SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3lxr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CQP_A_803A311_1
(ANTIGEN CD11A (P180))		 3lxr IPGB2
(Shigella
flexneri) 		5 / 10 LEU F 110
ILE F 108
TYR F 106
GLU F 162
VAL F  74
 None
 1.10A 1cqpA-3lxrF:
undetectable
1cqpB-3lxrF:
undetectable		 1cqpA-3lxrF:
23.47
1cqpB-3lxrF:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UT5_B_LOCB502_1
(TUBULIN BETA CHAIN)		 3lxr IPGB2
(Shigella
flexneri) 		5 / 12 LYS F 172
LEU F 173
ASN F 176
MET F 177
ILE F 108
 None
 0.97A 3ut5B-3lxrF:
undetectable		 3ut5B-3lxrF:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FCT_B_C2FB402_1
(THYMIDYLATE SYNTHASE)		 3lxr IPGB2
(Shigella
flexneri) 		3 / 3 ASN F  76
ASP F  92
GLY F  91
 None
 0.62A 5fctB-3lxrF:
undetectable		 5fctB-3lxrF:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UHC_C_RFPC1201_2
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 3lxr IPGB2
(Shigella
flexneri) 		3 / 3 PHE F  82
ASP F  80
LEU F 170
 None
 0.66A 5uhcC-3lxrF:
undetectable		 5uhcC-3lxrF:
9.90