SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3lxd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_A_CCSA47_0
(GLUTATHIONE
S-TRANSFERASE)		 3lxd FAD-DEPENDENT
PYRIDINE
NUCLEOTIDE-DISULPHID
E OXIDOREDUCTASE
(Novosphingobium
aromaticivorans) 		4 / 7 THR A 213
LEU A 181
GLY A 159
LEU A 165
 None
 0.85A 1gtiA-3lxdA:
undetectable		 1gtiA-3lxdA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_B_CCSB47_0
(GLUTATHIONE
S-TRANSFERASE)		 3lxd FAD-DEPENDENT
PYRIDINE
NUCLEOTIDE-DISULPHID
E OXIDOREDUCTASE
(Novosphingobium
aromaticivorans) 		4 / 7 THR A 213
LEU A 181
GLY A 159
LEU A 165
 None
 0.87A 1gtiB-3lxdA:
undetectable		 1gtiB-3lxdA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_E_CCSE47_0
(GLUTATHIONE
S-TRANSFERASE)		 3lxd FAD-DEPENDENT
PYRIDINE
NUCLEOTIDE-DISULPHID
E OXIDOREDUCTASE
(Novosphingobium
aromaticivorans) 		4 / 7 THR A 213
LEU A 181
GLY A 159
LEU A 165
 None
 0.83A 1gtiE-3lxdA:
undetectable		 1gtiE-3lxdA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG2_A_ADNA500_1
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)		 3lxd FAD-DEPENDENT
PYRIDINE
NUCLEOTIDE-DISULPHID
E OXIDOREDUCTASE
(Novosphingobium
aromaticivorans) 		5 / 12 GLY A 246
GLY A 164
GLY A 248
ALA A 134
VAL A 135
 None
 0.93A 1jg2A-3lxdA:
3.0		 1jg2A-3lxdA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NW3_A_SAMA500_0
(HISTONE
METHYLTRANSFERASE
DOT1L)		 3lxd FAD-DEPENDENT
PYRIDINE
NUCLEOTIDE-DISULPHID
E OXIDOREDUCTASE
(Novosphingobium
aromaticivorans) 		5 / 12 GLU A 166
ALA A 192
PHE A 363
LEU A 354
PHE A 199
 FAD  A 416 ( 4.3A)
None
None
None
None
 1.33A 1nw3A-3lxdA:
2.1		 1nw3A-3lxdA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_E_MK1E902_3
(POL POLYPROTEIN)		 3lxd FAD-DEPENDENT
PYRIDINE
NUCLEOTIDE-DISULPHID
E OXIDOREDUCTASE
(Novosphingobium
aromaticivorans) 		5 / 12 LEU A 301
ALA A 294
ASP A 295
GLY A 348
ILE A 299
 None
 0.91A 2avvE-3lxdA:
undetectable		 2avvE-3lxdA:
15.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F80_B_017B301_2
(POL POLYPROTEIN)		 3lxd FAD-DEPENDENT
PYRIDINE
NUCLEOTIDE-DISULPHID
E OXIDOREDUCTASE
(Novosphingobium
aromaticivorans) 		5 / 12 LEU A 301
ALA A 294
ASP A 295
GLY A 348
ILE A 299
 None
 0.95A 2f80B-3lxdA:
undetectable		 2f80B-3lxdA:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8G_B_017B401_1
(POL POLYPROTEIN)		 3lxd FAD-DEPENDENT
PYRIDINE
NUCLEOTIDE-DISULPHID
E OXIDOREDUCTASE
(Novosphingobium
aromaticivorans) 		5 / 12 LEU A 301
ALA A 294
ASP A 295
GLY A 348
ILE A 299
 None
 0.92A 2f8gA-3lxdA:
undetectable		 2f8gA-3lxdA:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS2_A_017A201_1
(PROTEASE)		 3lxd FAD-DEPENDENT
PYRIDINE
NUCLEOTIDE-DISULPHID
E OXIDOREDUCTASE
(Novosphingobium
aromaticivorans) 		5 / 12 LEU A 301
ALA A 294
ASP A 295
GLY A 348
ILE A 299
 None
 0.90A 2hs2A-3lxdA:
undetectable		 2hs2A-3lxdA:
13.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS2_A_017A201_2
(PROTEASE)		 3lxd FAD-DEPENDENT
PYRIDINE
NUCLEOTIDE-DISULPHID
E OXIDOREDUCTASE
(Novosphingobium
aromaticivorans) 		5 / 12 LEU A 301
ALA A 294
ASP A 295
GLY A 348
ILE A 299
 None
 0.93A 2hs2B-3lxdA:
undetectable		 2hs2B-3lxdA:
13.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_A_9CRA501_1
(CYTOCHROME P450 2C8)		 3lxd FAD-DEPENDENT
PYRIDINE
NUCLEOTIDE-DISULPHID
E OXIDOREDUCTASE
(Novosphingobium
aromaticivorans) 		5 / 11 GLY A 260
SER A 276
SER A 262
ALA A 288
VAL A 253
 None
 1.01A 2nnhA-3lxdA:
undetectable		 2nnhA-3lxdA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4K_A_DR7A301_1
(PROTEASE)		 3lxd FAD-DEPENDENT
PYRIDINE
NUCLEOTIDE-DISULPHID
E OXIDOREDUCTASE
(Novosphingobium
aromaticivorans) 		5 / 12 LEU A 301
ALA A 294
ASP A 295
GLY A 348
ILE A 299
 None
 0.91A 2o4kA-3lxdA:
undetectable		 2o4kA-3lxdA:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4L_A_TPVA403_1
(PROTEASE)		 3lxd FAD-DEPENDENT
PYRIDINE
NUCLEOTIDE-DISULPHID
E OXIDOREDUCTASE
(Novosphingobium
aromaticivorans) 		5 / 12 LEU A 301
ALA A 294
ASP A 295
GLY A 348
ILE A 299
 None
 0.90A 2o4lA-3lxdA:
undetectable		 2o4lA-3lxdA:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PLW_A_SAMA203_0
(RIBOSOMAL RNA
METHYLTRANSFERASE,
PUTATIVE)		 3lxd FAD-DEPENDENT
PYRIDINE
NUCLEOTIDE-DISULPHID
E OXIDOREDUCTASE
(Novosphingobium
aromaticivorans) 		5 / 12 ALA A 287
GLY A  20
GLY A 116
ILE A  26
ALA A 311
 None
FAD  A 416 (-3.3A)
FAD  A 416 (-3.6A)
None
None
 1.10A 2plwA-3lxdA:
undetectable		 2plwA-3lxdA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYM_A_1UNA1001_1
(PROTEASE RETROPEPSIN)		 3lxd FAD-DEPENDENT
PYRIDINE
NUCLEOTIDE-DISULPHID
E OXIDOREDUCTASE
(Novosphingobium
aromaticivorans) 		5 / 12 LEU A 301
ALA A 294
ASP A 295
GLY A 348
ILE A 299
 None
 0.93A 2pymA-3lxdA:
undetectable		 2pymA-3lxdA:
12.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZBP_A_SAMA300_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 3lxd FAD-DEPENDENT
PYRIDINE
NUCLEOTIDE-DISULPHID
E OXIDOREDUCTASE
(Novosphingobium
aromaticivorans) 		5 / 12 LEU A 165
GLY A 164
GLY A 246
LEU A 180
LEU A 211
 None
 1.08A 2zbpA-3lxdA:
undetectable		 2zbpA-3lxdA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CJT_G_SAMG302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 3lxd FAD-DEPENDENT
PYRIDINE
NUCLEOTIDE-DISULPHID
E OXIDOREDUCTASE
(Novosphingobium
aromaticivorans) 		5 / 12 LEU A 165
GLY A 164
GLY A 246
LEU A 180
LEU A 211
 None
 1.14A 3cjtG-3lxdA:
undetectable		 3cjtG-3lxdA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CJT_G_SAMG302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 3lxd FAD-DEPENDENT
PYRIDINE
NUCLEOTIDE-DISULPHID
E OXIDOREDUCTASE
(Novosphingobium
aromaticivorans) 		5 / 12 LEU A 165
GLY A 246
VAL A 135
LEU A 180
LEU A 211
 None
 1.06A 3cjtG-3lxdA:
undetectable		 3cjtG-3lxdA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYX_A_ROCA201_1
(HIV-1 PROTEASE)		 3lxd FAD-DEPENDENT
PYRIDINE
NUCLEOTIDE-DISULPHID
E OXIDOREDUCTASE
(Novosphingobium
aromaticivorans) 		5 / 12 LEU A 301
ALA A 294
ASP A 295
GLY A 348
ILE A 299
 None
 0.87A 3cyxA-3lxdA:
undetectable		 3cyxA-3lxdA:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D1Z_B_017B201_2
(HIV-1 PROTEASE)		 3lxd FAD-DEPENDENT
PYRIDINE
NUCLEOTIDE-DISULPHID
E OXIDOREDUCTASE
(Novosphingobium
aromaticivorans) 		5 / 12 LEU A 301
ALA A 294
ASP A 295
GLY A 348
ILE A 299
 None
 1.01A 3d1zB-3lxdA:
undetectable		 3d1zB-3lxdA:
13.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL1_A_DR7A100_1
(PROTEASE)		 3lxd FAD-DEPENDENT
PYRIDINE
NUCLEOTIDE-DISULPHID
E OXIDOREDUCTASE
(Novosphingobium
aromaticivorans) 		5 / 11 LEU A 301
ALA A 294
ASP A 295
GLY A 348
ILE A 299
 None
 0.97A 3el1A-3lxdA:
undetectable		 3el1A-3lxdA:
13.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F33_A_PFLA2001_1
(FERRITIN LIGHT CHAIN)		 3lxd FAD-DEPENDENT
PYRIDINE
NUCLEOTIDE-DISULPHID
E OXIDOREDUCTASE
(Novosphingobium
aromaticivorans) 		4 / 6 SER A 197
TYR A 200
LEU A 196
LEU A 165
 None
 0.99A 3f33A-3lxdA:
undetectable		 3f33A-3lxdA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G88_A_SAMA303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 3lxd FAD-DEPENDENT
PYRIDINE
NUCLEOTIDE-DISULPHID
E OXIDOREDUCTASE
(Novosphingobium
aromaticivorans) 		5 / 11 GLY A 284
ALA A 114
THR A 115
ALA A 311
ALA A 288
 FAD  A 416 (-3.2A)
FAD  A 416 (-4.4A)
FAD  A 416 (-4.2A)
None
None
 1.08A 3g88A-3lxdA:
undetectable		 3g88A-3lxdA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G88_B_SAMB303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 3lxd FAD-DEPENDENT
PYRIDINE
NUCLEOTIDE-DISULPHID
E OXIDOREDUCTASE
(Novosphingobium
aromaticivorans) 		5 / 11 GLY A 284
ALA A 114
THR A 115
ALA A 311
ALA A 288
 FAD  A 416 (-3.2A)
FAD  A 416 (-4.4A)
FAD  A 416 (-4.2A)
None
None
 1.09A 3g88B-3lxdA:
undetectable		 3g88B-3lxdA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_B_THHB643_0
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 3lxd FAD-DEPENDENT
PYRIDINE
NUCLEOTIDE-DISULPHID
E OXIDOREDUCTASE
(Novosphingobium
aromaticivorans) 		5 / 12 GLY A  16
VAL A 269
GLY A 284
ARG A  50
ILE A 283
 FAD  A 416 (-3.3A)
None
FAD  A 416 (-3.2A)
FAD  A 416 (-3.0A)
None
 1.07A 3k13B-3lxdA:
undetectable		 3k13B-3lxdA:
24.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_C_THHC643_0
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 3lxd FAD-DEPENDENT
PYRIDINE
NUCLEOTIDE-DISULPHID
E OXIDOREDUCTASE
(Novosphingobium
aromaticivorans) 		5 / 12 GLY A  16
VAL A 269
GLY A 284
ARG A  50
ILE A 283
 FAD  A 416 (-3.3A)
None
FAD  A 416 (-3.2A)
FAD  A 416 (-3.0A)
None
 1.07A 3k13C-3lxdA:
undetectable		 3k13C-3lxdA:
24.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_D_ROCD201_3
(HIV-1 PROTEASE)		 3lxd FAD-DEPENDENT
PYRIDINE
NUCLEOTIDE-DISULPHID
E OXIDOREDUCTASE
(Novosphingobium
aromaticivorans) 		5 / 12 LEU A 301
ALA A 294
ASP A 295
GLY A 348
ILE A 299
 None
 0.96A 3k4vD-3lxdA:
undetectable		 3k4vD-3lxdA:
13.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_A_CELA701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 3lxd FAD-DEPENDENT
PYRIDINE
NUCLEOTIDE-DISULPHID
E OXIDOREDUCTASE
(Novosphingobium
aromaticivorans) 		4 / 6 HIS A  19
VAL A  39
ILE A  67
LEU A  84
 FAD  A 416 (-4.3A)
None
None
None
 0.91A 3kk6A-3lxdA:
undetectable		 3kk6A-3lxdA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDT_D_ROCD100_2
(PROTEASE)		 3lxd FAD-DEPENDENT
PYRIDINE
NUCLEOTIDE-DISULPHID
E OXIDOREDUCTASE
(Novosphingobium
aromaticivorans) 		5 / 12 LEU A 301
ALA A 294
ASP A 295
GLY A 348
ILE A 299
 None
 0.96A 3ndtD-3lxdA:
undetectable		 3ndtD-3lxdA:
12.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDU_A_ROCA101_2
(PROTEASE)		 3lxd FAD-DEPENDENT
PYRIDINE
NUCLEOTIDE-DISULPHID
E OXIDOREDUCTASE
(Novosphingobium
aromaticivorans) 		5 / 12 LEU A 301
ALA A 294
ASP A 295
GLY A 348
ILE A 299
 None
 0.93A 3nduB-3lxdA:
undetectable		 3nduB-3lxdA:
12.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDU_D_ROCD100_2
(PROTEASE)		 3lxd FAD-DEPENDENT
PYRIDINE
NUCLEOTIDE-DISULPHID
E OXIDOREDUCTASE
(Novosphingobium
aromaticivorans) 		5 / 12 LEU A 301
ALA A 294
ASP A 295
GLY A 348
ILE A 299
 None
 0.96A 3nduD-3lxdA:
undetectable		 3nduD-3lxdA:
12.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXX_A_DR7A100_1
(HIV-1 PROTEASE)		 3lxd FAD-DEPENDENT
PYRIDINE
NUCLEOTIDE-DISULPHID
E OXIDOREDUCTASE
(Novosphingobium
aromaticivorans) 		5 / 12 LEU A 301
ALA A 294
ASP A 295
GLY A 348
ILE A 299
 None
 0.94A 3oxxA-3lxdA:
undetectable		 3oxxA-3lxdA:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXX_C_DR7C100_1
(HIV-1 PROTEASE)		 3lxd FAD-DEPENDENT
PYRIDINE
NUCLEOTIDE-DISULPHID
E OXIDOREDUCTASE
(Novosphingobium
aromaticivorans) 		5 / 12 LEU A 301
ALA A 294
ASP A 295
GLY A 348
ILE A 299
 None
 0.87A 3oxxC-3lxdA:
undetectable		 3oxxC-3lxdA:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXX_C_DR7C100_2
(HIV-1 PROTEASE)		 3lxd FAD-DEPENDENT
PYRIDINE
NUCLEOTIDE-DISULPHID
E OXIDOREDUCTASE
(Novosphingobium
aromaticivorans) 		5 / 11 LEU A 301
ALA A 294
ASP A 295
GLY A 348
ILE A 299
 None
 0.97A 3oxxD-3lxdA:
undetectable		 3oxxD-3lxdA:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWR_A_ROCA401_1
(PROTEASE)		 3lxd FAD-DEPENDENT
PYRIDINE
NUCLEOTIDE-DISULPHID
E OXIDOREDUCTASE
(Novosphingobium
aromaticivorans) 		5 / 12 LEU A 301
ALA A 294
ASP A 295
GLY A 348
ILE A 299
 None
 0.90A 3pwrA-3lxdA:
undetectable		 3pwrA-3lxdA:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKG_B_ROCB801_1
(PROTEASE)		 3lxd FAD-DEPENDENT
PYRIDINE
NUCLEOTIDE-DISULPHID
E OXIDOREDUCTASE
(Novosphingobium
aromaticivorans) 		5 / 12 LEU A 301
ALA A 294
ASP A 295
GLY A 348
ILE A 299
 None
 0.91A 3tkgA-3lxdA:
undetectable		 3tkgA-3lxdA:
11.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UR0_C_SVRC516_1
(RNA-DEPENDENT RNA
POLYMERASE)		 3lxd FAD-DEPENDENT
PYRIDINE
NUCLEOTIDE-DISULPHID
E OXIDOREDUCTASE
(Novosphingobium
aromaticivorans) 		5 / 9 GLY A 260
ALA A 259
ALA A  94
ASP A  92
LEU A  91
 None
 1.46A 3ur0C-3lxdA:
undetectable		 3ur0C-3lxdA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BBO_D_ACTD1113_0
(BLR5658 PROTEIN)		 3lxd FAD-DEPENDENT
PYRIDINE
NUCLEOTIDE-DISULPHID
E OXIDOREDUCTASE
(Novosphingobium
aromaticivorans) 		4 / 4 TRP A 113
LEU A  91
LEU A 277
THR A 275
 None
 1.44A 4bboD-3lxdA:
undetectable		 4bboD-3lxdA:
13.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HLA_A_017A200_1
(PROTEASE)		 3lxd FAD-DEPENDENT
PYRIDINE
NUCLEOTIDE-DISULPHID
E OXIDOREDUCTASE
(Novosphingobium
aromaticivorans) 		5 / 12 LEU A 301
ALA A 294
ASP A 295
GLY A 348
ILE A 299
 None
 0.99A 4hlaA-3lxdA:
undetectable		 4hlaA-3lxdA:
13.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N48_A_SAMA601_1
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 3lxd FAD-DEPENDENT
PYRIDINE
NUCLEOTIDE-DISULPHID
E OXIDOREDUCTASE
(Novosphingobium
aromaticivorans) 		4 / 5 ALA A 307
GLY A  20
ASP A 140
ASP A 285
 FAD  A 416 (-3.5A)
FAD  A 416 (-3.3A)
None
FAD  A 416 (-2.9A)
 0.82A 4n48A-3lxdA:
undetectable		 4n48A-3lxdA:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDT_A_ACTA409_0
(FAD:PROTEIN FMN
TRANSFERASE)		 3lxd FAD-DEPENDENT
PYRIDINE
NUCLEOTIDE-DISULPHID
E OXIDOREDUCTASE
(Novosphingobium
aromaticivorans) 		4 / 5 ILE A 238
VAL A 156
ILE A 158
VAL A 230
 None
 0.62A 4xdtA-3lxdA:
undetectable		 4xdtA-3lxdA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBQ_A_DIFA602_1
(SERUM ALBUMIN)		 3lxd FAD-DEPENDENT
PYRIDINE
NUCLEOTIDE-DISULPHID
E OXIDOREDUCTASE
(Novosphingobium
aromaticivorans) 		4 / 8 LEU A 171
ASN A 154
ALA A 155
GLU A 147
 None
 0.77A 4zbqA-3lxdA:
undetectable		 4zbqA-3lxdA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZ8_A_GCSA208_1
(GLUCANASE/CHITOSANAS
E)		 3lxd FAD-DEPENDENT
PYRIDINE
NUCLEOTIDE-DISULPHID
E OXIDOREDUCTASE
(Novosphingobium
aromaticivorans) 		4 / 7 GLU A  45
TYR A  48
ASP A 140
ALA A 141
 None
 1.13A 4zz8A-3lxdA:
undetectable		 4zz8A-3lxdA:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOC_B_SAMB401_0
(PAVINE
N-METHYLTRANSFERASE)		 3lxd FAD-DEPENDENT
PYRIDINE
NUCLEOTIDE-DISULPHID
E OXIDOREDUCTASE
(Novosphingobium
aromaticivorans) 		5 / 12 SER A  54
GLY A 161
GLY A 246
VAL A 187
LEU A 165
 FAD  A 416 (-3.2A)
None
None
None
None
 1.20A 5kocB-3lxdA:
undetectable		 5kocB-3lxdA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0T_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 3lxd FAD-DEPENDENT
PYRIDINE
NUCLEOTIDE-DISULPHID
E OXIDOREDUCTASE
(Novosphingobium
aromaticivorans) 		5 / 12 ILE A 283
HIS A  19
ALA A 311
ILE A 318
ALA A 314
 None
FAD  A 416 (-4.3A)
None
None
None
 1.06A 5n0tB-3lxdA:
undetectable		 5n0tB-3lxdA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T8H_B_478B401_1
(PROTEASE)		 3lxd FAD-DEPENDENT
PYRIDINE
NUCLEOTIDE-DISULPHID
E OXIDOREDUCTASE
(Novosphingobium
aromaticivorans) 		5 / 12 LEU A 301
ALA A 294
ASP A 295
GLY A 348
ILE A 299
 None
 0.88A 5t8hA-3lxdA:
undetectable		 5t8hA-3lxdA:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOP_B_C2FB3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 3lxd FAD-DEPENDENT
PYRIDINE
NUCLEOTIDE-DISULPHID
E OXIDOREDUCTASE
(Novosphingobium
aromaticivorans) 		5 / 12 GLY A  16
VAL A 269
GLY A 284
ARG A  50
ILE A 283
 FAD  A 416 (-3.3A)
None
FAD  A 416 (-3.2A)
FAD  A 416 (-3.0A)
None
 1.14A 5vopB-3lxdA:
undetectable		 5vopB-3lxdA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_B_HISB402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 3lxd FAD-DEPENDENT
PYRIDINE
NUCLEOTIDE-DISULPHID
E OXIDOREDUCTASE
(Novosphingobium
aromaticivorans) 		5 / 9 VAL A 187
LEU A 340
GLY A 193
LEU A 196
VAL A 191
 None
 1.24A 6czmA-3lxdA:
undetectable
6czmB-3lxdA:
undetectable		 6czmA-3lxdA:
21.76
6czmB-3lxdA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_C_HISC402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 3lxd FAD-DEPENDENT
PYRIDINE
NUCLEOTIDE-DISULPHID
E OXIDOREDUCTASE
(Novosphingobium
aromaticivorans) 		5 / 9 VAL A 187
LEU A 340
GLY A 193
LEU A 196
VAL A 191
 None
 1.31A 6czmB-3lxdA:
undetectable
6czmC-3lxdA:
undetectable		 6czmB-3lxdA:
21.76
6czmC-3lxdA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_E_HISE402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 3lxd FAD-DEPENDENT
PYRIDINE
NUCLEOTIDE-DISULPHID
E OXIDOREDUCTASE
(Novosphingobium
aromaticivorans) 		5 / 9 VAL A 187
LEU A 340
GLY A 193
LEU A 196
VAL A 191
 None
 1.28A 6czmD-3lxdA:
undetectable
6czmE-3lxdA:
undetectable		 6czmD-3lxdA:
21.76
6czmE-3lxdA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_F_HISF402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 3lxd FAD-DEPENDENT
PYRIDINE
NUCLEOTIDE-DISULPHID
E OXIDOREDUCTASE
(Novosphingobium
aromaticivorans) 		5 / 10 VAL A 187
LEU A 340
GLY A 193
LEU A 196
VAL A 191
 None
 1.25A 6czmE-3lxdA:
undetectable
6czmF-3lxdA:
undetectable		 6czmE-3lxdA:
21.76
6czmF-3lxdA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DIF_B_TPVB201_0
(HIV-1 PROTEASE)		 3lxd FAD-DEPENDENT
PYRIDINE
NUCLEOTIDE-DISULPHID
E OXIDOREDUCTASE
(Novosphingobium
aromaticivorans) 		5 / 12 LEU A 301
ALA A 294
ASP A 295
GLY A 348
ILE A 299
 None
 0.93A 6difA-3lxdA:
undetectable		 6difA-3lxdA:
12.53