SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3lyr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OT7_B_IU5B1002_1
(BILE ACID RECEPTOR)		 3lyr TRANSCRIPTION FACTOR
COE1
(Homo
sapiens) 		5 / 12 LEU A 192
HIS A 157
ARG A 173
PHE A  89
ILE A 108
 None
ZN  A   1 (-3.3A)
SO4  A 251 (-4.0A)
None
None
 1.45A 1ot7B-3lyrA:
undetectable		 1ot7B-3lyrA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HUO_A_PNNA304_0
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)		 3lyr TRANSCRIPTION FACTOR
COE1
(Homo
sapiens) 		4 / 4 GLN A  80
PRO A  81
VAL A  82
GLU A  83
 None
 1.13A 3huoA-3lyrA:
undetectable		 3huoA-3lyrA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O14_A_NIOA300_1
(ANTI-ECFSIGMA
FACTOR, CHRR)		 3lyr TRANSCRIPTION FACTOR
COE1
(Homo
sapiens) 		4 / 7 ARG A 129
SER A 216
VAL A 214
VAL A 225
 None
 0.64A 3o14A-3lyrA:
undetectable		 3o14A-3lyrA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJW_A_ACTA603_0
(CHOLINE OXIDASE)		 3lyr TRANSCRIPTION FACTOR
COE1
(Homo
sapiens) 		3 / 3 ARG A  63
HIS A 235
SER A  65
 None
 0.98A 4mjwA-3lyrA:
undetectable
4mjwB-3lyrA:
undetectable		 4mjwA-3lyrA:
18.16
4mjwB-3lyrA:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJW_B_ACTB603_0
(CHOLINE OXIDASE)		 3lyr TRANSCRIPTION FACTOR
COE1
(Homo
sapiens) 		3 / 3 SER A  65
ARG A  63
HIS A 235
 None
 0.96A 4mjwA-3lyrA:
undetectable
4mjwB-3lyrA:
undetectable		 4mjwA-3lyrA:
18.16
4mjwB-3lyrA:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RDX_A_HISA502_0
(HISTIDINE--TRNA
LIGASE)		 3lyr TRANSCRIPTION FACTOR
COE1
(Homo
sapiens) 		4 / 7 ARG A  28
GLY A  46
TYR A 116
GLY A  48
 None
 0.76A 4rdxA-3lyrA:
undetectable		 4rdxA-3lyrA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_A_SVRA205_2
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 3lyr TRANSCRIPTION FACTOR
COE1
(Homo
sapiens) 		4 / 6 PHE A 211
LEU A  62
PRO A  59
ARG A 209
 None
 1.36A 4yv5B-3lyrA:
undetectable		 4yv5B-3lyrA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_B_SVRB207_1
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 3lyr TRANSCRIPTION FACTOR
COE1
(Homo
sapiens) 		4 / 6 PHE A 211
LEU A  62
PRO A  59
ARG A 209
 None
 1.38A 4yv5A-3lyrA:
undetectable		 4yv5A-3lyrA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZC_A_ACTA401_0
(PROTON-GATED ION
CHANNEL)		 3lyr TRANSCRIPTION FACTOR
COE1
(Homo
sapiens) 		4 / 6 ILE A 108
PHE A  89
ILE A 159
GLU A 158
 None
 1.27A 4zzcA-3lyrA:
2.4
4zzcB-3lyrA:
2.5		 4zzcA-3lyrA:
19.52
4zzcB-3lyrA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZC_B_ACTB401_0
(PROTON-GATED ION
CHANNEL)		 3lyr TRANSCRIPTION FACTOR
COE1
(Homo
sapiens) 		4 / 6 ILE A 108
PHE A  89
ILE A 159
GLU A 158
 None
 1.26A 4zzcB-3lyrA:
2.5
4zzcC-3lyrA:
2.4		 4zzcB-3lyrA:
19.52
4zzcC-3lyrA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWZ_B_BEZB301_0
(14-3-3 PROTEIN
ZETA/DELTA)		 3lyr TRANSCRIPTION FACTOR
COE1
(Homo
sapiens) 		3 / 3 MET A  31
GLN A  32
ARG A 121
 None
 0.98A 5ewzB-3lyrA:
undetectable		 5ewzB-3lyrA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_C_SUEC1203_1
(NS3 PROTEASE)		 3lyr TRANSCRIPTION FACTOR
COE1
(Homo
sapiens) 		5 / 9 PHE A 190
VAL A 128
ILE A 159
LEU A 155
ARG A 129
 None
 1.18A 6c2mC-3lyrA:
undetectable		 6c2mC-3lyrA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNE_B_ACRB602_2
(-)		 3lyr TRANSCRIPTION FACTOR
COE1
(Homo
sapiens) 		4 / 8 VAL A  93
TYR A 127
TYR A 110
GLU A 158
 None
 1.32A 6gneB-3lyrA:
undetectable		 6gneB-3lyrA:
18.91