SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3lx2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EA1_A_TPFA470_1
(CYTOCHROME P450
51-LIKE RV0764C)
3lx2 DNA POLYMERASE
SLIDING CLAMP 2

(Thermococcus
kodakarensis)
4 / 8 PHE A  29
MET A  38
THR A  19
LEU A  16
None
1.18A 1ea1A-3lx2A:
undetectable
1ea1A-3lx2A:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_D_ESTD352_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)
3lx2 DNA POLYMERASE
SLIDING CLAMP 2

(Thermococcus
kodakarensis)
4 / 6 VAL A 101
GLY A 102
LEU A 103
GLU A  14
None
0.83A 1fduD-3lx2A:
undetectable
1fduD-3lx2A:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IE4_A_T44A128_1
(TRANSTHYRETIN)
3lx2 DNA POLYMERASE
SLIDING CLAMP 2

(Thermococcus
kodakarensis)
5 / 10 GLU A 190
ALA A 134
LEU A 187
GLU A 162
LEU A 179
None
1.31A 1ie4A-3lx2A:
undetectable
1ie4C-3lx2A:
undetectable
1ie4A-3lx2A:
22.58
1ie4C-3lx2A:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_F_TFPF211_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)
3lx2 DNA POLYMERASE
SLIDING CLAMP 2

(Thermococcus
kodakarensis)
4 / 7 LEU A  20
PHE A  76
LEU A  51
PHE A  71
None
0.95A 1wrlE-3lx2A:
undetectable
1wrlF-3lx2A:
undetectable
1wrlE-3lx2A:
17.90
1wrlF-3lx2A:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FT9_A_CHDA131_0
(FATTY ACID-BINDING
PROTEIN 2, LIVER)
3lx2 DNA POLYMERASE
SLIDING CLAMP 2

(Thermococcus
kodakarensis)
5 / 11 LEU A  73
LEU A  20
THR A 120
PRO A 121
LEU A  99
None
1.12A 2ft9A-3lx2A:
2.0
2ft9A-3lx2A:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PIW_A_T3A932_1
(ANDROGEN RECEPTOR)
3lx2 DNA POLYMERASE
SLIDING CLAMP 2

(Thermococcus
kodakarensis)
4 / 6 LEU A 141
VAL A 145
LYS A 146
ILE A 220
None
0.53A 2piwA-3lx2A:
undetectable
2piwA-3lx2A:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_D_RTZD2_1
(CYTOCHROME P450 2D6)
3lx2 DNA POLYMERASE
SLIDING CLAMP 2

(Thermococcus
kodakarensis)
5 / 9 PHE A 157
LEU A 141
VAL A 136
LEU A 228
ILE A 220
None
1.09A 3tbgD-3lx2A:
undetectable
3tbgD-3lx2A:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E3H_A_HQEA303_1
(CARBONIC ANHYDRASE 2)
3lx2 DNA POLYMERASE
SLIDING CLAMP 2

(Thermococcus
kodakarensis)
5 / 10 PHE A  29
LEU A  51
VAL A  49
LEU A  16
VAL A 240
None
1.05A 4e3hA-3lx2A:
undetectable
4e3hA-3lx2A:
22.71