SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3lwt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1M_B_CAMB2422_0
(CYTOCHROME P450-CAM)		 3lwt PHOSPHOINOSITIDE
PHOSPHATASE SAC1
(Saccharomyces
cerevisiae) 		4 / 8 THR X 162
VAL X 182
THR X 133
ILE X 209
 None
 0.79A 2a1mB-3lwtX:
undetectable		 2a1mB-3lwtX:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q8H_A_TF4A438_1
([PYRUVATE
DEHYDROGENASE
[LIPOAMIDE]] KINASE
ISOZYME 1)		 3lwt PHOSPHOINOSITIDE
PHOSPHATASE SAC1
(Saccharomyces
cerevisiae) 		4 / 6 LEU X  64
TYR X 111
ILE X  95
ILE X  62
 None
 1.00A 2q8hA-3lwtX:
undetectable		 2q8hA-3lwtX:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_D_KLND1499_1
(CYTOCHROME P450 3A4)		 3lwt PHOSPHOINOSITIDE
PHOSPHATASE SAC1
(Saccharomyces
cerevisiae) 		4 / 5 PHE X  16
SER X 102
PHE X  61
ILE X 104
 None
 1.36A 2v0mD-3lwtX:
undetectable		 2v0mD-3lwtX:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F33_A_PFLA2001_1
(FERRITIN LIGHT CHAIN)		 3lwt PHOSPHOINOSITIDE
PHOSPHATASE SAC1
(Saccharomyces
cerevisiae) 		4 / 6 LEU X 433
SER X 436
TYR X 437
LEU X 440
 None
 1.04A 3f33A-3lwtX:
undetectable		 3f33A-3lwtX:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_A_TOPA200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 3lwt PHOSPHOINOSITIDE
PHOSPHATASE SAC1
(Saccharomyces
cerevisiae) 		5 / 10 ALA X  56
VAL X  90
ALA X  70
ILE X  71
LEU X 119
 None
 1.14A 3fl9A-3lwtX:
undetectable		 3fl9A-3lwtX:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_F_TOPF200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 3lwt PHOSPHOINOSITIDE
PHOSPHATASE SAC1
(Saccharomyces
cerevisiae) 		5 / 10 ALA X  56
VAL X  90
ALA X  70
ILE X  71
LEU X 119
 None
 1.14A 3fl9F-3lwtX:
undetectable		 3fl9F-3lwtX:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MJR_A_AC2A301_1
(DEOXYCYTIDINE KINASE)		 3lwt PHOSPHOINOSITIDE
PHOSPHATASE SAC1
(Saccharomyces
cerevisiae) 		5 / 9 ILE X 204
GLU X 232
ARG X 154
ARG X 206
ASP X 152
 None
 1.35A 3mjrA-3lwtX:
undetectable		 3mjrA-3lwtX:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TGV_D_BEZD1_0
(HEME-BINDING PROTEIN
HUTZ)		 3lwt PHOSPHOINOSITIDE
PHOSPHATASE SAC1
(Saccharomyces
cerevisiae) 		4 / 6 ARG X  39
GLN X  34
PHE X  15
LEU X  41
 None
 1.43A 3tgvD-3lwtX:
undetectable		 3tgvD-3lwtX:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FIA_A_0U9A601_1
(CHOLESTEROL
24-HYDROXYLASE)		 3lwt PHOSPHOINOSITIDE
PHOSPHATASE SAC1
(Saccharomyces
cerevisiae) 		5 / 12 LEU X 194
PHE X 415
VAL X 420
ALA X 239
ALA X 192
 None
 1.28A 4fiaA-3lwtX:
undetectable		 4fiaA-3lwtX:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FIA_A_198A602_1
(CHOLESTEROL
24-HYDROXYLASE)		 3lwt PHOSPHOINOSITIDE
PHOSPHATASE SAC1
(Saccharomyces
cerevisiae) 		5 / 12 LEU X 194
PHE X 415
VAL X 420
ALA X 239
ALA X 192
 None
 1.28A 4fiaA-3lwtX:
undetectable		 4fiaA-3lwtX:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KF9_A_ACTA408_0
(GLUTATHIONE
S-TRANSFERASE
PROTEIN)		 3lwt PHOSPHOINOSITIDE
PHOSPHATASE SAC1
(Saccharomyces
cerevisiae) 		4 / 6 TYR X 296
THR X 255
PHE X 155
ARG X 154
 None
 1.40A 4kf9A-3lwtX:
undetectable		 4kf9A-3lwtX:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q1X_A_017A101_2
(ASPARTYL PROTEASE)		 3lwt PHOSPHOINOSITIDE
PHOSPHATASE SAC1
(Saccharomyces
cerevisiae) 		5 / 12 LEU X  18
ILE X  55
ILE X  72
GLY X  60
ILE X   5
 None
 0.91A 4q1xB-3lwtX:
undetectable		 4q1xB-3lwtX:
10.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AD9_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3lwt PHOSPHOINOSITIDE
PHOSPHATASE SAC1
(Saccharomyces
cerevisiae) 		4 / 7 ARG X 389
VAL X 321
PHE X 289
HIS X 288
 None
 1.27A 5ad9A-3lwtX:
undetectable
5ad9B-3lwtX:
undetectable		 5ad9A-3lwtX:
21.70
5ad9B-3lwtX:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AD9_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3lwt PHOSPHOINOSITIDE
PHOSPHATASE SAC1
(Saccharomyces
cerevisiae) 		4 / 7 ARG X 389
VAL X 322
PHE X 289
HIS X 288
 None
 1.43A 5ad9A-3lwtX:
undetectable
5ad9B-3lwtX:
undetectable		 5ad9A-3lwtX:
21.70
5ad9B-3lwtX:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_A_CVIA301_0
(REGULATORY PROTEIN
TETR)		 3lwt PHOSPHOINOSITIDE
PHOSPHATASE SAC1
(Saccharomyces
cerevisiae) 		5 / 12 ALA X  70
GLU X 163
LEU X 165
ILE X 179
TYR X 128
 None
 1.46A 5vlmA-3lwtX:
undetectable		 5vlmA-3lwtX:
16.47