SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3lyk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UWL_D_FOZD316_0
(THYMIDYLATE SYNTHASE)		 3lyk STRINGENT STARVATION
PROTEIN A HOMOLOG
(Haemophilus
influenzae) 		5 / 12 LEU A 132
LEU A 137
GLY A 138
ILE A 183
ALA A 182
 None
 1.09A 3uwlD-3lykA:
undetectable		 3uwlD-3lykA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V8V_A_SAMA801_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE L)		 3lyk STRINGENT STARVATION
PROTEIN A HOMOLOG
(Haemophilus
influenzae) 		5 / 12 SER A 195
ASP A 194
VAL A  28
PRO A  86
LEU A  88
 None
 0.82A 3v8vA-3lykA:
undetectable		 3v8vA-3lykA:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V8V_B_SAMB801_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE L)		 3lyk STRINGENT STARVATION
PROTEIN A HOMOLOG
(Haemophilus
influenzae) 		5 / 11 SER A 195
ASP A 194
VAL A  28
PRO A  86
LEU A  88
 None
 0.82A 3v8vB-3lykA:
undetectable		 3v8vB-3lykA:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVN_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 3lyk STRINGENT STARVATION
PROTEIN A HOMOLOG
(Haemophilus
influenzae) 		5 / 11 GLY A  57
THR A  58
THR A  61
ASP A  19
CYH A  22
 None
 1.29A 4qvnH-3lykA:
undetectable
4qvnI-3lykA:
undetectable		 4qvnH-3lykA:
21.69
4qvnI-3lykA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVN_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 3lyk STRINGENT STARVATION
PROTEIN A HOMOLOG
(Haemophilus
influenzae) 		5 / 10 GLY A  57
THR A  58
THR A  61
ASP A  19
CYH A  22
 None
 1.28A 4qvnV-3lykA:
undetectable
4qvnW-3lykA:
undetectable		 4qvnV-3lykA:
21.69
4qvnW-3lykA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVQ_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 3lyk STRINGENT STARVATION
PROTEIN A HOMOLOG
(Haemophilus
influenzae) 		5 / 11 GLY A  57
THR A  58
THR A  61
ASP A  19
CYH A  22
 None
 1.29A 4qvqH-3lykA:
undetectable
4qvqI-3lykA:
undetectable		 4qvqH-3lykA:
21.69
4qvqI-3lykA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVQ_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 3lyk STRINGENT STARVATION
PROTEIN A HOMOLOG
(Haemophilus
influenzae) 		5 / 11 GLY A  57
THR A  58
THR A  61
ASP A  19
CYH A  22
 None
 1.29A 4qvqV-3lykA:
undetectable
4qvqW-3lykA:
undetectable		 4qvqV-3lykA:
21.69
4qvqW-3lykA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWU_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 3lyk STRINGENT STARVATION
PROTEIN A HOMOLOG
(Haemophilus
influenzae) 		5 / 11 GLY A  57
THR A  58
THR A  61
ASP A  19
CYH A  22
 None
 1.27A 4qwuH-3lykA:
undetectable
4qwuI-3lykA:
undetectable		 4qwuH-3lykA:
21.69
4qwuI-3lykA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWU_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 3lyk STRINGENT STARVATION
PROTEIN A HOMOLOG
(Haemophilus
influenzae) 		5 / 11 GLY A  57
THR A  58
THR A  61
ASP A  19
CYH A  22
 None
 1.27A 4qwuV-3lykA:
undetectable
4qwuW-3lykA:
undetectable		 4qwuV-3lykA:
21.69
4qwuW-3lykA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CZ7_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 3lyk STRINGENT STARVATION
PROTEIN A HOMOLOG
(Haemophilus
influenzae) 		5 / 12 GLY A  57
THR A  58
THR A  61
ASP A  19
CYH A  22
 None
 1.28A 5cz7V-3lykA:
undetectable
5cz7W-3lykA:
undetectable		 5cz7V-3lykA:
21.69
5cz7W-3lykA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L66_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 3lyk STRINGENT STARVATION
PROTEIN A HOMOLOG
(Haemophilus
influenzae) 		5 / 12 GLY A  57
THR A  58
THR A  61
ASP A  19
CYH A  22
 None
 1.28A 5l66V-3lykA:
undetectable
5l66W-3lykA:
undetectable		 5l66V-3lykA:
21.69
5l66W-3lykA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWV_A_ACAA18_1
(SCRFP-TAG,GP41)		 3lyk STRINGENT STARVATION
PROTEIN A HOMOLOG
(Haemophilus
influenzae) 		5 / 12 GLY A 179
SER A 180
LYS A 181
GLU A 135
LEU A 136
 None
 1.25A 5nwvA-3lykA:
undetectable		 5nwvA-3lykA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOP_A_C2FA3001_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 3lyk STRINGENT STARVATION
PROTEIN A HOMOLOG
(Haemophilus
influenzae) 		3 / 3 ASP A  18
ASN A  16
ASP A  42
 None
 0.85A 5vopA-3lykA:
undetectable		 5vopA-3lykA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOP_B_C2FB3001_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 3lyk STRINGENT STARVATION
PROTEIN A HOMOLOG
(Haemophilus
influenzae) 		3 / 3 ASP A  18
ASN A  16
ASP A  42
 None
 0.89A 5vopB-3lykA:
undetectable		 5vopB-3lykA:
22.62