SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3lwa'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3008_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 3lwa SECRETED
THIOL-DISULFIDE
ISOMERASE
(Corynebacterium
glutamicum) 		4 / 7 GLU A  50
VAL A 191
VAL A 199
ALA A 185
 None
 0.87A 3kp6B-3lwaA:
undetectable		 3kp6B-3lwaA:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_C_RTZC2_1
(CYTOCHROME P450 2D6)		 3lwa SECRETED
THIOL-DISULFIDE
ISOMERASE
(Corynebacterium
glutamicum) 		5 / 10 THR A 159
LEU A 126
VAL A  86
LEU A 163
PHE A 157
 None
 1.50A 3tbgC-3lwaA:
undetectable		 3tbgC-3lwaA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3THR_C_C2FC1410_0
(GLYCINE
N-METHYLTRANSFERASE)		 3lwa SECRETED
THIOL-DISULFIDE
ISOMERASE
(Corynebacterium
glutamicum) 		3 / 3 ARG A 131
PRO A 167
PHE A 157
 None
 1.00A 3thrC-3lwaA:
undetectable		 3thrC-3lwaA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UIN_H_QI9H1226_0
(FAB 314.3)		 3lwa SECRETED
THIOL-DISULFIDE
ISOMERASE
(Corynebacterium
glutamicum) 		5 / 12 THR A 159
GLY A 165
GLY A  38
LEU A  61
PRO A  62
 None
 1.37A 4uinH-3lwaA:
undetectable
4uinL-3lwaA:
undetectable		 4uinH-3lwaA:
22.37
4uinL-3lwaA:
24.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5INZ_D_DVAD15_0
(THETA DEFENSIN-2,
D-PEPTIDE
THETA DEFENSIN-2,
L-PEPTIDE)		 3lwa SECRETED
THIOL-DISULFIDE
ISOMERASE
(Corynebacterium
glutamicum) 		3 / 3 GLY A  92
CYH A  98
CYH A  95
 None
 0.73A 5inzB-3lwaA:
undetectable		 5inzB-3lwaA:
9.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JMJ_A_ASCA201_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 3lwa SECRETED
THIOL-DISULFIDE
ISOMERASE
(Corynebacterium
glutamicum) 		4 / 5 GLY A 123
THR A 124
HIS A 181
SER A  79
 None
 1.16A 6jmjA-3lwaA:
2.6		 6jmjA-3lwaA:
22.92