SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3lwx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_B_SAMB1293_1
(GLYCINE
N-METHYLTRANSFERASE)		 3lwx NADH:UBIQUINONE
OXIDOREDUCTASE, NA
TRANSLOCATING, C
SUBUNIT
(Parabacteroides
distasonis) 		4 / 5 ASP A 176
SER A 177
ASN A 180
SER A 174
 None
None
GOL  A 272 (-3.5A)
None
 1.45A 1kiaB-3lwxA:
undetectable		 1kiaB-3lwxA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_C_SAMC2293_1
(GLYCINE
N-METHYLTRANSFERASE)		 3lwx NADH:UBIQUINONE
OXIDOREDUCTASE, NA
TRANSLOCATING, C
SUBUNIT
(Parabacteroides
distasonis) 		4 / 6 ASP A 176
SER A 177
ASN A 180
SER A 174
 None
None
GOL  A 272 (-3.5A)
None
 1.46A 1kiaC-3lwxA:
undetectable		 1kiaC-3lwxA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N2X_B_SAMB402_1
(S-ADENOSYL-METHYLTRA
NSFERASE MRAW)		 3lwx NADH:UBIQUINONE
OXIDOREDUCTASE, NA
TRANSLOCATING, C
SUBUNIT
(Parabacteroides
distasonis) 		4 / 5 ASP A 252
VAL A 225
SER A 248
GLN A 235
 GOL  A 273 (-3.0A)
None
None
GOL  A 273 (-3.4A)
 1.46A 1n2xB-3lwxA:
undetectable		 1n2xB-3lwxA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EFJ_A_37TA502_1
(3,7-DIMETHYLXANTHINE
METHYLTRANSFERASE)		 3lwx NADH:UBIQUINONE
OXIDOREDUCTASE, NA
TRANSLOCATING, C
SUBUNIT
(Parabacteroides
distasonis) 		5 / 12 TYR A 262
LEU A 160
ILE A  91
SER A  94
ILE A 112
 None
 1.41A 2efjA-3lwxA:
undetectable		 2efjA-3lwxA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_A_HSMA1161_1
(ALLERGEN ARG R 1)		 3lwx NADH:UBIQUINONE
OXIDOREDUCTASE, NA
TRANSLOCATING, C
SUBUNIT
(Parabacteroides
distasonis) 		4 / 5 VAL A 223
TYR A 237
VAL A 226
ASP A 239
 None
 1.30A 2x45A-3lwxA:
undetectable		 2x45A-3lwxA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAS_B_ADNB401_2
(PUTATIVE ADENOSINE
KINASE)		 3lwx NADH:UBIQUINONE
OXIDOREDUCTASE, NA
TRANSLOCATING, C
SUBUNIT
(Parabacteroides
distasonis) 		4 / 5 LEU A 117
ALA A 115
THR A 132
PHE A 146
 None
 1.39A 3vasB-3lwxA:
undetectable		 3vasB-3lwxA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5O_A_IPHA906_0
(PROTEIN ARGONAUTE-2)		 3lwx NADH:UBIQUINONE
OXIDOREDUCTASE, NA
TRANSLOCATING, C
SUBUNIT
(Parabacteroides
distasonis) 		4 / 5 PHE A 116
PRO A 144
VAL A 145
ALA A 115
 None
 1.06A 4w5oA-3lwxA:
undetectable		 4w5oA-3lwxA:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4C_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 3lwx NADH:UBIQUINONE
OXIDOREDUCTASE, NA
TRANSLOCATING, C
SUBUNIT
(Parabacteroides
distasonis) 		4 / 5 PHE A 116
PRO A 144
VAL A 145
ALA A 115
 None
 1.09A 4z4cA-3lwxA:
undetectable		 4z4cA-3lwxA:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4D_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 3lwx NADH:UBIQUINONE
OXIDOREDUCTASE, NA
TRANSLOCATING, C
SUBUNIT
(Parabacteroides
distasonis) 		4 / 5 PHE A 116
PRO A 144
VAL A 145
ALA A 115
 None
 1.07A 4z4dA-3lwxA:
undetectable		 4z4dA-3lwxA:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4E_A_IPHA906_0
(PROTEIN ARGONAUTE-2)		 3lwx NADH:UBIQUINONE
OXIDOREDUCTASE, NA
TRANSLOCATING, C
SUBUNIT
(Parabacteroides
distasonis) 		4 / 5 PHE A 116
PRO A 144
VAL A 145
ALA A 115
 None
 1.05A 4z4eA-3lwxA:
undetectable		 4z4eA-3lwxA:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T7B_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 3lwx NADH:UBIQUINONE
OXIDOREDUCTASE, NA
TRANSLOCATING, C
SUBUNIT
(Parabacteroides
distasonis) 		4 / 6 PHE A 116
PRO A 144
VAL A 145
ALA A 115
 None
 1.06A 5t7bA-3lwxA:
undetectable		 5t7bA-3lwxA:
13.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W4Z_A_RBFA502_1
(RIBOFLAVIN LYASE)		 3lwx NADH:UBIQUINONE
OXIDOREDUCTASE, NA
TRANSLOCATING, C
SUBUNIT
(Parabacteroides
distasonis) 		5 / 12 PHE A 187
ALA A 185
GLY A 211
PHE A 205
VAL A 223
 None
 0.97A 5w4zA-3lwxA:
undetectable		 5w4zA-3lwxA:
19.64