SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3lzk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZX_X_T3X500_1
(THYROID HORMONE
RECEPTOR BETA-1)		 3lzk FUMARYLACETOACETATE
HYDROLASE FAMILY
PROTEIN
(Sinorhizobium
meliloti) 		5 / 12 ILE A 260
ILE A 259
ALA A 143
MET A 166
LEU A  39
 None
 1.21A 1xzxX-3lzkA:
undetectable		 1xzxX-3lzkA:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YS6_A_GLYA431_0
(PHOSPHORIBOSYLGLYCIN
AMIDE SYNTHETASE)		 3lzk FUMARYLACETOACETATE
HYDROLASE FAMILY
PROTEIN
(Sinorhizobium
meliloti) 		4 / 8 ASP A 170
LYS A 191
GLY A 263
GLU A 141
 CA  A 339 (-3.5A)
CA  A 339 ( 3.9A)
CA  A 339 ( 4.1A)
CA  A 339 (-3.0A)
 0.97A 2ys6A-3lzkA:
undetectable		 2ys6A-3lzkA:
27.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZW9_A_SAMA801_0
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)		 3lzk FUMARYLACETOACETATE
HYDROLASE FAMILY
PROTEIN
(Sinorhizobium
meliloti) 		5 / 12 GLN A  80
SER A 194
GLY A 261
LEU A 244
TYR A 113
 None
 1.19A 2zw9A-3lzkA:
undetectable		 2zw9A-3lzkA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCO_B_CHDB1_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3lzk FUMARYLACETOACETATE
HYDROLASE FAMILY
PROTEIN
(Sinorhizobium
meliloti) 		4 / 4 LEU A  75
PRO A  74
LEU A  35
ARG A 163
 None
 1.22A 3hcoB-3lzkA:
undetectable		 3hcoB-3lzkA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RXF_A_4APA9_1
(CATIONIC TRYPSIN)		 3lzk FUMARYLACETOACETATE
HYDROLASE FAMILY
PROTEIN
(Sinorhizobium
meliloti) 		5 / 6 SER A 285
SER A 266
VAL A 265
GLY A 283
GLY A 229
 None
 1.48A 3rxfA-3lzkA:
undetectable		 3rxfA-3lzkA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_A_NCTA501_1
(CYTOCHROME P450 2A6)		 3lzk FUMARYLACETOACETATE
HYDROLASE FAMILY
PROTEIN
(Sinorhizobium
meliloti) 		4 / 7 PHE A 120
GLY A 115
ILE A 259
PHE A 196
 None
 0.87A 4ejjA-3lzkA:
undetectable		 4ejjA-3lzkA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAR_A_ERMA2001_2
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 1B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 3lzk FUMARYLACETOACETATE
HYDROLASE FAMILY
PROTEIN
(Sinorhizobium
meliloti) 		4 / 7 ILE A 177
VAL A  91
SER A 172
PHE A 305
 None
 1.21A 4iarA-3lzkA:
undetectable		 4iarA-3lzkA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L78_A_ACTA1327_0
(PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE)		 3lzk FUMARYLACETOACETATE
HYDROLASE FAMILY
PROTEIN
(Sinorhizobium
meliloti) 		4 / 4 VAL A 201
THR A 202
GLU A 205
GLU A 204
 None
 1.36A 4l78A-3lzkA:
undetectable		 4l78A-3lzkA:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_C_STRC601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 3lzk FUMARYLACETOACETATE
HYDROLASE FAMILY
PROTEIN
(Sinorhizobium
meliloti) 		5 / 12 ALA A 195
ILE A 136
ILE A 328
VAL A 312
VAL A 311
 None
 1.09A 4nkxC-3lzkA:
undetectable		 4nkxC-3lzkA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_D_STRD601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 3lzk FUMARYLACETOACETATE
HYDROLASE FAMILY
PROTEIN
(Sinorhizobium
meliloti) 		5 / 12 ALA A 195
ILE A 136
ILE A 328
VAL A 312
VAL A 311
 None
 1.08A 4nkxD-3lzkA:
undetectable		 4nkxD-3lzkA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4G_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 3lzk FUMARYLACETOACETATE
HYDROLASE FAMILY
PROTEIN
(Sinorhizobium
meliloti) 		4 / 6 LEU A 173
LYS A 191
PRO A 192
GLU A 139
 None
CA  A 339 ( 3.9A)
None
CA  A 339 (-3.4A)
 1.26A 4z4gA-3lzkA:
undetectable		 4z4gA-3lzkA:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW4_A_SAMA801_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE I)		 3lzk FUMARYLACETOACETATE
HYDROLASE FAMILY
PROTEIN
(Sinorhizobium
meliloti) 		5 / 12 GLY A 140
THR A 264
ASP A 170
CYH A 286
LEU A 223
 None
None
CA  A 339 (-3.5A)
None
None
 1.25A 5hw4A-3lzkA:
undetectable		 5hw4A-3lzkA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW4_C_SAMC801_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE I)		 3lzk FUMARYLACETOACETATE
HYDROLASE FAMILY
PROTEIN
(Sinorhizobium
meliloti) 		5 / 12 GLY A 140
THR A 264
ASP A 170
CYH A 286
LEU A 223
 None
None
CA  A 339 (-3.5A)
None
None
 1.23A 5hw4C-3lzkA:
undetectable		 5hw4C-3lzkA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KSG_B_NIZB809_1
(CATALASE-PEROXIDASE)		 3lzk FUMARYLACETOACETATE
HYDROLASE FAMILY
PROTEIN
(Sinorhizobium
meliloti) 		5 / 9 GLU A 141
GLU A 139
GLY A  84
SER A  85
LEU A 111
 CA  A 339 (-3.0A)
CA  A 339 (-3.4A)
None
None
None
 1.46A 5ksgB-3lzkA:
undetectable		 5ksgB-3lzkA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KSN_A_NIZA809_1
(CATALASE-PEROXIDASE)		 3lzk FUMARYLACETOACETATE
HYDROLASE FAMILY
PROTEIN
(Sinorhizobium
meliloti) 		5 / 9 GLU A 141
GLU A 139
GLY A  84
SER A  85
LEU A 111
 CA  A 339 (-3.0A)
CA  A 339 (-3.4A)
None
None
None
 1.46A 5ksnA-3lzkA:
undetectable		 5ksnA-3lzkA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KSN_B_NIZB809_1
(CATALASE-PEROXIDASE)		 3lzk FUMARYLACETOACETATE
HYDROLASE FAMILY
PROTEIN
(Sinorhizobium
meliloti) 		5 / 9 GLU A 141
GLU A 139
GLY A  84
SER A  85
LEU A 111
 CA  A 339 (-3.0A)
CA  A 339 (-3.4A)
None
None
None
 1.46A 5ksnB-3lzkA:
undetectable		 5ksnB-3lzkA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KT8_B_NIZB809_1
(CATALASE-PEROXIDASE)		 3lzk FUMARYLACETOACETATE
HYDROLASE FAMILY
PROTEIN
(Sinorhizobium
meliloti) 		5 / 9 GLU A 141
GLU A 139
GLY A  84
SER A  85
LEU A 111
 CA  A 339 (-3.0A)
CA  A 339 (-3.4A)
None
None
None
 1.45A 5kt8B-3lzkA:
undetectable		 5kt8B-3lzkA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SXS_B_NIZB806_1
(CATALASE-PEROXIDASE)		 3lzk FUMARYLACETOACETATE
HYDROLASE FAMILY
PROTEIN
(Sinorhizobium
meliloti) 		5 / 9 GLU A 141
GLU A 139
GLY A  84
SER A  85
LEU A 111
 CA  A 339 (-3.0A)
CA  A 339 (-3.4A)
None
None
None
 1.46A 5sxsB-3lzkA:
undetectable		 5sxsB-3lzkA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYI_B_NIZB805_1
(CATALASE-PEROXIDASE)		 3lzk FUMARYLACETOACETATE
HYDROLASE FAMILY
PROTEIN
(Sinorhizobium
meliloti) 		5 / 9 GLU A 141
GLU A 139
GLY A  84
SER A  85
LEU A 111
 CA  A 339 (-3.0A)
CA  A 339 (-3.4A)
None
None
None
 1.47A 5syiB-3lzkA:
undetectable		 5syiB-3lzkA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDQ_A_NIZA809_1
(CATALASE-PEROXIDASE)		 3lzk FUMARYLACETOACETATE
HYDROLASE FAMILY
PROTEIN
(Sinorhizobium
meliloti) 		5 / 9 GLU A 141
GLU A 139
GLY A  84
SER A  85
LEU A 111
 CA  A 339 (-3.0A)
CA  A 339 (-3.4A)
None
None
None
 1.42A 6cdqA-3lzkA:
undetectable		 6cdqA-3lzkA:
12.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDQ_B_NIZB808_1
(CATALASE-PEROXIDASE)		 3lzk FUMARYLACETOACETATE
HYDROLASE FAMILY
PROTEIN
(Sinorhizobium
meliloti) 		5 / 9 GLU A 141
GLU A 139
GLY A  84
SER A  85
LEU A 111
 CA  A 339 (-3.0A)
CA  A 339 (-3.4A)
None
None
None
 1.43A 6cdqB-3lzkA:
undetectable		 6cdqB-3lzkA:
12.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CFQ_B_NIZB809_1
(CATALASE-PEROXIDASE)		 3lzk FUMARYLACETOACETATE
HYDROLASE FAMILY
PROTEIN
(Sinorhizobium
meliloti) 		5 / 9 GLU A 141
GLU A 139
GLY A  84
SER A  85
LEU A 111
 CA  A 339 (-3.0A)
CA  A 339 (-3.4A)
None
None
None
 1.46A 6cfqB-3lzkA:
undetectable		 6cfqB-3lzkA:
12.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKU_A_ZMRA901_2
(SIALIDASE)		 3lzk FUMARYLACETOACETATE
HYDROLASE FAMILY
PROTEIN
(Sinorhizobium
meliloti) 		4 / 6 ASP A  83
ASN A 169
LEU A 219
SER A 285
 CA  A 339 (-3.0A)
None
None
None
 1.27A 6ekuA-3lzkA:
0.9		 6ekuA-3lzkA:
18.83