SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3lxu'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKO_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		 3lxu TRIPEPTIDYL-PEPTIDAS
E 2
(Drosophila
melanogaster) 		5 / 10 LEU X 514
VAL X 396
TYR X 399
GLY X 397
LEU X 515
 None
 1.37A 1fkoA-3lxuX:
2.8		 1fkoA-3lxuX:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L2I_B_CCSB417_0
(ESTROGEN RECEPTOR)		 3lxu TRIPEPTIDYL-PEPTIDAS
E 2
(Drosophila
melanogaster) 		4 / 6 PRO X 833
GLU X 929
GLN X 849
LYS X 830
 None
 1.21A 1l2iB-3lxuX:
undetectable		 1l2iB-3lxuX:
10.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LWF_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 3lxu TRIPEPTIDYL-PEPTIDAS
E 2
(Drosophila
melanogaster) 		5 / 9 LEU X 475
TYR X  30
TYR X  33
GLY X  35
LEU X 479
 None
 1.43A 1lwfA-3lxuX:
2.2		 1lwfA-3lxuX:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_B_DESB459_1
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 3lxu TRIPEPTIDYL-PEPTIDAS
E 2
(Drosophila
melanogaster) 		5 / 12 LEU X1193
LEU X1199
ALA X1200
LEU X1141
VAL X1134
 None
 1.28A 1s9pB-3lxuX:
undetectable		 1s9pB-3lxuX:
10.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SDT_B_MK1B902_1
(PROTEASE RETROPEPSIN)		 3lxu TRIPEPTIDYL-PEPTIDAS
E 2
(Drosophila
melanogaster) 		5 / 10 ILE X 549
GLY X 548
GLY X 431
ILE X 429
VAL X 651
 None
 0.92A 1sdtA-3lxuX:
undetectable		 1sdtA-3lxuX:
5.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOZ_A_CIAA501_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 3lxu TRIPEPTIDYL-PEPTIDAS
E 2
(Drosophila
melanogaster) 		5 / 12 ALA X  41
ILE X  40
ILE X 337
VAL X 366
ILE X 491
 None
 1.10A 1xozA-3lxuX:
undetectable		 1xozA-3lxuX:
13.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZ1_A_HLTA2001_1
(FERRITIN LIGHT CHAIN)		 3lxu TRIPEPTIDYL-PEPTIDAS
E 2
(Drosophila
melanogaster) 		4 / 4 LEU X 474
SER X 477
TYR X  33
LEU X  27
 None
 1.25A 1xz1A-3lxuX:
2.5		 1xz1A-3lxuX:
8.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZ3_A_ICFA201_1
(FERRITIN LIGHT CHAIN)		 3lxu TRIPEPTIDYL-PEPTIDAS
E 2
(Drosophila
melanogaster) 		4 / 4 LEU X 474
SER X 477
TYR X  33
LEU X  27
 None
 1.26A 1xz3A-3lxuX:
2.5		 1xz3A-3lxuX:
8.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_C_NFZC3219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 3lxu TRIPEPTIDYL-PEPTIDAS
E 2
(Drosophila
melanogaster) 		4 / 8 PHE X 210
LYS X  82
GLU X 259
GLY X 260
 None
 1.03A 1ykiC-3lxuX:
undetectable
1ykiD-3lxuX:
undetectable		 1ykiC-3lxuX:
11.26
1ykiD-3lxuX:
11.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOI_C_FRDC305_2
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 3lxu TRIPEPTIDYL-PEPTIDAS
E 2
(Drosophila
melanogaster) 		4 / 5 LEU X 757
PRO X 691
VAL X 690
ILE X 688
 None
 0.79A 2aoiB-3lxuX:
undetectable		 2aoiB-3lxuX:
5.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F6D_A_ACRA996_1
(GLUCOAMYLASE GLU1)		 3lxu TRIPEPTIDYL-PEPTIDAS
E 2
(Drosophila
melanogaster) 		4 / 7 HIS X 272
ASP X 145
THR X 274
GLY X 273
 None
 1.01A 2f6dA-3lxuX:
3.8		 2f6dA-3lxuX:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OTF_A_2TNA201_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 3lxu TRIPEPTIDYL-PEPTIDAS
E 2
(Drosophila
melanogaster) 		4 / 5 LEU X 474
SER X 281
GLY X 291
HIS X 467
 None
 0.90A 2otfA-3lxuX:
undetectable		 2otfA-3lxuX:
6.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5P_B_MK1B902_1
(PROTEASE)		 3lxu TRIPEPTIDYL-PEPTIDAS
E 2
(Drosophila
melanogaster) 		5 / 12 ASP X 335
VAL X 336
ILE X 476
GLY X  35
ILE X  40
 None
 1.02A 2r5pA-3lxuX:
undetectable		 2r5pA-3lxuX:
5.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5P_D_MK1D902_1
(PROTEASE)		 3lxu TRIPEPTIDYL-PEPTIDAS
E 2
(Drosophila
melanogaster) 		5 / 12 ASP X 335
VAL X 336
ILE X 476
GLY X  35
ILE X  40
 None
 1.02A 2r5pC-3lxuX:
undetectable		 2r5pC-3lxuX:
5.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VOU_B_ACTB1391_0
(2,6-DIHYDROXYPYRIDIN
E HYDROXYLASE)		 3lxu TRIPEPTIDYL-PEPTIDAS
E 2
(Drosophila
melanogaster) 		3 / 3 PRO X 488
GLY X 365
TYR X 571
 None
 0.73A 2vouB-3lxuX:
2.5		 2vouB-3lxuX:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WA2_B_SAMB1267_1
(NON-STRUCTURAL
PROTEIN 5)		 3lxu TRIPEPTIDYL-PEPTIDAS
E 2
(Drosophila
melanogaster) 		3 / 3 SER X 835
HIS X 922
ASP X 926
 None
 0.73A 2wa2B-3lxuX:
1.9		 2wa2B-3lxuX:
11.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2N_B_X2NB1479_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 3lxu TRIPEPTIDYL-PEPTIDAS
E 2
(Drosophila
melanogaster) 		5 / 12 PHE X 665
PHE X 779
PRO X 667
ALA X 668
ALA X 697
 None
 1.10A 2x2nB-3lxuX:
undetectable		 2x2nB-3lxuX:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABK_W_CHDW1059_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 3lxu TRIPEPTIDYL-PEPTIDAS
E 2
(Drosophila
melanogaster) 		4 / 5 ILE X 353
ARG X 319
MET X 321
THR X 322
 None
 1.27A 3abkN-3lxuX:
undetectable
3abkW-3lxuX:
undetectable		 3abkN-3lxuX:
16.39
3abkW-3lxuX:
4.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWC_A_SAMA501_0
(SPERMIDINE SYNTHASE)		 3lxu TRIPEPTIDYL-PEPTIDAS
E 2
(Drosophila
melanogaster) 		5 / 12 ILE X 394
GLY X 395
ASP X 387
VAL X 382
THR X 436
 None
 0.99A 3bwcA-3lxuX:
3.9		 3bwcA-3lxuX:
13.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKX_B_1UNB201_2
(PROTEASE)		 3lxu TRIPEPTIDYL-PEPTIDAS
E 2
(Drosophila
melanogaster) 		5 / 11 ASP X 335
VAL X 336
ILE X 476
GLY X  35
ILE X  40
 None
 1.00A 3ekxB-3lxuX:
undetectable		 3ekxB-3lxuX:
5.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCP_B_CHDB4_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3lxu TRIPEPTIDYL-PEPTIDAS
E 2
(Drosophila
melanogaster) 		3 / 3 GLY X  89
PRO X  85
LEU X 120
 None
 0.62A 3hcpB-3lxuX:
2.6		 3hcpB-3lxuX:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HKU_A_TORA300_2
(CARBONIC ANHYDRASE 2)		 3lxu TRIPEPTIDYL-PEPTIDAS
E 2
(Drosophila
melanogaster) 		3 / 3 GLU X 783
HIS X1016
THR X 695
 None
 0.82A 3hkuA-3lxuX:
undetectable		 3hkuA-3lxuX:
10.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_A_CGEA501_1
(CYTOCHROME P450 2B4)		 3lxu TRIPEPTIDYL-PEPTIDAS
E 2
(Drosophila
melanogaster) 		5 / 10 VAL X 648
ALA X 632
ILE X 566
VAL X 539
VAL X 564
 None
 1.01A 3me6A-3lxuX:
undetectable		 3me6A-3lxuX:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_A_CGEA501_1
(CYTOCHROME P450 2B4)		 3lxu TRIPEPTIDYL-PEPTIDAS
E 2
(Drosophila
melanogaster) 		5 / 10 VAL X 648
ALA X 632
ILE X 612
VAL X 564
VAL X 614
 None
 1.02A 3me6A-3lxuX:
undetectable		 3me6A-3lxuX:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_Y_BO2Y1403_1
(PROTEASOME COMPONENT
PRE2
PROTEASOME COMPONENT
C5)		 3lxu TRIPEPTIDYL-PEPTIDAS
E 2
(Drosophila
melanogaster) 		6 / 12 ALA X 465
ALA X 280
ALA X 469
VAL X 396
GLY X 441
ALA X 439
 None
 1.29A 3mg0Y-3lxuX:
undetectable
3mg0Z-3lxuX:
undetectable		 3mg0Y-3lxuX:
9.25
3mg0Z-3lxuX:
9.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MNP_A_DEXA784_1
(GLUCOCORTICOID
RECEPTOR)		 3lxu TRIPEPTIDYL-PEPTIDAS
E 2
(Drosophila
melanogaster) 		5 / 12 GLY X  75
VAL X 256
ARG X 838
LEU X 209
CYH X 207
 None
 1.12A 3mnpA-3lxuX:
undetectable		 3mnpA-3lxuX:
11.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MNP_A_DEXA784_1
(GLUCOCORTICOID
RECEPTOR)		 3lxu TRIPEPTIDYL-PEPTIDAS
E 2
(Drosophila
melanogaster) 		5 / 12 GLY X  75
VAL X 256
LEU X 209
CYH X 207
ILE X 135
 None
 1.04A 3mnpA-3lxuX:
undetectable		 3mnpA-3lxuX:
11.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QOW_A_SAMA417_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE)		 3lxu TRIPEPTIDYL-PEPTIDAS
E 2
(Drosophila
melanogaster) 		3 / 3 THR X1273
ASP X 176
GLU X 182
 None
 0.80A 3qowA-3lxuX:
2.9		 3qowA-3lxuX:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T01_A_PPFA503_1
(PHOSPHONOACETATE
HYDROLASE)		 3lxu TRIPEPTIDYL-PEPTIDAS
E 2
(Drosophila
melanogaster) 		4 / 7 THR X1273
HIS X1297
ILE X1268
HIS X1293
 None
 1.08A 3t01A-3lxuX:
2.6		 3t01A-3lxuX:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF3_B_SAMB301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 3lxu TRIPEPTIDYL-PEPTIDAS
E 2
(Drosophila
melanogaster) 		5 / 12 GLY X 781
ALA X 694
ALA X 697
VAL X 751
ASP X1007
 None
 1.42A 4df3B-3lxuX:
2.6		 4df3B-3lxuX:
11.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJW_A_SRYA2001_2
(TRANSCRIPTIONAL
REGULATOR TCAR)		 3lxu TRIPEPTIDYL-PEPTIDAS
E 2
(Drosophila
melanogaster) 		4 / 6 GLU X1270
ILE X1268
GLU X 182
HIS X1299
 None
 1.09A 4ejwB-3lxuX:
undetectable		 4ejwB-3lxuX:
8.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_C_CLQC303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3lxu TRIPEPTIDYL-PEPTIDAS
E 2
(Drosophila
melanogaster) 		4 / 5 GLY X 354
MET X 357
ASN X 358
GLU X 877
 None
 1.15A 4fglC-3lxuX:
2.8		 4fglC-3lxuX:
10.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KHP_A_PARA1606_1
(16S RIBOSOMAL RNA
30S RIBOSOMAL
PROTEIN S9
30S RIBOSOMAL
PROTEIN S10)		 3lxu TRIPEPTIDYL-PEPTIDAS
E 2
(Drosophila
melanogaster) 		3 / 3 TYR X 633
ARG X 631
SER X 642
 None
 0.99A 4khpI-3lxuX:
undetectable
4khpJ-3lxuX:
undetectable		 4khpI-3lxuX:
7.41
4khpJ-3lxuX:
6.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LV9_A_20JA602_1
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 3lxu TRIPEPTIDYL-PEPTIDAS
E 2
(Drosophila
melanogaster) 		5 / 7 TYR X 486
VAL X 367
ARG X 493
ILE X 495
ALA X 494
 None
 1.17A 4lv9A-3lxuX:
undetectable		 4lv9A-3lxuX:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1Z_A_MXMA807_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 3lxu TRIPEPTIDYL-PEPTIDAS
E 2
(Drosophila
melanogaster) 		6 / 12 VAL X 367
ILE X  40
GLY X 470
ALA X 473
LEU X 475
LEU X 524
 None
 1.41A 4o1zA-3lxuX:
0.0		 4o1zA-3lxuX:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BMV_C_VLBC507_2
(TUBULIN ALPHA-1B
CHAIN)		 3lxu TRIPEPTIDYL-PEPTIDAS
E 2
(Drosophila
melanogaster) 		4 / 7 VAL X 472
ILE X 476
VAL X 367
ILE X 394
 None
 0.78A 5bmvC-3lxuX:
undetectable		 5bmvC-3lxuX:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECL_D_ILED602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 3lxu TRIPEPTIDYL-PEPTIDAS
E 2
(Drosophila
melanogaster) 		4 / 6 ALA X 471
VAL X 472
VAL X 396
HIS X 467
 None
 0.85A 5eclD-3lxuX:
undetectable		 5eclD-3lxuX:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GTR_A_ESTA601_2
(ESTROGEN RECEPTOR)		 3lxu TRIPEPTIDYL-PEPTIDAS
E 2
(Drosophila
melanogaster) 		4 / 5 LEU X 643
LEU X 590
PHE X 537
LEU X 605
 None
 1.05A 5gtrA-3lxuX:
undetectable		 5gtrA-3lxuX:
11.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HES_A_032A401_2
(MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT)		 3lxu TRIPEPTIDYL-PEPTIDAS
E 2
(Drosophila
melanogaster) 		4 / 6 PHE X1320
PHE X1164
VAL X1307
ASP X1318
 None
 1.28A 5hesA-3lxuX:
undetectable		 5hesA-3lxuX:
12.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_K_IPHK101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)		 3lxu TRIPEPTIDYL-PEPTIDAS
E 2
(Drosophila
melanogaster) 		4 / 6 VAL X 468
HIS X 467
CYH X 438
LEU X 514
 None
 1.41A 5hrqH-3lxuX:
undetectable
5hrqK-3lxuX:
undetectable
5hrqL-3lxuX:
undetectable		 5hrqH-3lxuX:
2.37
5hrqK-3lxuX:
2.13
5hrqL-3lxuX:
2.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OSP_A_ACTA403_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 3lxu TRIPEPTIDYL-PEPTIDAS
E 2
(Drosophila
melanogaster) 		4 / 7 VAL X 864
ILE X 866
VAL X 822
ALA X 938
 None
 0.72A 5ospA-3lxuX:
undetectable		 5ospA-3lxuX:
13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OSR_A_ACTA402_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 3lxu TRIPEPTIDYL-PEPTIDAS
E 2
(Drosophila
melanogaster) 		4 / 7 VAL X 864
ILE X 866
VAL X 822
ALA X 938
 None
 0.75A 5osrA-3lxuX:
undetectable		 5osrA-3lxuX:
13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TT3_A_EZLA303_1
(ALPHA-CARBONIC
ANHYDRASE)		 3lxu TRIPEPTIDYL-PEPTIDAS
E 2
(Drosophila
melanogaster) 		5 / 10 VAL X 360
VAL X 361
LEU X 393
ALA X 370
PRO X 385
 None
 1.30A 5tt3A-3lxuX:
undetectable		 5tt3A-3lxuX:
10.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_H_CVIH301_0
(REGULATORY PROTEIN
TETR)		 3lxu TRIPEPTIDYL-PEPTIDAS
E 2
(Drosophila
melanogaster) 		5 / 12 MET X 357
ALA X 370
GLU X 343
VAL X 382
CYH X 428
 None
 1.37A 5vlmH-3lxuX:
undetectable		 5vlmH-3lxuX:
9.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZMQ_I_PACI1_0
(SERINE PROTEASE NS3
SERINE PROTEASE
SUBUNIT NS2B
PEPTIDE
PAC-DLY-DLY-DAR)		 3lxu TRIPEPTIDYL-PEPTIDAS
E 2
(Drosophila
melanogaster) 		3 / 3 VAL X1307
TYR X1304
GLU X1322
 None
 0.92A 5zmqD-3lxuX:
undetectable
5zmqE-3lxuX:
undetectable		 5zmqD-3lxuX:
8.34
5zmqE-3lxuX:
3.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_G_EU7G101_0
(MATRIX PROTEIN 2)		 3lxu TRIPEPTIDYL-PEPTIDAS
E 2
(Drosophila
melanogaster) 		5 / 9 ALA X 370
ALA X 372
SER X 371
GLY X 395
GLY X 434
 None
 1.14A 6bklE-3lxuX:
undetectable
6bklF-3lxuX:
undetectable
6bklG-3lxuX:
undetectable
6bklH-3lxuX:
undetectable		 6bklE-3lxuX:
1.70
6bklF-3lxuX:
1.70
6bklG-3lxuX:
1.70
6bklH-3lxuX:
1.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BPL_B_PA1B605_1
(LIPID A EXPORT
ATP-BINDING/PERMEASE
PROTEIN MSBA)		 3lxu TRIPEPTIDYL-PEPTIDAS
E 2
(Drosophila
melanogaster) 		3 / 3 ARG X 838
ARG X 307
ARG X 921
 None
 1.05A 6bplA-3lxuX:
2.2
6bplB-3lxuX:
3.8		 6bplA-3lxuX:
4.52
6bplB-3lxuX:
4.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_A_EY4A501_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 3lxu TRIPEPTIDYL-PEPTIDAS
E 2
(Drosophila
melanogaster) 		4 / 5 GLN X 433
VAL X 435
PRO X 647
THR X 381
 None
 1.37A 6cduA-3lxuX:
3.4
6cduB-3lxuX:
3.1		 6cduA-3lxuX:
13.16
6cduB-3lxuX:
13.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_I_EY4I500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 3lxu TRIPEPTIDYL-PEPTIDAS
E 2
(Drosophila
melanogaster) 		4 / 5 GLN X 433
VAL X 435
PRO X 647
THR X 381
 None
 1.42A 6cduI-3lxuX:
3.0
6cduJ-3lxuX:
3.6		 6cduI-3lxuX:
13.16
6cduJ-3lxuX:
13.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EU9_B_REAB601_1
(RETINOIC ACID
RECEPTOR)		 3lxu TRIPEPTIDYL-PEPTIDAS
E 2
(Drosophila
melanogaster) 		5 / 10 VAL X 382
SER X 424
GLY X 431
GLY X 511
VAL X 435
 None
 1.18A 6eu9B-3lxuX:
undetectable		 6eu9B-3lxuX:
5.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G2P_A_TRPA502_0
(FLAVIN-DEPENDENT
L-TRYPTOPHAN OXIDASE
VIOA)		 3lxu TRIPEPTIDYL-PEPTIDAS
E 2
(Drosophila
melanogaster) 		4 / 7 ARG X 333
TYR X 486
LEU X 475
VAL X 472
 None
 1.32A 6g2pA-3lxuX:
undetectable		 6g2pA-3lxuX:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HQB_A_PQNA2001_0
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 3lxu TRIPEPTIDYL-PEPTIDAS
E 2
(Drosophila
melanogaster) 		5 / 10 SER X 371
GLY X 373
LEU X 457
GLY X 342
LEU X 250
 None
 1.36A 6hqbA-3lxuX:
4.4
6hqbJ-3lxuX:
undetectable		 6hqbA-3lxuX:
4.36
6hqbJ-3lxuX:
3.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NJ9_K_SAMK500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 3lxu TRIPEPTIDYL-PEPTIDAS
E 2
(Drosophila
melanogaster) 		5 / 12 GLY X 513
GLY X 395
GLY X 397
VAL X 468
ASP X 387
 None
 1.01A 6nj9K-3lxuX:
2.9		 6nj9K-3lxuX:
15.24