SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3m3i'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VM1_A_TAZA504_1
(BETA-LACTAMASE SHV-1)		 3m3i PUTATIVE
UNCHARACTERIZED
PROTEIN
(Leishmania
major) 		3 / 3 ASP A 175
TYR A 176
GLU A  33
 None
 0.86A 1vm1A-3m3iA:
undetectable		 1vm1A-3m3iA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IXL_A_PACA5000_0
(ARYLMALONATE
DECARBOXYLASE)		 3m3i PUTATIVE
UNCHARACTERIZED
PROTEIN
(Leishmania
major) 		5 / 10 CYH A  59
THR A  60
SER A  63
GLY A  29
GLY A  28
 None
 1.18A 3ixlA-3m3iA:
undetectable		 3ixlA-3m3iA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K9F_F_LFXF0_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		 3m3i PUTATIVE
UNCHARACTERIZED
PROTEIN
(Leishmania
major) 		4 / 5 ARG A 125
ARG A 134
GLY A 135
GLU A 133
 None
 1.29A 3k9fA-3m3iA:
undetectable
3k9fB-3m3iA:
undetectable
3k9fC-3m3iA:
undetectable		 3k9fA-3m3iA:
18.14
3k9fB-3m3iA:
18.14
3k9fC-3m3iA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AQL_A_TXCA1452_2
(GUANINE DEAMINASE)		 3m3i PUTATIVE
UNCHARACTERIZED
PROTEIN
(Leishmania
major) 		4 / 5 HIS A  66
LEU A  84
LEU A  58
ASP A  82
 None
 1.18A 4aqlA-3m3iA:
undetectable		 4aqlA-3m3iA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BQF_A_QPSA951_1
(ALPHA-GLUCAN
PHOSPHORYLASE 2,
CYTOSOLIC)		 3m3i PUTATIVE
UNCHARACTERIZED
PROTEIN
(Leishmania
major) 		4 / 6 GLY A 159
ARG A 125
GLU A 136
ARG A 131
 None
 1.49A 4bqfA-3m3iA:
undetectable		 4bqfA-3m3iA:
14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R82_A_ACTA205_0
(OXIDOREDUCTASE)		 3m3i PUTATIVE
UNCHARACTERIZED
PROTEIN
(Leishmania
major) 		4 / 5 SER A 150
GLY A 149
GLU A  27
PHE A  57
 None
 1.08A 4r82A-3m3iA:
undetectable
4r82B-3m3iA:
undetectable		 4r82A-3m3iA:
22.46
4r82B-3m3iA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNV_A_QI9A602_0
(CYTOCHROME P450 2D6)		 3m3i PUTATIVE
UNCHARACTERIZED
PROTEIN
(Leishmania
major) 		5 / 9 GLU A  74
SER A  65
VAL A 128
VAL A 166
LEU A  86
 None
 1.41A 4wnvA-3m3iA:
undetectable		 4wnvA-3m3iA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EQP_A_BUWA601_1
(CHOLINESTERASE)		 3m3i PUTATIVE
UNCHARACTERIZED
PROTEIN
(Leishmania
major) 		4 / 8 GLY A 173
THR A  53
SER A  72
TYR A 176
 None
 1.16A 6eqpA-3m3iA:
undetectable		 6eqpA-3m3iA:
12.74