SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3lzd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YVM_A_TMGA501_1
(METHIONINE
AMINOPEPTIDASE)		 3lzd DPH2
(Pyrococcus
horikoshii) 		4 / 7 CYH A 163
TYR A 165
CYH A 287
HIS A 184
 SF4  A 343 (-2.3A)
None
SF4  A 343 (-2.3A)
SO4  A 344 (-4.2A)
 1.40A 1yvmA-3lzdA:
undetectable		 1yvmA-3lzdA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HBB_D_TMQD614_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3lzd DPH2
(Pyrococcus
horikoshii) 		5 / 10 ALA A  73
ILE A  91
ILE A   5
PRO A   6
ILE A  24
 None
 1.19A 3hbbD-3lzdA:
undetectable		 3hbbD-3lzdA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK6_B_HCZB262_1
(GLUTAMATE RECEPTOR 2)		 3lzd DPH2
(Pyrococcus
horikoshii) 		5 / 10 ILE A 178
PRO A 201
SER A 180
GLY A 179
LEU A 176
 None
 1.39A 3ik6B-3lzdA:
undetectable
3ik6E-3lzdA:
undetectable		 3ik6B-3lzdA:
22.42
3ik6E-3lzdA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UVV_A_T3A501_1
(THYROID HORMONE
RECEPTOR ALPHA)		 3lzd DPH2
(Pyrococcus
horikoshii) 		5 / 12 ILE A 109
ALA A 134
LEU A 138
LEU A 176
ILE A 178
 None
 0.82A 3uvvA-3lzdA:
undetectable		 3uvvA-3lzdA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGJ_A_1PQA304_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3lzd DPH2
(Pyrococcus
horikoshii) 		4 / 8 ILE A  75
GLY A  39
ASN A  44
GLU A  35
 None
 1.02A 4fgjA-3lzdA:
2.6
4fgjB-3lzdA:
2.6		 4fgjA-3lzdA:
22.25
4fgjB-3lzdA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IIL_A_RBFA401_2
(MEMBRANE LIPOPROTEIN
TPN38(B))		 3lzd DPH2
(Pyrococcus
horikoshii) 		4 / 8 PRO A 291
VAL A 290
ASN A 270
GLN A 241
 None
None
None
SF4  A 343 ( 4.4A)
 1.02A 4iilA-3lzdA:
4.0		 4iilA-3lzdA:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JEC_B_478B401_3
(HIV-1 PROTEASE)		 3lzd DPH2
(Pyrococcus
horikoshii) 		3 / 3 ASP A  60
LEU A  84
VAL A  88
 None
 0.58A 4jecB-3lzdA:
undetectable		 4jecB-3lzdA:
13.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_A_ACTA505_0
(RNA POLYMERASE
3D-POL)		 3lzd DPH2
(Pyrococcus
horikoshii) 		3 / 3 CYH A  59
ASN A  55
LYS A 238
 SF4  A 343 (-2.3A)
None
None
 1.27A 4k50A-3lzdA:
undetectable		 4k50A-3lzdA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PD4_C_AOQC4003_1
(CYTOCHROME B)		 3lzd DPH2
(Pyrococcus
horikoshii) 		5 / 12 PHE A 320
GLY A 187
ILE A 182
LEU A 292
ILE A 222
 None
 1.01A 4pd4C-3lzdA:
undetectable		 4pd4C-3lzdA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4POO_B_SAMB301_0
(PUTATIVE RNA
METHYLASE)		 3lzd DPH2
(Pyrococcus
horikoshii) 		5 / 12 GLY A 325
ASP A 151
ILE A 154
SER A 155
SER A  80
 None
 1.23A 4pooB-3lzdA:
3.0		 4pooB-3lzdA:
22.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6BXL_A_SAMA401_0
(2-(3-AMINO-3-CARBOXY
PROPYL)HISTIDINE
SYNTHASE)		 3lzd DPH2
(Pyrococcus
horikoshii) 		10 / 12 TYR A  56
LEU A 161
GLY A 162
HIS A 184
SER A 236
LYS A 238
GLN A 241
ASP A 268
CYH A 287
VAL A 290
 None
SO4  A 344 (-3.8A)
SO4  A 344 (-3.5A)
SO4  A 344 (-4.2A)
None
None
SF4  A 343 ( 4.4A)
None
SF4  A 343 (-2.3A)
None
 0.45A 6bxlA-3lzdA:
52.9		 6bxlA-3lzdA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6BXL_A_SAMA401_0
(2-(3-AMINO-3-CARBOXY
PROPYL)HISTIDINE
SYNTHASE)		 3lzd DPH2
(Pyrococcus
horikoshii) 		10 / 12 TYR A  56
LEU A 161
GLY A 162
HIS A 184
SER A 236
LYS A 238
GLN A 241
CYH A 287
VAL A 290
ASP A 293
 None
SO4  A 344 (-3.8A)
SO4  A 344 (-3.5A)
SO4  A 344 (-4.2A)
None
None
SF4  A 343 ( 4.4A)
SF4  A 343 (-2.3A)
None
None
 0.46A 6bxlA-3lzdA:
52.9		 6bxlA-3lzdA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6BXL_B_SAMB401_0
(2-(3-AMINO-3-CARBOXY
PROPYL)HISTIDINE
SYNTHASE)		 3lzd DPH2
(Pyrococcus
horikoshii) 		11 / 12 LEU A 161
GLY A 162
HIS A 184
SER A 236
LYS A 238
GLN A 241
VAL A 269
CYH A 287
ARG A 289
VAL A 290
ASP A 293
 SO4  A 344 (-3.8A)
SO4  A 344 (-3.5A)
SO4  A 344 (-4.2A)
None
None
SF4  A 343 ( 4.4A)
None
SF4  A 343 (-2.3A)
SO4  A 344 (-4.0A)
None
None
 0.59A 6bxlB-3lzdA:
50.5		 6bxlB-3lzdA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6BXL_B_SAMB401_0
(2-(3-AMINO-3-CARBOXY
PROPYL)HISTIDINE
SYNTHASE)		 3lzd DPH2
(Pyrococcus
horikoshii) 		9 / 12 TYR A  56
LEU A 161
GLY A 162
HIS A 184
LYS A 238
GLN A 241
CYH A 287
ARG A 289
ASP A 293
 None
SO4  A 344 (-3.8A)
SO4  A 344 (-3.5A)
SO4  A 344 (-4.2A)
None
SF4  A 343 ( 4.4A)
SF4  A 343 (-2.3A)
SO4  A 344 (-4.0A)
None
 0.82A 6bxlB-3lzdA:
50.5		 6bxlB-3lzdA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6BXM_A_SAMA402_0
(DIPHTHAMIDE
BIOSYNTHESIS ENZYME
DPH2)		 3lzd DPH2
(Pyrococcus
horikoshii) 		8 / 12 LEU A 161
GLY A 162
SER A 236
LYS A 238
GLN A 241
VAL A 269
CYH A 287
ARG A 289
 SO4  A 344 (-3.8A)
SO4  A 344 (-3.5A)
None
None
SF4  A 343 ( 4.4A)
None
SF4  A 343 (-2.3A)
SO4  A 344 (-4.0A)
 0.56A 6bxmA-3lzdA:
20.1		 6bxmA-3lzdA:
38.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6BXM_A_SAMA402_0
(DIPHTHAMIDE
BIOSYNTHESIS ENZYME
DPH2)		 3lzd DPH2
(Pyrococcus
horikoshii) 		7 / 12 LEU A 161
GLY A 162
SER A 236
LYS A 238
VAL A 269
ARG A 289
ASP A 293
 SO4  A 344 (-3.8A)
SO4  A 344 (-3.5A)
None
None
None
SO4  A 344 (-4.0A)
None
 0.87A 6bxmA-3lzdA:
20.1		 6bxmA-3lzdA:
38.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6BXN_A_SAMA901_0
(DIPHTHAMIDE
BIOSYNTHESIS ENZYME
DPH2)		 3lzd DPH2
(Pyrococcus
horikoshii) 		6 / 12 HIS A 184
SER A 236
LYS A 238
VAL A 269
ARG A 289
ASP A 293
 SO4  A 344 (-4.2A)
None
None
None
SO4  A 344 (-4.0A)
None
 1.00A 6bxnA-3lzdA:
34.5		 6bxnA-3lzdA:
38.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6BXN_A_SAMA901_0
(DIPHTHAMIDE
BIOSYNTHESIS ENZYME
DPH2)		 3lzd DPH2
(Pyrococcus
horikoshii) 		8 / 12 LEU A 161
HIS A 184
SER A 236
LYS A 238
GLN A 241
VAL A 269
CYH A 287
ARG A 289
 SO4  A 344 (-3.8A)
SO4  A 344 (-4.2A)
None
None
SF4  A 343 ( 4.4A)
None
SF4  A 343 (-2.3A)
SO4  A 344 (-4.0A)
 0.60A 6bxnA-3lzdA:
34.5		 6bxnA-3lzdA:
38.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6BXN_B_SAMB901_0
(DIPHTHAMIDE
BIOSYNTHESIS ENZYME
DPH2)		 3lzd DPH2
(Pyrococcus
horikoshii) 		9 / 12 LEU A 161
GLY A 162
HIS A 184
SER A 236
LYS A 238
GLN A 241
VAL A 269
CYH A 287
ARG A 289
 SO4  A 344 (-3.8A)
SO4  A 344 (-3.5A)
SO4  A 344 (-4.2A)
None
None
SF4  A 343 ( 4.4A)
None
SF4  A 343 (-2.3A)
SO4  A 344 (-4.0A)
 0.61A 6bxnB-3lzdA:
20.3		 6bxnB-3lzdA:
38.44