SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3m2r'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_B_ADNB602_2
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 3m2r METHYL-COENZYME M
REDUCTASE I SUBUNIT
BETA
(Methanothermobac
ter
marburgensis) 		4 / 5 THR B 355
THR B 382
GLU B 219
THR B 216
 None
 1.03A 1d4fB-3m2rB:
undetectable		 1d4fB-3m2rB:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7L_C_SAMC685_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 3m2r METHYL-COENZYME M
REDUCTASE I SUBUNIT
BETA
(Methanothermobac
ter
marburgensis) 		4 / 8 ALA B 159
ASP B  77
ILE B  78
ILE B  85
 None
 0.86A 1p7lD-3m2rB:
undetectable		 1p7lD-3m2rB:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7L_C_SAMC885_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 3m2r METHYL-COENZYME M
REDUCTASE I SUBUNIT
BETA
(Methanothermobac
ter
marburgensis) 		4 / 8 ALA B 159
ASP B  77
ILE B  78
ILE B  85
 None
 0.87A 1p7lC-3m2rB:
undetectable		 1p7lC-3m2rB:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_A_SAMA385_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 3m2r METHYL-COENZYME M
REDUCTASE I SUBUNIT
BETA
(Methanothermobac
ter
marburgensis) 		4 / 8 ALA B 159
ASP B  77
ILE B  78
ILE B  85
 None
 0.85A 1rg9B-3m2rB:
undetectable		 1rg9B-3m2rB:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_B_SAMB485_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 3m2r METHYL-COENZYME M
REDUCTASE I SUBUNIT
BETA
(Methanothermobac
ter
marburgensis) 		4 / 8 ALA B 159
ASP B  77
ILE B  78
ILE B  85
 None
 0.85A 1rg9A-3m2rB:
undetectable		 1rg9A-3m2rB:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_C_SAMC585_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 3m2r METHYL-COENZYME M
REDUCTASE I SUBUNIT
BETA
(Methanothermobac
ter
marburgensis) 		4 / 8 ALA B 159
ASP B  77
ILE B  78
ILE B  85
 None
 0.85A 1rg9D-3m2rB:
undetectable		 1rg9D-3m2rB:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_C_SAMC685_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 3m2r METHYL-COENZYME M
REDUCTASE I SUBUNIT
BETA
(Methanothermobac
ter
marburgensis) 		4 / 8 ALA B 159
ASP B  77
ILE B  78
ILE B  85
 None
 0.86A 1rg9C-3m2rB:
undetectable		 1rg9C-3m2rB:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AA6_B_STRB402_1
(MINERALOCORTICOID
RECEPTOR)		 3m2r METHYL-COENZYME M
REDUCTASE I SUBUNIT
BETA
(Methanothermobac
ter
marburgensis) 		5 / 12 LEU B 310
ALA B 307
GLN B 244
MET B 236
THR B 296
 None
 1.46A 2aa6B-3m2rB:
undetectable		 2aa6B-3m2rB:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BLA_A_CP6A302_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3m2r METHYL-COENZYME M
REDUCTASE I SUBUNIT
BETA
(Methanothermobac
ter
marburgensis) 		5 / 11 ILE B  78
ALA B  82
ASN B  49
ILE B 175
ILE B  53
 None
 1.27A 2blaA-3m2rB:
undetectable		 2blaA-3m2rB:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNI_A_MTKA501_2
(CYTOCHROME P450 2C8)		 3m2r METHYL-COENZYME M
REDUCTASE I SUBUNIT
BETA
(Methanothermobac
ter
marburgensis) 		4 / 8 ILE B  85
ILE B  93
ASN B 174
VAL B 160
 None
 0.67A 2nniA-3m2rB:
undetectable		 2nniA-3m2rB:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX4_B_ML1B233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3m2r METHYL-COENZYME M
REDUCTASE I SUBUNIT
BETA
(Methanothermobac
ter
marburgensis) 		4 / 7 GLY B 326
THR B 330
PHE B 359
PHE B 375
 None
 1.17A 2qx4A-3m2rB:
undetectable
2qx4B-3m2rB:
undetectable		 2qx4A-3m2rB:
20.36
2qx4B-3m2rB:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZBZ_A_VDXA501_1
(CYTOCHROME P450-SU1)		 3m2r METHYL-COENZYME M
REDUCTASE I SUBUNIT
BETA
(Methanothermobac
ter
marburgensis) 		5 / 11 LEU B 161
VAL B 160
SER B 128
ILE B 175
ALA B  89
 None
 1.17A 2zbzA-3m2rB:
undetectable		 2zbzA-3m2rB:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BPX_A_SALA257_1
(TRANSCRIPTIONAL
REGULATOR)		 3m2r METHYL-COENZYME M
REDUCTASE I SUBUNIT
BETA
(Methanothermobac
ter
marburgensis) 		4 / 8 SER B 215
ALA B 389
THR B 382
THR B 355
 None
 0.95A 3bpxA-3m2rB:
undetectable
3bpxB-3m2rB:
undetectable		 3bpxA-3m2rB:
15.16
3bpxB-3m2rB:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CCF_B_BEZB261_0
(CYCLOPROPANE-FATTY-A
CYL-PHOSPHOLIPID
SYNTHASE)		 3m2r METHYL-COENZYME M
REDUCTASE I SUBUNIT
BETA
(Methanothermobac
ter
marburgensis) 		4 / 8 ASN B 335
ILE B 338
TRP B 302
TYR B 334
 None
 1.32A 3ccfB-3m2rB:
undetectable		 3ccfB-3m2rB:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F78_A_ICFA1_1
(INTEGRIN ALPHA-L)		 3m2r METHYL-COENZYME M
REDUCTASE I SUBUNIT
BETA
(Methanothermobac
ter
marburgensis) 		5 / 9 ILE B 142
ILE B  85
GLU B  54
LEU B  76
LYS B  58
 None
 1.36A 3f78A-3m2rB:
undetectable		 3f78A-3m2rB:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCP_B_CHDB4_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3m2r METHYL-COENZYME M
REDUCTASE I SUBUNIT
BETA
(Methanothermobac
ter
marburgensis) 		3 / 3 GLY B 295
PRO B 345
LEU B 299
 None
 0.62A 3hcpB-3m2rB:
undetectable		 3hcpB-3m2rB:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JZJ_A_ACRA405_1
(ACARBOSE/MALTOSE
BINDING PROTEIN GACH)		 3m2r METHYL-COENZYME M
REDUCTASE I SUBUNIT
BETA
(Methanothermobac
ter
marburgensis) 		5 / 12 GLY B 240
GLU B 219
ALA B 222
ASP B 348
GLY B 377
 None
 1.14A 3jzjA-3m2rB:
undetectable		 3jzjA-3m2rB:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGY_A_GLYA510_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 3m2r METHYL-COENZYME M
REDUCTASE I SUBUNIT
BETA
(Methanothermobac
ter
marburgensis) 		4 / 6 ILE B  85
GLU B 145
ALA B  88
ASN B 144
 None
 1.08A 3pgyA-3m2rB:
undetectable
3pgyB-3m2rB:
undetectable		 3pgyA-3m2rB:
23.22
3pgyB-3m2rB:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RAE_F_LFXF101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		 3m2r METHYL-COENZYME M
REDUCTASE I SUBUNIT
BETA
(Methanothermobac
ter
marburgensis) 		3 / 4 SER B 420
GLY B 107
GLU B  83
 None
 0.65A 3raeA-3m2rB:
undetectable
3raeC-3m2rB:
undetectable		 3raeA-3m2rB:
21.37
3raeC-3m2rB:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UR0_B_SVRB516_1
(RNA-DEPENDENT RNA
POLYMERASE)		 3m2r METHYL-COENZYME M
REDUCTASE I SUBUNIT
BETA
(Methanothermobac
ter
marburgensis) 		4 / 7 ALA B 321
ALA B 401
ASP B 400
ARG B 322
 None
 0.61A 3ur0B-3m2rB:
1.5		 3ur0B-3m2rB:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NDN_C_SAMC405_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 3m2r METHYL-COENZYME M
REDUCTASE I SUBUNIT
BETA
(Methanothermobac
ter
marburgensis) 		4 / 8 ALA B 159
ASP B  77
ILE B  78
ILE B  85
 None
 0.92A 4ndnD-3m2rB:
undetectable		 4ndnD-3m2rB:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_B_SAMB601_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 3m2r METHYL-COENZYME M
REDUCTASE I SUBUNIT
BETA
(Methanothermobac
ter
marburgensis) 		5 / 12 ALA B 308
GLY B 309
ASP B 271
GLY B 240
ASN B 247
 None
 0.81A 4obwB-3m2rB:
undetectable		 4obwB-3m2rB:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNU_A_QDNA602_1
(CYTOCHROME P450 2D6)		 3m2r METHYL-COENZYME M
REDUCTASE I SUBUNIT
BETA
(Methanothermobac
ter
marburgensis) 		5 / 11 LEU B 310
GLY B 350
LEU B 331
ALA B 389
SER B 385
 None
 1.10A 4wnuA-3m2rB:
undetectable		 4wnuA-3m2rB:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XT8_A_TMQA302_1
(RV2671)		 3m2r METHYL-COENZYME M
REDUCTASE I SUBUNIT
BETA
(Methanothermobac
ter
marburgensis) 		5 / 12 ILE B  85
GLY B  80
ALA B  82
ARG B 111
GLU B  54
 None
 1.28A 4xt8A-3m2rB:
undetectable		 4xt8A-3m2rB:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YMG_B_SAMB1001_0
(PUTATIVE
SAM-DEPENDENT
O-METHYLTRANFERASE)		 3m2r METHYL-COENZYME M
REDUCTASE I SUBUNIT
BETA
(Methanothermobac
ter
marburgensis) 		5 / 12 GLY B 162
TYR B 170
SER B 167
ALA B  56
ALA B 158
 None
 1.27A 4ymgB-3m2rB:
undetectable		 4ymgB-3m2rB:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GSN_A_MMZA503_1
(FLAVIN-CONTAINING
MONOOXYGENASE)		 3m2r METHYL-COENZYME M
REDUCTASE I SUBUNIT
BETA
(Methanothermobac
ter
marburgensis) 		3 / 3 ASN B 317
SER B 329
SER B 328
 None
 0.72A 5gsnA-3m2rB:
undetectable		 5gsnA-3m2rB:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJC_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 3m2r METHYL-COENZYME M
REDUCTASE I SUBUNIT
BETA
(Methanothermobac
ter
marburgensis) 		4 / 7 LEU B 106
ILE B  42
THR B  45
MET B 178
 None
 1.03A 5ljcA-3m2rB:
undetectable		 5ljcA-3m2rB:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T8S_B_SAMB402_0
(S-ADENOSYLMETHIONINE
SYNTHASE)		 3m2r METHYL-COENZYME M
REDUCTASE I SUBUNIT
BETA
(Methanothermobac
ter
marburgensis) 		4 / 8 ALA B 159
ASP B  77
ILE B  78
ILE B  85
 None
 0.89A 5t8sA-3m2rB:
undetectable		 5t8sA-3m2rB:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V0V_A_8QPA613_1
(SERUM ALBUMIN)		 3m2r METHYL-COENZYME M
REDUCTASE I SUBUNIT
BETA
(Methanothermobac
ter
marburgensis) 		4 / 8 ALA B 308
VAL B 252
THR B 314
GLY B 245
 None
 0.83A 5v0vA-3m2rB:
undetectable		 5v0vA-3m2rB:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_A_GLYA715_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 3m2r METHYL-COENZYME M
REDUCTASE I SUBUNIT
BETA
(Methanothermobac
ter
marburgensis) 		4 / 6 ASP B 100
SER B 118
ARG B 120
ARG B  44
 None
 1.04A 6dwdA-3m2rB:
undetectable
6dwdC-3m2rB:
2.1		 6dwdA-3m2rB:
20.76
6dwdC-3m2rB:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECE_C_DVAC3010_0
(VLM2
DODECADEPSIPEPTIDE)		 3m2r METHYL-COENZYME M
REDUCTASE I SUBUNIT
BETA
(Methanothermobac
ter
marburgensis) 		3 / 3 ALA B 304
PHE B 388
GLN B 220
 None
 0.74A 6eceA-3m2rB:
undetectable		 6eceA-3m2rB:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6J20_A_GBQA1201_0
(SUBSTANCE-P
RECEPTOR,ENDOLYSIN)		 3m2r METHYL-COENZYME M
REDUCTASE I SUBUNIT
BETA
(Methanothermobac
ter
marburgensis) 		5 / 12 PRO B 131
VAL B 133
THR B 101
ILE B  93
PHE B 121
 None
 1.35A 6j20A-3m2rB:
undetectable		 6j20A-3m2rB:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NM4_B_SAMB402_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
PRDM9)		 3m2r METHYL-COENZYME M
REDUCTASE I SUBUNIT
BETA
(Methanothermobac
ter
marburgensis) 		5 / 9 ALA B 158
GLY B 162
LEU B 161
GLY B  52
ARG B  72
 None
 1.16A 6nm4B-3m2rB:
undetectable		 6nm4B-3m2rB:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_C_FFOC404_0
(THYMIDYLATE SYNTHASE)		 3m2r METHYL-COENZYME M
REDUCTASE I SUBUNIT
BETA
(Methanothermobac
ter
marburgensis) 		5 / 10 PHE B 362
ILE B 380
LEU B 185
GLY B 377
ASN B 376
 None
 1.43A 6r2eC-3m2rB:
undetectable		 6r2eC-3m2rB:
20.53