SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3lxy'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DQY_C_CHDC3_0
(LIVER
CARBOXYLESTERASE 1)		 3lxy 4-HYDROXYTHREONINE-4
-PHOSPHATE
DEHYDROGENASE
(Yersinia
pestis) 		4 / 6 LEU A  45
LEU A  57
PRO A  12
VAL A  37
 None
 0.96A 2dqyC-3lxyA:
undetectable		 2dqyC-3lxyA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLD_B_GW6B2_2
(GLUCOCORTICOID
RECEPTOR)		 3lxy 4-HYDROXYTHREONINE-4
-PHOSPHATE
DEHYDROGENASE
(Yersinia
pestis) 		4 / 8 LEU A 289
ALA A 116
LEU A 117
ILE A 188
 None
 0.94A 3cldB-3lxyA:
undetectable		 3cldB-3lxyA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDV_B_CL6B506_1
(CHOLESTEROL
24-HYDROXYLASE)		 3lxy 4-HYDROXYTHREONINE-4
-PHOSPHATE
DEHYDROGENASE
(Yersinia
pestis) 		5 / 12 LEU A 319
THR A  11
ILE A  10
ALA A 115
ALA A 322
 None
 0.97A 3mdvB-3lxyA:
undetectable		 3mdvB-3lxyA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_A_0LIA1004_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 3lxy 4-HYDROXYTHREONINE-4
-PHOSPHATE
DEHYDROGENASE
(Yersinia
pestis) 		5 / 11 ALA A  39
LEU A  43
GLY A  17
VAL A  98
GLY A  19
 None
 0.81A 3zosA-3lxyA:
undetectable
3zosB-3lxyA:
undetectable		 3zosA-3lxyA:
22.47
3zosB-3lxyA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DTZ_B_LDPB501_1
(CYTOCHROME P450 BM3
VARIANT 8C8)		 3lxy 4-HYDROXYTHREONINE-4
-PHOSPHATE
DEHYDROGENASE
(Yersinia
pestis) 		4 / 6 ALA A 180
ALA A 230
PRO A 229
THR A 226
 None
 1.06A 4dtzB-3lxyA:
undetectable		 4dtzB-3lxyA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODO_B_FK5B203_2
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD)		 3lxy 4-HYDROXYTHREONINE-4
-PHOSPHATE
DEHYDROGENASE
(Yersinia
pestis) 		3 / 3 ALA A 247
GLN A 277
GLY A 278
 None
 0.59A 4odoC-3lxyA:
undetectable		 4odoC-3lxyA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZME_A_ADNA1002_1
(MYOSIN HEAVY CHAIN
KINASE A)		 3lxy 4-HYDROXYTHREONINE-4
-PHOSPHATE
DEHYDROGENASE
(Yersinia
pestis) 		5 / 11 PHE A 251
ALA A 247
GLY A 208
VAL A 161
LEU A 271
 None
 1.10A 4zmeA-3lxyA:
undetectable		 4zmeA-3lxyA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEN_A_VDYA201_2
(CDL2.2)		 3lxy 4-HYDROXYTHREONINE-4
-PHOSPHATE
DEHYDROGENASE
(Yersinia
pestis) 		5 / 12 VAL A 206
ILE A 239
LEU A 241
GLY A 243
PRO A 244
 None
None
None
SUC  A 701 (-4.0A)
SUC  A 701 (-4.0A)
 1.01A 5ienA-3lxyA:
undetectable		 5ienA-3lxyA:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGJ_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 3lxy 4-HYDROXYTHREONINE-4
-PHOSPHATE
DEHYDROGENASE
(Yersinia
pestis) 		3 / 3 VAL A 262
VAL A 161
GLN A 277
 None
 0.61A 5qgjA-3lxyA:
undetectable		 5qgjA-3lxyA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGN_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 3lxy 4-HYDROXYTHREONINE-4
-PHOSPHATE
DEHYDROGENASE
(Yersinia
pestis) 		3 / 3 VAL A 262
VAL A 161
GLN A 277
 None
 0.58A 5qgnA-3lxyA:
undetectable		 5qgnA-3lxyA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGV_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 3lxy 4-HYDROXYTHREONINE-4
-PHOSPHATE
DEHYDROGENASE
(Yersinia
pestis) 		3 / 3 VAL A 262
VAL A 161
GLN A 277
 None
 0.62A 5qgvA-3lxyA:
undetectable		 5qgvA-3lxyA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGW_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 3lxy 4-HYDROXYTHREONINE-4
-PHOSPHATE
DEHYDROGENASE
(Yersinia
pestis) 		3 / 3 VAL A 262
VAL A 161
GLN A 277
 None
 0.63A 5qgwA-3lxyA:
undetectable		 5qgwA-3lxyA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGX_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 3lxy 4-HYDROXYTHREONINE-4
-PHOSPHATE
DEHYDROGENASE
(Yersinia
pestis) 		3 / 3 VAL A 262
VAL A 161
GLN A 277
 None
 0.62A 5qgxA-3lxyA:
undetectable		 5qgxA-3lxyA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGY_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 3lxy 4-HYDROXYTHREONINE-4
-PHOSPHATE
DEHYDROGENASE
(Yersinia
pestis) 		3 / 3 VAL A 262
VAL A 161
GLN A 277
 None
 0.63A 5qgyA-3lxyA:
undetectable		 5qgyA-3lxyA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGZ_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 3lxy 4-HYDROXYTHREONINE-4
-PHOSPHATE
DEHYDROGENASE
(Yersinia
pestis) 		3 / 3 VAL A 262
VAL A 161
GLN A 277
 None
 0.64A 5qgzA-3lxyA:
undetectable		 5qgzA-3lxyA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH0_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 3lxy 4-HYDROXYTHREONINE-4
-PHOSPHATE
DEHYDROGENASE
(Yersinia
pestis) 		3 / 3 VAL A 262
VAL A 161
GLN A 277
 None
 0.63A 5qh0A-3lxyA:
undetectable		 5qh0A-3lxyA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH1_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 3lxy 4-HYDROXYTHREONINE-4
-PHOSPHATE
DEHYDROGENASE
(Yersinia
pestis) 		3 / 3 VAL A 262
VAL A 161
GLN A 277
 None
 0.62A 5qh1A-3lxyA:
undetectable		 5qh1A-3lxyA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH2_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 3lxy 4-HYDROXYTHREONINE-4
-PHOSPHATE
DEHYDROGENASE
(Yersinia
pestis) 		3 / 3 VAL A 262
VAL A 161
GLN A 277
 None
 0.63A 5qh2A-3lxyA:
undetectable		 5qh2A-3lxyA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH3_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 3lxy 4-HYDROXYTHREONINE-4
-PHOSPHATE
DEHYDROGENASE
(Yersinia
pestis) 		3 / 3 VAL A 262
VAL A 161
GLN A 277
 None
 0.64A 5qh3A-3lxyA:
undetectable		 5qh3A-3lxyA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH4_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 3lxy 4-HYDROXYTHREONINE-4
-PHOSPHATE
DEHYDROGENASE
(Yersinia
pestis) 		3 / 3 VAL A 262
VAL A 161
GLN A 277
 None
 0.62A 5qh4A-3lxyA:
undetectable		 5qh4A-3lxyA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH6_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 3lxy 4-HYDROXYTHREONINE-4
-PHOSPHATE
DEHYDROGENASE
(Yersinia
pestis) 		3 / 3 VAL A 262
VAL A 161
GLN A 277
 None
 0.63A 5qh6A-3lxyA:
undetectable		 5qh6A-3lxyA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH7_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 3lxy 4-HYDROXYTHREONINE-4
-PHOSPHATE
DEHYDROGENASE
(Yersinia
pestis) 		3 / 3 VAL A 262
VAL A 161
GLN A 277
 None
 0.63A 5qh7A-3lxyA:
undetectable		 5qh7A-3lxyA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QHA_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 3lxy 4-HYDROXYTHREONINE-4
-PHOSPHATE
DEHYDROGENASE
(Yersinia
pestis) 		3 / 3 VAL A 262
VAL A 161
GLN A 277
 None
 0.67A 5qhaA-3lxyA:
undetectable		 5qhaA-3lxyA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QHC_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 3lxy 4-HYDROXYTHREONINE-4
-PHOSPHATE
DEHYDROGENASE
(Yersinia
pestis) 		3 / 3 VAL A 262
VAL A 161
GLN A 277
 None
 0.62A 5qhcA-3lxyA:
undetectable		 5qhcA-3lxyA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QHH_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 3lxy 4-HYDROXYTHREONINE-4
-PHOSPHATE
DEHYDROGENASE
(Yersinia
pestis) 		3 / 3 VAL A 262
VAL A 161
GLN A 277
 None
 0.63A 5qhhA-3lxyA:
undetectable		 5qhhA-3lxyA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TL8_A_X2NA502_1
(PROTEIN CYP51)		 3lxy 4-HYDROXYTHREONINE-4
-PHOSPHATE
DEHYDROGENASE
(Yersinia
pestis) 		5 / 12 PHE A 114
ALA A  46
ALA A  48
LEU A  74
THR A 119
 None
 1.25A 5tl8A-3lxyA:
undetectable		 5tl8A-3lxyA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA806_0
(GEPHYRIN)		 3lxy 4-HYDROXYTHREONINE-4
-PHOSPHATE
DEHYDROGENASE
(Yersinia
pestis) 		4 / 4 MET A 219
GLY A 220
HIS A 221
GLY A 214
 None
 1.46A 6fgdA-3lxyA:
undetectable		 6fgdA-3lxyA:
24.02