SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ly5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AKD_A_CAMA420_0
(CYTOCHROME P450CAM)		 3ly5 ATP-DEPENDENT RNA
HELICASE DDX18
(Homo
sapiens) 		5 / 11 PHE A 233
VAL A 270
GLY A 269
ASP A 333
VAL A 306
 None
 1.19A 1akdA-3ly5A:
undetectable		 1akdA-3ly5A:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1N_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 3ly5 ATP-DEPENDENT RNA
HELICASE DDX18
(Homo
sapiens) 		5 / 11 PHE A 233
VAL A 270
GLY A 269
ASP A 333
VAL A 306
 None
 1.17A 2a1nA-3ly5A:
undetectable		 2a1nA-3ly5A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BFP_A_H4BA1290_1
(PTERIDINE REDUCTASE
1)		 3ly5 ATP-DEPENDENT RNA
HELICASE DDX18
(Homo
sapiens) 		4 / 8 PHE A 322
LEU A 312
LEU A 354
LEU A 327
 None
 0.69A 2bfpA-3ly5A:
undetectable		 2bfpA-3ly5A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BFP_B_H4BB1290_1
(PTERIDINE REDUCTASE
1)		 3ly5 ATP-DEPENDENT RNA
HELICASE DDX18
(Homo
sapiens) 		4 / 8 PHE A 322
LEU A 312
LEU A 354
LEU A 327
 None
 0.64A 2bfpB-3ly5A:
2.8		 2bfpB-3ly5A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BFP_C_H4BC1290_1
(PTERIDINE REDUCTASE
1)		 3ly5 ATP-DEPENDENT RNA
HELICASE DDX18
(Homo
sapiens) 		4 / 8 PHE A 322
LEU A 312
LEU A 354
LEU A 327
 None
 0.88A 2bfpC-3ly5A:
2.4		 2bfpC-3ly5A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CP4_A_CAMA416_0
(CYTOCHROME P450-CAM)		 3ly5 ATP-DEPENDENT RNA
HELICASE DDX18
(Homo
sapiens) 		5 / 10 PHE A 233
VAL A 270
GLY A 269
ASP A 333
VAL A 306
 None
 1.29A 2cp4A-3ly5A:
undetectable		 2cp4A-3ly5A:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_C_AERC601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 3ly5 ATP-DEPENDENT RNA
HELICASE DDX18
(Homo
sapiens) 		4 / 6 LEU A 240
ASP A 218
GLU A 215
ALA A 232
 None
 1.17A 4nkvC-3ly5A:
undetectable		 4nkvC-3ly5A:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_F_SAMF501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 3ly5 ATP-DEPENDENT RNA
HELICASE DDX18
(Homo
sapiens) 		5 / 10 GLY A 283
GLU A 294
LEU A 312
ARG A 311
ALA A 307
 None
 1.02A 5o96E-3ly5A:
undetectable
5o96F-3ly5A:
undetectable		 5o96E-3ly5A:
20.75
5o96F-3ly5A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E5Z_A_CCSA106_0
(PROTEIN/NUCLEIC ACID
DEGLYCASE DJ-1)		 3ly5 ATP-DEPENDENT RNA
HELICASE DDX18
(Homo
sapiens) 		5 / 10 GLY A 253
ASN A 250
ILE A 304
THR A 281
HIS A 280
 None
 1.08A 6e5zA-3ly5A:
undetectable		 6e5zA-3ly5A:
24.89