SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3lvu'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_A_SAMA1001_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 3lvu ABC TRANSPORTER,
PERIPLASMIC
SUBSTRATE-BINDING
PROTEIN
(Ruegeria
pomeroyi) 		5 / 12 ALA A 421
ALA A 335
PRO A 326
GLY A 432
GLY A 422
 None
None
GOL  A 604 ( 4.6A)
GOL  A 604 (-3.2A)
None
 1.16A 2igtA-3lvuA:
undetectable		 2igtA-3lvuA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_B_SAMB1002_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 3lvu ABC TRANSPORTER,
PERIPLASMIC
SUBSTRATE-BINDING
PROTEIN
(Ruegeria
pomeroyi) 		5 / 12 ALA A 421
ALA A 335
PRO A 326
GLY A 432
GLY A 422
 None
None
GOL  A 604 ( 4.6A)
GOL  A 604 (-3.2A)
None
 1.14A 2igtB-3lvuA:
undetectable		 2igtB-3lvuA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQT_A_30ZA1920_1
(ANDROGEN RECEPTOR)		 3lvu ABC TRANSPORTER,
PERIPLASMIC
SUBSTRATE-BINDING
PROTEIN
(Ruegeria
pomeroyi) 		4 / 6 PRO A 501
GLY A 502
ASN A 503
LEU A 538
 None
 0.84A 3zqtA-3lvuA:
undetectable		 3zqtA-3lvuA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IJI_H_BEZH501_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN YIBF)		 3lvu ABC TRANSPORTER,
PERIPLASMIC
SUBSTRATE-BINDING
PROTEIN
(Ruegeria
pomeroyi) 		4 / 7 ASN A 521
ALA A 525
VAL A 563
ARG A 333
 None
 1.14A 4ijiH-3lvuA:
undetectable		 4ijiH-3lvuA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PXM_B_ESTB2000_1
(ESTROGEN RECEPTOR)		 3lvu ABC TRANSPORTER,
PERIPLASMIC
SUBSTRATE-BINDING
PROTEIN
(Ruegeria
pomeroyi) 		5 / 11 LEU A 338
ALA A 339
LEU A 411
ILE A 425
GLY A 466
 None
 1.23A 4pxmB-3lvuA:
undetectable		 4pxmB-3lvuA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z90_F_4LEF402_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 3lvu ABC TRANSPORTER,
PERIPLASMIC
SUBSTRATE-BINDING
PROTEIN
(Ruegeria
pomeroyi) 		5 / 7 LEU A 440
LEU A 462
ALA A 339
ALA A 335
LEU A 438
 None
None
None
None
GOL  A 604 (-4.5A)
 1.46A 4z90F-3lvuA:
undetectable
4z90G-3lvuA:
undetectable
4z90H-3lvuA:
undetectable
4z90J-3lvuA:
undetectable		 4z90F-3lvuA:
21.88
4z90G-3lvuA:
21.88
4z90H-3lvuA:
21.88
4z90J-3lvuA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND7_B_TA1B601_2
(TUBULIN BETA-2B
CHAIN)		 3lvu ABC TRANSPORTER,
PERIPLASMIC
SUBSTRATE-BINDING
PROTEIN
(Ruegeria
pomeroyi) 		3 / 3 THR A 364
PRO A 355
ARG A 356
 None
 0.68A 5nd7B-3lvuA:
undetectable		 5nd7B-3lvuA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_C_RFPC502_1
(RIFAMPIN
MONOOXYGENASE)		 3lvu ABC TRANSPORTER,
PERIPLASMIC
SUBSTRATE-BINDING
PROTEIN
(Ruegeria
pomeroyi) 		5 / 12 MET A 315
ARG A 333
PRO A 389
THR A 392
GLY A 391
 None
 1.04A 6brdC-3lvuA:
undetectable		 6brdC-3lvuA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_B_HISB402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 3lvu ABC TRANSPORTER,
PERIPLASMIC
SUBSTRATE-BINDING
PROTEIN
(Ruegeria
pomeroyi) 		5 / 9 VAL A 319
ASN A 321
LEU A 522
GLY A 515
LEU A 486
 None
 1.34A 6czmA-3lvuA:
undetectable
6czmB-3lvuA:
undetectable		 6czmA-3lvuA:
22.03
6czmB-3lvuA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_C_HISC402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 3lvu ABC TRANSPORTER,
PERIPLASMIC
SUBSTRATE-BINDING
PROTEIN
(Ruegeria
pomeroyi) 		5 / 9 VAL A 319
ASN A 321
LEU A 522
GLY A 515
LEU A 486
 None
 1.34A 6czmB-3lvuA:
undetectable
6czmC-3lvuA:
1.1		 6czmB-3lvuA:
22.03
6czmC-3lvuA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_E_HISE402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 3lvu ABC TRANSPORTER,
PERIPLASMIC
SUBSTRATE-BINDING
PROTEIN
(Ruegeria
pomeroyi) 		5 / 9 VAL A 319
ASN A 321
LEU A 522
GLY A 515
LEU A 486
 None
 1.33A 6czmD-3lvuA:
undetectable
6czmE-3lvuA:
2.6		 6czmD-3lvuA:
22.03
6czmE-3lvuA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IE8_A_CHDA201_0
(REGULATORY PROTEIN)		 3lvu ABC TRANSPORTER,
PERIPLASMIC
SUBSTRATE-BINDING
PROTEIN
(Ruegeria
pomeroyi) 		5 / 12 LEU A 490
ILE A 467
LEU A 418
ARG A 331
LEU A 337
 None
 1.05A 6ie8A-3lvuA:
undetectable		 6ie8A-3lvuA:
24.72