SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3m4a'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_D_CCSD47_0
(GLUTATHIONE
S-TRANSFERASE)		 3m4a PUTATIVE TYPE I
TOPOISOMERASE
(Deinococcus
radiodurans) 		4 / 7 THR A 322
LEU A 318
GLY A 320
LEU A 102
 None
 1.01A 1gtiD-3m4aA:
undetectable		 1gtiD-3m4aA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PJ7_A_FFOA2887_1
(N,N-DIMETHYLGLYCINE
OXIDASE)		 3m4a PUTATIVE TYPE I
TOPOISOMERASE
(Deinococcus
radiodurans) 		3 / 3 ASP A 208
THR A 206
GLU A 221
 None
 0.72A 1pj7A-3m4aA:
undetectable		 1pj7A-3m4aA:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA1_1
(CES1 PROTEIN)		 3m4a PUTATIVE TYPE I
TOPOISOMERASE
(Deinococcus
radiodurans) 		5 / 12 ALA A 248
GLY A 243
LEU A 328
LEU A  95
LEU A 102
 None
 1.02A 1ya4A-3m4aA:
undetectable		 1ya4A-3m4aA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_F_SC2F1291_1
(FICOLIN-2)		 3m4a PUTATIVE TYPE I
TOPOISOMERASE
(Deinococcus
radiodurans) 		4 / 6 LEU A   8
SER A  57
ASP A  59
GLU A  63
 None
 1.20A 2j2pE-3m4aA:
undetectable
2j2pF-3m4aA:
undetectable		 2j2pE-3m4aA:
20.74
2j2pF-3m4aA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDM_B_AGGB1462_1
(INTEGRIN ALPHA-IIB
INTEGRIN BETA-3)		 3m4a PUTATIVE TYPE I
TOPOISOMERASE
(Deinococcus
radiodurans) 		5 / 12 LEU A 278
ASP A 277
TYR A 225
ASN A 223
ALA A 235
 None
 1.33A 2vdmA-3m4aA:
undetectable
2vdmB-3m4aA:
undetectable		 2vdmA-3m4aA:
20.69
2vdmB-3m4aA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2N_C_X2NC1479_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 3m4a PUTATIVE TYPE I
TOPOISOMERASE
(Deinococcus
radiodurans) 		5 / 12 PHE A 136
ALA A 134
ALA A 182
THR A 166
MET A 192
 None
 1.34A 2x2nC-3m4aA:
undetectable		 2x2nC-3m4aA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2N_D_X2ND1479_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 3m4a PUTATIVE TYPE I
TOPOISOMERASE
(Deinococcus
radiodurans) 		5 / 12 PHE A 136
ALA A 134
ALA A 182
THR A 166
MET A 192
 None
 1.39A 2x2nD-3m4aA:
undetectable		 2x2nD-3m4aA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L4D_A_TPFA490_1
(STEROL 14-ALPHA
DEMETHYLASE)		 3m4a PUTATIVE TYPE I
TOPOISOMERASE
(Deinococcus
radiodurans) 		5 / 8 PHE A 136
ALA A 134
ALA A 182
THR A 166
MET A 192
 None
 1.40A 3l4dA-3m4aA:
undetectable		 3l4dA-3m4aA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L4D_B_TPFB490_1
(STEROL 14-ALPHA
DEMETHYLASE)		 3m4a PUTATIVE TYPE I
TOPOISOMERASE
(Deinococcus
radiodurans) 		5 / 9 PHE A 136
ALA A 134
ALA A 182
THR A 166
MET A 192
 None
 1.33A 3l4dB-3m4aA:
undetectable		 3l4dB-3m4aA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L4D_C_TPFC490_1
(STEROL 14-ALPHA
DEMETHYLASE)		 3m4a PUTATIVE TYPE I
TOPOISOMERASE
(Deinococcus
radiodurans) 		5 / 9 PHE A 136
ALA A 134
ALA A 182
THR A 166
MET A 192
 None
 1.37A 3l4dC-3m4aA:
undetectable		 3l4dC-3m4aA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M7R_A_VDXA425_2
(VITAMIN D3 RECEPTOR)		 3m4a PUTATIVE TYPE I
TOPOISOMERASE
(Deinococcus
radiodurans) 		5 / 9 LEU A 251
ARG A 239
TRP A 241
LEU A  95
VAL A 271
 None
 1.45A 3m7rA-3m4aA:
undetectable		 3m7rA-3m4aA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFR_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3m4a PUTATIVE TYPE I
TOPOISOMERASE
(Deinococcus
radiodurans) 		4 / 6 ARG A 286
VAL A 266
PHE A 295
GLU A 260
 None
 1.42A 3ufrA-3m4aA:
undetectable
3ufrB-3m4aA:
undetectable		 3ufrA-3m4aA:
21.54
3ufrB-3m4aA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_B_CHDB506_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3m4a PUTATIVE TYPE I
TOPOISOMERASE
(Deinococcus
radiodurans) 		3 / 3 ARG A 239
ARG A 135
LYS A 181
 None
 1.46A 3w1wA-3m4aA:
undetectable
3w1wB-3m4aA:
undetectable		 3w1wA-3m4aA:
22.79
3w1wB-3m4aA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B9Z_A_ACRA1818_1
(ALPHA-GLUCOSIDASE,
PUTATIVE, ADG31B)		 3m4a PUTATIVE TYPE I
TOPOISOMERASE
(Deinococcus
radiodurans) 		5 / 12 LEU A 222
ILE A 217
GLU A 228
ARG A 121
ASP A 112
 None
 1.31A 4b9zA-3m4aA:
undetectable		 4b9zA-3m4aA:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQE_A_AG2A506_1
(HOMOSPERMIDINE
SYNTHASE)		 3m4a PUTATIVE TYPE I
TOPOISOMERASE
(Deinococcus
radiodurans) 		4 / 6 ARG A 156
ARG A 216
ARG A 145
ASP A 141
 None
 1.37A 4xqeA-3m4aA:
undetectable		 4xqeA-3m4aA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND3_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 3m4a PUTATIVE TYPE I
TOPOISOMERASE
(Deinococcus
radiodurans) 		5 / 12 LEU A 195
LEU A 126
ALA A 125
ARG A 216
ARG A 121
 None
 1.27A 5nd3B-3m4aA:
undetectable		 5nd3B-3m4aA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGT_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 3m4a PUTATIVE TYPE I
TOPOISOMERASE
(Deinococcus
radiodurans) 		3 / 3 VAL A  54
TYR A  51
GLN A  52
 None
 0.75A 5qgtA-3m4aA:
undetectable		 5qgtA-3m4aA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BER_A_DVAA2_0
(E(DVA)DP(DGL)(DHI)(D
PR)N(DAL)(DPR))		 3m4a PUTATIVE TYPE I
TOPOISOMERASE
(Deinococcus
radiodurans) 		3 / 3 GLU A  61
ASP A  82
PRO A  81
 None
 0.78A 6berA-3m4aA:
undetectable		 6berA-3m4aA:
3.96