SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ly9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EII_A_RTLA135_1
(CELLULAR
RETINOL-BINDING
PROTEIN II)		 3ly9 TRANSCRIPTIONAL
ACTIVATOR CADC
(Escherichia
coli) 		4 / 7 TYR A 374
THR A 229
SER A 449
GLN A 303
 None
 1.15A 1eiiA-3ly9A:
undetectable		 1eiiA-3ly9A:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_D_BRLD503_1
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 3ly9 TRANSCRIPTIONAL
ACTIVATOR CADC
(Escherichia
coli) 		5 / 12 GLY A 224
SER A 230
LEU A 348
LEU A 330
LEU A 307
 None
 1.32A 1fm6D-3ly9A:
undetectable		 1fm6D-3ly9A:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_A_SAMA301_0
(HEMK PROTEIN)		 3ly9 TRANSCRIPTIONAL
ACTIVATOR CADC
(Escherichia
coli) 		5 / 12 ILE A 201
ILE A 221
SER A 449
ASN A 244
PRO A 481
 None
 1.22A 1sg9A-3ly9A:
undetectable		 1sg9A-3ly9A:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q83_A_ADNA1_1
(YTAA PROTEIN)		 3ly9 TRANSCRIPTIONAL
ACTIVATOR CADC
(Escherichia
coli) 		4 / 7 ILE A 440
ILE A 418
LEU A 381
ILE A 422
 None
 0.87A 2q83A-3ly9A:
undetectable		 2q83A-3ly9A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K8M_B_ACRB820_1
(ALPHA-AMYLASE, SUSG)		 3ly9 TRANSCRIPTIONAL
ACTIVATOR CADC
(Escherichia
coli) 		4 / 7 TYR A 453
GLU A 447
LEU A 456
ASN A 441
 None
 1.36A 3k8mB-3ly9A:
undetectable		 3k8mB-3ly9A:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LOQ_A_ACTA278_0
(UNIVERSAL STRESS
PROTEIN)		 3ly9 TRANSCRIPTIONAL
ACTIVATOR CADC
(Escherichia
coli) 		3 / 3 SER A 417
GLY A 443
SER A 449
 None
 0.60A 3loqA-3ly9A:
undetectable		 3loqA-3ly9A:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J03_A_FVSA603_1
(BIFUNCTIONAL EPOXIDE
HYDROLASE 2)		 3ly9 TRANSCRIPTIONAL
ACTIVATOR CADC
(Escherichia
coli) 		6 / 12 ILE A 384
TYR A 374
LEU A 226
LEU A 330
LEU A 347
HIS A 344
 None
 1.40A 4j03A-3ly9A:
undetectable		 4j03A-3ly9A:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K0B_B_SAMB504_1
(S-ADENOSYLMETHIONINE
SYNTHASE)		 3ly9 TRANSCRIPTIONAL
ACTIVATOR CADC
(Escherichia
coli) 		4 / 8 HIS A 240
ASP A 200
SER A 253
ASP A 198
 None
 1.05A 4k0bB-3ly9A:
undetectable		 4k0bB-3ly9A:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K7G_B_ACTB902_0
(3-HYDROXYPROLINE
DEHYDRATSE)		 3ly9 TRANSCRIPTIONAL
ACTIVATOR CADC
(Escherichia
coli) 		4 / 7 ASP A 345
SER A 354
TRP A 488
HIS A 349
 None
 1.22A 4k7gB-3ly9A:
undetectable		 4k7gB-3ly9A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L7I_B_SAMB501_1
(S-ADENOSYLMETHIONINE
SYNTHASE)		 3ly9 TRANSCRIPTIONAL
ACTIVATOR CADC
(Escherichia
coli) 		4 / 8 HIS A 240
ASP A 200
SER A 253
ASP A 198
 None
 1.08A 4l7iB-3ly9A:
undetectable		 4l7iB-3ly9A:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_D_ADND401_2
(ADENOSINE KINASE)		 3ly9 TRANSCRIPTIONAL
ACTIVATOR CADC
(Escherichia
coli) 		4 / 5 LEU A 307
SER A 311
LEU A 231
LEU A 326
 None
 1.26A 4n09D-3ly9A:
undetectable		 4n09D-3ly9A:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PO0_A_NPSA603_1
(SERUM ALBUMIN)		 3ly9 TRANSCRIPTIONAL
ACTIVATOR CADC
(Escherichia
coli) 		5 / 10 LEU A 330
LEU A 326
VAL A 227
LEU A 231
LEU A 310
 None
 1.15A 4po0A-3ly9A:
undetectable		 4po0A-3ly9A:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XO7_B_ASDB402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 3ly9 TRANSCRIPTIONAL
ACTIVATOR CADC
(Escherichia
coli) 		4 / 7 TYR A 341
ILE A 259
HIS A 344
LEU A 348
 None
 1.25A 4xo7B-3ly9A:
undetectable		 4xo7B-3ly9A:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0P_A_TE4A201_1
(BETA-LACTOGLOBULIN)		 3ly9 TRANSCRIPTIONAL
ACTIVATOR CADC
(Escherichia
coli) 		5 / 12 LEU A 381
ILE A 418
ILE A 407
VAL A 425
LEU A 455
 None
 1.02A 4y0pA-3ly9A:
undetectable		 4y0pA-3ly9A:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z90_E_4LEE401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 3ly9 TRANSCRIPTIONAL
ACTIVATOR CADC
(Escherichia
coli) 		5 / 7 LEU A 226
THR A 325
LEU A 326
THR A 233
THR A 229
 None
 1.19A 4z90A-3ly9A:
2.8
4z90B-3ly9A:
undetectable
4z90C-3ly9A:
2.2
4z90D-3ly9A:
undetectable
4z90E-3ly9A:
undetectable		 4z90A-3ly9A:
21.13
4z90B-3ly9A:
21.13
4z90C-3ly9A:
21.13
4z90D-3ly9A:
21.13
4z90E-3ly9A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z90_E_4LEE401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 3ly9 TRANSCRIPTIONAL
ACTIVATOR CADC
(Escherichia
coli) 		4 / 7 THR A 325
LEU A 326
THR A 233
THR A 229
 None
 0.91A 4z90A-3ly9A:
2.8
4z90B-3ly9A:
undetectable
4z90C-3ly9A:
2.2
4z90D-3ly9A:
undetectable
4z90E-3ly9A:
undetectable		 4z90A-3ly9A:
21.13
4z90B-3ly9A:
21.13
4z90C-3ly9A:
21.13
4z90D-3ly9A:
21.13
4z90E-3ly9A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z91_F_4LEF401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 3ly9 TRANSCRIPTIONAL
ACTIVATOR CADC
(Escherichia
coli) 		4 / 7 THR A 233
THR A 229
THR A 325
LEU A 326
 None
 0.89A 4z91F-3ly9A:
2.9
4z91G-3ly9A:
3.0
4z91H-3ly9A:
1.9
4z91I-3ly9A:
3.0
4z91J-3ly9A:
2.1		 4z91F-3ly9A:
21.13
4z91G-3ly9A:
21.13
4z91H-3ly9A:
21.13
4z91I-3ly9A:
21.13
4z91J-3ly9A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z91_F_4LEF401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 3ly9 TRANSCRIPTIONAL
ACTIVATOR CADC
(Escherichia
coli) 		4 / 7 THR A 325
LEU A 326
THR A 233
THR A 229
 None
 0.88A 4z91F-3ly9A:
2.9
4z91G-3ly9A:
3.0
4z91H-3ly9A:
1.9
4z91I-3ly9A:
3.0
4z91J-3ly9A:
2.1		 4z91F-3ly9A:
21.13
4z91G-3ly9A:
21.13
4z91H-3ly9A:
21.13
4z91I-3ly9A:
21.13
4z91J-3ly9A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZOW_A_CLMA500_0
(MULTIDRUG
TRANSPORTER MDFA)		 3ly9 TRANSCRIPTIONAL
ACTIVATOR CADC
(Escherichia
coli) 		5 / 11 MET A 322
LEU A 326
LEU A 310
LEU A 307
LEU A 257
 None
 0.97A 4zowA-3ly9A:
undetectable		 4zowA-3ly9A:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_Z_BEZZ801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 3ly9 TRANSCRIPTIONAL
ACTIVATOR CADC
(Escherichia
coli) 		4 / 4 ILE A 302
GLY A 334
ILE A 294
LEU A 300
 None
 0.79A 5dzkl-3ly9A:
undetectable
5dzkz-3ly9A:
undetectable		 5dzkl-3ly9A:
18.82
5dzkz-3ly9A:
3.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA309_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 3ly9 TRANSCRIPTIONAL
ACTIVATOR CADC
(Escherichia
coli) 		4 / 4 LEU A 194
GLY A 254
SER A 253
SER A 251
 None
 0.98A 5uunA-3ly9A:
1.6		 5uunA-3ly9A:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB306_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 3ly9 TRANSCRIPTIONAL
ACTIVATOR CADC
(Escherichia
coli) 		4 / 4 LEU A 194
GLY A 254
SER A 253
SER A 251
 None
 0.98A 5uunB-3ly9A:
undetectable		 5uunB-3ly9A:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_C_GMJC301_1
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 3ly9 TRANSCRIPTIONAL
ACTIVATOR CADC
(Escherichia
coli) 		4 / 6 LEU A 455
TYR A 374
ASP A 225
GLN A 303
 None
 1.08A 6djzC-3ly9A:
undetectable		 6djzC-3ly9A:
19.03