SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3lv8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JJP_A_KLNA413_1
(CYTOCHROME P450
113A1)		 3lv8 THYMIDYLATE KINASE
(Vibrio
cholerae) 		5 / 12 ALA A  89
LEU A  88
ALA A  87
THR A  36
ILE A  32
 None
 1.25A 2jjpA-3lv8A:
undetectable		 2jjpA-3lv8A:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_A_AG2A672_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 3lv8 THYMIDYLATE KINASE
(Vibrio
cholerae) 		4 / 7 LEU A 175
ASP A 179
MET A 101
GLN A 104
 None
 1.06A 2qqcA-3lv8A:
undetectable
2qqcF-3lv8A:
undetectable		 2qqcA-3lv8A:
16.13
2qqcF-3lv8A:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RHM_B_BEZB194_0
(PUTATIVE KINASE)		 3lv8 THYMIDYLATE KINASE
(Vibrio
cholerae) 		4 / 5 ILE A 198
ARG A 199
ARG A 200
ASP A 197
 None
 1.33A 2rhmB-3lv8A:
10.8		 2rhmB-3lv8A:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXO_B_TACB1211_1
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)		 3lv8 THYMIDYLATE KINASE
(Vibrio
cholerae) 		5 / 11 LEU A  70
LEU A  63
LEU A 121
ILE A 157
ILE A 113
 None
None
None
TMP  A 214 (-3.3A)
None
 1.21A 2uxoB-3lv8A:
undetectable		 2uxoB-3lv8A:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_A_CHDA151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 3lv8 THYMIDYLATE KINASE
(Vibrio
cholerae) 		4 / 7 ILE A 113
GLY A 110
VAL A  72
ARG A 156
 None
None
TYD  A 215 (-4.1A)
None
 0.91A 3elzA-3lv8A:
undetectable		 3elzA-3lv8A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_C_RTZC1_1
(CYTOCHROME P450 2D6)		 3lv8 THYMIDYLATE KINASE
(Vibrio
cholerae) 		5 / 12 GLY A  10
LEU A  11
GLU A  12
SER A 102
PHE A 165
 None
None
TYD  A 215 (-2.8A)
TMP  A 214 ( 4.2A)
None
 1.29A 3tbgC-3lv8A:
undetectable		 3tbgC-3lv8A:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_A_CHDA1503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3lv8 THYMIDYLATE KINASE
(Vibrio
cholerae) 		4 / 8 ILE A 198
LEU A 202
VAL A  95
GLY A  96
 None
 0.89A 3w1wA-3lv8A:
undetectable		 3w1wA-3lv8A:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRI_B_CAMB502_0
(CAMPHOR
5-MONOOXYGENASE)		 3lv8 THYMIDYLATE KINASE
(Vibrio
cholerae) 		4 / 5 GLY A  42
THR A  44
ILE A  84
VAL A  83
 None
 0.91A 3wriB-3lv8A:
undetectable		 3wriB-3lv8A:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LG1_A_SAMA301_0
(PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21D)		 3lv8 THYMIDYLATE KINASE
(Vibrio
cholerae) 		5 / 12 ALA A 188
GLY A  13
GLY A 144
LEU A 145
ALA A 187
 None
ADP  A 213 (-3.4A)
None
None
None
 1.11A 4lg1A-3lv8A:
undetectable		 4lg1A-3lv8A:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LG1_B_SAMB301_0
(PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21D)		 3lv8 THYMIDYLATE KINASE
(Vibrio
cholerae) 		5 / 12 ALA A 188
GLY A  13
GLY A 144
LEU A 145
ALA A 187
 None
ADP  A 213 (-3.4A)
None
None
None
 1.14A 4lg1B-3lv8A:
undetectable		 4lg1B-3lv8A:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LG1_C_SAMC301_0
(PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21D)		 3lv8 THYMIDYLATE KINASE
(Vibrio
cholerae) 		5 / 12 ALA A 188
GLY A  13
GLY A 144
LEU A 145
ALA A 187
 None
ADP  A 213 (-3.4A)
None
None
None
 1.11A 4lg1C-3lv8A:
undetectable		 4lg1C-3lv8A:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5PHH_A_LDPA414_1
(LYSINE-SPECIFIC
DEMETHYLASE 4D)		 3lv8 THYMIDYLATE KINASE
(Vibrio
cholerae) 		4 / 6 GLU A  12
ALA A  14
LEU A  11
TYR A 106
 TYD  A 215 (-2.8A)
ADP  A 213 (-4.2A)
None
TYD  A 215 ( 3.8A)
 1.11A 5phhA-3lv8A:
undetectable		 5phhA-3lv8A:
27.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_F_CVIF301_1
(REGULATORY PROTEIN
TETR)		 3lv8 THYMIDYLATE KINASE
(Vibrio
cholerae) 		4 / 8 ILE A 157
ARG A 156
VAL A  72
ASP A  65
 TMP  A 214 (-3.3A)
None
TYD  A 215 (-4.1A)
CL  A 222 ( 4.7A)
 1.10A 5vlmF-3lv8A:
1.4		 5vlmF-3lv8A:
21.58