HIV-1 PROTEASE)		 3lun ULILYSIN
(Methanosarcina
acetivorans) 		5 / 12 ALA A 209
ASP A 207
VAL A 175
ILE A  93
ILE A 205
 None
 1.01A 3d20A-3lunA:
undetectable		 3d20A-3lunA:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKT_B_017B200_2
(PROTEASE)		 3lun ULILYSIN
(Methanosarcina
acetivorans) 		5 / 9 ALA A 209
ASP A 207
VAL A 175
ILE A  93
ILE A 205
 None
 0.97A 3ektB-3lunA:
undetectable		 3ektB-3lunA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKT_D_017D200_2
(PROTEASE)		 3lun ULILYSIN
(Methanosarcina
acetivorans) 		5 / 11 ALA A 209
ASP A 207
VAL A 175
ILE A  93
ILE A 205
 None
 0.97A 3ektD-3lunA:
undetectable		 3ektD-3lunA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKV_A_478A200_2
(PROTEASE)		 3lun ULILYSIN
(Methanosarcina
acetivorans) 		5 / 9 ALA A 209
ASP A 207
VAL A 175
ILE A  93
ILE A 205
 None
 1.01A 3ekvB-3lunA:
undetectable		 3ekvB-3lunA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKV_A_478A200_2
(PROTEASE)		 3lun ULILYSIN
(Methanosarcina
acetivorans) 		5 / 9 ALA A 209
ASP A 207
VAL A 175
VAL A 203
ILE A 205
 None
 1.10A 3ekvB-3lunA:
undetectable		 3ekvB-3lunA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKX_B_1UNB201_2
(PROTEASE)		 3lun ULILYSIN
(Methanosarcina
acetivorans) 		6 / 11 ALA A 209
ASP A 207
VAL A 175
ILE A  82
VAL A 203
ILE A 205
 None
 1.12A 3ekxB-3lunA:
undetectable		 3ekxB-3lunA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKX_B_1UNB201_2
(PROTEASE)		 3lun ULILYSIN
(Methanosarcina
acetivorans) 		6 / 11 ALA A 209
ASP A 207
VAL A 175
ILE A  93
VAL A 203
ILE A 205
 None
 1.11A 3ekxB-3lunA:
undetectable		 3ekxB-3lunA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HY7_A_097A801_1
(A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 5)		 3lun ULILYSIN
(Methanosarcina
acetivorans) 		6 / 9 LEU A 188
THR A 225
HIS A 228
GLU A 229
HIS A 232
HIS A 238
 None
None
ZN  A 999 (-3.1A)
ZN  A 999 ( 3.8A)
ZN  A 999 (-3.1A)
ZN  A 999 (-3.0A)
 0.47A 3hy7A-3lunA:
14.7		 3hy7A-3lunA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HY7_B_097B801_1
(A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 5)		 3lun ULILYSIN
(Methanosarcina
acetivorans) 		6 / 9 LEU A 188
THR A 225
HIS A 228
GLU A 229
HIS A 232
HIS A 238
 None
None
ZN  A 999 (-3.1A)
ZN  A 999 ( 3.8A)
ZN  A 999 (-3.1A)
ZN  A 999 (-3.0A)
 0.47A 3hy7B-3lunA:
14.9		 3hy7B-3lunA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW2_A_017A401_1
(GAG-POL POLYPROTEIN)		 3lun ULILYSIN
(Methanosarcina
acetivorans) 		6 / 12 ALA A 209
ASP A 207
VAL A 175
ILE A  93
VAL A 203
ILE A 205
 None
 1.31A 3jw2A-3lunA:
undetectable		 3jw2A-3lunA:
16.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_B_ROCB201_3
(HIV-1 PROTEASE)		 3lun ULILYSIN
(Methanosarcina
acetivorans) 		6 / 12 ALA A 209
ASP A 207
VAL A 175
ILE A  82
VAL A 203
ILE A 205
 None
 1.18A 3k4vB-3lunA:
undetectable		 3k4vB-3lunA:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_B_ROCB201_3
(HIV-1 PROTEASE)		 3lun ULILYSIN
(Methanosarcina
acetivorans) 		6 / 12 ALA A 209
ASP A 207
VAL A 175
ILE A  93
VAL A 203
ILE A 205
 None
 1.12A 3k4vB-3lunA:
undetectable		 3k4vB-3lunA:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_D_ROCD201_1
(HIV-1 PROTEASE)		 3lun ULILYSIN
(Methanosarcina
acetivorans) 		5 / 12 ALA A 209
ASP A 207
VAL A 175
ILE A  82
ILE A 205
 None
 0.87A 3k4vC-3lunA:
undetectable		 3k4vC-3lunA:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_D_ROCD201_1
(HIV-1 PROTEASE)		 3lun ULILYSIN
(Methanosarcina
acetivorans) 		6 / 12 ALA A 209
ASP A 207
VAL A 175
ILE A  93
VAL A 203
ILE A 205
 None
 1.13A 3k4vC-3lunA:
undetectable		 3k4vC-3lunA:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEC_A_HAEA272_1
(COLLAGENASE 3)		 3lun ULILYSIN
(Methanosarcina
acetivorans) 		4 / 5 HIS A 228
GLU A 229
HIS A 232
HIS A 238
 ZN  A 999 (-3.1A)
ZN  A 999 ( 3.8A)
ZN  A 999 (-3.1A)
ZN  A 999 (-3.0A)
 0.34A 3kecA-3lunA:
8.0		 3kecA-3lunA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEC_B_HAEB271_1
(COLLAGENASE 3)		 3lun ULILYSIN
(Methanosarcina
acetivorans) 		3 / 3 HIS A 228
GLU A 229
HIS A 232
 ZN  A 999 (-3.1A)
ZN  A 999 ( 3.8A)
ZN  A 999 (-3.1A)
 0.19A 3kecB-3lunA:
8.0		 3kecB-3lunA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LIK_A_HAEA302_1
(MACROPHAGE
METALLOELASTASE)		 3lun ULILYSIN
(Methanosarcina
acetivorans) 		4 / 5 HIS A 228
GLU A 229
HIS A 232
HIS A 238
 ZN  A 999 (-3.1A)
ZN  A 999 ( 3.8A)
ZN  A 999 (-3.1A)
ZN  A 999 (-3.0A)
 0.37A 3likA-3lunA:
8.6		 3likA-3lunA:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LIL_A_HAEA302_1
(MACROPHAGE
METALLOELASTASE)		 3lun ULILYSIN
(Methanosarcina
acetivorans) 		4 / 4 HIS A 228
GLU A 229
HIS A 232
HIS A 238
 ZN  A 999 (-3.1A)
ZN  A 999 ( 3.8A)
ZN  A 999 (-3.1A)
ZN  A 999 (-3.0A)
 0.38A 3lilA-3lunA:
8.5		 3lilA-3lunA:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LJG_A_HAEA301_1
(MACROPHAGE
METALLOELASTASE)		 3lun ULILYSIN
(Methanosarcina
acetivorans) 		5 / 5 ILE A 187
HIS A 228
GLU A 229
HIS A 232
HIS A 238
 None
ZN  A 999 (-3.1A)
ZN  A 999 ( 3.8A)
ZN  A 999 (-3.1A)
ZN  A 999 (-3.0A)
 0.51A 3ljgA-3lunA:
8.6		 3ljgA-3lunA:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LKA_A_HAEA269_1
(MACROPHAGE
METALLOELASTASE)		 3lun ULILYSIN
(Methanosarcina
acetivorans) 		4 / 5 HIS A 228
GLU A 229
HIS A 232
HIS A 238
 ZN  A 999 (-3.1A)
ZN  A 999 ( 3.8A)
ZN  A 999 (-3.1A)
ZN  A 999 (-3.0A)
 0.37A 3lkaA-3lunA:
8.4		 3lkaA-3lunA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LZS_A_017A200_1
(HIV-1 PROTEASE)		 3lun ULILYSIN
(Methanosarcina
acetivorans) 		5 / 12 ALA A 209
ASP A 207
VAL A 175
ILE A  93
ILE A 205
 None
 0.90A 3lzsA-3lunA:
undetectable		 3lzsA-3lunA:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LZS_A_017A200_2
(HIV-1 PROTEASE)		 3lun ULILYSIN
(Methanosarcina
acetivorans) 		5 / 12 ALA A 209
ASP A 207
VAL A 175
ILE A  93
ILE A 205
 None
 0.97A 3lzsB-3lunA:
undetectable		 3lzsB-3lunA:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LZU_A_017A200_1
(HIV-1 PROTEASE)		 3lun ULILYSIN
(Methanosarcina
acetivorans) 		5 / 12 ALA A 209
ASP A 207
VAL A 175
ILE A  93
ILE A 205
 None
 0.99A 3lzuA-3lunA:
undetectable		 3lzuA-3lunA:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MWS_B_017B201_2
(HIV-1 PROTEASE)		 3lun ULILYSIN
(Methanosarcina
acetivorans) 		5 / 12 ALA A 209
ASP A 207
VAL A 175
ILE A  93
ILE A 205
 None
 1.00A 3mwsB-3lunA:
undetectable		 3mwsB-3lunA:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDT_D_ROCD100_2
(PROTEASE)		 3lun ULILYSIN
(Methanosarcina
acetivorans) 		6 / 12 ALA A 209
ASP A 207
VAL A 175
ILE A  93
VAL A 203
ILE A 205
 None
 1.13A 3ndtD-3lunA:
undetectable		 3ndtD-3lunA:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU6_B_478B401_2
(PROTEASE)		 3lun ULILYSIN
(Methanosarcina
acetivorans) 		5 / 10 ALA A 209
ASP A 207
VAL A 175
ILE A  93
ILE A 205
 None
 0.93A 3nu6B-3lunA:
undetectable		 3nu6B-3lunA:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NUO_B_478B478_2
(PROTEASE)		 3lun ULILYSIN
(Methanosarcina
acetivorans) 		5 / 9 ALA A 209
ASP A 207
VAL A 175
ILE A  93
ILE A 205
 None
 0.94A 3nuoB-3lunA:
undetectable		 3nuoB-3lunA:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXC_A_ROCA401_1
(PROTEASE)		 3lun ULILYSIN
(Methanosarcina
acetivorans) 		5 / 12 ALA A 209
ASP A 207
VAL A 175
ILE A  82
ILE A 205
 None
 0.88A 3oxcA-3lunA:
undetectable		 3oxcA-3lunA:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXC_A_ROCA401_1
(PROTEASE)		 3lun ULILYSIN
(Methanosarcina
acetivorans) 		6 / 12 ALA A 209
ASP A 207
VAL A 175
ILE A  93
VAL A 203
ILE A 205
 None
 1.09A 3oxcA-3lunA:
undetectable		 3oxcA-3lunA:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXW_B_017B200_2
(HIV-1 PROTEASE)		 3lun ULILYSIN
(Methanosarcina
acetivorans) 		5 / 10 ALA A 209
ASP A 207
VAL A 175
ILE A  82
ILE A 205
 None
 1.04A 3oxwB-3lunA:
undetectable		 3oxwB-3lunA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWR_A_ROCA401_3
(PROTEASE)		 3lun ULILYSIN
(Methanosarcina
acetivorans) 		5 / 12 ALA A 209
ASP A 207
VAL A 175
ILE A  82
ILE A 205
 None
 0.88A 3pwrB-3lunA:
undetectable		 3pwrB-3lunA:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWR_A_ROCA401_3
(PROTEASE)		 3lun ULILYSIN
(Methanosarcina
acetivorans) 		5 / 12 ALA A 209
ASP A 207
VAL A 175
ILE A  93
ILE A 205
 None
 0.89A 3pwrB-3lunA:
undetectable		 3pwrB-3lunA:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S38_A_CUA803_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3lun ULILYSIN
(Methanosarcina
acetivorans) 		3 / 3 HIS A 238
HIS A 232
HIS A 228
 ZN  A 999 (-3.0A)
ZN  A 999 (-3.1A)
ZN  A 999 (-3.1A)
 0.76A 3s38A-3lunA:
undetectable		 3s38A-3lunA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKW_B_017B401_1
(PROTEASE)		 3lun ULILYSIN
(Methanosarcina
acetivorans) 		5 / 12 ALA A 209
ASP A 207
VAL A 175
ILE A  93
ILE A 205
 None
 0.97A 3tkwA-3lunA:
undetectable		 3tkwA-3lunA:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKW_B_017B401_2
(PROTEASE)		 3lun ULILYSIN
(Methanosarcina
acetivorans) 		6 / 12 ALA A 209
ASP A 207
VAL A 175
ILE A  82
VAL A 203
ILE A 205
 None
 1.25A 3tkwB-3lunA:
undetectable		 3tkwB-3lunA:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKW_B_017B401_2
(PROTEASE)		 3lun ULILYSIN
(Methanosarcina
acetivorans) 		6 / 12 ALA A 209
ASP A 207
VAL A 175
ILE A  93
VAL A 203
ILE A 205
 None
 1.23A 3tkwB-3lunA:
undetectable		 3tkwB-3lunA:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7B_A_HAEA1273_1
(COLLAGENASE 3)		 3lun ULILYSIN
(Methanosarcina
acetivorans) 		4 / 6 HIS A 228
GLU A 229
HIS A 232
HIS A 238
 ZN  A 999 (-3.1A)
ZN  A 999 ( 3.8A)
ZN  A 999 (-3.1A)
ZN  A 999 (-3.0A)
 0.29A 4a7bA-3lunA:
8.0		 4a7bA-3lunA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BZ6_B_SHHB700_1
(HISTONE DEACETYLASE
8)		 3lun ULILYSIN
(Methanosarcina
acetivorans) 		5 / 12 ASP A 242
HIS A 232
PRO A 265
HIS A 238
TYR A 292
 None
ZN  A 999 (-3.1A)
None
ZN  A 999 (-3.0A)
ZN  A 999 ( 4.9A)
 1.42A 4bz6A-3lunA:
undetectable
4bz6B-3lunA:
undetectable		 4bz6A-3lunA:
18.28
4bz6B-3lunA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQC_A_017A101_1
(ASPARTYL PROTEASE)		 3lun ULILYSIN
(Methanosarcina
acetivorans) 		6 / 10 ALA A 209
ASP A 207
VAL A 175
ILE A  93
VAL A 203
ILE A 205
 None
 1.23A 4dqcA-3lunA:
undetectable		 4dqcA-3lunA:
16.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQE_B_017B101_1
(ASPARTYL PROTEASE)		 3lun ULILYSIN
(Methanosarcina
acetivorans) 		6 / 11 ALA A 209
ASP A 207
VAL A 175
ILE A  93
VAL A 203
ILE A 205
 None
 1.22A 4dqeA-3lunA:
undetectable		 4dqeA-3lunA:
16.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQH_B_017B101_1
(WILD-TYPE HIV-1
PROTEASE DIMER)		 3lun ULILYSIN
(Methanosarcina
acetivorans) 		5 / 11 ALA A 209
ASP A 207
VAL A 175
ILE A  93
ILE A 205
 None
 0.99A 4dqhA-3lunA:
undetectable		 4dqhA-3lunA:
16.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KJL_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3lun ULILYSIN
(Methanosarcina
acetivorans) 		5 / 12 ILE A  82
ALA A 216
PHE A 210
ILE A  91
ILE A  87
 None
 1.05A 4kjlA-3lunA:
undetectable		 4kjlA-3lunA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LL3_A_017A202_2
(PROTEASE)		 3lun ULILYSIN
(Methanosarcina
acetivorans) 		5 / 9 ALA A 209
ASP A 207
VAL A 175
VAL A 203
ILE A 205
 None
 1.22A 4ll3B-3lunA:
undetectable		 4ll3B-3lunA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJV_D_RITD500_1
(PROTEASE)		 3lun ULILYSIN
(Methanosarcina
acetivorans) 		6 / 11 ASP A 207
VAL A  71
ILE A  87
GLY A 211
ILE A  93
ILE A 173
 None
 1.48A 4njvC-3lunA:
undetectable		 4njvC-3lunA:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGF_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 3lun ULILYSIN
(Methanosarcina
acetivorans) 		4 / 6 GLU A 229
THR A 225
HIS A 177
LEU A 179
 ZN  A 999 ( 3.8A)
None
None
None
 1.15A 4pgfA-3lunA:
undetectable		 4pgfA-3lunA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PTJ_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3lun ULILYSIN
(Methanosarcina
acetivorans) 		5 / 12 ILE A  82
ALA A 216
PHE A 210
ILE A  91
ILE A  87
 None
 1.05A 4ptjA-3lunA:
undetectable		 4ptjA-3lunA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5J_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3lun ULILYSIN
(Methanosarcina
acetivorans) 		5 / 12 ILE A  82
ALA A 216
PHE A 210
ILE A  91
ILE A  87
 None
 1.08A 4x5jA-3lunA:
undetectable		 4x5jA-3lunA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_A_SORA1342_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 3lun ULILYSIN
(Methanosarcina
acetivorans) 		4 / 7 ILE A 205
CYH A 176
LEU A 179
GLY A 189
 None
 0.75A 5a06A-3lunA:
undetectable		 5a06A-3lunA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_B_SORB1342_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 3lun ULILYSIN
(Methanosarcina
acetivorans) 		4 / 7 ILE A 205
CYH A 176
LEU A 179
GLY A 189
 None
 0.73A 5a06B-3lunA:
undetectable		 5a06B-3lunA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_C_SORC1342_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 3lun ULILYSIN
(Methanosarcina
acetivorans) 		4 / 7 ILE A 205
CYH A 176
LEU A 179
GLY A 189
 None
 0.75A 5a06C-3lunA:
undetectable		 5a06C-3lunA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_E_SORE1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 3lun ULILYSIN
(Methanosarcina
acetivorans) 		4 / 7 ILE A 205
CYH A 176
LEU A 179
GLY A 189
 None
 0.77A 5a06E-3lunA:
undetectable		 5a06E-3lunA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_F_SORF1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 3lun ULILYSIN
(Methanosarcina
acetivorans) 		4 / 7 ILE A 205
CYH A 176
LEU A 179
GLY A 189
 None
 0.75A 5a06F-3lunA:
undetectable		 5a06F-3lunA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K9D_A_ACTA405_0
(DIHYDROOROTATE
DEHYDROGENASE
(QUINONE),
MITOCHONDRIAL)		 3lun ULILYSIN
(Methanosarcina
acetivorans) 		3 / 3 GLN A 305
THR A 259
ASP A 254
 None
CA  A 998 (-3.6A)
CA  A 998 (-2.8A)
 0.56A 5k9dA-3lunA:
undetectable		 5k9dA-3lunA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQY_B_017B101_1
(PROTEASE E35D-DRV)		 3lun ULILYSIN
(Methanosarcina
acetivorans) 		5 / 12 ALA A 209
ASP A 207
VAL A 175
ILE A  93
ILE A 205
 None
 0.94A 5kqyA-3lunA:
undetectable		 5kqyA-3lunA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5J_A_HAEA306_1
(MACROPHAGE
METALLOELASTASE)		 3lun ULILYSIN
(Methanosarcina
acetivorans) 		4 / 4 HIS A 228
GLU A 229
HIS A 232
HIS A 238
 ZN  A 999 (-3.1A)
ZN  A 999 ( 3.8A)
ZN  A 999 (-3.1A)
ZN  A 999 (-3.0A)
 0.37A 5n5jA-3lunA:
8.6		 5n5jA-3lunA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5K_A_HAEA306_1
(MACROPHAGE
METALLOELASTASE)		 3lun ULILYSIN
(Methanosarcina
acetivorans) 		5 / 5 ILE A 187
HIS A 228
GLU A 229
HIS A 232
HIS A 238
 None
ZN  A 999 (-3.1A)
ZN  A 999 ( 3.8A)
ZN  A 999 (-3.1A)
ZN  A 999 (-3.0A)
 0.56A 5n5kA-3lunA:
8.7		 5n5kA-3lunA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T2Z_B_017B201_1
(PROTEASE)		 3lun ULILYSIN
(Methanosarcina
acetivorans) 		5 / 12 ALA A 209
ASP A 207
VAL A 175
ILE A  93
ILE A 205
 None
 0.95A 5t2zA-3lunA:
undetectable		 5t2zA-3lunA:
16.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DIF_B_TPVB201_1
(HIV-1 PROTEASE)		 3lun ULILYSIN
(Methanosarcina
acetivorans) 		5 / 12 GLY A 223
ILE A  82
ILE A  91
VAL A 203
ILE A 205
 None
 0.88A 6difB-3lunA:
undetectable		 6difB-3lunA:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DIL_B_TPVB201_1
(HIV-1 PROTEASE)		 3lun ULILYSIN
(Methanosarcina
acetivorans) 		6 / 12 GLY A 223
VAL A 175
ILE A  82
ILE A  91
VAL A 203
ILE A 205
 None
 1.28A 6dilB-3lunA:
undetectable		 6dilB-3lunA:
14.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
7DFR_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 3lun ULILYSIN
(Methanosarcina
acetivorans) 		5 / 12 ILE A  82
ALA A 216
PHE A 210
ILE A  91
ILE A  87
 None
 1.03A 7dfrA-3lunA:
undetectable		 7dfrA-3lunA:
21.51