SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3lxx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HKK_A_ALEA300_1
(CARBONIC ANHYDRASE 2)		 3lxx GTPASE IMAP FAMILY
MEMBER 4
(Homo
sapiens) 		4 / 6 HIS A  57
ASN A  48
ILE A  50
THR A  66
 None
None
None
MG  A 402 (-2.9A)
 1.17A 2hkkA-3lxxA:
undetectable		 2hkkA-3lxxA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IEO_A_017A402_2
(PROTEASE)		 3lxx GTPASE IMAP FAMILY
MEMBER 4
(Homo
sapiens) 		5 / 12 LEU A 117
GLY A 113
VAL A  84
VAL A  36
VAL A  34
 None
 0.91A 2ieoB-3lxxA:
undetectable		 2ieoB-3lxxA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODR_A_FK5A201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD,
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP1A CHIMERA)		 3lxx GTPASE IMAP FAMILY
MEMBER 4
(Homo
sapiens) 		5 / 12 LEU A 205
LEU A  31
ILE A  33
LEU A  81
ILE A 152
 None
 1.01A 4odrA-3lxxA:
undetectable
4odrB-3lxxA:
undetectable		 4odrA-3lxxA:
15.48
4odrB-3lxxA:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKZ_A_SNPA414_0
(AROMATIC
PEROXYGENASE)		 3lxx GTPASE IMAP FAMILY
MEMBER 4
(Homo
sapiens) 		4 / 5 PHE A 153
VAL A 212
MET A 179
VAL A 121
 None
 0.99A 6ekzA-3lxxA:
undetectable		 6ekzA-3lxxA:
19.75