SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3m49'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBM_B_RTLB951_0
(PROTEIN (CARTILAGE
OLIGOMERIC MATRIX
PROTEIN))		 3m49 TRANSKETOLASE
(Bacillus
anthracis) 		4 / 4 THR A 430
LEU A 428
LEU A 330
GLN A 331
 None
 1.24A 1fbmA-3m49A:
undetectable		 1fbmA-3m49A:
5.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICT_D_T44D129_2
(TRANSTHYRETIN)		 3m49 TRANSKETOLASE
(Bacillus
anthracis) 		4 / 7 THR A 108
LEU A  79
SER A  80
VAL A 111
 None
 0.74A 1ictD-3m49A:
undetectable		 1ictD-3m49A:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JNO_A_DVAA6_0
(GRAMICIDIN A)		 3m49 TRANSKETOLASE
(Bacillus
anthracis) 		3 / 3 ALA A 367
VAL A 372
TRP A 342
 GOL  A 705 ( 3.8A)
None
None
 0.67A 1jnoA-3m49A:
undetectable		 1jnoA-3m49A:
1.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JNO_B_DVAB6_0
(GRAMICIDIN A)		 3m49 TRANSKETOLASE
(Bacillus
anthracis) 		3 / 3 ALA A 367
VAL A 372
TRP A 342
 GOL  A 705 ( 3.8A)
None
None
 0.67A 1jnoB-3m49A:
undetectable		 1jnoB-3m49A:
1.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JO3_A_DVAA6_0
(GRAMICIDIN B)		 3m49 TRANSKETOLASE
(Bacillus
anthracis) 		3 / 3 ALA A 367
VAL A 372
TRP A 342
 GOL  A 705 ( 3.8A)
None
None
 0.86A 1jo3A-3m49A:
undetectable		 1jo3A-3m49A:
2.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JO3_B_DVAB6_0
(GRAMICIDIN B)		 3m49 TRANSKETOLASE
(Bacillus
anthracis) 		3 / 3 ALA A 367
VAL A 372
TRP A 342
 GOL  A 705 ( 3.8A)
None
None
 0.85A 1jo3B-3m49A:
undetectable		 1jo3B-3m49A:
2.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JO4_A_DVAA6_0
(GRAMICIDIN C)		 3m49 TRANSKETOLASE
(Bacillus
anthracis) 		3 / 3 ALA A 367
VAL A 372
TRP A 342
 GOL  A 705 ( 3.8A)
None
None
 0.81A 1jo4A-3m49A:
undetectable		 1jo4A-3m49A:
2.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JO4_B_DVAB6_0
(GRAMICIDIN C)		 3m49 TRANSKETOLASE
(Bacillus
anthracis) 		3 / 3 ALA A 367
VAL A 372
TRP A 342
 GOL  A 705 ( 3.8A)
None
None
 0.81A 1jo4B-3m49A:
undetectable		 1jo4B-3m49A:
2.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_A_ACTA1872_0
(FPRA)		 3m49 TRANSKETOLASE
(Bacillus
anthracis) 		4 / 5 ASN A 140
ALA A 136
ASP A 148
GLU A 132
 None
 1.27A 1lqtA-3m49A:
undetectable
1lqtB-3m49A:
undetectable		 1lqtA-3m49A:
21.36
1lqtB-3m49A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_A_ACTA1429_0
(FPRA)		 3m49 TRANSKETOLASE
(Bacillus
anthracis) 		4 / 5 ASN A 140
ALA A 136
ASP A 148
GLU A 132
 None
 1.27A 1lquA-3m49A:
undetectable
1lquB-3m49A:
undetectable		 1lquA-3m49A:
21.36
1lquB-3m49A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAG_A_DVAA6_0
(GRAMICIDIN A)		 3m49 TRANSKETOLASE
(Bacillus
anthracis) 		3 / 3 ALA A 367
VAL A 372
TRP A 342
 GOL  A 705 ( 3.8A)
None
None
 0.72A 1magA-3m49A:
undetectable		 1magA-3m49A:
1.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAG_B_DVAB6_0
(GRAMICIDIN A)		 3m49 TRANSKETOLASE
(Bacillus
anthracis) 		3 / 3 ALA A 367
VAL A 372
TRP A 342
 GOL  A 705 ( 3.8A)
None
None
 0.72A 1magB-3m49A:
undetectable		 1magB-3m49A:
1.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NG8_A_DVAA6_0
(GRAMICIDIN A)		 3m49 TRANSKETOLASE
(Bacillus
anthracis) 		3 / 3 ALA A 367
VAL A 372
TRP A 342
 GOL  A 705 ( 3.8A)
None
None
 0.73A 1ng8A-3m49A:
undetectable		 1ng8A-3m49A:
2.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NG8_B_DVAB6_0
(GRAMICIDIN A)		 3m49 TRANSKETOLASE
(Bacillus
anthracis) 		3 / 3 ALA A 367
VAL A 372
TRP A 342
 GOL  A 705 ( 3.8A)
None
None
 0.73A 1ng8B-3m49A:
undetectable		 1ng8B-3m49A:
2.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NRM_A_DVAA6_0
(GRAMICIDIN A)		 3m49 TRANSKETOLASE
(Bacillus
anthracis) 		3 / 3 ALA A 367
VAL A 372
TRP A 342
 GOL  A 705 ( 3.8A)
None
None
 0.85A 1nrmA-3m49A:
undetectable		 1nrmA-3m49A:
1.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NRM_B_DVAB6_0
(GRAMICIDIN A)		 3m49 TRANSKETOLASE
(Bacillus
anthracis) 		3 / 3 ALA A 367
VAL A 372
TRP A 342
 GOL  A 705 ( 3.8A)
None
None
 0.85A 1nrmB-3m49A:
undetectable		 1nrmB-3m49A:
1.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NRU_A_DVAA6_0
(GRAMICIDIN A)		 3m49 TRANSKETOLASE
(Bacillus
anthracis) 		3 / 3 ALA A 367
VAL A 372
TRP A 342
 GOL  A 705 ( 3.8A)
None
None
 0.76A 1nruA-3m49A:
undetectable		 1nruA-3m49A:
1.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NRU_B_DVAB6_0
(GRAMICIDIN A)		 3m49 TRANSKETOLASE
(Bacillus
anthracis) 		3 / 3 ALA A 367
VAL A 372
TRP A 342
 GOL  A 705 ( 3.8A)
None
None
 0.76A 1nruB-3m49A:
undetectable		 1nruB-3m49A:
1.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OLT_A_SAMA501_0
(OXYGEN-INDEPENDENT
COPROPORPHYRINOGEN
III OXIDASE)		 3m49 TRANSKETOLASE
(Bacillus
anthracis) 		5 / 12 THR A 247
GLU A 244
ASP A 185
GLY A 156
PHE A 199
 FMT  A 721 (-4.1A)
None
None
TDP  A 701 ( 3.7A)
None
 1.21A 1oltA-3m49A:
undetectable		 1oltA-3m49A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXQ_A_IMNA2001_1
(SERUM ALBUMIN)		 3m49 TRANSKETOLASE
(Bacillus
anthracis) 		5 / 10 ALA A 418
ALA A 131
LEU A 135
LEU A 428
LEU A 171
 None
 1.17A 2bxqA-3m49A:
undetectable		 2bxqA-3m49A:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DM6_A_IMNA1401_1
(NADP-DEPENDENT
LEUKOTRIENE B4
12-HYDROXYDEHYDROGEN
ASE)		 3m49 TRANSKETOLASE
(Bacillus
anthracis) 		5 / 10 ILE A   5
ILE A  13
GLU A   6
ILE A  10
TYR A  40
 FMT  A 718 ( 4.3A)
None
None
None
None
 1.16A 2dm6A-3m49A:
2.7
2dm6B-3m49A:
2.8		 2dm6A-3m49A:
19.49
2dm6B-3m49A:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LH8_A_VIBA1_1
(MAJOR PRION PROTEIN)		 3m49 TRANSKETOLASE
(Bacillus
anthracis) 		4 / 6 PRO A 103
ASP A  87
ASP A  88
TYR A  74
 None
 1.33A 2lh8A-3m49A:
undetectable		 2lh8A-3m49A:
10.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNI_A_MTKA501_2
(CYTOCHROME P450 2C8)		 3m49 TRANSKETOLASE
(Bacillus
anthracis) 		5 / 8 ILE A 226
ILE A  10
ARG A 246
VAL A 245
ALA A  35
 None
None
PEG  A 717 (-4.8A)
None
None
 1.19A 2nniA-3m49A:
undetectable		 2nniA-3m49A:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VIN_A_505A1247_1
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR CHAIN B)		 3m49 TRANSKETOLASE
(Bacillus
anthracis) 		5 / 8 ASP A 159
SER A 169
GLY A 121
CYH A 155
GLY A 119
 None
 1.42A 2vinA-3m49A:
undetectable		 2vinA-3m49A:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZM9_A_ACAA502_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 3m49 TRANSKETOLASE
(Bacillus
anthracis) 		4 / 8 MET A 334
ALA A 333
TYR A 139
GLY A 427
 None
 0.79A 2zm9A-3m49A:
undetectable		 2zm9A-3m49A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B2R_A_VDNA1_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 3m49 TRANSKETOLASE
(Bacillus
anthracis) 		5 / 12 ILE A 635
LEU A 633
ALA A 613
ILE A 614
PHE A 653
 None
 1.05A 3b2rA-3m49A:
undetectable		 3b2rA-3m49A:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B2R_B_VDNB1_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 3m49 TRANSKETOLASE
(Bacillus
anthracis) 		5 / 11 ILE A 635
LEU A 633
ALA A 613
ILE A 614
PHE A 653
 None
 1.03A 3b2rB-3m49A:
undetectable		 3b2rB-3m49A:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL0_A_1UNA201_2
(PROTEASE)		 3m49 TRANSKETOLASE
(Bacillus
anthracis) 		5 / 9 LEU A 442
VAL A 164
GLY A 127
ILE A 422
ALA A 445
 None
 1.03A 3el0B-3m49A:
undetectable		 3el0B-3m49A:
8.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_A_CHDA151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 3m49 TRANSKETOLASE
(Bacillus
anthracis) 		4 / 7 TYR A 408
ILE A 422
GLY A 378
LEU A 171
 None
 0.83A 3elzA-3m49A:
undetectable		 3elzA-3m49A:
9.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O14_A_NIOA300_1
(ANTI-ECFSIGMA
FACTOR, CHRR)		 3m49 TRANSKETOLASE
(Bacillus
anthracis) 		4 / 7 SER A 546
VAL A 583
VAL A 545
LEU A 527
 None
 0.84A 3o14A-3m49A:
undetectable		 3o14A-3m49A:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_A_SAMA300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3m49 TRANSKETOLASE
(Bacillus
anthracis) 		5 / 12 ALA A 423
GLY A 421
GLY A 426
MET A 128
ALA A 449
 None
 1.06A 3ou6A-3m49A:
undetectable		 3ou6A-3m49A:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_B_SAMB300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3m49 TRANSKETOLASE
(Bacillus
anthracis) 		5 / 12 ALA A 423
GLY A 421
GLY A 426
MET A 128
ALA A 449
 None
 1.05A 3ou6B-3m49A:
undetectable		 3ou6B-3m49A:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_B_SAMB300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3m49 TRANSKETOLASE
(Bacillus
anthracis) 		5 / 12 ALA A 423
GLY A 421
GLY A 426
MET A 128
ALA A 449
 None
 1.06A 3ou7B-3m49A:
2.1		 3ou7B-3m49A:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQW_C_ACHC323_0
(ELIC PENTAMERIC
LIGAND GATED ION
CHANNEL FROM ERWINIA
CHRYSANTHEMI)		 3m49 TRANSKETOLASE
(Bacillus
anthracis) 		4 / 8 ASN A 657
GLU A 664
LEU A 633
PHE A 612
 None
 1.06A 3rqwC-3m49A:
undetectable
3rqwD-3m49A:
undetectable		 3rqwC-3m49A:
17.80
3rqwD-3m49A:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3N_A_MIYA2001_1
(TETX2 PROTEIN)		 3m49 TRANSKETOLASE
(Bacillus
anthracis) 		5 / 11 MET A 161
HIS A  68
GLY A 156
GLY A 193
ASN A 196
 None
TDP  A 701 (-4.0A)
TDP  A 701 ( 3.7A)
None
None
 1.04A 3v3nA-3m49A:
1.1		 3v3nA-3m49A:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3N_D_MIYD2001_1
(TETX2 PROTEIN)		 3m49 TRANSKETOLASE
(Bacillus
anthracis) 		5 / 11 MET A 161
HIS A  68
GLY A 156
GLY A 193
ASN A 196
 None
TDP  A 701 (-4.0A)
TDP  A 701 ( 3.7A)
None
None
 1.05A 3v3nD-3m49A:
undetectable		 3v3nD-3m49A:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1476_0
(MJ0495-LIKE PROTEIN)		 3m49 TRANSKETOLASE
(Bacillus
anthracis) 		4 / 5 ILE A 406
ALA A 418
HIS A 134
MET A 130
 None
 1.05A 4ac9B-3m49A:
undetectable
4ac9C-3m49A:
2.9		 4ac9B-3m49A:
23.94
4ac9C-3m49A:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1476_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 3m49 TRANSKETOLASE
(Bacillus
anthracis) 		4 / 5 ILE A 406
ALA A 418
HIS A 134
MET A 130
 None
 1.04A 4acaB-3m49A:
undetectable
4acaC-3m49A:
undetectable		 4acaB-3m49A:
23.94
4acaC-3m49A:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CEV_A_GAIA407_0
(PROTEIN (ARGINASE))		 3m49 TRANSKETOLASE
(Bacillus
anthracis) 		4 / 6 ARG A  59
HIS A  49
LEU A  77
ASP A 112
 None
 1.22A 4cevA-3m49A:
undetectable
4cevB-3m49A:
undetectable		 4cevA-3m49A:
21.12
4cevB-3m49A:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CEV_C_GAIC409_0
(PROTEIN (ARGINASE))		 3m49 TRANSKETOLASE
(Bacillus
anthracis) 		4 / 6 ASP A 112
ARG A  59
HIS A  49
LEU A  77
 None
 1.21A 4cevA-3m49A:
undetectable
4cevC-3m49A:
undetectable		 4cevA-3m49A:
21.12
4cevC-3m49A:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CEV_D_GAID410_0
(PROTEIN (ARGINASE))		 3m49 TRANSKETOLASE
(Bacillus
anthracis) 		4 / 6 ARG A  59
HIS A  49
LEU A  77
ASP A 112
 None
 1.24A 4cevD-3m49A:
2.4
4cevE-3m49A:
undetectable		 4cevD-3m49A:
21.12
4cevE-3m49A:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CEV_F_GAIF411_0
(PROTEIN (ARGINASE))		 3m49 TRANSKETOLASE
(Bacillus
anthracis) 		4 / 6 ARG A  59
HIS A  49
LEU A  77
ASP A 112
 None
 1.24A 4cevE-3m49A:
undetectable
4cevF-3m49A:
undetectable		 4cevE-3m49A:
21.12
4cevF-3m49A:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7H_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE OXYGENASE)		 3m49 TRANSKETOLASE
(Bacillus
anthracis) 		3 / 3 ARG A 493
THR A 619
TRP A 622
 None
 1.21A 4d7hA-3m49A:
undetectable		 4d7hA-3m49A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DUB_B_LDPB501_1
(CYTOCHROME P450 BM3
VARIANT 9D7)		 3m49 TRANSKETOLASE
(Bacillus
anthracis) 		4 / 6 PHE A 396
GLY A 127
LEU A 177
VAL A 126
 None
 0.90A 4dubB-3m49A:
undetectable		 4dubB-3m49A:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E3A_B_ADNB500_1
(SUGAR KINASE PROTEIN)		 3m49 TRANSKETOLASE
(Bacillus
anthracis) 		6 / 12 ILE A 122
ASP A 159
GLY A 119
GLY A 121
LEU A 180
GLY A  67
 None
 1.13A 4e3aB-3m49A:
undetectable		 4e3aB-3m49A:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G2Z_A_ID8A711_1
(LACTOTRANSFERRIN)		 3m49 TRANSKETOLASE
(Bacillus
anthracis) 		3 / 3 PRO A 103
TYR A  74
GLY A  69
 None
 0.71A 4g2zA-3m49A:
undetectable		 4g2zA-3m49A:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_A_CHDA504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3m49 TRANSKETOLASE
(Bacillus
anthracis) 		4 / 8 MET A 589
VAL A 603
VAL A 626
GLY A 627
 None
FMT  A 715 (-4.9A)
None
None
 0.99A 4mk4A-3m49A:
undetectable		 4mk4A-3m49A:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_B_CHDB502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3m49 TRANSKETOLASE
(Bacillus
anthracis) 		4 / 6 PHE A 375
MET A 390
ILE A 368
VAL A 459
 None
 1.31A 4mk4B-3m49A:
undetectable		 4mk4B-3m49A:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RN6_A_15UA301_1
(THROMBIN HEAVY CHAIN)		 3m49 TRANSKETOLASE
(Bacillus
anthracis) 		5 / 10 TYR A 207
TRP A 212
LEU A 160
ALA A 153
GLY A 119
 None
 1.40A 4rn6A-3m49A:
undetectable		 4rn6A-3m49A:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_C_377C401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3m49 TRANSKETOLASE
(Bacillus
anthracis) 		4 / 6 GLU A 593
TYR A 625
LEU A 604
PHE A 592
 None
 1.26A 4twdB-3m49A:
undetectable
4twdC-3m49A:
undetectable		 4twdB-3m49A:
19.07
4twdC-3m49A:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_E_377E401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3m49 TRANSKETOLASE
(Bacillus
anthracis) 		4 / 6 GLU A 593
TYR A 625
LEU A 604
PHE A 592
 None
 1.22A 4twdD-3m49A:
undetectable
4twdE-3m49A:
undetectable		 4twdD-3m49A:
19.07
4twdE-3m49A:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_F_377F401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3m49 TRANSKETOLASE
(Bacillus
anthracis) 		4 / 7 GLU A 593
TYR A 625
LEU A 604
PHE A 592
 None
 1.20A 4twdF-3m49A:
undetectable
4twdJ-3m49A:
undetectable		 4twdF-3m49A:
19.07
4twdJ-3m49A:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_G_377G401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3m49 TRANSKETOLASE
(Bacillus
anthracis) 		4 / 6 GLU A 593
TYR A 625
LEU A 604
PHE A 592
 None
 1.08A 4twdF-3m49A:
undetectable
4twdG-3m49A:
undetectable		 4twdF-3m49A:
19.07
4twdG-3m49A:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_J_377J401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3m49 TRANSKETOLASE
(Bacillus
anthracis) 		4 / 6 GLU A 593
TYR A 625
LEU A 604
PHE A 592
 None
 1.19A 4twdI-3m49A:
undetectable
4twdJ-3m49A:
undetectable		 4twdI-3m49A:
19.07
4twdJ-3m49A:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UGL_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE)		 3m49 TRANSKETOLASE
(Bacillus
anthracis) 		3 / 3 ARG A 493
THR A 619
TRP A 622
 None
 1.13A 4uglA-3m49A:
undetectable		 4uglA-3m49A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G6C_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE OXYGENASE)		 3m49 TRANSKETOLASE
(Bacillus
anthracis) 		3 / 3 ARG A 493
THR A 619
TRP A 622
 None
 1.20A 5g6cA-3m49A:
undetectable		 5g6cA-3m49A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKQ_A_JMSA602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3m49 TRANSKETOLASE
(Bacillus
anthracis) 		3 / 3 VAL A 214
SER A 202
MET A 161
 None
 0.68A 5ikqA-3m49A:
undetectable		 5ikqA-3m49A:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JGL_B_SAMB301_0
(UBIE/COQ5 FAMILY
METHYLTRANSFERASE,
PUTATIVE)		 3m49 TRANSKETOLASE
(Bacillus
anthracis) 		5 / 12 ALA A 125
GLY A 127
MET A 130
ALA A 153
GLY A 121
 None
 1.07A 5jglB-3m49A:
3.7		 5jglB-3m49A:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA609_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 3m49 TRANSKETOLASE
(Bacillus
anthracis) 		3 / 3 HIS A  68
HIS A 102
ARG A  93
 TDP  A 701 (-4.0A)
None
None
 1.00A 6b58A-3m49A:
4.0		 6b58A-3m49A:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EU9_D_READ601_1
(RETINOIC ACID
RECEPTOR)		 3m49 TRANSKETOLASE
(Bacillus
anthracis) 		4 / 7 LEU A 242
PHE A  62
LEU A  73
GLY A  67
 None
 0.74A 6eu9D-3m49A:
undetectable		 6eu9D-3m49A:
10.86