SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3lxq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_A_FOLA605_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3lxq UNCHARACTERIZED
PROTEIN VP1736
(Vibrio
parahaemolyticus) 		5 / 12 ALA A 426
LEU A 290
LEU A 481
ILE A 527
TYR A 493
 None
 1.14A 1qzfA-3lxqA:
2.5		 1qzfA-3lxqA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_B_FOLB609_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3lxq UNCHARACTERIZED
PROTEIN VP1736
(Vibrio
parahaemolyticus) 		5 / 12 ALA A 426
LEU A 290
LEU A 481
ILE A 527
TYR A 493
 None
 1.14A 1qzfB-3lxqA:
undetectable		 1qzfB-3lxqA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_C_FOLC613_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3lxq UNCHARACTERIZED
PROTEIN VP1736
(Vibrio
parahaemolyticus) 		5 / 12 ALA A 426
LEU A 290
LEU A 481
ILE A 527
TYR A 493
 None
 1.14A 1qzfC-3lxqA:
undetectable		 1qzfC-3lxqA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_D_FOLD617_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3lxq UNCHARACTERIZED
PROTEIN VP1736
(Vibrio
parahaemolyticus) 		5 / 12 ALA A 426
LEU A 290
LEU A 481
ILE A 527
TYR A 493
 None
 1.15A 1qzfD-3lxqA:
undetectable		 1qzfD-3lxqA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_E_FOLE621_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3lxq UNCHARACTERIZED
PROTEIN VP1736
(Vibrio
parahaemolyticus) 		5 / 12 ALA A 426
LEU A 290
LEU A 481
ILE A 527
TYR A 493
 None
 1.15A 1qzfE-3lxqA:
undetectable		 1qzfE-3lxqA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SV5_A_65BA600_0
(REVERSE
TRANSCRIPTASE)		 3lxq UNCHARACTERIZED
PROTEIN VP1736
(Vibrio
parahaemolyticus) 		5 / 10 LEU A 422
LYS A 425
VAL A 401
TYR A 379
TYR A 423
 None
 1.39A 1sv5A-3lxqA:
undetectable		 1sv5A-3lxqA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TKQ_B_DVAB8_0
(GRAMICIDIN A)		 3lxq UNCHARACTERIZED
PROTEIN VP1736
(Vibrio
parahaemolyticus) 		4 / 5 VAL A 412
GLY A 413
VAL A 417
TRP A 415
 None
 1.24A 1tkqB-3lxqA:
undetectable		 1tkqB-3lxqA:
3.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q63_A_1UNA1001_2
(PROTEASE RETROPEPSIN)		 3lxq UNCHARACTERIZED
PROTEIN VP1736
(Vibrio
parahaemolyticus) 		3 / 3 ARG A 534
ASN A 542
THR A 548
 None
 0.85A 2q63A-3lxqA:
undetectable		 2q63A-3lxqA:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_B_RIMB299_1
(MATRIX PROTEIN 2)		 3lxq UNCHARACTERIZED
PROTEIN VP1736
(Vibrio
parahaemolyticus) 		4 / 6 LEU A 368
LEU A 367
ILE A 553
ARG A 284
 None
 0.96A 2rlfB-3lxqA:
undetectable
2rlfC-3lxqA:
undetectable		 2rlfB-3lxqA:
8.23
2rlfC-3lxqA:
8.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9H_A_TOPA1160_1
(DIHYDROFOLATE
REDUCTASE)		 3lxq UNCHARACTERIZED
PROTEIN VP1736
(Vibrio
parahaemolyticus) 		5 / 10 ALA A 488
LEU A 290
VAL A 288
ILE A 378
PHE A 430
 None
 1.13A 2w9hA-3lxqA:
undetectable		 2w9hA-3lxqA:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APW_B_DP0B190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 3lxq UNCHARACTERIZED
PROTEIN VP1736
(Vibrio
parahaemolyticus) 		5 / 12 ILE A 553
PHE A 499
PHE A 484
LEU A 290
PHE A 430
 None
 1.28A 3apwB-3lxqA:
undetectable		 3apwB-3lxqA:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZY_D_BRLD478_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3lxq UNCHARACTERIZED
PROTEIN VP1736
(Vibrio
parahaemolyticus) 		4 / 4 ILE A 527
GLN A 321
ILE A 498
LEU A 303
 None
 1.29A 3dzyD-3lxqA:
undetectable		 3dzyD-3lxqA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJD_A_C2FA315_0
(UNCHARACTERIZED
PROTEIN)		 3lxq UNCHARACTERIZED
PROTEIN VP1736
(Vibrio
parahaemolyticus) 		5 / 11 THR A 548
ILE A 553
THR A 567
PHE A 322
ILE A 289
 None
 1.38A 3ijdA-3lxqA:
undetectable		 3ijdA-3lxqA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MJR_A_AC2A301_1
(DEOXYCYTIDINE KINASE)		 3lxq UNCHARACTERIZED
PROTEIN VP1736
(Vibrio
parahaemolyticus) 		5 / 9 ILE A 539
ASP A 608
PHE A 609
TYR A 326
LEU A 588
 None
 1.49A 3mjrA-3lxqA:
1.6		 3mjrA-3lxqA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_D_9PLD501_1
(CYTOCHROME P450 2A6)		 3lxq UNCHARACTERIZED
PROTEIN VP1736
(Vibrio
parahaemolyticus) 		5 / 10 PHE A 392
VAL A 352
PHE A 391
GLY A 335
THR A 328
 None
 1.21A 3t3rD-3lxqA:
undetectable		 3t3rD-3lxqA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QTU_D_SAMD301_1
(PUTATIVE
METHYLTRANSFERASE
BUD23)		 3lxq UNCHARACTERIZED
PROTEIN VP1736
(Vibrio
parahaemolyticus) 		4 / 5 LEU A 433
SER A 434
ASP A 427
ASP A 486
 None
 1.31A 4qtuD-3lxqA:
undetectable		 4qtuD-3lxqA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XZK_A_AG2A700_1
(PUTATIVE
NAD(+)--ARGININE
ADP-RIBOSYLTRANSFERA
SE VIS)		 3lxq UNCHARACTERIZED
PROTEIN VP1736
(Vibrio
parahaemolyticus) 		4 / 7 SER A 635
TYR A 638
ARG A 349
SER A 348
 None
 1.20A 4xzkA-3lxqA:
undetectable		 4xzkA-3lxqA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z7F_D_FOLD201_0
(FOLATE ECF
TRANSPORTER)		 3lxq UNCHARACTERIZED
PROTEIN VP1736
(Vibrio
parahaemolyticus) 		5 / 11 ALA A 365
PHE A 391
ASN A 387
ASN A 384
THR A 390
 None
 1.25A 4z7fD-3lxqA:
0.0		 4z7fD-3lxqA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_C_FK5C201_1
(FK506-BINDING
PROTEIN 1)		 3lxq UNCHARACTERIZED
PROTEIN VP1736
(Vibrio
parahaemolyticus) 		5 / 10 TYR A 379
VAL A 333
ILE A 336
LEU A 443
PHE A 377
 None
 1.27A 5hw8C-3lxqA:
undetectable
5hw8H-3lxqA:
undetectable		 5hw8C-3lxqA:
14.89
5hw8H-3lxqA:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUN_A_ACTA804_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3lxq UNCHARACTERIZED
PROTEIN VP1736
(Vibrio
parahaemolyticus) 		4 / 5 GLY A 296
GLN A 298
VAL A 474
SER A 294
 None
 1.31A 5vunA-3lxqA:
undetectable		 5vunA-3lxqA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_B_HFGB1002_0
(PROLYL-TRNA
SYNTHETASE (PRORS))		 3lxq UNCHARACTERIZED
PROTEIN VP1736
(Vibrio
parahaemolyticus) 		5 / 12 LEU A 443
GLU A 337
VAL A 339
GLU A 293
HIS A 450
 None
 1.41A 5xiqB-3lxqA:
undetectable		 5xiqB-3lxqA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_F_TA1F502_2
(TUBULIN BETA CHAIN)		 3lxq UNCHARACTERIZED
PROTEIN VP1736
(Vibrio
parahaemolyticus) 		4 / 5 LEU A 287
THR A 548
PRO A 344
ARG A 334
 None
None
None
CL  A   1 (-4.5A)
 1.07A 6ew0F-3lxqA:
undetectable		 6ew0F-3lxqA:
11.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_G_TA1G501_2
(TUBULIN BETA CHAIN)		 3lxq UNCHARACTERIZED
PROTEIN VP1736
(Vibrio
parahaemolyticus) 		4 / 6 LEU A 287
THR A 548
PRO A 344
ARG A 334
 None
None
None
CL  A   1 (-4.5A)
 1.07A 6ew0G-3lxqA:
undetectable		 6ew0G-3lxqA:
11.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NCS_A_ACTA303_0
(N-ACETYLNEURAMINIC
ACID (SIALIC ACID)
SYNTHETASE)		 3lxq UNCHARACTERIZED
PROTEIN VP1736
(Vibrio
parahaemolyticus) 		3 / 3 ILE A 364
THR A 363
PRO A 546
 None
 0.55A 6ncsA-3lxqA:
undetectable		 6ncsA-3lxqA:
20.89