SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3lws'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_D_TFPD207_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 3lws AROMATIC AMINO ACID
BETA-ELIMINATING
LYASE/THREONINE
ALDOLASE
(Exiguobacterium
sibiricum) 		4 / 8 SER A   7
LEU A 319
LEU A 339
PHE A 271
 None
 0.92A 1wrlC-3lwsA:
undetectable
1wrlD-3lwsA:
undetectable		 1wrlC-3lwsA:
15.92
1wrlD-3lwsA:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXM_A_IMNA2001_1
(SERUM ALBUMIN)		 3lws AROMATIC AMINO ACID
BETA-ELIMINATING
LYASE/THREONINE
ALDOLASE
(Exiguobacterium
sibiricum) 		4 / 8 ALA A 220
PHE A 221
ALA A 225
LEU A 215
 None
 0.77A 2bxmA-3lwsA:
undetectable		 2bxmA-3lwsA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_E_SNLE5001_1
(MINERALOCORTICOID
RECEPTOR)		 3lws AROMATIC AMINO ACID
BETA-ELIMINATING
LYASE/THREONINE
ALDOLASE
(Exiguobacterium
sibiricum) 		5 / 12 LEU A 126
LEU A 123
GLN A 144
LEU A 142
LEU A 171
 None
 1.09A 2oaxE-3lwsA:
undetectable		 2oaxE-3lwsA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGN_A_PCFA1179_1
(WNT INHIBITORY
FACTOR 1)		 3lws AROMATIC AMINO ACID
BETA-ELIMINATING
LYASE/THREONINE
ALDOLASE
(Exiguobacterium
sibiricum) 		4 / 5 ILE A 199
PHE A 179
VAL A  25
PHE A  51
 None
 1.13A 2ygnA-3lwsA:
undetectable		 2ygnA-3lwsA:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_L_TFPL201_1
(PROTEIN S100-A4)		 3lws AROMATIC AMINO ACID
BETA-ELIMINATING
LYASE/THREONINE
ALDOLASE
(Exiguobacterium
sibiricum) 		4 / 7 GLY A 206
PHE A 315
PHE A 271
PHE A 289
 LLP  A 205 ( 2.4A)
None
None
None
 1.10A 3ko0L-3lwsA:
undetectable
3ko0N-3lwsA:
undetectable		 3ko0L-3lwsA:
15.81
3ko0N-3lwsA:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_T_TFPT201_1
(PROTEIN S100-A4)		 3lws AROMATIC AMINO ACID
BETA-ELIMINATING
LYASE/THREONINE
ALDOLASE
(Exiguobacterium
sibiricum) 		4 / 7 PHE A 289
GLY A 206
PHE A 315
PHE A 271
 None
LLP  A 205 ( 2.4A)
None
None
 1.04A 3ko0R-3lwsA:
undetectable
3ko0T-3lwsA:
undetectable		 3ko0R-3lwsA:
15.81
3ko0T-3lwsA:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDV_A_CL6A506_1
(CHOLESTEROL
24-HYDROXYLASE)		 3lws AROMATIC AMINO ACID
BETA-ELIMINATING
LYASE/THREONINE
ALDOLASE
(Exiguobacterium
sibiricum) 		5 / 9 LEU A 182
PHE A 179
LEU A  59
ILE A 201
ALA A 193
 None
 1.05A 3mdvA-3lwsA:
undetectable		 3mdvA-3lwsA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PHA_B_ACRB701_1
(ALPHA-GLUCOSIDASE)		 3lws AROMATIC AMINO ACID
BETA-ELIMINATING
LYASE/THREONINE
ALDOLASE
(Exiguobacterium
sibiricum) 		5 / 12 ASP A 235
ILE A 227
ILE A 243
ILE A  47
ASP A  40
 None
 1.49A 3phaB-3lwsA:
undetectable		 3phaB-3lwsA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJW_A_ACTA603_0
(CHOLINE OXIDASE)		 3lws AROMATIC AMINO ACID
BETA-ELIMINATING
LYASE/THREONINE
ALDOLASE
(Exiguobacterium
sibiricum) 		3 / 3 ARG A  79
HIS A 110
SER A  82
 None
 1.03A 4mjwA-3lwsA:
undetectable
4mjwB-3lwsA:
undetectable		 4mjwA-3lwsA:
22.42
4mjwB-3lwsA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_A_CHDA503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3lws AROMATIC AMINO ACID
BETA-ELIMINATING
LYASE/THREONINE
ALDOLASE
(Exiguobacterium
sibiricum) 		5 / 10 LEU A 140
LEU A 142
LEU A 178
ILE A 160
THR A 188
 None
 1.33A 4mk4A-3lwsA:
undetectable		 4mk4A-3lwsA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WH5_A_3QBA204_1
(LINCOSAMIDE
RESISTANCE PROTEIN)		 3lws AROMATIC AMINO ACID
BETA-ELIMINATING
LYASE/THREONINE
ALDOLASE
(Exiguobacterium
sibiricum) 		5 / 12 GLY A 175
ASP A 174
PHE A 221
ILE A 199
ALA A 216
 None
LLP  A 205 ( 2.9A)
None
None
None
 1.23A 4wh5A-3lwsA:
undetectable		 4wh5A-3lwsA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IAO_C_URFC301_1
(BIFUNCTIONAL PROTEIN
PYRR)		 3lws AROMATIC AMINO ACID
BETA-ELIMINATING
LYASE/THREONINE
ALDOLASE
(Exiguobacterium
sibiricum) 		3 / 3 ARG A 177
HIS A  97
ARG A 145
 LLP  A 205 ( 2.9A)
LLP  A 205 ( 3.3A)
LLP  A 205 ( 4.4A)
 1.12A 5iaoC-3lwsA:
2.7		 5iaoC-3lwsA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IAO_F_URFF301_1
(BIFUNCTIONAL PROTEIN
PYRR)		 3lws AROMATIC AMINO ACID
BETA-ELIMINATING
LYASE/THREONINE
ALDOLASE
(Exiguobacterium
sibiricum) 		3 / 3 ARG A 177
HIS A  97
ARG A 145
 LLP  A 205 ( 2.9A)
LLP  A 205 ( 3.3A)
LLP  A 205 ( 4.4A)
 1.13A 5iaoF-3lwsA:
2.9		 5iaoF-3lwsA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IK1_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 3lws AROMATIC AMINO ACID
BETA-ELIMINATING
LYASE/THREONINE
ALDOLASE
(Exiguobacterium
sibiricum) 		4 / 5 PHE A  51
LEU A 207
GLY A 209
ILE A 243
 None
 0.88A 5ik1A-3lwsA:
undetectable		 5ik1A-3lwsA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KB6_B_ADNB401_1
(ADENOSINE KINASE)		 3lws AROMATIC AMINO ACID
BETA-ELIMINATING
LYASE/THREONINE
ALDOLASE
(Exiguobacterium
sibiricum) 		6 / 12 GLY A  60
ILE A 201
ALA A 216
GLY A 217
ALA A  64
ILE A 214
 None
 1.42A 5kb6B-3lwsA:
undetectable		 5kb6B-3lwsA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJE_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 3lws AROMATIC AMINO ACID
BETA-ELIMINATING
LYASE/THREONINE
ALDOLASE
(Exiguobacterium
sibiricum) 		5 / 12 PHE A 289
ALA A 264
LEU A 274
ARG A 344
ILE A  15
 None
 1.08A 5ljeA-3lwsA:
undetectable		 5ljeA-3lwsA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFP_A_8W5A804_2
(GLUCOCORTICOID
RECEPTOR)		 3lws AROMATIC AMINO ACID
BETA-ELIMINATING
LYASE/THREONINE
ALDOLASE
(Exiguobacterium
sibiricum) 		4 / 4 LEU A 178
MET A 257
ILE A 214
LEU A 207
 None
 1.37A 5nfpA-3lwsA:
undetectable		 5nfpA-3lwsA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NY7_A_NCAA303_0
(AMIDASE)		 3lws AROMATIC AMINO ACID
BETA-ELIMINATING
LYASE/THREONINE
ALDOLASE
(Exiguobacterium
sibiricum) 		4 / 6 ARG A 145
GLY A 148
GLU A 329
SER A 331
 LLP  A 205 ( 4.4A)
None
None
None
 1.05A 5ny7A-3lwsA:
undetectable		 5ny7A-3lwsA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NY7_A_NCAA303_0
(AMIDASE)		 3lws AROMATIC AMINO ACID
BETA-ELIMINATING
LYASE/THREONINE
ALDOLASE
(Exiguobacterium
sibiricum) 		4 / 6 ARG A 145
GLY A 149
GLU A 329
SER A 331
 LLP  A 205 ( 4.4A)
None
None
None
 0.82A 5ny7A-3lwsA:
undetectable		 5ny7A-3lwsA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_B_8LXB501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3lws AROMATIC AMINO ACID
BETA-ELIMINATING
LYASE/THREONINE
ALDOLASE
(Exiguobacterium
sibiricum) 		5 / 12 LEU A 132
ARG A 167
ILE A 129
ILE A 192
LEU A 142
 None
 1.18A 5y2tB-3lwsA:
undetectable		 5y2tB-3lwsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_A_CYZA1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 3lws AROMATIC AMINO ACID
BETA-ELIMINATING
LYASE/THREONINE
ALDOLASE
(Exiguobacterium
sibiricum) 		5 / 10 PRO A 143
SER A 286
LEU A 123
ILE A 147
GLY A 148
 None
 1.18A 6dlzA-3lwsA:
2.6
6dlzD-3lwsA:
3.8		 6dlzA-3lwsA:
14.08
6dlzD-3lwsA:
14.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_C_CYZC1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 3lws AROMATIC AMINO ACID
BETA-ELIMINATING
LYASE/THREONINE
ALDOLASE
(Exiguobacterium
sibiricum) 		5 / 10 ILE A 147
GLY A 148
PRO A 143
SER A 286
LEU A 123
 None
 1.18A 6dlzB-3lwsA:
3.3
6dlzC-3lwsA:
2.6		 6dlzB-3lwsA:
14.08
6dlzC-3lwsA:
14.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_A_CYZA1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 3lws AROMATIC AMINO ACID
BETA-ELIMINATING
LYASE/THREONINE
ALDOLASE
(Exiguobacterium
sibiricum) 		5 / 10 PRO A 143
SER A 286
LEU A 123
ILE A 147
GLY A 148
 None
 1.19A 6dm1A-3lwsA:
2.6
6dm1D-3lwsA:
3.8		 6dm1A-3lwsA:
14.08
6dm1D-3lwsA:
14.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_C_CYZC1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 3lws AROMATIC AMINO ACID
BETA-ELIMINATING
LYASE/THREONINE
ALDOLASE
(Exiguobacterium
sibiricum) 		5 / 10 ILE A 147
GLY A 148
PRO A 143
SER A 286
LEU A 123
 None
 1.18A 6dm1B-3lwsA:
3.4
6dm1C-3lwsA:
2.6		 6dm1B-3lwsA:
14.08
6dm1C-3lwsA:
14.08