SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3m4f'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XQL_A_4AXA605_1
(ALANINE RACEMASE)		 3m4f ENDO-1,4-BETA-XYLANA
SE
(Acidomyces
acidophilus) 		4 / 8 PHE A 150
TYR A  93
TYR A  35
ARG A 138
 None
None
CXS  A 206 (-3.9A)
CXS  A 206 (-3.9A)
 0.98A 1xqlA-3m4fA:
undetectable
1xqlB-3m4fA:
undetectable		 1xqlA-3m4fA:
18.46
1xqlB-3m4fA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XQL_B_4AXB505_1
(ALANINE RACEMASE)		 3m4f ENDO-1,4-BETA-XYLANA
SE
(Acidomyces
acidophilus) 		4 / 8 TYR A  35
ARG A 138
PHE A 150
TYR A  93
 CXS  A 206 (-3.9A)
CXS  A 206 (-3.9A)
None
None
 0.99A 1xqlA-3m4fA:
undetectable
1xqlB-3m4fA:
undetectable		 1xqlA-3m4fA:
18.46
1xqlB-3m4fA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BTE_D_LEUD1893_0
(AMINOACYL-TRNA
SYNTHETASE)		 3m4f ENDO-1,4-BETA-XYLANA
SE
(Acidomyces
acidophilus) 		4 / 8 ASP A 127
SER A 126
TYR A 131
HIS A 171
 CXS  A 207 (-3.6A)
CXS  A 207 (-3.4A)
None
None
 1.35A 2bteD-3m4fA:
undetectable		 2bteD-3m4fA:
11.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q5S_A_ACHA1289_0
(MULTIDRUG-EFFLUX
TRANSPORTER 1
REGULATOR)		 3m4f ENDO-1,4-BETA-XYLANA
SE
(Acidomyces
acidophilus) 		4 / 6 VAL A  62
ASN A  36
TYR A  93
GLU A 102
 None
 1.22A 3q5sA-3m4fA:
undetectable		 3q5sA-3m4fA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V1F_A_BQ1A1087_0
(F0F1 ATP SYNTHASE
SUBUNIT C)		 3m4f ENDO-1,4-BETA-XYLANA
SE
(Acidomyces
acidophilus) 		3 / 3 GLU A 102
ALA A 101
PHE A 150
 None
 0.66A 4v1fA-3m4fA:
undetectable		 4v1fA-3m4fA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V1F_C_BQ1C1087_0
(F0F1 ATP SYNTHASE
SUBUNIT C)		 3m4f ENDO-1,4-BETA-XYLANA
SE
(Acidomyces
acidophilus) 		3 / 3 GLU A 102
ALA A 101
PHE A 150
 None
 0.66A 4v1fC-3m4fA:
undetectable		 4v1fC-3m4fA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XRG_A_AG2A502_1
(HOMOSPERMIDINE
SYNTHASE)		 3m4f ENDO-1,4-BETA-XYLANA
SE
(Acidomyces
acidophilus) 		5 / 12 GLU A 192
VAL A 106
TYR A 104
TYR A  89
ASP A  60
 None
None
None
None
CXS  A 206 ( 4.4A)
 1.42A 4xrgA-3m4fA:
undetectable		 4xrgA-3m4fA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AMI_B_EF2B151_1
(CEREBLON ISOFORM 4)		 3m4f ENDO-1,4-BETA-XYLANA
SE
(Acidomyces
acidophilus) 		4 / 8 ASN A 113
PRO A 114
SER A  88
TYR A  81
 None
 1.32A 5amiB-3m4fA:
undetectable		 5amiB-3m4fA:
21.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TZO_A_7V7A202_1
(ENDO-1,4-BETA-XYLANA
SE A)		 3m4f ENDO-1,4-BETA-XYLANA
SE
(Acidomyces
acidophilus) 		5 / 12 VAL A  62
TRP A  95
TYR A 104
PRO A 142
TRP A 154
 None
None
None
CXS  A 206 ( 4.3A)
None
 0.81A 5tzoA-3m4fA:
26.8		 5tzoA-3m4fA:
39.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TZO_C_7V7C201_1
(ENDO-1,4-BETA-XYLANA
SE A)		 3m4f ENDO-1,4-BETA-XYLANA
SE
(Acidomyces
acidophilus) 		5 / 12 VAL A  62
TRP A  95
TYR A 104
PRO A 142
TRP A 154
 None
None
None
CXS  A 206 ( 4.3A)
None
 0.83A 5tzoC-3m4fA:
26.7		 5tzoC-3m4fA:
39.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_C_AQ4C602_1
(CYTOCHROME P450 1A1)		 3m4f ENDO-1,4-BETA-XYLANA
SE
(Acidomyces
acidophilus) 		3 / 3 SER A  86
SER A  88
ALA A  40
 None
 0.49A 6dwnC-3m4fA:
undetectable		 6dwnC-3m4fA:
18.18