SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3lwg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBY_A_9CRA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3lwg HP0420 HOMOLOGUE
(Helicobacter
felis) 		5 / 12 ILE A  56
ALA A  59
ALA A  60
LEU A  38
ALA A  24
 None
 1.07A 1fbyA-3lwgA:
undetectable		 1fbyA-3lwgA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBY_B_9CRB1500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3lwg HP0420 HOMOLOGUE
(Helicobacter
felis) 		5 / 12 ILE A  56
ALA A  59
ALA A  60
LEU A  38
ALA A  24
 None
 1.08A 1fbyB-3lwgA:
undetectable		 1fbyB-3lwgA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N4H_A_REAA500_1
(NUCLEAR RECEPTOR
ROR-BETA)		 3lwg HP0420 HOMOLOGUE
(Helicobacter
felis) 		5 / 11 ILE A  86
ALA A  84
VAL A 119
VAL A  80
ALA A  60
 None
 1.12A 1n4hA-3lwgA:
undetectable		 1n4hA-3lwgA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_E_9CRE1500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3lwg HP0420 HOMOLOGUE
(Helicobacter
felis) 		5 / 12 ILE A  56
ALA A  59
ALA A  60
LEU A  38
ALA A  24
 None
 0.98A 1xdkE-3lwgA:
undetectable		 1xdkE-3lwgA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W67_C_VIVC301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 3lwg HP0420 HOMOLOGUE
(Helicobacter
felis) 		5 / 12 ALA A  60
PHE A  94
ILE A  86
LEU A  82
VAL A  80
 None
 1.15A 3w67C-3lwgA:
undetectable		 3w67C-3lwgA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_B_ADNB402_1
(PROBABLE SUGAR
KINASE PROTEIN)		 3lwg HP0420 HOMOLOGUE
(Helicobacter
felis) 		5 / 9 ILE A 126
ALA A  96
CYH A  66
ALA A  67
ILE A 108
 None
 1.09A 4lbgB-3lwgA:
undetectable		 4lbgB-3lwgA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OAD_A_CLMA206_0
(GNAT SUPERFAMILY
ACETYLTRANSFERASE
PA4794)		 3lwg HP0420 HOMOLOGUE
(Helicobacter
felis) 		4 / 4 ALA A  60
ALA A  63
ALA A  64
ALA A  67
 None
 0.11A 4oadA-3lwgA:
undetectable		 4oadA-3lwgA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OAE_A_CLMA208_0
(GNAT SUPERFAMILY
ACETYLTRANSFERASE
PA4794)		 3lwg HP0420 HOMOLOGUE
(Helicobacter
felis) 		4 / 4 ALA A  60
ALA A  63
ALA A  64
ALA A  67
 None
 0.13A 4oaeA-3lwgA:
undetectable		 4oaeA-3lwgA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ENT_C_MIYC901_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT
ACRB,MULTIDRUG
EFFLUX PUMP SUBUNIT
ACRB)		 3lwg HP0420 HOMOLOGUE
(Helicobacter
felis) 		5 / 9 PHE A  55
GLY A  58
SER A  61
ILE A  56
ALA A  53
 None
 1.45A 5entC-3lwgA:
undetectable		 5entC-3lwgA:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UAN_A_9CRA503_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3lwg HP0420 HOMOLOGUE
(Helicobacter
felis) 		5 / 12 ILE A  56
ALA A  59
ALA A  60
LEU A  38
ALA A  24
 None
 0.96A 5uanA-3lwgA:
undetectable		 5uanA-3lwgA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QGB_A_BEZA701_0
(MONO(2-HYDROXYETHYL)
TEREPHTHALATE
HYDROLASE)		 3lwg HP0420 HOMOLOGUE
(Helicobacter
felis) 		5 / 11 GLY A  54
LEU A  38
ALA A  24
ALA A  60
PHE A  94
 None
 1.36A 6qgbA-3lwgA:
undetectable		 6qgbA-3lwgA:
12.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QGB_E_BEZE701_0
(MONO(2-HYDROXYETHYL)
TEREPHTHALATE
HYDROLASE)		 3lwg HP0420 HOMOLOGUE
(Helicobacter
felis) 		5 / 11 GLY A  54
LEU A  38
ALA A  24
ALA A  60
PHE A  94
 None
 1.33A 6qgbE-3lwgA:
undetectable		 6qgbE-3lwgA:
12.74