SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3lvr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_A_HLTA4001_1
(SERUM ALBUMIN)		 3lvr ARF-GAP WITH SH3
DOMAIN, ANK REPEAT
AND PH
DOMAIN-CONTAINING
PROTEIN 3,
ADP-RIBOSYLATION
FACTOR 6
(Homo
sapiens;
synthetic
construct) 		4 / 5 ARG E  95
ALA E  99
ASP E  22
GLY E  20
 None
None
CA  E 739 (-4.9A)
None
 1.10A 1e7bA-3lvrE:
undetectable		 1e7bA-3lvrE:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4001_1
(SERUM ALBUMIN)		 3lvr ARF-GAP WITH SH3
DOMAIN, ANK REPEAT
AND PH
DOMAIN-CONTAINING
PROTEIN 3,
ADP-RIBOSYLATION
FACTOR 6
(Homo
sapiens;
synthetic
construct) 		4 / 5 ARG E  95
ALA E  99
ASP E  22
GLY E  20
 None
None
CA  E 739 (-4.9A)
None
 1.16A 1e7cA-3lvrE:
undetectable		 1e7cA-3lvrE:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_A_ACTA3003_0
(BETA-CARBONIC
ANHYDRASE)		 3lvr ARF-GAP WITH SH3
DOMAIN, ANK REPEAT
AND PH
DOMAIN-CONTAINING
PROTEIN 3,
ADP-RIBOSYLATION
FACTOR 6
(Homo
sapiens;
synthetic
construct) 		4 / 8 CYH E 464
ASP E 443
CYH E 441
GLY E 445
 ZN  E 735 (-2.2A)
None
ZN  E 735 (-2.4A)
None
 0.99A 1ekjA-3lvrE:
undetectable
1ekjB-3lvrE:
2.6		 1ekjA-3lvrE:
17.14
1ekjB-3lvrE:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OQ5_A_CELA701_1
(CARBONIC ANHYDRASE
II)		 3lvr ARF-GAP WITH SH3
DOMAIN, ANK REPEAT
AND PH
DOMAIN-CONTAINING
PROTEIN 3,
ADP-RIBOSYLATION
FACTOR 6
(Homo
sapiens;
synthetic
construct) 		5 / 12 ASN E 455
HIS E 468
VAL E 432
LEU E 459
THR E 460
 None
 1.13A 1oq5A-3lvrE:
undetectable		 1oq5A-3lvrE:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S14_A_NOVA1300_1
(TOPOISOMERASE IV
SUBUNIT B)		 3lvr ARF-GAP WITH SH3
DOMAIN, ANK REPEAT
AND PH
DOMAIN-CONTAINING
PROTEIN 3,
ADP-RIBOSYLATION
FACTOR 6
(Homo
sapiens;
synthetic
construct) 		5 / 12 GLU E 102
ARG E 105
PRO E  72
ILE E  70
ARG E  75
 None
 1.39A 1s14A-3lvrE:
undetectable		 1s14A-3lvrE:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S14_B_NOVB2300_1
(TOPOISOMERASE IV
SUBUNIT B)		 3lvr ARF-GAP WITH SH3
DOMAIN, ANK REPEAT
AND PH
DOMAIN-CONTAINING
PROTEIN 3,
ADP-RIBOSYLATION
FACTOR 6
(Homo
sapiens;
synthetic
construct) 		5 / 12 GLU E 102
ARG E 105
PRO E  72
ILE E  70
ARG E  75
 None
 1.41A 1s14B-3lvrE:
undetectable		 1s14B-3lvrE:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q0I_A_BEZA990_0
(QUINOLONE SIGNAL
RESPONSE PROTEIN)		 3lvr ARF-GAP WITH SH3
DOMAIN, ANK REPEAT
AND PH
DOMAIN-CONTAINING
PROTEIN 3,
ADP-RIBOSYLATION
FACTOR 6
(Homo
sapiens;
synthetic
construct) 		4 / 8 ASP E 443
LEU E 456
HIS E 468
HIS E 538
 None
 0.72A 2q0iA-3lvrE:
undetectable		 2q0iA-3lvrE:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_A_CHDA702_0
(FERROCHELATASE)		 3lvr ARF-GAP WITH SH3
DOMAIN, ANK REPEAT
AND PH
DOMAIN-CONTAINING
PROTEIN 3,
ADP-RIBOSYLATION
FACTOR 6
(Homo
sapiens;
synthetic
construct) 		3 / 3 LEU E 577
PRO E 578
ARG E 550
 None
 0.66A 2qd5A-3lvrE:
4.7		 2qd5A-3lvrE:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRH_A_NIOA200_1
(PROTEIN HP0721)		 3lvr ARF-GAP WITH SH3
DOMAIN, ANK REPEAT
AND PH
DOMAIN-CONTAINING
PROTEIN 3,
ADP-RIBOSYLATION
FACTOR 6
(Homo
sapiens;
synthetic
construct) 		4 / 7 GLY E 165
ILE E  85
MET E  14
LEU E 166
 None
 1.02A 2xrhA-3lvrE:
undetectable		 2xrhA-3lvrE:
12.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G1U_C_ADNC438_1
(ADENOSYLHOMOCYSTEINA
SE)		 3lvr ARF-GAP WITH SH3
DOMAIN, ANK REPEAT
AND PH
DOMAIN-CONTAINING
PROTEIN 3,
ADP-RIBOSYLATION
FACTOR 6
(Homo
sapiens;
synthetic
construct) 		5 / 12 LEU E 486
GLU E 490
LYS E 643
LEU E 495
GLY E 457
 None
 1.43A 3g1uC-3lvrE:
undetectable		 3g1uC-3lvrE:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PYY_B_STIB4_2
(V-ABL ABELSON MURINE
LEUKEMIA VIRAL
ONCOGENE HOMOLOG 1
ISOFORM B VARIANT)		 3lvr ARF-GAP WITH SH3
DOMAIN, ANK REPEAT
AND PH
DOMAIN-CONTAINING
PROTEIN 3,
ADP-RIBOSYLATION
FACTOR 6
(Homo
sapiens;
synthetic
construct) 		4 / 5 VAL E  88
ILE E  29
MET E  14
ARG E  71
 None
None
None
CA  E 739 ( 4.3A)
 1.50A 3pyyB-3lvrE:
undetectable		 3pyyB-3lvrE:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCJ_A_AZMA229_1
(CARBONIC ANHYDRASE)		 3lvr ARF-GAP WITH SH3
DOMAIN, ANK REPEAT
AND PH
DOMAIN-CONTAINING
PROTEIN 3,
ADP-RIBOSYLATION
FACTOR 6
(Homo
sapiens;
synthetic
construct) 		5 / 10 CYH E 464
ASP E 443
CYH E 441
GLY E 445
ALA E 446
 ZN  E 735 (-2.2A)
None
ZN  E 735 (-2.4A)
None
ZN  E 735 ( 4.4A)
 1.17A 3ucjA-3lvrE:
4.3		 3ucjA-3lvrE:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCJ_B_AZMB229_2
(CARBONIC ANHYDRASE)		 3lvr ARF-GAP WITH SH3
DOMAIN, ANK REPEAT
AND PH
DOMAIN-CONTAINING
PROTEIN 3,
ADP-RIBOSYLATION
FACTOR 6
(Homo
sapiens;
synthetic
construct) 		5 / 10 CYH E 464
ASP E 443
CYH E 441
GLY E 445
ALA E 446
 ZN  E 735 (-2.2A)
None
ZN  E 735 (-2.4A)
None
ZN  E 735 ( 4.4A)
 1.13A 3ucjB-3lvrE:
undetectable		 3ucjB-3lvrE:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AX8_A_SAMA1474_0
(WBDD)		 3lvr ARF-GAP WITH SH3
DOMAIN, ANK REPEAT
AND PH
DOMAIN-CONTAINING
PROTEIN 3,
ADP-RIBOSYLATION
FACTOR 6
(Homo
sapiens;
synthetic
construct) 		5 / 12 GLY E  25
ALA E  23
ILE E  29
VAL E  87
ILE E  85
 GDP  E 737 (-3.2A)
GDP  E 737 ( 4.4A)
None
None
None
 0.86A 4ax8A-3lvrE:
3.0		 4ax8A-3lvrE:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZT_A_SAMA1472_0
(METHYLTRANSFERASE
WBDD)		 3lvr ARF-GAP WITH SH3
DOMAIN, ANK REPEAT
AND PH
DOMAIN-CONTAINING
PROTEIN 3,
ADP-RIBOSYLATION
FACTOR 6
(Homo
sapiens;
synthetic
construct) 		5 / 12 GLY E  25
ALA E  23
ILE E  29
VAL E  87
ILE E  85
 GDP  E 737 (-3.2A)
GDP  E 737 ( 4.4A)
None
None
None
 0.86A 4aztA-3lvrE:
2.5		 4aztA-3lvrE:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZV_A_SAMA1474_0
(WBDD)		 3lvr ARF-GAP WITH SH3
DOMAIN, ANK REPEAT
AND PH
DOMAIN-CONTAINING
PROTEIN 3,
ADP-RIBOSYLATION
FACTOR 6
(Homo
sapiens;
synthetic
construct) 		5 / 12 GLY E  25
ALA E  23
ILE E  29
VAL E  87
ILE E  85
 GDP  E 737 (-3.2A)
GDP  E 737 ( 4.4A)
None
None
None
 0.84A 4azvA-3lvrE:
3.3		 4azvA-3lvrE:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MA8_C_Z80C301_1
(MAJOR PRION PROTEIN)		 3lvr ARF-GAP WITH SH3
DOMAIN, ANK REPEAT
AND PH
DOMAIN-CONTAINING
PROTEIN 3,
ADP-RIBOSYLATION
FACTOR 6
(Homo
sapiens;
synthetic
construct) 		4 / 5 LEU E 166
GLY E 165
ILE E  29
LYS E  32
 None
 1.08A 4ma8C-3lvrE:
undetectable		 4ma8C-3lvrE:
11.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UW0_A_SAMA1506_0
(WBDD)		 3lvr ARF-GAP WITH SH3
DOMAIN, ANK REPEAT
AND PH
DOMAIN-CONTAINING
PROTEIN 3,
ADP-RIBOSYLATION
FACTOR 6
(Homo
sapiens;
synthetic
construct) 		5 / 12 GLY E  25
ALA E  23
ILE E  29
VAL E  87
ILE E  85
 GDP  E 737 (-3.2A)
GDP  E 737 ( 4.4A)
None
None
None
 1.00A 4uw0A-3lvrE:
2.2		 4uw0A-3lvrE:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SXQ_B_NIZB808_1
(CATALASE-PEROXIDASE)		 3lvr ARF-GAP WITH SH3
DOMAIN, ANK REPEAT
AND PH
DOMAIN-CONTAINING
PROTEIN 3,
ADP-RIBOSYLATION
FACTOR 6
(Homo
sapiens;
synthetic
construct) 		4 / 8 VAL E  61
GLY E 165
LEU E 169
THR E 167
 None
 1.02A 5sxqB-3lvrE:
undetectable		 5sxqB-3lvrE:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYJ_A_NIZA809_1
(CATALASE-PEROXIDASE)		 3lvr ARF-GAP WITH SH3
DOMAIN, ANK REPEAT
AND PH
DOMAIN-CONTAINING
PROTEIN 3,
ADP-RIBOSYLATION
FACTOR 6
(Homo
sapiens;
synthetic
construct) 		4 / 8 VAL E  61
GLY E 165
LEU E 169
THR E 167
 None
 1.02A 5syjA-3lvrE:
undetectable		 5syjA-3lvrE:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYJ_B_NIZB809_1
(CATALASE-PEROXIDASE)		 3lvr ARF-GAP WITH SH3
DOMAIN, ANK REPEAT
AND PH
DOMAIN-CONTAINING
PROTEIN 3,
ADP-RIBOSYLATION
FACTOR 6
(Homo
sapiens;
synthetic
construct) 		4 / 8 VAL E  61
GLY E 165
LEU E 169
THR E 167
 None
 1.00A 5syjB-3lvrE:
undetectable		 5syjB-3lvrE:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6APH_A_ADNA501_1
(ADENOSYLHOMOCYSTEINA
SE)		 3lvr ARF-GAP WITH SH3
DOMAIN, ANK REPEAT
AND PH
DOMAIN-CONTAINING
PROTEIN 3,
ADP-RIBOSYLATION
FACTOR 6
(Homo
sapiens;
synthetic
construct) 		5 / 12 LEU E 486
GLU E 490
LYS E 643
LEU E 495
GLY E 457
 None
 1.46A 6aphA-3lvrE:
5.8		 6aphA-3lvrE:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_B_ADNB501_1
(-)		 3lvr ARF-GAP WITH SH3
DOMAIN, ANK REPEAT
AND PH
DOMAIN-CONTAINING
PROTEIN 3,
ADP-RIBOSYLATION
FACTOR 6
(Homo
sapiens;
synthetic
construct) 		5 / 12 LEU E 486
GLU E 490
LYS E 643
LEU E 495
GLY E 457
 None
 1.39A 6gbnB-3lvrE:
2.9		 6gbnB-3lvrE:
20.53