SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3lwf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HMY_A_SAMA328_0
(HAEIII
METHYLTRANSFERASE)		 3lwf PUTATIVE
TRANSCRIPTIONAL
REGULATOR
(Listeria
innocua) 		4 / 8 ILE A  13
THR A  14
PRO A  48
LEU A  49
 None
None
SO4  A 148 ( 4.5A)
None
 0.90A 1hmyA-3lwfA:
undetectable		 1hmyA-3lwfA:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_A_DIFA1375_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 3lwf PUTATIVE
TRANSCRIPTIONAL
REGULATOR
(Listeria
innocua) 		3 / 3 LEU A  42
TYR A  41
GLN A  44
 None
 0.68A 2wekA-3lwfA:
undetectable		 2wekA-3lwfA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAS_A_ADNA401_1
(PUTATIVE ADENOSINE
KINASE)		 3lwf PUTATIVE
TRANSCRIPTIONAL
REGULATOR
(Listeria
innocua) 		5 / 12 ILE A  79
LEU A  83
GLY A  53
THR A  82
GLY A  69
 None
 1.03A 3vasA-3lwfA:
undetectable		 3vasA-3lwfA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQL_B_SALB602_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 3lwf PUTATIVE
TRANSCRIPTIONAL
REGULATOR
(Listeria
innocua) 		4 / 7 LEU A  67
THR A  14
ILE A  79
GLY A  53
 None
 0.96A 4eqlB-3lwfA:
undetectable		 4eqlB-3lwfA:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IK6_B_LURB201_1
(TRANSTHYRETIN)		 3lwf PUTATIVE
TRANSCRIPTIONAL
REGULATOR
(Listeria
innocua) 		4 / 8 LEU A  11
THR A 118
ALA A  76
VAL A 114
 None
 0.90A 4ik6B-3lwfA:
undetectable		 4ik6B-3lwfA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L39_B_SALB601_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 3lwf PUTATIVE
TRANSCRIPTIONAL
REGULATOR
(Listeria
innocua) 		4 / 7 LEU A  67
THR A  14
ILE A  79
GLY A  53
 None
 0.93A 4l39B-3lwfA:
undetectable		 4l39B-3lwfA:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1E_B_C2FB4000_0
(DIHYDROPTEROATE
SYNTHASE DHPS)		 3lwf PUTATIVE
TRANSCRIPTIONAL
REGULATOR
(Listeria
innocua) 		5 / 12 ILE A  58
ILE A  79
LEU A  83
GLY A  53
ASN A  51
 None
None
None
None
SO4  A 148 (-3.0A)
 1.15A 4o1eB-3lwfA:
undetectable		 4o1eB-3lwfA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E4D_B_BEZB203_0
(HYDROXYNITRILE LYASE)		 3lwf PUTATIVE
TRANSCRIPTIONAL
REGULATOR
(Listeria
innocua) 		4 / 4 VAL A  55
ALA A  52
ILE A  79
THR A  82
 None
 0.90A 5e4dB-3lwfA:
undetectable		 5e4dB-3lwfA:
25.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJD_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 3lwf PUTATIVE
TRANSCRIPTIONAL
REGULATOR
(Listeria
innocua) 		5 / 9 LEU A  37
ILE A  54
THR A  14
ILE A  31
LEU A  83
 None
 1.22A 5ljdA-3lwfA:
undetectable		 5ljdA-3lwfA:
20.69