SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3lw2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_B_ROFB501_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 3lw2 PLASMINOGEN
ACTIVATOR INHIBITOR
1
(Mus
musculus) 		3 / 3 MET A  62
ASN A 167
GLN A 322
 None
 1.02A 1xoqB-3lw2A:
undetectable		 1xoqB-3lw2A:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_C_8MOC501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		 3lw2 PLASMINOGEN
ACTIVATOR INHIBITOR
1
(Mus
musculus) 		5 / 10 PHE A 278
ILE A 326
ILE A 237
LEU A 275
PHE A 358
 None
 1.09A 1z11C-3lw2A:
undetectable		 1z11C-3lw2A:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_D_8MOD501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		 3lw2 PLASMINOGEN
ACTIVATOR INHIBITOR
1
(Mus
musculus) 		5 / 10 PHE A 278
ILE A 326
ILE A 237
LEU A 275
PHE A 358
 None
 1.11A 1z11D-3lw2A:
undetectable		 1z11D-3lw2A:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_A_DIFA1376_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 3lw2 PLASMINOGEN
ACTIVATOR INHIBITOR
1
(Mus
musculus) 		4 / 8 LEU A 165
LEU A  46
ALA A  44
MET A 295
 None
 0.98A 2wekA-3lw2A:
undetectable		 2wekA-3lw2A:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VQR_B_ACTB1002_0
(PUTATIVE
OXIDOREDUCTASE)		 3lw2 PLASMINOGEN
ACTIVATOR INHIBITOR
1
(Mus
musculus) 		4 / 5 ASP A 297
GLY A  52
ASP A 305
THR A  50
 None
 1.11A 3vqrB-3lw2A:
undetectable		 3vqrB-3lw2A:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1479_0
(MJ0495-LIKE PROTEIN)		 3lw2 PLASMINOGEN
ACTIVATOR INHIBITOR
1
(Mus
musculus) 		4 / 5 THR A  93
ILE A  91
GLU A  90
PHE A 372
 None
 1.45A 4ac9C-3lw2A:
undetectable		 4ac9C-3lw2A:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1479_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 3lw2 PLASMINOGEN
ACTIVATOR INHIBITOR
1
(Mus
musculus) 		4 / 5 THR A  93
ILE A  91
GLU A  90
PHE A 372
 None
 1.43A 4acaC-3lw2A:
undetectable		 4acaC-3lw2A:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 3lw2 PLASMINOGEN
ACTIVATOR INHIBITOR
1
(Mus
musculus) 		5 / 12 ALA A 335
SER A 336
VAL A 324
ASN A 167
SER A  40
 None
 1.07A 4c49A-3lw2A:
43.0		 4c49A-3lw2A:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_B_MXMB606_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3lw2 PLASMINOGEN
ACTIVATOR INHIBITOR
1
(Mus
musculus) 		6 / 12 MET A 298
VAL A 317
VAL A  42
LEU A  46
ALA A 340
LEU A 286
 None
 1.40A 4m11B-3lw2A:
undetectable		 4m11B-3lw2A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MBS_B_MRVB1101_2
(CHIMERA PROTEIN OF
C-C CHEMOKINE
RECEPTOR TYPE 5 AND
RUBREDOXIN)		 3lw2 PLASMINOGEN
ACTIVATOR INHIBITOR
1
(Mus
musculus) 		4 / 5 TYR A 228
THR A 251
LEU A 254
THR A 369
 None
 1.49A 4mbsB-3lw2A:
undetectable		 4mbsB-3lw2A:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_A_AERA601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 3lw2 PLASMINOGEN
ACTIVATOR INHIBITOR
1
(Mus
musculus) 		4 / 5 LEU A 273
ASP A 222
GLU A 225
VAL A 361
 None
 1.25A 4nkvA-3lw2A:
undetectable		 4nkvA-3lw2A:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_B_AERB601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 3lw2 PLASMINOGEN
ACTIVATOR INHIBITOR
1
(Mus
musculus) 		4 / 5 ARG A 271
ASP A 222
GLU A 225
VAL A 361
 None
 1.05A 4nkvB-3lw2A:
undetectable		 4nkvB-3lw2A:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5O_A_IPHA906_0
(PROTEIN ARGONAUTE-2)		 3lw2 PLASMINOGEN
ACTIVATOR INHIBITOR
1
(Mus
musculus) 		4 / 5 PHE A  15
PRO A  36
VAL A  39
ALA A  12
 None
 1.33A 4w5oA-3lw2A:
undetectable		 4w5oA-3lw2A:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4D_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 3lw2 PLASMINOGEN
ACTIVATOR INHIBITOR
1
(Mus
musculus) 		4 / 5 PHE A  15
PRO A  36
VAL A  39
ALA A  12
 None
 1.34A 4z4dA-3lw2A:
undetectable		 4z4dA-3lw2A:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4E_A_IPHA906_0
(PROTEIN ARGONAUTE-2)		 3lw2 PLASMINOGEN
ACTIVATOR INHIBITOR
1
(Mus
musculus) 		4 / 5 PHE A  15
PRO A  36
VAL A  39
ALA A  12
 None
 1.31A 4z4eA-3lw2A:
undetectable		 4z4eA-3lw2A:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWJ_D_QELD503_1
(NMDA GLUTAMATE
RECEPTOR SUBUNIT
GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 2B)		 3lw2 PLASMINOGEN
ACTIVATOR INHIBITOR
1
(Mus
musculus) 		5 / 12 THR A  13
LEU A 258
PRO A  36
GLN A  21
THR A 215
 None
 1.39A 5ewjC-3lw2A:
undetectable
5ewjD-3lw2A:
undetectable		 5ewjC-3lw2A:
22.42
5ewjD-3lw2A:
22.70