SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3lwb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_F_TOPF1159_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 3lwb D-ALANINE--D-ALANINE
LIGASE
(Mycobacterium
tuberculosis) 		5 / 10 ILE A 362
LEU A 314
LEU A 357
PHE A 114
THR A 364
 None
 1.22A 2w9sF-3lwbA:
undetectable		 2w9sF-3lwbA:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MBS_B_MRVB1101_2
(CHIMERA PROTEIN OF
C-C CHEMOKINE
RECEPTOR TYPE 5 AND
RUBREDOXIN)		 3lwb D-ALANINE--D-ALANINE
LIGASE
(Mycobacterium
tuberculosis) 		4 / 5 THR A 360
LEU A 243
THR A 333
MET A 334
 None
 1.14A 4mbsB-3lwbA:
undetectable		 4mbsB-3lwbA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O0U_A_ADNA501_1
(AURORA KINASE A)		 3lwb D-ALANINE--D-ALANINE
LIGASE
(Mycobacterium
tuberculosis) 		5 / 6 VAL A 317
ALA A 302
LEU A 164
THR A 155
LEU A 159
 None
 1.31A 4o0uA-3lwbA:
undetectable		 4o0uA-3lwbA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_C_SAMC301_0
(UNCHARACTERIZED
PROTEIN)		 3lwb D-ALANINE--D-ALANINE
LIGASE
(Mycobacterium
tuberculosis) 		5 / 12 ALA A 141
SER A 146
GLY A 149
ALA A 302
GLU A 244
 None
 1.26A 4r29C-3lwbA:
undetectable		 4r29C-3lwbA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_A_RBFA201_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 3lwb D-ALANINE--D-ALANINE
LIGASE
(Mycobacterium
tuberculosis) 		5 / 12 ALA A  31
ILE A  34
LEU A 117
GLY A 140
GLN A 128
 None
 1.13A 4r38A-3lwbA:
undetectable		 4r38A-3lwbA:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_B_RBFB201_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 3lwb D-ALANINE--D-ALANINE
LIGASE
(Mycobacterium
tuberculosis) 		5 / 12 ALA A  31
ILE A  34
LEU A 117
GLY A 140
GLN A 128
 None
 1.09A 4r38B-3lwbA:
undetectable		 4r38B-3lwbA:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_C_RBFC201_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 3lwb D-ALANINE--D-ALANINE
LIGASE
(Mycobacterium
tuberculosis) 		5 / 12 ALA A  31
ILE A  34
LEU A 117
GLY A 140
GLN A 128
 None
 1.11A 4r38C-3lwbA:
undetectable		 4r38C-3lwbA:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_D_RBFD201_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 3lwb D-ALANINE--D-ALANINE
LIGASE
(Mycobacterium
tuberculosis) 		5 / 12 ALA A  31
ILE A  34
LEU A 117
GLY A 140
GLN A 128
 None
 1.08A 4r38D-3lwbA:
undetectable		 4r38D-3lwbA:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3lwb D-ALANINE--D-ALANINE
LIGASE
(Mycobacterium
tuberculosis) 		3 / 3 VAL A  11
LEU A 243
MET A 245
 None
 0.90A 5ikrA-3lwbA:
undetectable		 5ikrA-3lwbA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J4N_A_AG2A501_1
(ARGININE/AGMATINE
ANTIPORTER)		 3lwb D-ALANINE--D-ALANINE
LIGASE
(Mycobacterium
tuberculosis) 		4 / 6 SER A 253
GLY A 256
MET A 346
ILE A 298
 None
 0.85A 5j4nA-3lwbA:
undetectable		 5j4nA-3lwbA:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OSP_A_ACTA403_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 3lwb D-ALANINE--D-ALANINE
LIGASE
(Mycobacterium
tuberculosis) 		4 / 7 VAL A  48
ILE A  46
VAL A 113
ALA A  14
 None
 0.64A 5ospA-3lwbA:
undetectable		 5ospA-3lwbA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OSR_A_ACTA402_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 3lwb D-ALANINE--D-ALANINE
LIGASE
(Mycobacterium
tuberculosis) 		4 / 7 VAL A  48
ILE A  46
VAL A 113
ALA A  14
 None
 0.66A 5osrA-3lwbA:
2.1		 5osrA-3lwbA:
21.05