SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3lup'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VM1_A_TAZA504_1
(BETA-LACTAMASE SHV-1)		 3lup DEGV FAMILY PROTEIN
(Streptococcus
agalactiae) 		3 / 3 ASP A  46
TYR A  49
GLU A  39
 None
 0.83A 1vm1A-3lupA:
undetectable		 1vm1A-3lupA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZGY_A_BRLA503_2
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 3lup DEGV FAMILY PROTEIN
(Streptococcus
agalactiae) 		4 / 5 ILE A 119
ILE A 100
ILE A  93
LEU A  85
 None
None
ELA  A 301 (-4.1A)
None
 0.84A 1zgyA-3lupA:
undetectable		 1zgyA-3lupA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F9W_A_PAUA6002_0
(PANTOTHENATE KINASE)		 3lup DEGV FAMILY PROTEIN
(Streptococcus
agalactiae) 		4 / 8 THR A 117
GLY A 125
THR A 279
ILE A 155
 None
 0.97A 2f9wA-3lupA:
3.8
2f9wB-3lupA:
undetectable		 2f9wA-3lupA:
21.78
2f9wB-3lupA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_D_SALD1300_1
(LYSR-TYPE REGULATORY
PROTEIN)		 3lup DEGV FAMILY PROTEIN
(Streptococcus
agalactiae) 		5 / 12 ILE A   6
GLY A  86
LEU A 103
PHE A  96
ILE A 100
 None
 1.16A 2y7kD-3lupA:
undetectable		 2y7kD-3lupA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C6G_A_VD3A701_1
(CYTOCHROME P450 2R1)		 3lup DEGV FAMILY PROTEIN
(Streptococcus
agalactiae) 		5 / 12 LEU A 167
ALA A 236
GLY A 270
ILE A 198
THR A 120
 None
None
None
None
ELA  A 301 (-4.4A)
 0.96A 3c6gA-3lupA:
undetectable		 3c6gA-3lupA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C6G_A_VD3A701_1
(CYTOCHROME P450 2R1)		 3lup DEGV FAMILY PROTEIN
(Streptococcus
agalactiae) 		5 / 12 LEU A 167
ALA A 275
ALA A 236
ILE A 198
THR A 120
 None
ELA  A 301 ( 4.2A)
None
None
ELA  A 301 (-4.4A)
 1.07A 3c6gA-3lupA:
undetectable		 3c6gA-3lupA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_B_D2VB602_1
(CYTOCHROME P450 2R1)		 3lup DEGV FAMILY PROTEIN
(Streptococcus
agalactiae) 		5 / 12 LEU A 167
ALA A 275
ALA A 236
ILE A 198
THR A 120
 None
ELA  A 301 ( 4.2A)
None
None
ELA  A 301 (-4.4A)
 1.09A 3czhB-3lupA:
undetectable		 3czhB-3lupA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EBZ_B_017B201_2
(PROTEASE)		 3lup DEGV FAMILY PROTEIN
(Streptococcus
agalactiae) 		5 / 11 ALA A 230
ILE A 278
VAL A 218
ILE A 159
ILE A 119
 None
 0.97A 3ebzB-3lupA:
undetectable		 3ebzB-3lupA:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QXY_A_SAMA6734_0
(N-LYSINE
METHYLTRANSFERASE
SETD6)		 3lup DEGV FAMILY PROTEIN
(Streptococcus
agalactiae) 		5 / 12 VAL A 161
ALA A 273
GLY A 272
TYR A  49
HIS A 268
 None
None
None
None
ELA  A 301 (-3.6A)
 1.11A 3qxyA-3lupA:
undetectable		 3qxyA-3lupA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RC0_B_SAMB480_0
(N-LYSINE
METHYLTRANSFERASE
SETD6)		 3lup DEGV FAMILY PROTEIN
(Streptococcus
agalactiae) 		5 / 12 VAL A 161
ALA A 273
GLY A 272
TYR A  49
HIS A 268
 None
None
None
None
ELA  A 301 (-3.6A)
 1.12A 3rc0B-3lupA:
undetectable		 3rc0B-3lupA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UM5_B_CP6B709_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3lup DEGV FAMILY PROTEIN
(Streptococcus
agalactiae) 		5 / 10 ILE A  28
VAL A  25
THR A 117
ILE A 119
ILE A  89
 ELA  A 301 ( 4.5A)
None
None
None
None
 1.19A 3um5B-3lupA:
undetectable		 3um5B-3lupA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WXO_A_NIZA802_1
(CATALASE-PEROXIDASE)		 3lup DEGV FAMILY PROTEIN
(Streptococcus
agalactiae) 		4 / 8 LEU A 110
ILE A 112
GLY A  86
ILE A   6
 None
 0.83A 3wxoA-3lupA:
undetectable		 3wxoA-3lupA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7A_B_RGZB601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 3lup DEGV FAMILY PROTEIN
(Streptococcus
agalactiae) 		5 / 12 LEU A  69
LEU A  72
LEU A  76
ILE A 112
ILE A   6
 None
GOL  A 302 ( 4.2A)
None
None
None
 0.97A 4a7aB-3lupA:
undetectable		 4a7aB-3lupA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EB4_D_D16D402_1
(THYMIDYLATE SYNTHASE)		 3lup DEGV FAMILY PROTEIN
(Streptococcus
agalactiae) 		5 / 10 PHE A  88
ILE A 100
GLY A  95
PHE A  96
LYS A 118
 None
 0.99A 4eb4D-3lupA:
undetectable		 4eb4D-3lupA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G48_B_1FLB1375_1
(DNA POLYMERASE III
SUBUNIT BETA)		 3lup DEGV FAMILY PROTEIN
(Streptococcus
agalactiae) 		5 / 9 LEU A  13
THR A   7
LEU A   5
PRO A 115
LEU A  85
 None
 1.37A 5g48B-3lupA:
undetectable		 5g48B-3lupA:
24.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KPC_A_SAMA401_0
(PAVINE
N-METHYLTRANSFERASE)		 3lup DEGV FAMILY PROTEIN
(Streptococcus
agalactiae) 		6 / 12 GLY A  86
LEU A  73
VAL A  84
ALA A   4
LEU A  85
ALA A 131
 None
 1.30A 5kpcA-3lupA:
undetectable		 5kpcA-3lupA:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L6E_A_SAMA601_0
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)		 3lup DEGV FAMILY PROTEIN
(Streptococcus
agalactiae) 		5 / 12 ILE A 100
PRO A  64
LEU A  26
PHE A  96
GLY A  95
 None
None
GOL  A 302 (-4.9A)
None
None
 1.17A 5l6eA-3lupA:
undetectable		 5l6eA-3lupA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_B_8NUB3001_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		 3lup DEGV FAMILY PROTEIN
(Streptococcus
agalactiae) 		4 / 5 ASP A 224
ILE A 217
PHE A 276
TYR A 227
 None
 1.00A 6a93B-3lupA:
undetectable		 6a93B-3lupA:
23.77