SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3m2t'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM9_A_9CRA201_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3m2t PROBABLE
DEHYDROGENASE
(Chromobacterium
violaceum) 		3 / 3 GLN A  25
ILE A  52
HIS A  46
 None
None
SO4  A 359 (-3.6A)
 0.54A 1fm9A-3m2tA:
undetectable		 1fm9A-3m2tA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K74_A_9CRA463_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3m2t PROBABLE
DEHYDROGENASE
(Chromobacterium
violaceum) 		3 / 3 GLN A  25
ILE A  52
HIS A  46
 None
None
SO4  A 359 (-3.6A)
 0.57A 1k74A-3m2tA:
undetectable		 1k74A-3m2tA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LWF_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 3m2t PROBABLE
DEHYDROGENASE
(Chromobacterium
violaceum) 		5 / 9 LEU A 109
VAL A 122
VAL A  93
GLY A 121
LEU A 106
 None
 1.46A 1lwfA-3m2tA:
undetectable		 1lwfA-3m2tA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS2_B_017B203_1
(PROTEASE)		 3m2t PROBABLE
DEHYDROGENASE
(Chromobacterium
violaceum) 		4 / 6 LEU A 184
LYS A 127
ARG A 133
GLY A 289
 None
 1.21A 2hs2B-3m2tA:
undetectable		 2hs2B-3m2tA:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_A_STIA600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3m2t PROBABLE
DEHYDROGENASE
(Chromobacterium
violaceum) 		4 / 6 LEU A  24
VAL A 119
VAL A  71
ILE A   4
 None
 1.02A 2hyyA-3m2tA:
undetectable		 2hyyA-3m2tA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IDK_B_C2FB1420_0
(GLYCINE
N-METHYLTRANSFERASE)		 3m2t PROBABLE
DEHYDROGENASE
(Chromobacterium
violaceum) 		5 / 10 LEU A 152
MET A 236
SER A 313
HIS A 180
THR A 317
 None
None
None
NAD  A 358 (-4.6A)
None
 1.49A 2idkA-3m2tA:
0.7
2idkB-3m2tA:
0.1
2idkC-3m2tA:
1.1
2idkD-3m2tA:
2.1		 2idkA-3m2tA:
24.21
2idkB-3m2tA:
24.21
2idkC-3m2tA:
24.21
2idkD-3m2tA:
24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMM_A_SAMA301_0
(UPF0217 PROTEIN
AF_1056)		 3m2t PROBABLE
DEHYDROGENASE
(Chromobacterium
violaceum) 		5 / 9 LEU A   8
ILE A  11
GLY A  10
GLY A  74
SER A  22
 None
None
NAD  A 358 (-3.2A)
NAD  A 358 (-3.7A)
None
 1.13A 2qmmA-3m2tA:
undetectable		 2qmmA-3m2tA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZMB_A_PXBA692_1
(LACTOTRANSFERRIN)		 3m2t PROBABLE
DEHYDROGENASE
(Chromobacterium
violaceum) 		3 / 3 PRO A  99
GLU A 107
TYR A 318
 None
 0.76A 2zmbA-3m2tA:
1.9		 2zmbA-3m2tA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IIZ_A_SAMA1501_0
(BIOTIN SYNTHETASE,
PUTATIVE)		 3m2t PROBABLE
DEHYDROGENASE
(Chromobacterium
violaceum) 		5 / 12 SER A 120
ARG A 306
ILE A 321
LEU A 106
TYR A 318
 None
 1.36A 3iizA-3m2tA:
undetectable		 3iizA-3m2tA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_C_30BC500_1
(GENOME POLYPROTEIN)		 3m2t PROBABLE
DEHYDROGENASE
(Chromobacterium
violaceum) 		5 / 12 VAL A  93
GLY A  90
ARG A 115
ALA A 112
ASP A 111
 None
 1.05A 3keeC-3m2tA:
undetectable		 3keeC-3m2tA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M0W_E_P77E203_1
(PROTEIN S100-A4)		 3m2t PROBABLE
DEHYDROGENASE
(Chromobacterium
violaceum) 		4 / 8 SER A 116
SER A 120
PHE A  80
LEU A 314
 None
 1.00A 3m0wE-3m2tA:
undetectable
3m0wF-3m2tA:
undetectable
3m0wG-3m2tA:
undetectable
3m0wH-3m2tA:
undetectable		 3m0wE-3m2tA:
15.12
3m0wF-3m2tA:
15.12
3m0wG-3m2tA:
15.12
3m0wH-3m2tA:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_B_GJZB506_1
(CHOLESTEROL
24-HYDROXYLASE)		 3m2t PROBABLE
DEHYDROGENASE
(Chromobacterium
violaceum) 		4 / 6 PHE A 215
ILE A 186
ALA A 185
ALA A 211
 None
 1.03A 3mdrB-3m2tA:
undetectable		 3mdrB-3m2tA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9S_A_BEZA264_0
(CARNITINYL-COA
DEHYDRATASE)		 3m2t PROBABLE
DEHYDROGENASE
(Chromobacterium
violaceum) 		4 / 6 ALA A 185
ILE A 150
LEU A 152
ALA A 211
 None
 0.88A 3r9sA-3m2tA:
undetectable		 3r9sA-3m2tA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9S_C_BEZC264_0
(CARNITINYL-COA
DEHYDRATASE)		 3m2t PROBABLE
DEHYDROGENASE
(Chromobacterium
violaceum) 		4 / 6 ALA A 185
ILE A 150
LEU A 152
ALA A 211
 None
 0.83A 3r9sC-3m2tA:
undetectable		 3r9sC-3m2tA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_A_RTZA1_1
(CYTOCHROME P450 2D6)		 3m2t PROBABLE
DEHYDROGENASE
(Chromobacterium
violaceum) 		5 / 12 LEU A 184
PHE A 188
LEU A 135
GLY A 289
PHE A 128
 None
 1.36A 3tbgA-3m2tA:
undetectable		 3tbgA-3m2tA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GH8_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 3m2t PROBABLE
DEHYDROGENASE
(Chromobacterium
violaceum) 		5 / 12 ILE A  29
ASP A  68
LEU A  67
ILE A  52
PRO A  53
 None
 1.19A 4gh8B-3m2tA:
undetectable		 4gh8B-3m2tA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I1R_A_LZUA801_1
(MUCOSA-ASSOCIATED
LYMPHOID TISSUE
LYMPHOMA
TRANSLOCATION
PROTEIN 1)		 3m2t PROBABLE
DEHYDROGENASE
(Chromobacterium
violaceum) 		5 / 12 VAL A  95
LEU A  78
VAL A   9
LEU A  84
LEU A  62
 None
NAD  A 358 (-4.1A)
None
None
None
 1.08A 4i1rA-3m2tA:
3.5		 4i1rA-3m2tA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JXC_A_SAMA402_0
(FEFE-HYDROGENASE
MATURASE)		 3m2t PROBABLE
DEHYDROGENASE
(Chromobacterium
violaceum) 		5 / 12 SER A 120
ARG A 306
ILE A 321
LEU A 106
TYR A 318
 None
 1.35A 4jxcA-3m2tA:
undetectable		 4jxcA-3m2tA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NQA_A_9CRA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3m2t PROBABLE
DEHYDROGENASE
(Chromobacterium
violaceum) 		5 / 11 ILE A 321
ALA A 178
GLN A 177
LEU A 175
ALA A 176
 None
 1.17A 4nqaA-3m2tA:
undetectable		 4nqaA-3m2tA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z12_B_9CRB501_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3m2t PROBABLE
DEHYDROGENASE
(Chromobacterium
violaceum) 		3 / 3 GLN A  25
ILE A  52
HIS A  46
 None
None
SO4  A 359 (-3.6A)
 0.70A 5z12B-3m2tA:
undetectable		 5z12B-3m2tA:
13.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D8P_B_ACTB804_0
(UNCHARACTERIZED
PROTEIN)		 3m2t PROBABLE
DEHYDROGENASE
(Chromobacterium
violaceum) 		4 / 4 HIS A  79
VAL A   9
LEU A  78
ALA A  73
 NAD  A 358 (-4.4A)
None
NAD  A 358 (-4.1A)
NAD  A 358 (-4.0A)
 1.37A 6d8pB-3m2tA:
2.7		 6d8pB-3m2tA:
19.48