SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3lye'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOH_C_FRDC305_1
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 3lye OXALOACETATE ACETYL
HYDROLASE
(Cryphonectria
parasitica) 		4 / 5 ASP A  95
GLY A  92
PRO A 314
ALA A 315
 None
 0.91A 2aohA-3lyeA:
undetectable		 2aohA-3lyeA:
15.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_B_SAMB300_1
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 3lye OXALOACETATE ACETYL
HYDROLASE
(Cryphonectria
parasitica) 		4 / 5 GLY A 180
HIS A  79
ASP A  85
ASP A 254
 None
 1.10A 2oxtB-3lyeA:
undetectable		 2oxtB-3lyeA:
24.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XCT_H_CPFH1020_1
(DNA GYRASE SUBUNIT
B, DNA GYRASE
SUBUNIT A)		 3lye OXALOACETATE ACETYL
HYDROLASE
(Cryphonectria
parasitica) 		3 / 3 ARG A 229
GLU A 259
SER A 109
 None
 0.87A 2xctD-3lyeA:
undetectable		 2xctD-3lyeA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZA_A_FOLA164_0
(DIHYDROFOLATE
REDUCTASE)		 3lye OXALOACETATE ACETYL
HYDROLASE
(Cryphonectria
parasitica) 		5 / 12 GLU A 184
ILE A 306
LEU A 280
TYR A 173
THR A 158
 CA  A 501 ( 4.4A)
None
None
None
None
 1.26A 2zzaA-3lyeA:
undetectable		 2zzaA-3lyeA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PFG_A_SAMA264_1
(N-METHYLTRANSFERASE)		 3lye OXALOACETATE ACETYL
HYDROLASE
(Cryphonectria
parasitica) 		3 / 3 TYR A 160
TYR A 173
GLU A 184
 None
None
CA  A 501 ( 4.4A)
 0.44A 3pfgA-3lyeA:
2.4		 3pfgA-3lyeA:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_D_9PLD1_1
(CYTOCHROME P450 2A13)		 3lye OXALOACETATE ACETYL
HYDROLASE
(Cryphonectria
parasitica) 		4 / 8 ALA A 102
PHE A 107
PHE A 307
ALA A 310
 None
 0.93A 3t3sD-3lyeA:
undetectable		 3t3sD-3lyeA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q1Y_A_017A106_1
(ASPARTYL PROTEASE)		 3lye OXALOACETATE ACETYL
HYDROLASE
(Cryphonectria
parasitica) 		5 / 10 GLY A 114
ILE A 142
GLY A  92
ILE A 306
VAL A 178
 CA  A 501 ( 4.6A)
None
None
None
None
 0.94A 4q1yA-3lyeA:
undetectable		 4q1yA-3lyeA:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEN_B_VDYB201_1
(CDL2.2)		 3lye OXALOACETATE ACETYL
HYDROLASE
(Cryphonectria
parasitica) 		5 / 10 PRO A 151
VAL A 255
ILE A 306
LEU A 280
PRO A 278
 None
 1.16A 5ienB-3lyeA:
undetectable		 5ienB-3lyeA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JNC_D_ACTD305_0
(CARBONIC ANHYDRASE 4)		 3lye OXALOACETATE ACETYL
HYDROLASE
(Cryphonectria
parasitica) 		4 / 5 ALA A 253
ALA A 228
ILE A 210
LEU A 207
 None
 0.35A 5jncD-3lyeA:
undetectable		 5jncD-3lyeA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YBB_A_SAMA601_0
(TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT)		 3lye OXALOACETATE ACETYL
HYDROLASE
(Cryphonectria
parasitica) 		5 / 12 GLY A 159
THR A 158
GLY A 161
THR A 216
LEU A 220
 None
 1.04A 5ybbA-3lyeA:
undetectable		 5ybbA-3lyeA:
21.61