SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3luy'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_A_DVAA6_0
(GRAMICIDIN A)		 3luy PROBABLE CHORISMATE
MUTASE
(Bifidobacterium
adolescentis) 		3 / 3 ALA A 186
VAL A 188
TRP A  56
 None
 0.99A 1gmkA-3luyA:
undetectable
1gmkB-3luyA:
undetectable		 1gmkA-3luyA:
3.92
1gmkB-3luyA:
3.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_C_DVAC6_0
(GRAMICIDIN A)		 3luy PROBABLE CHORISMATE
MUTASE
(Bifidobacterium
adolescentis) 		3 / 3 ALA A 186
VAL A 188
TRP A  56
 None
 1.00A 1gmkC-3luyA:
undetectable
1gmkD-3luyA:
undetectable		 1gmkC-3luyA:
3.92
1gmkD-3luyA:
3.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PJ7_A_FFOA2887_1
(N,N-DIMETHYLGLYCINE
OXIDASE)		 3luy PROBABLE CHORISMATE
MUTASE
(Bifidobacterium
adolescentis) 		3 / 3 ASP A 255
THR A 253
GLU A  62
 None
 0.82A 1pj7A-3luyA:
undetectable		 1pj7A-3luyA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
209D_C_DVAC2_0
(N8-ACTINOMYCIN D)		 3luy PROBABLE CHORISMATE
MUTASE
(Bifidobacterium
adolescentis) 		3 / 3 THR A 111
PRO A 133
THR A 131
 None
 0.82A 209dC-3luyA:
undetectable		 209dC-3luyA:
4.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCT_B_ASDB1223_1
(GLUTATHIONE
S-TRANSFERASE A2)		 3luy PROBABLE CHORISMATE
MUTASE
(Bifidobacterium
adolescentis) 		4 / 8 ILE A  46
GLY A  57
LEU A   6
LEU A  37
 None
 0.89A 2vctB-3luyA:
undetectable		 2vctB-3luyA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_P_ASDP1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 3luy PROBABLE CHORISMATE
MUTASE
(Bifidobacterium
adolescentis) 		4 / 8 LEU A 180
ALA A  50
LEU A  47
ALA A  79
 None
 0.58A 2vcvP-3luyA:
undetectable		 2vcvP-3luyA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB2_A_DM5A602_1
(SERUM ALBUMIN)		 3luy PROBABLE CHORISMATE
MUTASE
(Bifidobacterium
adolescentis) 		4 / 7 PRO A 104
VAL A  98
ALA A  96
PHE A 123
 None
 1.08A 4lb2A-3luyA:
undetectable		 4lb2A-3luyA:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_A_SVRA205_2
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 3luy PROBABLE CHORISMATE
MUTASE
(Bifidobacterium
adolescentis) 		4 / 6 PHE A  30
LEU A 192
ASN A 200
PRO A 195
 None
 1.30A 4yv5B-3luyA:
undetectable		 4yv5B-3luyA:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5D_B_SAMB303_0
(METHYLTRANSFERASE)		 3luy PROBABLE CHORISMATE
MUTASE
(Bifidobacterium
adolescentis) 		5 / 12 VAL A 206
ILE A  58
GLU A 187
ALA A  23
ALA A  86
 None
 1.06A 5n5dB-3luyA:
undetectable		 5n5dB-3luyA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_H_RITH602_1
(CYTOCHROME P450 3A5)		 3luy PROBABLE CHORISMATE
MUTASE
(Bifidobacterium
adolescentis) 		5 / 12 LEU A  76
GLY A  53
PHE A  85
ALA A  86
GLY A  55
 None
 1.01A 5veuH-3luyA:
undetectable		 5veuH-3luyA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C06_D_FI8D1404_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		 3luy PROBABLE CHORISMATE
MUTASE
(Bifidobacterium
adolescentis) 		3 / 3 ARG A 244
LYS A 242
ARG A 185
 None
 1.04A 6c06D-3luyA:
undetectable		 6c06D-3luyA:
undetectable