SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3m0e'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETA_1_T441128_1
(TRANSTHYRETIN)		 3m0e TRANSCRIPTIONAL
REGULATOR (NTRC
FAMILY)
(Aquifex
aeolicus) 		4 / 5 LEU A 251
GLU A 205
ALA A 249
LEU A 296
 None
 1.21A 1eta1-3m0eA:
undetectable		 1eta1-3m0eA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETA_1_T441128_1
(TRANSTHYRETIN)		 3m0e TRANSCRIPTIONAL
REGULATOR (NTRC
FAMILY)
(Aquifex
aeolicus) 		4 / 5 LYS A 250
GLU A 205
ALA A 249
LEU A 245
 None
 1.20A 1eta1-3m0eA:
undetectable		 1eta1-3m0eA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETA_2_T442129_1
(TRANSTHYRETIN)		 3m0e TRANSCRIPTIONAL
REGULATOR (NTRC
FAMILY)
(Aquifex
aeolicus) 		4 / 5 LYS A 250
GLU A 205
ALA A 249
LEU A 245
 None
 1.18A 1eta2-3m0eA:
undetectable		 1eta2-3m0eA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETB_2_T442129_1
(TRANSTHYRETIN)		 3m0e TRANSCRIPTIONAL
REGULATOR (NTRC
FAMILY)
(Aquifex
aeolicus) 		4 / 6 LYS A 250
GLU A 205
ALA A 249
LEU A 245
 None
 1.26A 1etb2-3m0eA:
undetectable		 1etb2-3m0eA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QHY_A_CLMA999_0
(CHLORAMPHENICOL
PHOSPHOTRANSFERASE)		 3m0e TRANSCRIPTIONAL
REGULATOR (NTRC
FAMILY)
(Aquifex
aeolicus) 		5 / 12 VAL A 362
ILE A 363
ILE A 375
PHE A 339
VAL A 384
 None
 1.07A 1qhyA-3m0eA:
2.5		 1qhyA-3m0eA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZW9_B_SAMB801_1
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)		 3m0e TRANSCRIPTIONAL
REGULATOR (NTRC
FAMILY)
(Aquifex
aeolicus) 		4 / 8 ILE A 165
ASN A 280
SER A 169
ARG A 357
 None
ATP  A 400 (-4.2A)
ATP  A 400 (-2.6A)
ATP  A 400 (-3.3A)
 1.02A 2zw9B-3m0eA:
2.5		 2zw9B-3m0eA:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3006_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 3m0e TRANSCRIPTIONAL
REGULATOR (NTRC
FAMILY)
(Aquifex
aeolicus) 		4 / 6 ASN A 355
ILE A 307
GLU A 168
ASN A 280
 None
None
None
ATP  A 400 (-4.2A)
 1.32A 3kp6A-3m0eA:
undetectable
3kp6B-3m0eA:
undetectable		 3kp6A-3m0eA:
22.51
3kp6B-3m0eA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQW_C_ACHC323_0
(ELIC PENTAMERIC
LIGAND GATED ION
CHANNEL FROM ERWINIA
CHRYSANTHEMI)		 3m0e TRANSCRIPTIONAL
REGULATOR (NTRC
FAMILY)
(Aquifex
aeolicus) 		4 / 8 ASN A 282
GLU A 306
GLU A 304
TYR A 297
 None
 1.05A 3rqwC-3m0eA:
undetectable
3rqwD-3m0eA:
undetectable		 3rqwC-3m0eA:
19.35
3rqwD-3m0eA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQW_J_ACHJ323_0
(ELIC PENTAMERIC
LIGAND GATED ION
CHANNEL FROM ERWINIA
CHRYSANTHEMI)		 3m0e TRANSCRIPTIONAL
REGULATOR (NTRC
FAMILY)
(Aquifex
aeolicus) 		4 / 8 GLU A 306
GLU A 304
TYR A 297
ASN A 282
 None
 1.04A 3rqwF-3m0eA:
undetectable
3rqwJ-3m0eA:
undetectable		 3rqwF-3m0eA:
19.35
3rqwJ-3m0eA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RV5_C_DXCC92_0
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 3m0e TRANSCRIPTIONAL
REGULATOR (NTRC
FAMILY)
(Aquifex
aeolicus) 		4 / 4 VAL A 192
PHE A 226
PHE A 209
VAL A 254
 None
 1.39A 3rv5C-3m0eA:
undetectable
3rv5D-3m0eA:
undetectable		 3rv5C-3m0eA:
16.92
3rv5D-3m0eA:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZMD_A_SALA201_1
(PUTATIVE
TRANSCRIPTIONAL
REGULATOR)		 3m0e TRANSCRIPTIONAL
REGULATOR (NTRC
FAMILY)
(Aquifex
aeolicus) 		4 / 8 ARG A 253
LEU A 252
ARG A 299
GLU A 256
 None
 1.47A 3zmdA-3m0eA:
undetectable
3zmdB-3m0eA:
undetectable		 3zmdA-3m0eA:
19.25
3zmdB-3m0eA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CEV_A_GAIA407_0
(PROTEIN (ARGINASE))		 3m0e TRANSCRIPTIONAL
REGULATOR (NTRC
FAMILY)
(Aquifex
aeolicus) 		4 / 6 ARG A 313
GLU A 315
MET A 146
ASP A 316
 None
 1.40A 4cevA-3m0eA:
4.0
4cevB-3m0eA:
undetectable		 4cevA-3m0eA:
25.38
4cevB-3m0eA:
25.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CEV_B_GAIB408_0
(PROTEIN (ARGINASE))		 3m0e TRANSCRIPTIONAL
REGULATOR (NTRC
FAMILY)
(Aquifex
aeolicus) 		4 / 5 ARG A 313
GLU A 315
MET A 146
ASP A 316
 None
 1.40A 4cevB-3m0eA:
0.7
4cevC-3m0eA:
0.7		 4cevB-3m0eA:
25.38
4cevC-3m0eA:
25.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CEV_C_GAIC409_0
(PROTEIN (ARGINASE))		 3m0e TRANSCRIPTIONAL
REGULATOR (NTRC
FAMILY)
(Aquifex
aeolicus) 		4 / 6 MET A 146
ASP A 316
ARG A 313
GLU A 315
 None
 1.40A 4cevA-3m0eA:
4.0
4cevC-3m0eA:
undetectable		 4cevA-3m0eA:
25.38
4cevC-3m0eA:
25.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CEV_D_GAID410_0
(PROTEIN (ARGINASE))		 3m0e TRANSCRIPTIONAL
REGULATOR (NTRC
FAMILY)
(Aquifex
aeolicus) 		4 / 6 ARG A 313
GLU A 315
MET A 146
ASP A 316
 None
 1.43A 4cevD-3m0eA:
3.6
4cevE-3m0eA:
3.5		 4cevD-3m0eA:
25.38
4cevE-3m0eA:
25.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CEV_F_GAIF411_0
(PROTEIN (ARGINASE))		 3m0e TRANSCRIPTIONAL
REGULATOR (NTRC
FAMILY)
(Aquifex
aeolicus) 		4 / 6 ARG A 313
GLU A 315
MET A 146
ASP A 316
 None
 1.42A 4cevE-3m0eA:
3.4
4cevF-3m0eA:
3.4		 4cevE-3m0eA:
25.38
4cevF-3m0eA:
25.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CEV_F_GAIF412_0
(PROTEIN (ARGINASE))		 3m0e TRANSCRIPTIONAL
REGULATOR (NTRC
FAMILY)
(Aquifex
aeolicus) 		4 / 5 MET A 146
ASP A 316
ARG A 313
GLU A 315
 None
 1.41A 4cevD-3m0eA:
3.6
4cevF-3m0eA:
3.7		 4cevD-3m0eA:
25.38
4cevF-3m0eA:
25.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_A_GCSA303_1
(CHITOSANASE)		 3m0e TRANSCRIPTIONAL
REGULATOR (NTRC
FAMILY)
(Aquifex
aeolicus) 		4 / 6 GLU A 304
ILE A 283
THR A 166
TYR A 298
 None
 1.09A 4qwpA-3m0eA:
undetectable		 4qwpA-3m0eA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_B_GCSB302_1
(CHITOSANASE)		 3m0e TRANSCRIPTIONAL
REGULATOR (NTRC
FAMILY)
(Aquifex
aeolicus) 		4 / 5 GLU A 304
ILE A 283
THR A 166
TYR A 298
 None
 1.06A 4qwpB-3m0eA:
undetectable		 4qwpB-3m0eA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_H_377H401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3m0e TRANSCRIPTIONAL
REGULATOR (NTRC
FAMILY)
(Aquifex
aeolicus) 		4 / 6 ASN A 282
GLU A 306
GLU A 304
TYR A 297
 None
 1.26A 4twdG-3m0eA:
undetectable
4twdH-3m0eA:
undetectable		 4twdG-3m0eA:
18.46
4twdH-3m0eA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y03_B_SALB801_1
(PROTEIN POLYBROMO-1)		 3m0e TRANSCRIPTIONAL
REGULATOR (NTRC
FAMILY)
(Aquifex
aeolicus) 		4 / 5 LEU A 380
ALA A 321
ASN A 322
ILE A 318
 None
 1.07A 4y03B-3m0eA:
undetectable		 4y03B-3m0eA:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K9D_A_CE9A402_0
(DIHYDROOROTATE
DEHYDROGENASE
(QUINONE),
MITOCHONDRIAL)		 3m0e TRANSCRIPTIONAL
REGULATOR (NTRC
FAMILY)
(Aquifex
aeolicus) 		5 / 12 LEU A 320
ALA A 321
PHE A 324
PHE A 339
LEU A 380
 None
 1.02A 5k9dA-3m0eA:
undetectable		 5k9dA-3m0eA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BEC_C_RBTC601_1
(SCAFFOLD PROTEIN D13)		 3m0e TRANSCRIPTIONAL
REGULATOR (NTRC
FAMILY)
(Aquifex
aeolicus) 		5 / 12 PRO A 190
PHE A 191
VAL A 271
PHE A 204
PHE A 227
 None
 1.27A 6becA-3m0eA:
undetectable
6becB-3m0eA:
undetectable
6becC-3m0eA:
undetectable		 6becA-3m0eA:
18.93
6becB-3m0eA:
18.93
6becC-3m0eA:
18.93