SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3lyl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)		 3lyl 3-OXOACYL-(ACYL-CARR
IER-PROTEIN)
REDUCTASE
(Francisella
tularensis) 		5 / 12 TYR A 154
ILE A  17
GLY A 140
ALA A 159
GLY A 185
 None
 1.08A 1kiaA-3lylA:
8.1		 1kiaA-3lylA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_B_SAMB1293_0
(GLYCINE
N-METHYLTRANSFERASE)		 3lyl 3-OXOACYL-(ACYL-CARR
IER-PROTEIN)
REDUCTASE
(Francisella
tularensis) 		5 / 12 TYR A 154
ILE A  17
GLY A 140
ALA A 159
GLY A 185
 None
 1.09A 1kiaB-3lylA:
8.1		 1kiaB-3lylA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_C_SAMC2293_0
(GLYCINE
N-METHYLTRANSFERASE)		 3lyl 3-OXOACYL-(ACYL-CARR
IER-PROTEIN)
REDUCTASE
(Francisella
tularensis) 		5 / 12 TYR A 154
ILE A  17
GLY A 140
ALA A 159
GLY A 185
 None
 1.09A 1kiaC-3lylA:
7.8		 1kiaC-3lylA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_B_SAMB1293_0
(GLYCINE
N-METHYLTRANSFERASE)		 3lyl 3-OXOACYL-(ACYL-CARR
IER-PROTEIN)
REDUCTASE
(Francisella
tularensis) 		5 / 12 TYR A 154
ILE A  17
GLY A 140
ALA A 159
GLY A 185
 None
 1.11A 1nbhB-3lylA:
7.6		 1nbhB-3lylA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)		 3lyl 3-OXOACYL-(ACYL-CARR
IER-PROTEIN)
REDUCTASE
(Francisella
tularensis) 		5 / 12 TYR A 154
ILE A  17
GLY A 140
ALA A 159
GLY A 185
 None
 1.16A 1nbiA-3lylA:
7.6		 1nbiA-3lylA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_B_SAMB1293_0
(GLYCINE
N-METHYLTRANSFERASE)		 3lyl 3-OXOACYL-(ACYL-CARR
IER-PROTEIN)
REDUCTASE
(Francisella
tularensis) 		5 / 12 TYR A 154
ILE A  17
GLY A 140
ALA A 159
GLY A 185
 None
 1.16A 1nbiB-3lylA:
7.7		 1nbiB-3lylA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_A_9CRA501_1
(CYTOCHROME P450 2C8)		 3lyl 3-OXOACYL-(ACYL-CARR
IER-PROTEIN)
REDUCTASE
(Francisella
tularensis) 		5 / 11 SER A 165
ILE A 137
SER A 138
ALA A 226
ILE A 177
 None
 1.11A 2nnhA-3lylA:
undetectable		 2nnhA-3lylA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRQ_A_ERYA195_1
(REPRESSOR PROTEIN
MPHR(A))		 3lyl 3-OXOACYL-(ACYL-CARR
IER-PROTEIN)
REDUCTASE
(Francisella
tularensis) 		4 / 5 ASN A 176
ARG A 135
ASN A 180
ALA A 169
 None
 1.46A 3frqA-3lylA:
undetectable		 3frqA-3lylA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRQ_B_ERYB195_1
(REPRESSOR PROTEIN
MPHR(A))		 3lyl 3-OXOACYL-(ACYL-CARR
IER-PROTEIN)
REDUCTASE
(Francisella
tularensis) 		4 / 7 ASN A 176
ARG A 135
ASN A 180
ALA A 169
 None
 1.45A 3frqB-3lylA:
undetectable		 3frqB-3lylA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ONN_A_ACTA271_0
(PROTEIN SSM1)		 3lyl 3-OXOACYL-(ACYL-CARR
IER-PROTEIN)
REDUCTASE
(Francisella
tularensis) 		4 / 5 GLY A  16
GLU A  20
GLY A  18
PRO A 215
 None
 1.08A 3onnA-3lylA:
5.0		 3onnA-3lylA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_A_FUNA201_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		 3lyl 3-OXOACYL-(ACYL-CARR
IER-PROTEIN)
REDUCTASE
(Francisella
tularensis) 		5 / 11 SER A 138
ILE A 139
VAL A 222
VAL A  21
ILE A  85
 None
 1.35A 3rf4A-3lylA:
undetectable
3rf4C-3lylA:
undetectable		 3rf4A-3lylA:
18.80
3rf4C-3lylA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_C_FUNC203_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		 3lyl 3-OXOACYL-(ACYL-CARR
IER-PROTEIN)
REDUCTASE
(Francisella
tularensis) 		5 / 11 ILE A  85
SER A 138
ILE A 139
VAL A 222
VAL A  21
 None
 1.37A 3rf4B-3lylA:
undetectable
3rf4C-3lylA:
undetectable		 3rf4B-3lylA:
18.80
3rf4C-3lylA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UBO_B_ADNB353_2
(ADENOSINE KINASE)		 3lyl 3-OXOACYL-(ACYL-CARR
IER-PROTEIN)
REDUCTASE
(Francisella
tularensis) 		4 / 5 SER A 141
ILE A  17
TYR A 154
GLY A 185
 None
 1.00A 3uboB-3lylA:
6.9		 3uboB-3lylA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FIM_A_CELA711_1
(LACTOTRANSFERRIN)		 3lyl 3-OXOACYL-(ACYL-CARR
IER-PROTEIN)
REDUCTASE
(Francisella
tularensis) 		5 / 9 GLU A  20
GLY A  18
VAL A  10
GLU A  43
GLY A  58
 None
 1.43A 4fimA-3lylA:
undetectable		 4fimA-3lylA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J4V_A_SVRA301_1
(NUCLEOCAPSID PROTEIN)		 3lyl 3-OXOACYL-(ACYL-CARR
IER-PROTEIN)
REDUCTASE
(Francisella
tularensis) 		5 / 11 GLY A 185
ASN A 241
ALA A 247
VAL A 142
ILE A 218
 None
 1.48A 4j4vA-3lylA:
undetectable		 4j4vA-3lylA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W7P_A_SAMA501_0
(OXAC)		 3lyl 3-OXOACYL-(ACYL-CARR
IER-PROTEIN)
REDUCTASE
(Francisella
tularensis) 		5 / 12 ALA A  13
GLY A  18
LEU A   9
VAL A  87
LEU A  59
 None
 1.20A 5w7pA-3lylA:
undetectable		 5w7pA-3lylA:
21.86