SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3lvv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHF_A_FOLA187_0
(DIHYDROFOLATE
REDUCTASE)		 3lvv GLUTAMATE--CYSTEINE
LIGASE
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 553
ALA A 603
PHE A 562
GLN A 564
ILE A 493
 None
 1.17A 1dhfA-3lvvA:
undetectable		 1dhfA-3lvvA:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E6W_C_ESTC302_1
(SHORT CHAIN
3-HYDROXYACYL-COA
DEHYDROGENASE)		 3lvv GLUTAMATE--CYSTEINE
LIGASE
(Saccharomyces
cerevisiae) 		4 / 4 ALA A 485
GLN A 477
TYR A 486
LEU A 659
 None
 1.41A 1e6wC-3lvvA:
undetectable		 1e6wC-3lvvA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EIZ_A_SAMA301_1
(FTSJ)		 3lvv GLUTAMATE--CYSTEINE
LIGASE
(Saccharomyces
cerevisiae) 		3 / 3 ASP A 166
ASP A  59
ASP A 172
 PGE  A 698 (-4.3A)
None
None
 0.69A 1eizA-3lvvA:
undetectable		 1eizA-3lvvA:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EJ0_A_SAMA301_1
(FTSJ)		 3lvv GLUTAMATE--CYSTEINE
LIGASE
(Saccharomyces
cerevisiae) 		3 / 3 ASP A 166
ASP A  59
ASP A 172
 PGE  A 698 (-4.3A)
None
None
 0.75A 1ej0A-3lvvA:
undetectable		 1ej0A-3lvvA:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NW3_A_SAMA500_0
(HISTONE
METHYLTRANSFERASE
DOT1L)		 3lvv GLUTAMATE--CYSTEINE
LIGASE
(Saccharomyces
cerevisiae) 		5 / 12 GLY A  38
ALA A 457
PHE A  34
LEU A  30
ASN A 275
 None
 1.21A 1nw3A-3lvvA:
undetectable		 1nw3A-3lvvA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q97_B_ADNB486_1
(SR PROTEIN KINASE)		 3lvv GLUTAMATE--CYSTEINE
LIGASE
(Saccharomyces
cerevisiae) 		4 / 4 VAL A 158
ALA A 302
LEU A 638
PHE A 614
 None
 1.25A 1q97B-3lvvA:
0.0		 1q97B-3lvvA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T9W_A_NFNA6002_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 3lvv GLUTAMATE--CYSTEINE
LIGASE
(Saccharomyces
cerevisiae) 		4 / 7 GLN A 477
ALA A 611
PHE A 296
GLU A 482
 None
 1.25A 1t9wA-3lvvA:
3.6		 1t9wA-3lvvA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_A_SAMA301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 3lvv GLUTAMATE--CYSTEINE
LIGASE
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 659
LEU A 607
ARG A 591
ALA A 485
ALA A 484
 None
 1.17A 2bm9A-3lvvA:
undetectable		 2bm9A-3lvvA:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JJ8_C_AZZC1211_1
(DEOXYNUCLEOSIDE
KINASE)		 3lvv GLUTAMATE--CYSTEINE
LIGASE
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 276
LEU A  30
PHE A 437
GLN A 441
PHE A 450
 None
 1.30A 2jj8C-3lvvA:
undetectable		 2jj8C-3lvvA:
16.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1498_1
(CYTOCHROME P450 3A4)		 3lvv GLUTAMATE--CYSTEINE
LIGASE
(Saccharomyces
cerevisiae) 		5 / 9 ARG A 324
SER A 360
LEU A 200
ALA A 320
GLY A 209
 None
 1.21A 2v0mB-3lvvA:
undetectable		 2v0mB-3lvvA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XNR_A_ACTA1001_0
(NUCLEAR
POLYADENYLATED
RNA-BINDING PROTEIN
3)		 3lvv GLUTAMATE--CYSTEINE
LIGASE
(Saccharomyces
cerevisiae) 		3 / 3 SER A 297
ARG A 602
GLN A 477
 None
 0.95A 2xnrA-3lvvA:
1.3		 2xnrA-3lvvA:
8.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGP_A_PCFA1213_0
(WNT INHIBITORY
FACTOR 1)		 3lvv GLUTAMATE--CYSTEINE
LIGASE
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 561
LEU A 489
ILE A 553
PHE A 471
VAL A 513
 None
 1.15A 2ygpA-3lvvA:
undetectable		 2ygpA-3lvvA:
14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGQ_A_PCFA1275_0
(WNT INHIBITORY
FACTOR 1)		 3lvv GLUTAMATE--CYSTEINE
LIGASE
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 561
LEU A 489
ILE A 553
PHE A 471
VAL A 513
 None
 1.02A 2ygqA-3lvvA:
undetectable		 2ygqA-3lvvA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZVJ_A_SAMA301_1
(CATECHOL
O-METHYLTRANSFERASE)		 3lvv GLUTAMATE--CYSTEINE
LIGASE
(Saccharomyces
cerevisiae) 		4 / 6 TYR A 507
SER A 536
GLN A 564
ASP A 540
 None
 1.22A 2zvjA-3lvvA:
undetectable		 2zvjA-3lvvA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A9E_B_REAB1_1
(RETINOIC ACID
RECEPTOR ALPHA)		 3lvv GLUTAMATE--CYSTEINE
LIGASE
(Saccharomyces
cerevisiae) 		5 / 11 ILE A 504
ARG A 538
PHE A 565
VAL A 469
LEU A 448
 None
 1.41A 3a9eB-3lvvA:
undetectable		 3a9eB-3lvvA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWM_A_SAMA301_0
(CATECHOL
O-METHYLTRANSFERASE)		 3lvv GLUTAMATE--CYSTEINE
LIGASE
(Saccharomyces
cerevisiae) 		5 / 12 VAL A 158
GLY A 259
ILE A 191
ASN A 192
SER A 181
 None
 1.09A 3bwmA-3lvvA:
undetectable		 3bwmA-3lvvA:
14.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DOU_A_SAMA1_1
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 3lvv GLUTAMATE--CYSTEINE
LIGASE
(Saccharomyces
cerevisiae) 		3 / 3 ASP A 166
ASP A  59
ASP A 172
 PGE  A 698 (-4.3A)
None
None
 0.66A 3douA-3lvvA:
undetectable		 3douA-3lvvA:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQA_A_DX4A270_0
(PTERIDINE REDUCTASE
1)		 3lvv GLUTAMATE--CYSTEINE
LIGASE
(Saccharomyces
cerevisiae) 		4 / 6 ARG A 313
PHE A 474
TYR A 486
PRO A 473
 LBP  A 693 (-4.2A)
None
None
None
 1.22A 3jqaA-3lvvA:
undetectable		 3jqaA-3lvvA:
18.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQA_B_DX4B270_0
(PTERIDINE REDUCTASE
1)		 3lvv GLUTAMATE--CYSTEINE
LIGASE
(Saccharomyces
cerevisiae) 		4 / 6 ARG A 313
PHE A 474
TYR A 486
PRO A 473
 LBP  A 693 (-4.2A)
None
None
None
 1.31A 3jqaB-3lvvA:
undetectable		 3jqaB-3lvvA:
18.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQA_C_DX4C270_0
(PTERIDINE REDUCTASE
1)		 3lvv GLUTAMATE--CYSTEINE
LIGASE
(Saccharomyces
cerevisiae) 		4 / 6 ARG A 313
PHE A 474
TYR A 486
PRO A 473
 LBP  A 693 (-4.2A)
None
None
None
 1.19A 3jqaC-3lvvA:
undetectable		 3jqaC-3lvvA:
18.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQA_D_DX4D270_0
(PTERIDINE REDUCTASE
1)		 3lvv GLUTAMATE--CYSTEINE
LIGASE
(Saccharomyces
cerevisiae) 		4 / 6 ARG A 313
PHE A 474
TYR A 486
PRO A 473
 LBP  A 693 (-4.2A)
None
None
None
 1.18A 3jqaD-3lvvA:
undetectable		 3jqaD-3lvvA:
18.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_D_TFPD201_1
(PROTEIN S100-A4)		 3lvv GLUTAMATE--CYSTEINE
LIGASE
(Saccharomyces
cerevisiae) 		4 / 8 GLY A 371
PHE A 437
PHE A 450
PHE A 410
 None
 0.92A 3ko0D-3lvvA:
undetectable
3ko0E-3lvvA:
undetectable		 3ko0D-3lvvA:
10.31
3ko0E-3lvvA:
10.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_J_TFPJ201_1
(PROTEIN S100-A4)		 3lvv GLUTAMATE--CYSTEINE
LIGASE
(Saccharomyces
cerevisiae) 		4 / 8 PHE A 450
PHE A 410
GLY A 371
PHE A 437
 None
 1.04A 3ko0B-3lvvA:
undetectable
3ko0J-3lvvA:
undetectable		 3ko0B-3lvvA:
10.31
3ko0J-3lvvA:
10.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_S_TFPS201_1
(PROTEIN S100-A4)		 3lvv GLUTAMATE--CYSTEINE
LIGASE
(Saccharomyces
cerevisiae) 		4 / 7 PHE A 450
PHE A 410
GLY A 371
PHE A 437
 None
 1.04A 3ko0K-3lvvA:
undetectable
3ko0S-3lvvA:
undetectable		 3ko0K-3lvvA:
10.31
3ko0S-3lvvA:
10.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_T_TFPT201_1
(PROTEIN S100-A4)		 3lvv GLUTAMATE--CYSTEINE
LIGASE
(Saccharomyces
cerevisiae) 		4 / 7 PHE A 450
PHE A 410
GLY A 371
PHE A 437
 None
 1.11A 3ko0R-3lvvA:
undetectable
3ko0T-3lvvA:
undetectable		 3ko0R-3lvvA:
10.31
3ko0T-3lvvA:
10.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M8P_A_65BA562_0
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H
P51 RT)		 3lvv GLUTAMATE--CYSTEINE
LIGASE
(Saccharomyces
cerevisiae) 		5 / 11 LEU A 645
VAL A 667
PHE A 481
LEU A 479
GLU A 654
 None
 1.38A 3m8pA-3lvvA:
0.3
3m8pB-3lvvA:
2.5		 3m8pA-3lvvA:
21.04
3m8pB-3lvvA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Q_A_9PLA501_1
(CYTOCHROME P450 2A6)		 3lvv GLUTAMATE--CYSTEINE
LIGASE
(Saccharomyces
cerevisiae) 		5 / 10 PHE A 471
PHE A 474
PHE A 289
ILE A 550
PHE A 554
 None
 1.27A 3t3qA-3lvvA:
undetectable		 3t3qA-3lvvA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Q_B_9PLB501_1
(CYTOCHROME P450 2A6)		 3lvv GLUTAMATE--CYSTEINE
LIGASE
(Saccharomyces
cerevisiae) 		5 / 10 PHE A 471
PHE A 474
PHE A 289
ILE A 550
PHE A 554
 None
 1.32A 3t3qB-3lvvA:
undetectable		 3t3qB-3lvvA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Q_C_9PLC501_1
(CYTOCHROME P450 2A6)		 3lvv GLUTAMATE--CYSTEINE
LIGASE
(Saccharomyces
cerevisiae) 		5 / 10 PHE A 471
PHE A 474
PHE A 289
ILE A 550
PHE A 554
 None
 1.32A 3t3qC-3lvvA:
undetectable		 3t3qC-3lvvA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Q_D_9PLD501_1
(CYTOCHROME P450 2A6)		 3lvv GLUTAMATE--CYSTEINE
LIGASE
(Saccharomyces
cerevisiae) 		5 / 10 PHE A 471
PHE A 474
PHE A 289
ILE A 550
PHE A 554
 None
 1.32A 3t3qD-3lvvA:
undetectable		 3t3qD-3lvvA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5K_B_08JB2_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 3lvv GLUTAMATE--CYSTEINE
LIGASE
(Saccharomyces
cerevisiae) 		4 / 7 VAL A  56
LEU A 154
LEU A 156
ASN A 635
 None
 0.95A 3u5kB-3lvvA:
undetectable		 3u5kB-3lvvA:
10.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_B_0LIB1000_2
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		 3lvv GLUTAMATE--CYSTEINE
LIGASE
(Saccharomyces
cerevisiae) 		3 / 3 TYR A 254
MET A 255
ILE A 317
 None
None
LBP  A 693 (-4.7A)
 0.83A 4c8bB-3lvvA:
undetectable		 4c8bB-3lvvA:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HVC_B_HFGB1602_0
(BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE)		 3lvv GLUTAMATE--CYSTEINE
LIGASE
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 596
VAL A 566
TRP A  47
PHE A 474
GLY A  48
 None
None
None
None
ADP  A 694 (-3.6A)
 1.26A 4hvcB-3lvvA:
undetectable		 4hvcB-3lvvA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M6T_A_SAMA201_0
(RNA POLYMERASE
II-ASSOCIATED FACTOR
1 HOMOLOG, LINKER,
RNA
POLYMERASE-ASSOCIATE
D PROTEIN LEO1)		 3lvv GLUTAMATE--CYSTEINE
LIGASE
(Saccharomyces
cerevisiae) 		4 / 4 ILE A 168
VAL A  56
VAL A  69
ARG A  99
 None
 1.36A 4m6tA-3lvvA:
undetectable		 4m6tA-3lvvA:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NC3_A_ERMA1202_1
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 3lvv GLUTAMATE--CYSTEINE
LIGASE
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 367
ASP A 366
VAL A 365
SER A 364
ALA A 290
 None
 1.27A 4nc3A-3lvvA:
undetectable		 4nc3A-3lvvA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVN_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 3lvv GLUTAMATE--CYSTEINE
LIGASE
(Saccharomyces
cerevisiae) 		5 / 9 ALA A 611
THR A 610
ALA A 298
VAL A 618
ASP A 524
 None
 1.23A 4qvnK-3lvvA:
undetectable
4qvnL-3lvvA:
undetectable		 4qvnK-3lvvA:
15.74
4qvnL-3lvvA:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVN_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 3lvv GLUTAMATE--CYSTEINE
LIGASE
(Saccharomyces
cerevisiae) 		5 / 9 ALA A 611
THR A 610
ALA A 298
VAL A 618
ASP A 524
 None
 1.23A 4qvnY-3lvvA:
undetectable
4qvnZ-3lvvA:
undetectable		 4qvnY-3lvvA:
15.74
4qvnZ-3lvvA:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_C_377C401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3lvv GLUTAMATE--CYSTEINE
LIGASE
(Saccharomyces
cerevisiae) 		4 / 6 TYR A 666
GLU A 119
TYR A 595
LEU A 598
 None
 1.31A 4twdB-3lvvA:
undetectable
4twdC-3lvvA:
undetectable		 4twdB-3lvvA:
18.29
4twdC-3lvvA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_G_377G401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3lvv GLUTAMATE--CYSTEINE
LIGASE
(Saccharomyces
cerevisiae) 		4 / 6 TYR A 666
GLU A 119
TYR A 595
LEU A 598
 None
 1.38A 4twdF-3lvvA:
2.1
4twdG-3lvvA:
undetectable		 4twdF-3lvvA:
18.29
4twdG-3lvvA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCK_A_SAMA2409_1
(RNA-DIRECTED RNA
POLYMERASE L)		 3lvv GLUTAMATE--CYSTEINE
LIGASE
(Saccharomyces
cerevisiae) 		3 / 3 SER A 628
ASP A 256
ASP A 229
 None
 0.80A 4uckA-3lvvA:
undetectable		 4uckA-3lvvA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WAN_C_ACTC303_0
(BRANCHPOINT-BRIDGING
PROTEIN)		 3lvv GLUTAMATE--CYSTEINE
LIGASE
(Saccharomyces
cerevisiae) 		3 / 3 ASP A 366
ARG A 324
PRO A 358
 None
 0.88A 4wanC-3lvvA:
3.6		 4wanC-3lvvA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WH5_A_3QBA204_1
(LINCOSAMIDE
RESISTANCE PROTEIN)		 3lvv GLUTAMATE--CYSTEINE
LIGASE
(Saccharomyces
cerevisiae) 		5 / 12 PHE A 410
PHE A  34
ILE A  33
GLN A 455
PHE A 437
 None
 1.40A 4wh5A-3lvvA:
undetectable		 4wh5A-3lvvA:
12.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XPB_A_COCA702_1
(TRANSPORTER)		 3lvv GLUTAMATE--CYSTEINE
LIGASE
(Saccharomyces
cerevisiae) 		5 / 10 ASP A 256
VAL A 316
GLY A 163
SER A 257
MET A 262
 None
None
PGE  A 698 (-4.4A)
None
LBP  A 693 (-3.6A)
 1.40A 4xpbA-3lvvA:
undetectable		 4xpbA-3lvvA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUE_B_SAMB303_0
(CATECHOL
O-METHYLTRANSFERASE)		 3lvv GLUTAMATE--CYSTEINE
LIGASE
(Saccharomyces
cerevisiae) 		5 / 12 VAL A 158
GLY A 259
ILE A 191
ASN A 192
SER A 181
 None
 1.04A 4xueB-3lvvA:
undetectable		 4xueB-3lvvA:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBQ_A_DIFA601_1
(SERUM ALBUMIN)		 3lvv GLUTAMATE--CYSTEINE
LIGASE
(Saccharomyces
cerevisiae) 		5 / 11 LEU A 489
VAL A 488
PHE A 271
GLY A  48
LEU A 267
 None
None
None
ADP  A 694 (-3.6A)
None
 1.34A 4zbqA-3lvvA:
undetectable		 4zbqA-3lvvA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNW_B_TA1B902_1
(TUBULIN BETA-2B
CHAIN)		 3lvv GLUTAMATE--CYSTEINE
LIGASE
(Saccharomyces
cerevisiae) 		5 / 12 VAL A 269
LEU A 596
LEU A 492
LEU A 592
ARG A 602
 None
 1.19A 5hnwB-3lvvA:
undetectable		 5hnwB-3lvvA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNY_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 3lvv GLUTAMATE--CYSTEINE
LIGASE
(Saccharomyces
cerevisiae) 		5 / 12 VAL A 269
LEU A 596
LEU A 492
LEU A 592
ARG A 602
 None
 1.21A 5hnyB-3lvvA:
undetectable		 5hnyB-3lvvA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JW1_B_CELB602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3lvv GLUTAMATE--CYSTEINE
LIGASE
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 186
ALA A 308
VAL A 316
GLY A 319
ALA A 320
 None
 0.91A 5jw1B-3lvvA:
undetectable		 5jw1B-3lvvA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NUJ_A_Z80A201_1
(BETA-LACTOGLOBULIN)		 3lvv GLUTAMATE--CYSTEINE
LIGASE
(Saccharomyces
cerevisiae) 		4 / 8 ALA A 407
LEU A 367
ILE A 415
ASN A 387
 None
 0.85A 5nujA-3lvvA:
undetectable		 5nujA-3lvvA:
8.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UH6_C_RFPC1201_2
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 3lvv GLUTAMATE--CYSTEINE
LIGASE
(Saccharomyces
cerevisiae) 		4 / 4 ARG A 234
PHE A 237
LEU A 246
PRO A 336
 None
 1.40A 5uh6C-3lvvA:
0.0		 5uh6C-3lvvA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UMW_B_RBFB201_1
(GLYOXALASE/BLEOMYCIN
RESISANCE
PROTEIN/DIOXYGENASE)		 3lvv GLUTAMATE--CYSTEINE
LIGASE
(Saccharomyces
cerevisiae) 		4 / 7 ARG A 591
TYR A 595
GLU A 119
LEU A 659
 None
 0.99A 5umwB-3lvvA:
undetectable
5umwE-3lvvA:
undetectable		 5umwB-3lvvA:
7.21
5umwE-3lvvA:
7.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1805_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 3lvv GLUTAMATE--CYSTEINE
LIGASE
(Saccharomyces
cerevisiae) 		5 / 9 GLY A 392
LEU A 369
ILE A  27
PHE A 450
ILE A 276
 None
 0.95A 5vkqC-3lvvA:
undetectable
5vkqD-3lvvA:
undetectable		 5vkqC-3lvvA:
16.79
5vkqD-3lvvA:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_H_CVIH301_1
(REGULATORY PROTEIN
TETR)		 3lvv GLUTAMATE--CYSTEINE
LIGASE
(Saccharomyces
cerevisiae) 		4 / 8 GLN A  35
GLY A  38
GLN A 441
ASP A  43
 None
 0.97A 5vlmH-3lvvA:
undetectable		 5vlmH-3lvvA:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W7B_B_PA1B204_1
(ACYLOXYACYL
HYDROLASE SMALL
SUBUNIT
ACYLOXYACYL
HYDROLASE LARGE
SUBUNIT)		 3lvv GLUTAMATE--CYSTEINE
LIGASE
(Saccharomyces
cerevisiae) 		3 / 3 GLY A 209
ASN A 339
ARG A 329
 None
 0.75A 5w7bD-3lvvA:
undetectable		 5w7bD-3lvvA:
10.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W7B_B_PA1B204_1
(ACYLOXYACYL
HYDROLASE SMALL
SUBUNIT
ACYLOXYACYL
HYDROLASE LARGE
SUBUNIT)		 3lvv GLUTAMATE--CYSTEINE
LIGASE
(Saccharomyces
cerevisiae) 		3 / 3 GLY A 344
ASN A 339
ARG A 329
 None
 0.69A 5w7bD-3lvvA:
undetectable		 5w7bD-3lvvA:
10.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AZ3_1_PAR11802_1
(RRNA ALPHA
RIBOSOMAL PROTEIN
UL4
RIBOSOMAL PROTEIN
UL15
RIBOSOMAL PROTEIN
EL15)		 3lvv GLUTAMATE--CYSTEINE
LIGASE
(Saccharomyces
cerevisiae) 		3 / 3 ARG A 329
LYS A 249
ARG A 324
 None
 1.43A 6az3C-3lvvA:
undetectable
6az3L-3lvvA:
undetectable
6az3M-3lvvA:
undetectable		 6az3C-3lvvA:
9.26
6az3L-3lvvA:
8.16
6az3M-3lvvA:
8.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRX_A_H8GA1201_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		 3lvv GLUTAMATE--CYSTEINE
LIGASE
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 367
VAL A 365
SER A 364
THR A 447
ALA A 290
 None
 1.22A 6drxA-3lvvA:
undetectable		 6drxA-3lvvA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HCO_A_FY5A1003_0
(ATP-BINDING CASSETTE
SUB-FAMILY G MEMBER
2)		 3lvv GLUTAMATE--CYSTEINE
LIGASE
(Saccharomyces
cerevisiae) 		5 / 11 THR A 382
ASN A 383
VAL A 513
MET A 510
ILE A 415
 None
 1.44A 6hcoA-3lvvA:
undetectable
6hcoB-3lvvA:
undetectable		 6hcoA-3lvvA:
20.41
6hcoB-3lvvA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JNH_A_ASCA201_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 3lvv GLUTAMATE--CYSTEINE
LIGASE
(Saccharomyces
cerevisiae) 		5 / 7 GLY A 574
PHE A 575
HIS A 589
SER A 587
SER A 586
 None
 1.32A 6jnhA-3lvvA:
undetectable		 6jnhA-3lvvA:
13.29