SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3lzx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KNY_A_KANA558_1
(KANAMYCIN
NUCLEOTIDYLTRANSFERA
SE)		 3lzx FERREDOXIN--NADP
REDUCTASE 2
(Bacillus
subtilis) 		4 / 7 ASP A 147
GLU A 107
GLU A  87
GLU A 108
 None
 1.15A 1knyA-3lzxA:
undetectable
1knyB-3lzxA:
undetectable		 1knyA-3lzxA:
23.77
1knyB-3lzxA:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WMQ_A_HISA2001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 3lzx FERREDOXIN--NADP
REDUCTASE 2
(Bacillus
subtilis) 		4 / 6 ARG A 186
ARG A 190
GLY A 163
HIS A 184
 NAP  A2000 (-3.9A)
NAP  A2000 (-4.0A)
NAP  A2000 (-3.3A)
NAP  A2000 (-4.1A)
 1.00A 1wmqA-3lzxA:
undetectable		 1wmqA-3lzxA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WMQ_B_HISB1001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 3lzx FERREDOXIN--NADP
REDUCTASE 2
(Bacillus
subtilis) 		4 / 6 ARG A 186
ARG A 190
GLY A 163
HIS A 184
 NAP  A2000 (-3.9A)
NAP  A2000 (-4.0A)
NAP  A2000 (-3.3A)
NAP  A2000 (-4.1A)
 1.00A 1wmqB-3lzxA:
undetectable		 1wmqB-3lzxA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WPU_B_HISB1001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 3lzx FERREDOXIN--NADP
REDUCTASE 2
(Bacillus
subtilis) 		4 / 6 ARG A 186
ARG A 190
GLY A 163
HIS A 184
 NAP  A2000 (-3.9A)
NAP  A2000 (-4.0A)
NAP  A2000 (-3.3A)
NAP  A2000 (-4.1A)
 1.01A 1wpuB-3lzxA:
undetectable		 1wpuB-3lzxA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRQ_B_HISB1001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 3lzx FERREDOXIN--NADP
REDUCTASE 2
(Bacillus
subtilis) 		4 / 6 ARG A 186
ARG A 190
GLY A 163
HIS A 184
 NAP  A2000 (-3.9A)
NAP  A2000 (-4.0A)
NAP  A2000 (-3.3A)
NAP  A2000 (-4.1A)
 1.01A 1wrqB-3lzxA:
undetectable		 1wrqB-3lzxA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_G_BEZG3385_0
(CES1 PROTEIN)		 3lzx FERREDOXIN--NADP
REDUCTASE 2
(Bacillus
subtilis) 		3 / 3 SER A 112
VAL A  93
LEU A 103
 None
 0.75A 1yajG-3lzxA:
undetectable		 1yajG-3lzxA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3B_B_FOLB401_1
(DIHYDROFOLATE
REDUCTASE)		 3lzx FERREDOXIN--NADP
REDUCTASE 2
(Bacillus
subtilis) 		3 / 3 GLU A  75
GLN A  67
ARG A  65
 None
 0.87A 2w3bB-3lzxA:
1.7		 2w3bB-3lzxA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z0Y_A_SAMA300_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA0657)		 3lzx FERREDOXIN--NADP
REDUCTASE 2
(Bacillus
subtilis) 		5 / 9 ALA A 283
GLY A  19
GLY A  16
ILE A 296
ALA A 303
 None
None
FAD  A1000 (-3.4A)
FAD  A1000 (-3.7A)
None
 0.95A 2z0yA-3lzxA:
2.9		 2z0yA-3lzxA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FSU_A_C2FA995_0
(5,10-METHYLENETETRAH
YDROFOLATE REDUCTASE)		 3lzx FERREDOXIN--NADP
REDUCTASE 2
(Bacillus
subtilis) 		5 / 12 THR A 118
ASN A  71
GLN A  67
LEU A  46
LEU A  73
 None
 1.39A 3fsuA-3lzxA:
undetectable		 3fsuA-3lzxA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LP9_D_SPMD230_1
(LS-24)		 3lzx FERREDOXIN--NADP
REDUCTASE 2
(Bacillus
subtilis) 		3 / 3 GLU A 235
GLU A 179
ASN A 205
 None
 0.76A 3lp9B-3lzxA:
undetectable
3lp9D-3lzxA:
undetectable		 3lp9B-3lzxA:
21.04
3lp9D-3lzxA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXV_B_478B200_2
(HIV-1 PROTEASE)		 3lzx FERREDOXIN--NADP
REDUCTASE 2
(Bacillus
subtilis) 		5 / 10 VAL A  33
ILE A  35
GLY A  19
VAL A  18
ILE A  10
 None
None
None
FAD  A1000 (-3.7A)
None
 1.09A 3oxvB-3lzxA:
undetectable		 3oxvB-3lzxA:
14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RGF_A_BAXA465_2
(CYCLIN-DEPENDENT
KINASE 8)		 3lzx FERREDOXIN--NADP
REDUCTASE 2
(Bacillus
subtilis) 		4 / 7 LEU A 173
VAL A 157
VAL A 146
LEU A 237
 None
 0.77A 3rgfA-3lzxA:
undetectable		 3rgfA-3lzxA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WSJ_A_MK1A201_2
(PROTEASE)		 3lzx FERREDOXIN--NADP
REDUCTASE 2
(Bacillus
subtilis) 		4 / 7 LEU A 252
ALA A 119
VAL A 115
ILE A 255
 None
FAD  A1000 (-3.3A)
None
None
 0.77A 3wsjB-3lzxA:
undetectable		 3wsjB-3lzxA:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7U_D_YTZD802_1
(SEPIAPTERIN
REDUCTASE)		 3lzx FERREDOXIN--NADP
REDUCTASE 2
(Bacillus
subtilis) 		4 / 8 LEU A  49
PHE A 124
PRO A  51
GLN A  67
 FAD  A1000 ( 4.5A)
FAD  A1000 (-4.9A)
None
None
 1.18A 4j7uD-3lzxA:
3.1		 4j7uD-3lzxA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JTR_A_IBPA401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 3lzx FERREDOXIN--NADP
REDUCTASE 2
(Bacillus
subtilis) 		4 / 8 VAL A 244
TYR A 246
LEU A 226
LEU A 224
 None
NAP  A2000 (-3.5A)
None
None
 1.01A 4jtrA-3lzxA:
undetectable		 4jtrA-3lzxA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K4Y_A_ACTA502_0
(RNA-DEPENDENT RNA
POLYMERASE)		 3lzx FERREDOXIN--NADP
REDUCTASE 2
(Bacillus
subtilis) 		4 / 5 LYS A 128
LEU A 129
GLU A 138
LEU A 142
 None
 1.28A 4k4yA-3lzxA:
undetectable		 4k4yA-3lzxA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N48_B_SAMB601_0
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 3lzx FERREDOXIN--NADP
REDUCTASE 2
(Bacillus
subtilis) 		5 / 12 GLY A 122
PHE A 124
ILE A  35
GLY A  16
LEU A  20
 FAD  A1000 (-3.7A)
FAD  A1000 (-4.9A)
None
FAD  A1000 (-3.4A)
None
 1.13A 4n48B-3lzxA:
undetectable		 4n48B-3lzxA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE0_A_40LA1101_0
(PHOSPHATIDYLINOSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC
SUBUNIT DELTA
ISOFORM)		 3lzx FERREDOXIN--NADP
REDUCTASE 2
(Bacillus
subtilis) 		5 / 12 PRO A 212
ILE A 183
VAL A 180
ASP A 241
ASN A 141
 None
 1.28A 4xe0A-3lzxA:
undetectable		 4xe0A-3lzxA:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YJI_A_TYLA502_1
(ARYL ACYLAMIDASE)		 3lzx FERREDOXIN--NADP
REDUCTASE 2
(Bacillus
subtilis) 		4 / 7 LEU A  86
GLY A  15
GLY A  16
ILE A  70
 None
FAD  A1000 ( 4.8A)
FAD  A1000 (-3.4A)
None
 0.70A 4yjiA-3lzxA:
undetectable		 4yjiA-3lzxA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E72_A_SAMA400_0
(N2,
N2-DIMETHYLGUANOSINE
TRNA
METHYLTRANSFERASE)		 3lzx FERREDOXIN--NADP
REDUCTASE 2
(Bacillus
subtilis) 		5 / 12 ILE A 286
PHE A 281
GLY A  14
ILE A  12
ILE A 277
 None
None
FAD  A1000 (-3.1A)
None
None
 1.06A 5e72A-3lzxA:
3.4		 5e72A-3lzxA:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIP_B_HFGB1003_0
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 3lzx FERREDOXIN--NADP
REDUCTASE 2
(Bacillus
subtilis) 		5 / 12 GLU A 228
VAL A 229
PRO A 209
THR A 208
HIS A 200
 None
 1.36A 5xipB-3lzxA:
undetectable		 5xipB-3lzxA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9Y_A_ACTA409_0
(UNCHARACTERIZED
PROTEIN KDOO)		 3lzx FERREDOXIN--NADP
REDUCTASE 2
(Bacillus
subtilis) 		3 / 3 LYS A 125
PRO A 126
LYS A 128
 None
 1.05A 5y9yA-3lzxA:
undetectable		 5y9yA-3lzxA:
23.64