SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3lwu'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQ5_A_PAUA6001_0
(PANTOTHENATE KINASE)		 3lwu SUCCINYLGLUTAMATE
DESUCCINYLASE/ASPART
OACYLASE
(Shewanella
frigidimarina) 		5 / 9 ASP A 171
HIS A 173
LEU A 159
ILE A  81
ASN A  77
 None
ZN  A 374 (-3.1A)
None
None
None
 1.23A 1sq5A-3lwuA:
0.0		 1sq5A-3lwuA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQ5_C_PAUC6002_0
(PANTOTHENATE KINASE)		 3lwu SUCCINYLGLUTAMATE
DESUCCINYLASE/ASPART
OACYLASE
(Shewanella
frigidimarina) 		5 / 9 ASP A 171
HIS A 173
LEU A 159
ILE A  81
ASN A  77
 None
ZN  A 374 (-3.1A)
None
None
None
 1.24A 1sq5C-3lwuA:
0.0		 1sq5C-3lwuA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQ5_D_PAUD6004_0
(PANTOTHENATE KINASE)		 3lwu SUCCINYLGLUTAMATE
DESUCCINYLASE/ASPART
OACYLASE
(Shewanella
frigidimarina) 		5 / 10 ASP A 171
HIS A 173
LEU A 159
ILE A  81
ASN A  77
 None
ZN  A 374 (-3.1A)
None
None
None
 1.22A 1sq5D-3lwuA:
undetectable		 1sq5D-3lwuA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_A_ROFA502_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 3lwu SUCCINYLGLUTAMATE
DESUCCINYLASE/ASPART
OACYLASE
(Shewanella
frigidimarina) 		3 / 3 ASN A  77
TRP A 101
GLN A  40
 None
 0.99A 1xoqA-3lwuA:
undetectable		 1xoqA-3lwuA:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AVP_A_MV2A313_1
(PANTOTHENATE KINASE)		 3lwu SUCCINYLGLUTAMATE
DESUCCINYLASE/ASPART
OACYLASE
(Shewanella
frigidimarina) 		4 / 7 ASP A 171
HIS A 173
LEU A 159
ILE A  81
 None
ZN  A 374 (-3.1A)
None
None
 0.91A 3avpA-3lwuA:
undetectable		 3avpA-3lwuA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P4W_B_DSFB319_1
(GLR4197 PROTEIN)		 3lwu SUCCINYLGLUTAMATE
DESUCCINYLASE/ASPART
OACYLASE
(Shewanella
frigidimarina) 		5 / 9 TYR A 265
ILE A 262
VAL A 271
ILE A  39
ILE A  70
 None
 1.02A 3p4wB-3lwuA:
undetectable		 3p4wB-3lwuA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P4W_D_DSFD319_1
(GLR4197 PROTEIN)		 3lwu SUCCINYLGLUTAMATE
DESUCCINYLASE/ASPART
OACYLASE
(Shewanella
frigidimarina) 		5 / 10 TYR A 265
ILE A 262
VAL A 271
ILE A  39
ILE A  70
 None
 1.04A 3p4wD-3lwuA:
undetectable		 3p4wD-3lwuA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P4W_E_DSFE319_1
(GLR4197 PROTEIN)		 3lwu SUCCINYLGLUTAMATE
DESUCCINYLASE/ASPART
OACYLASE
(Shewanella
frigidimarina) 		5 / 10 TYR A 265
ILE A 262
VAL A 271
ILE A  39
ILE A  70
 None
 1.04A 3p4wE-3lwuA:
undetectable		 3p4wE-3lwuA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UG8_A_IMNA2001_2
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 3lwu SUCCINYLGLUTAMATE
DESUCCINYLASE/ASPART
OACYLASE
(Shewanella
frigidimarina) 		3 / 3 TYR A 183
GLU A 186
TYR A 287
 None
 0.93A 3ug8A-3lwuA:
undetectable		 3ug8A-3lwuA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4S0V_A_SUVA2001_1
(HUMAN OREXIN
RECEPTOR TYPE 2
FUSION PROTEIN TO P.
ABYSII GLYCOGEN
SYNTHASE)		 3lwu SUCCINYLGLUTAMATE
DESUCCINYLASE/ASPART
OACYLASE
(Shewanella
frigidimarina) 		5 / 12 VAL A   9
GLN A  40
ILE A  54
ASN A  51
TYR A  38
 None
 1.34A 4s0vA-3lwuA:
2.2		 4s0vA-3lwuA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XPB_A_COCA702_1
(TRANSPORTER)		 3lwu SUCCINYLGLUTAMATE
DESUCCINYLASE/ASPART
OACYLASE
(Shewanella
frigidimarina) 		5 / 10 ASP A 167
GLY A 270
SER A  36
GLY A  29
MET A  28
 None
 1.46A 4xpbA-3lwuA:
1.9		 4xpbA-3lwuA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4F_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 3lwu SUCCINYLGLUTAMATE
DESUCCINYLASE/ASPART
OACYLASE
(Shewanella
frigidimarina) 		4 / 7 LEU A 288
TYR A 287
PRO A 204
LEU A 201
 None
 0.91A 4z4fA-3lwuA:
2.1		 4z4fA-3lwuA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BPH_A_ACTA403_0
(D-ALANINE--D-ALANINE
LIGASE)		 3lwu SUCCINYLGLUTAMATE
DESUCCINYLASE/ASPART
OACYLASE
(Shewanella
frigidimarina) 		4 / 6 TYR A 291
LYS A 361
GLY A 175
SER A 178
 UNL  A 373 ( 4.4A)
UNL  A 373 ( 2.9A)
UNL  A 373 ( 3.5A)
None
 1.23A 5bphA-3lwuA:
2.0		 5bphA-3lwuA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BPH_B_ACTB404_0
(D-ALANINE--D-ALANINE
LIGASE)		 3lwu SUCCINYLGLUTAMATE
DESUCCINYLASE/ASPART
OACYLASE
(Shewanella
frigidimarina) 		4 / 7 TYR A 291
LYS A 361
GLY A 175
SER A 178
 UNL  A 373 ( 4.4A)
UNL  A 373 ( 2.9A)
UNL  A 373 ( 3.5A)
None
 1.14A 5bphB-3lwuA:
undetectable		 5bphB-3lwuA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BPH_D_ACTD403_0
(D-ALANINE--D-ALANINE
LIGASE)		 3lwu SUCCINYLGLUTAMATE
DESUCCINYLASE/ASPART
OACYLASE
(Shewanella
frigidimarina) 		4 / 6 TYR A 291
LYS A 361
GLY A 175
SER A 178
 UNL  A 373 ( 4.4A)
UNL  A 373 ( 2.9A)
UNL  A 373 ( 3.5A)
None
 1.22A 5bphD-3lwuA:
undetectable		 5bphD-3lwuA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DB5_A_CYSA503_0
(CYSTEINE DESULFURASE)		 3lwu SUCCINYLGLUTAMATE
DESUCCINYLASE/ASPART
OACYLASE
(Shewanella
frigidimarina) 		4 / 8 ALA A 210
HIS A  44
ASN A 100
ARG A 103
 None
ZN  A 374 (-3.1A)
None
None
 1.21A 5db5A-3lwuA:
undetectable
5db5B-3lwuA:
undetectable		 5db5A-3lwuA:
23.52
5db5B-3lwuA:
23.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGV_A_ZITA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 3lwu SUCCINYLGLUTAMATE
DESUCCINYLASE/ASPART
OACYLASE
(Shewanella
frigidimarina) 		5 / 12 GLY A 175
GLU A 257
ALA A  41
SER A 196
ILE A 197
 UNL  A 373 ( 3.5A)
None
None
None
None
 1.12A 5igvA-3lwuA:
undetectable		 5igvA-3lwuA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGY_A_ERYA403_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 3lwu SUCCINYLGLUTAMATE
DESUCCINYLASE/ASPART
OACYLASE
(Shewanella
frigidimarina) 		5 / 12 GLY A 175
GLU A 257
ALA A  41
SER A 196
ILE A 197
 UNL  A 373 ( 3.5A)
None
None
None
None
 1.18A 5igyA-3lwuA:
undetectable		 5igyA-3lwuA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_A_SAMA501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 3lwu SUCCINYLGLUTAMATE
DESUCCINYLASE/ASPART
OACYLASE
(Shewanella
frigidimarina) 		5 / 11 LEU A 318
PRO A 317
GLU A 310
SER A 337
LEU A 338
 None
 1.09A 5o96A-3lwuA:
undetectable
5o96B-3lwuA:
undetectable		 5o96A-3lwuA:
24.94
5o96B-3lwuA:
24.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODI_D_ACTD202_0
(METHYL-VIOLOGEN
REDUCING
HYDROGENASE, SUBUNIT
D)		 3lwu SUCCINYLGLUTAMATE
DESUCCINYLASE/ASPART
OACYLASE
(Shewanella
frigidimarina) 		3 / 3 HIS A 119
GLU A 118
TRP A 115
 None
 0.96A 5odiD-3lwuA:
3.0		 5odiD-3lwuA:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODQ_D_ACTD202_0
(METHYL-VIOLOGEN
REDUCING
HYDROGENASE, SUBUNIT
D)		 3lwu SUCCINYLGLUTAMATE
DESUCCINYLASE/ASPART
OACYLASE
(Shewanella
frigidimarina) 		3 / 3 HIS A 119
GLU A 118
TRP A 115
 None
 0.96A 5odqD-3lwuA:
2.7		 5odqD-3lwuA:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODR_D_ACTD202_0
(METHYL-VIOLOGEN
REDUCING
HYDROGENASE, SUBUNIT
D)		 3lwu SUCCINYLGLUTAMATE
DESUCCINYLASE/ASPART
OACYLASE
(Shewanella
frigidimarina) 		3 / 3 HIS A 119
GLU A 118
TRP A 115
 None
 0.94A 5odrD-3lwuA:
2.9		 5odrD-3lwuA:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T7B_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 3lwu SUCCINYLGLUTAMATE
DESUCCINYLASE/ASPART
OACYLASE
(Shewanella
frigidimarina) 		4 / 7 LEU A 288
TYR A 287
PRO A 204
LEU A 201
 None
 0.93A 5t7bA-3lwuA:
2.0		 5t7bA-3lwuA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YOD_D_BEZD201_0
(NS3 PROTEASE)		 3lwu SUCCINYLGLUTAMATE
DESUCCINYLASE/ASPART
OACYLASE
(Shewanella
frigidimarina) 		4 / 5 HIS A 181
ALA A 245
SER A 178
GLY A 175
 UNL  A 373 ( 3.7A)
None
None
UNL  A 373 ( 3.5A)
 1.21A 5yodD-3lwuA:
undetectable		 5yodD-3lwuA:
19.07