SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3lxm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A7Y_A_DVAA8_0
(ACTINOMYCIN D)		 3lxm ASPARTATE
CARBAMOYLTRANSFERASE
(Yersinia
pestis) 		3 / 3 THR A 137
THR A 139
PRO A 136
 None
 0.80A 1a7yA-3lxmA:
undetectable		 1a7yA-3lxmA:
3.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A7Y_B_DVAB2_0
(ACTINOMYCIN D)		 3lxm ASPARTATE
CARBAMOYLTRANSFERASE
(Yersinia
pestis) 		3 / 3 THR A 139
PRO A 136
THR A 137
 None
 0.82A 1a7yB-3lxmA:
undetectable		 1a7yB-3lxmA:
3.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DSC_C_DVAC2_0
(ACTINOMYCIN D)		 3lxm ASPARTATE
CARBAMOYLTRANSFERASE
(Yersinia
pestis) 		3 / 3 THR A 139
PRO A 136
THR A 137
 None
 0.94A 1dscC-3lxmA:
undetectable		 1dscC-3lxmA:
3.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DSC_C_DVAC8_0
(ACTINOMYCIN D)		 3lxm ASPARTATE
CARBAMOYLTRANSFERASE
(Yersinia
pestis) 		3 / 3 THR A 137
THR A 139
PRO A 136
 None
 0.65A 1dscC-3lxmA:
undetectable		 1dscC-3lxmA:
3.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FJA_C_DVAC8_0
(ACTINOMYCIN D)		 3lxm ASPARTATE
CARBAMOYLTRANSFERASE
(Yersinia
pestis) 		3 / 3 THR A 137
THR A 139
PRO A 136
 None
 0.80A 1fjaC-3lxmA:
undetectable		 1fjaC-3lxmA:
3.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FJA_D_DVAD8_0
(ACTINOMYCIN D)		 3lxm ASPARTATE
CARBAMOYLTRANSFERASE
(Yersinia
pestis) 		3 / 3 THR A 137
THR A 139
PRO A 136
 None
 0.80A 1fjaD-3lxmA:
undetectable		 1fjaD-3lxmA:
3.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXB_A_ROCA100_2
(HIV-1 PROTEASE)		 3lxm ASPARTATE
CARBAMOYLTRANSFERASE
(Yersinia
pestis) 		3 / 3 ARG A 270
THR A 281
VAL A 278
 None
 0.94A 1hxbA-3lxmA:
undetectable		 1hxbA-3lxmA:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I3W_E_DVAE2_0
(ACTINOMYCIN D)		 3lxm ASPARTATE
CARBAMOYLTRANSFERASE
(Yersinia
pestis) 		3 / 3 THR A 139
PRO A 136
THR A 137
 None
 0.87A 1i3wE-3lxmA:
undetectable		 1i3wE-3lxmA:
3.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I3W_E_DVAE8_0
(ACTINOMYCIN D)		 3lxm ASPARTATE
CARBAMOYLTRANSFERASE
(Yersinia
pestis) 		3 / 3 THR A 137
THR A 139
PRO A 136
 None
 0.82A 1i3wE-3lxmA:
undetectable		 1i3wE-3lxmA:
3.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I3W_F_DVAF8_0
(ACTINOMYCIN D)		 3lxm ASPARTATE
CARBAMOYLTRANSFERASE
(Yersinia
pestis) 		3 / 3 THR A 137
THR A 139
PRO A 136
 None
 0.81A 1i3wF-3lxmA:
undetectable		 1i3wF-3lxmA:
3.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I3W_G_DVAG2_0
(ACTINOMYCIN D)		 3lxm ASPARTATE
CARBAMOYLTRANSFERASE
(Yersinia
pestis) 		3 / 3 THR A 139
PRO A 136
THR A 137
 None
 0.86A 1i3wG-3lxmA:
undetectable		 1i3wG-3lxmA:
3.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I3W_G_DVAG8_0
(ACTINOMYCIN D)		 3lxm ASPARTATE
CARBAMOYLTRANSFERASE
(Yersinia
pestis) 		3 / 3 THR A 137
THR A 139
PRO A 136
 None
 0.78A 1i3wG-3lxmA:
undetectable		 1i3wG-3lxmA:
3.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I3W_H_DVAH8_0
(ACTINOMYCIN D)		 3lxm ASPARTATE
CARBAMOYLTRANSFERASE
(Yersinia
pestis) 		3 / 3 THR A 137
THR A 139
PRO A 136
 None
 0.79A 1i3wH-3lxmA:
undetectable		 1i3wH-3lxmA:
3.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MNV_D_DVAD2_0
(ACTINOMYCIN D)		 3lxm ASPARTATE
CARBAMOYLTRANSFERASE
(Yersinia
pestis) 		3 / 3 THR A 139
PRO A 136
THR A 137
 None
 0.81A 1mnvD-3lxmA:
undetectable		 1mnvD-3lxmA:
3.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MNV_D_DVAD8_0
(ACTINOMYCIN D)		 3lxm ASPARTATE
CARBAMOYLTRANSFERASE
(Yersinia
pestis) 		3 / 3 THR A 137
THR A 139
PRO A 136
 None
 0.73A 1mnvD-3lxmA:
undetectable		 1mnvD-3lxmA:
3.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NH8_A_HISA289_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 3lxm ASPARTATE
CARBAMOYLTRANSFERASE
(Yersinia
pestis) 		4 / 5 ASP A 142
LEU A  25
ALA A 176
LEU A 173
 None
 1.00A 1nh8A-3lxmA:
undetectable		 1nh8A-3lxmA:
25.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OVF_B_DVAB2_0
(ACTINOMYCIN D)		 3lxm ASPARTATE
CARBAMOYLTRANSFERASE
(Yersinia
pestis) 		3 / 3 THR A 139
PRO A 136
THR A 137
 None
 0.87A 1ovfB-3lxmA:
undetectable		 1ovfB-3lxmA:
3.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QFI_A_DVAA8_0
(ACTINOMYCIN X2)		 3lxm ASPARTATE
CARBAMOYLTRANSFERASE
(Yersinia
pestis) 		3 / 3 THR A 137
THR A 139
PRO A 136
 None
 0.79A 1qfiA-3lxmA:
undetectable		 1qfiA-3lxmA:
3.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_F_DVAF2_0
(7-AMINO-ACTINOMYCIN
D)		 3lxm ASPARTATE
CARBAMOYLTRANSFERASE
(Yersinia
pestis) 		3 / 3 THR A 139
PRO A 136
THR A 137
 None
 0.86A 1unjF-3lxmA:
undetectable		 1unjF-3lxmA:
3.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_F_DVAF8_0
(7-AMINO-ACTINOMYCIN
D)		 3lxm ASPARTATE
CARBAMOYLTRANSFERASE
(Yersinia
pestis) 		3 / 3 THR A 137
THR A 139
PRO A 136
 None
 0.85A 1unjF-3lxmA:
undetectable		 1unjF-3lxmA:
3.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_L_DVAL2_0
(7-AMINO-ACTINOMYCIN
D)		 3lxm ASPARTATE
CARBAMOYLTRANSFERASE
(Yersinia
pestis) 		3 / 3 THR A 139
PRO A 136
THR A 137
 None
 0.82A 1unjL-3lxmA:
undetectable		 1unjL-3lxmA:
3.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_L_DVAL8_0
(7-AMINO-ACTINOMYCIN
D)		 3lxm ASPARTATE
CARBAMOYLTRANSFERASE
(Yersinia
pestis) 		3 / 3 THR A 137
THR A 139
PRO A 136
 None
 0.76A 1unjL-3lxmA:
undetectable		 1unjL-3lxmA:
3.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_R_DVAR2_0
(7-AMINO-ACTINOMYCIN
D)		 3lxm ASPARTATE
CARBAMOYLTRANSFERASE
(Yersinia
pestis) 		3 / 3 THR A 139
PRO A 136
THR A 137
 None
 0.78A 1unjR-3lxmA:
undetectable		 1unjR-3lxmA:
3.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_R_DVAR8_0
(7-AMINO-ACTINOMYCIN
D)		 3lxm ASPARTATE
CARBAMOYLTRANSFERASE
(Yersinia
pestis) 		3 / 3 THR A 137
THR A 139
PRO A 136
 None
 0.77A 1unjR-3lxmA:
undetectable		 1unjR-3lxmA:
3.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_W_DVAW8_0
(7-AMINO-ACTINOMYCIN
D)		 3lxm ASPARTATE
CARBAMOYLTRANSFERASE
(Yersinia
pestis) 		3 / 3 THR A 137
THR A 139
PRO A 136
 None
 0.76A 1unjW-3lxmA:
undetectable		 1unjW-3lxmA:
3.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_X_DVAX2_0
(7-AMINO-ACTINOMYCIN
D)		 3lxm ASPARTATE
CARBAMOYLTRANSFERASE
(Yersinia
pestis) 		3 / 3 THR A 139
PRO A 136
THR A 137
 None
 0.77A 1unjX-3lxmA:
undetectable		 1unjX-3lxmA:
3.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_X_DVAX8_0
(7-AMINO-ACTINOMYCIN
D)		 3lxm ASPARTATE
CARBAMOYLTRANSFERASE
(Yersinia
pestis) 		3 / 3 THR A 137
THR A 139
PRO A 136
 None
 0.76A 1unjX-3lxmA:
undetectable		 1unjX-3lxmA:
3.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNM_E_DVAE2_0
(7-AMINOACTINOMYCIN D)		 3lxm ASPARTATE
CARBAMOYLTRANSFERASE
(Yersinia
pestis) 		3 / 3 THR A 139
PRO A 136
THR A 137
 None
 0.80A 1unmE-3lxmA:
undetectable		 1unmE-3lxmA:
3.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNM_E_DVAE8_0
(7-AMINOACTINOMYCIN D)		 3lxm ASPARTATE
CARBAMOYLTRANSFERASE
(Yersinia
pestis) 		3 / 3 THR A 137
THR A 139
PRO A 136
 None
 0.76A 1unmE-3lxmA:
undetectable		 1unmE-3lxmA:
3.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNM_F_DVAF2_0
(7-AMINOACTINOMYCIN D)		 3lxm ASPARTATE
CARBAMOYLTRANSFERASE
(Yersinia
pestis) 		3 / 3 THR A 139
PRO A 136
THR A 137
 None
 0.78A 1unmF-3lxmA:
undetectable		 1unmF-3lxmA:
3.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNM_F_DVAF8_0
(7-AMINOACTINOMYCIN D)		 3lxm ASPARTATE
CARBAMOYLTRANSFERASE
(Yersinia
pestis) 		3 / 3 THR A 137
THR A 139
PRO A 136
 None
 0.73A 1unmF-3lxmA:
undetectable		 1unmF-3lxmA:
3.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WSV_B_THHB4001_0
(AMINOMETHYLTRANSFERA
SE)		 3lxm ASPARTATE
CARBAMOYLTRANSFERASE
(Yersinia
pestis) 		5 / 12 ILE A  96
VAL A 100
PHE A  50
CYH A  48
LEU A 115
 None
 1.14A 1wsvB-3lxmA:
undetectable		 1wsvB-3lxmA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC2_E_NCAE507_0
(NAD-DEPENDENT
DEACETYLASE 2)		 3lxm ASPARTATE
CARBAMOYLTRANSFERASE
(Yersinia
pestis) 		4 / 7 LEU A 216
ASN A 157
ILE A 158
ASP A 224
 None
 0.92A 1yc2E-3lxmA:
5.2		 1yc2E-3lxmA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
209D_C_DVAC8_0
(N8-ACTINOMYCIN D)		 3lxm ASPARTATE
CARBAMOYLTRANSFERASE
(Yersinia
pestis) 		3 / 3 THR A 137
THR A 139
PRO A 136
 None
 0.87A 209dC-3lxmA:
undetectable		 209dC-3lxmA:
3.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E1Q_D_SALD5006_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 3lxm ASPARTATE
CARBAMOYLTRANSFERASE
(Yersinia
pestis) 		4 / 5 ARG A 106
PHE A  49
THR A  56
LEU A  58
 PG4  A 312 (-3.0A)
None
PG4  A 312 (-4.3A)
None
 1.43A 2e1qD-3lxmA:
undetectable		 2e1qD-3lxmA:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OUZ_A_C3DA999_0
(ESTROGEN RECEPTOR)		 3lxm ASPARTATE
CARBAMOYLTRANSFERASE
(Yersinia
pestis) 		6 / 12 LEU A 173
LEU A  16
LEU A  25
LEU A 140
LEU A 141
LEU A 153
 None
 1.32A 2ouzA-3lxmA:
undetectable		 2ouzA-3lxmA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QAK_A_1UNA1001_2
(PROTEASE RETROPEPSIN)		 3lxm ASPARTATE
CARBAMOYLTRANSFERASE
(Yersinia
pestis) 		3 / 3 ARG A 270
THR A 281
VAL A 278
 None
 0.93A 2qakA-3lxmA:
undetectable		 2qakA-3lxmA:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CV9_A_VDXA501_1
(CYTOCHROME P450-SU1)		 3lxm ASPARTATE
CARBAMOYLTRANSFERASE
(Yersinia
pestis) 		5 / 9 LEU A 140
SER A  17
ILE A  13
ILE A 125
GLY A 121
 None
 1.27A 3cv9A-3lxmA:
undetectable		 3cv9A-3lxmA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G1U_C_ADNC438_2
(ADENOSYLHOMOCYSTEINA
SE)		 3lxm ASPARTATE
CARBAMOYLTRANSFERASE
(Yersinia
pestis) 		4 / 5 THR A 145
THR A 169
HIS A 135
HIS A 266
 None
None
PG4  A 312 (-4.5A)
None
 1.24A 3g1uC-3lxmA:
10.4		 3g1uC-3lxmA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HIV_D_DVAD2_0
(ACTINOMYCIN D)		 3lxm ASPARTATE
CARBAMOYLTRANSFERASE
(Yersinia
pestis) 		3 / 3 THR A 139
PRO A 136
THR A 137
 None
 0.85A 4hivD-3lxmA:
undetectable		 4hivD-3lxmA:
3.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZT_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 2)		 3lxm ASPARTATE
CARBAMOYLTRANSFERASE
(Yersinia
pestis) 		3 / 3 PHE A 185
THR A 149
LEU A 173
 None
 0.78A 4qztA-3lxmA:
undetectable		 4qztA-3lxmA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MWY_A_YNUA1101_0
(MINERALOCORTICOID
RECEPTOR)		 3lxm ASPARTATE
CARBAMOYLTRANSFERASE
(Yersinia
pestis) 		5 / 12 LEU A 216
SER A 253
SER A 252
LEU A 255
MET A 228
 None
 1.04A 5mwyA-3lxmA:
undetectable		 5mwyA-3lxmA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FCB_A_SAMA405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 3lxm ASPARTATE
CARBAMOYLTRANSFERASE
(Yersinia
pestis) 		4 / 8 PRO A 136
SER A  59
SER A  63
PHE A  60
 None
 1.24A 6fcbA-3lxmA:
undetectable		 6fcbA-3lxmA:
20.58