SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ly1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S14_A_NOVA1300_1
(TOPOISOMERASE IV
SUBUNIT B)		 3ly1 PUTATIVE
HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Pectobacterium
atrosepticum) 		5 / 12 ASN A 309
SER A 312
ASP A 310
ASP A 298
ILE A 254
 None
 1.46A 1s14A-3ly1A:
undetectable		 1s14A-3ly1A:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BTE_D_LEUD1893_0
(AMINOACYL-TRNA
SYNTHETASE)		 3ly1 PUTATIVE
HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Pectobacterium
atrosepticum) 		4 / 8 SER A 235
TYR A 264
HIS A 103
HIS A 104
 None
EDO  A   2 (-4.8A)
EDO  A   2 ( 4.4A)
None
 1.05A 2bteD-3ly1A:
undetectable		 2bteD-3ly1A:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0G_A_LEUA1887_0
(AMINOACYL-TRNA
SYNTHETASE)		 3ly1 PUTATIVE
HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Pectobacterium
atrosepticum) 		4 / 8 SER A 235
TYR A 264
HIS A 103
HIS A 104
 None
EDO  A   2 (-4.8A)
EDO  A   2 ( 4.4A)
None
 1.35A 2v0gA-3ly1A:
undetectable		 2v0gA-3ly1A:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LPS_A_NOVA901_1
(TOPOISOMERASE IV
SUBUNIT B)		 3ly1 PUTATIVE
HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Pectobacterium
atrosepticum) 		5 / 12 ASN A 309
SER A 312
ASP A 310
ASP A 298
ILE A 254
 None
 1.42A 3lpsA-3ly1A:
undetectable		 3lpsA-3ly1A:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N3I_A_ROCA201_2
(PROTEASE)		 3ly1 PUTATIVE
HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Pectobacterium
atrosepticum) 		4 / 6 ILE A 370
ASP A 228
ILE A 197
GLY A 195
 None
 0.80A 3n3iA-3ly1A:
undetectable		 3n3iA-3ly1A:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R0L_D_ACTD127_0
(PHOSPHOLIPASE A2 CB)		 3ly1 PUTATIVE
HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Pectobacterium
atrosepticum) 		4 / 5 PHE A 148
ILE A 121
GLY A 143
HIS A 147
 None
None
EDO  A  23 ( 3.3A)
EDO  A   4 (-3.9A)
 1.39A 3r0lD-3ly1A:
undetectable		 3r0lD-3ly1A:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3V_A_TOPA193_1
(DIHYDROFOLATE
REDUCTASE)		 3ly1 PUTATIVE
HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Pectobacterium
atrosepticum) 		4 / 5 ASP A 219
LEU A 248
ILE A 125
PHE A 148
 PLP  A 500 (-2.7A)
None
None
None
 1.02A 3s3vA-3ly1A:
undetectable		 3s3vA-3ly1A:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_B_CHDB505_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3ly1 PUTATIVE
HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Pectobacterium
atrosepticum) 		5 / 12 LEU A 323
LEU A 320
LEU A 317
ILE A 394
SER A 330
 None
 1.03A 4f4dB-3ly1A:
undetectable		 4f4dB-3ly1A:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JQ1_B_NPSB401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 3ly1 PUTATIVE
HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Pectobacterium
atrosepticum) 		4 / 8 VAL A 266
TYR A 264
HIS A 104
ILE A 245
 None
EDO  A   2 (-4.8A)
None
None
 0.73A 4jq1B-3ly1A:
undetectable		 4jq1B-3ly1A:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K38_A_SAMA504_0
(ANAEROBIC
SULFATASE-MATURATING
ENZYME
KP18CYS PEPTIDE)		 3ly1 PUTATIVE
HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Pectobacterium
atrosepticum) 		5 / 12 GLN A 347
LEU A 343
VAL A 341
LEU A 325
CYH A 368
 None
 1.38A 4k38A-3ly1A:
undetectable
4k38D-3ly1A:
undetectable		 4k38A-3ly1A:
21.13
4k38D-3ly1A:
4.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNW_B_RTZB602_2
(CYTOCHROME P450 2D6)		 3ly1 PUTATIVE
HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Pectobacterium
atrosepticum) 		3 / 3 GLU A 119
ILE A 151
ALA A 124
 None
 0.61A 4wnwB-3ly1A:
undetectable		 4wnwB-3ly1A:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BS8_G_MFXG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 3ly1 PUTATIVE
HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Pectobacterium
atrosepticum) 		4 / 7 ALA A 256
ASP A 310
GLY A 332
GLU A 331
 None
 0.85A 5bs8A-3ly1A:
3.5
5bs8C-3ly1A:
3.4
5bs8D-3ly1A:
undetectable		 5bs8A-3ly1A:
22.31
5bs8C-3ly1A:
22.31
5bs8D-3ly1A:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTG_F_LFXF101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 3ly1 PUTATIVE
HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Pectobacterium
atrosepticum) 		4 / 7 ALA A 256
ASP A 310
GLY A 332
GLU A 331
 None
 0.85A 5btgA-3ly1A:
3.5
5btgC-3ly1A:
3.4
5btgD-3ly1A:
undetectable		 5btgA-3ly1A:
22.31
5btgC-3ly1A:
22.31
5btgD-3ly1A:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_A_1N1A501_1
(PROTEIN-TYROSINE
KINASE 6)		 3ly1 PUTATIVE
HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Pectobacterium
atrosepticum) 		6 / 12 VAL A 262
ALA A 292
LEU A 293
GLY A  97
GLU A 282
LEU A 100
 None
 1.22A 5h2uA-3ly1A:
undetectable		 5h2uA-3ly1A:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JGL_B_SAMB301_1
(UBIE/COQ5 FAMILY
METHYLTRANSFERASE,
PUTATIVE)		 3ly1 PUTATIVE
HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Pectobacterium
atrosepticum) 		3 / 3 ASP A 219
ASN A 192
PHE A 251
 PLP  A 500 (-2.7A)
PLP  A 500 (-3.8A)
EDO  A   2 ( 4.1A)
 0.88A 5jglB-3ly1A:
2.2		 5jglB-3ly1A:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5D_B_SAMB303_0
(METHYLTRANSFERASE)		 3ly1 PUTATIVE
HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Pectobacterium
atrosepticum) 		5 / 12 LEU A 100
ALA A 101
VAL A 106
ALA A 123
ALA A 265
 None
 0.98A 5n5dB-3ly1A:
3.2		 5n5dB-3ly1A:
22.03