SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3m4p'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CEA_A_ACAA90_1
(PLASMINOGEN)		 3m4p ASPARAGINYL-TRNA
SYNTHETASE, PUTATIVE
(Entamoeba
histolytica) 		4 / 8 TYR A 240
ARG A 227
TYR A 226
THR A 177
 4AD  A 500 ( 3.5A)
4AD  A 500 (-3.1A)
None
None
 1.40A 1ceaA-3m4pA:
undetectable
1ceaB-3m4pA:
undetectable		 1ceaA-3m4pA:
12.44
1ceaB-3m4pA:
12.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HTT_B_HISB450_0
(HISTIDYL-TRNA
SYNTHETASE)		 3m4p ASPARAGINYL-TRNA
SYNTHETASE, PUTATIVE
(Entamoeba
histolytica) 		5 / 12 ARG A 227
GLU A 246
TYR A 351
GLY A 378
GLY A 418
 4AD  A 500 (-3.1A)
None
None
4AD  A 500 ( 4.3A)
None
 1.00A 1httB-3m4pA:
15.1		 1httB-3m4pA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HTT_D_HISD450_0
(HISTIDYL-TRNA
SYNTHETASE)		 3m4p ASPARAGINYL-TRNA
SYNTHETASE, PUTATIVE
(Entamoeba
histolytica) 		5 / 12 ARG A 227
GLU A 246
TYR A 351
GLY A 378
GLY A 418
 4AD  A 500 (-3.1A)
None
None
4AD  A 500 ( 4.3A)
None
 1.06A 1httD-3m4pA:
15.1		 1httD-3m4pA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M8D_A_CLWA906_1
(INDUCIBLE NITRIC
OXIDE SYNTHASE)		 3m4p ASPARAGINYL-TRNA
SYNTHETASE, PUTATIVE
(Entamoeba
histolytica) 		4 / 5 PRO A 175
VAL A 212
MET A 222
GLU A 172
 None
 1.45A 1m8dA-3m4pA:
undetectable		 1m8dA-3m4pA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M8D_B_CLWB907_1
(INDUCIBLE NITRIC
OXIDE SYNTHASE)		 3m4p ASPARAGINYL-TRNA
SYNTHETASE, PUTATIVE
(Entamoeba
histolytica) 		4 / 5 PRO A 175
VAL A 212
MET A 222
GLU A 172
 None
 1.47A 1m8dB-3m4pA:
undetectable		 1m8dB-3m4pA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ITZ_A_IREA2021_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 3m4p ASPARAGINYL-TRNA
SYNTHETASE, PUTATIVE
(Entamoeba
histolytica) 		3 / 3 LEU A 237
LEU A 223
MET A 222
 4AD  A 500 (-4.4A)
None
None
 0.87A 2itzA-3m4pA:
undetectable		 2itzA-3m4pA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_A_CHDA1503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3m4p ASPARAGINYL-TRNA
SYNTHETASE, PUTATIVE
(Entamoeba
histolytica) 		4 / 8 ILE A 375
LEU A 421
VAL A 266
MET A 271
 None
 0.70A 3w1wA-3m4pA:
undetectable		 3w1wA-3m4pA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNW_A_T3A501_2
(THYROID HORMONE
RECEPTOR ALPHA)		 3m4p ASPARAGINYL-TRNA
SYNTHETASE, PUTATIVE
(Entamoeba
histolytica) 		3 / 3 ILE A 341
MET A 352
ARG A 381
 None
None
4AD  A 500 (-3.3A)
 0.87A 4lnwA-3m4pA:
undetectable		 4lnwA-3m4pA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNX_A_T3A502_2
(THYROID HORMONE
RECEPTOR ALPHA)		 3m4p ASPARAGINYL-TRNA
SYNTHETASE, PUTATIVE
(Entamoeba
histolytica) 		3 / 3 ILE A 341
MET A 352
ARG A 381
 None
None
4AD  A 500 (-3.3A)
 0.88A 4lnxA-3m4pA:
undetectable		 4lnxA-3m4pA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O7G_B_ASCB304_0
(PROBABLE
TRANSMEMBRANE
ASCORBATE
FERRIREDUCTASE 2)		 3m4p ASPARAGINYL-TRNA
SYNTHETASE, PUTATIVE
(Entamoeba
histolytica) 		4 / 6 ILE A 382
TYR A 405
PHE A 350
ASN A 395
 None
 1.46A 4o7gB-3m4pA:
undetectable		 4o7gB-3m4pA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTD_E_GFNE101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 3m4p ASPARAGINYL-TRNA
SYNTHETASE, PUTATIVE
(Entamoeba
histolytica) 		4 / 7 ALA A 300
ASP A 332
ARG A 328
GLY A 373
 None
 1.01A 5btdA-3m4pA:
1.0
5btdB-3m4pA:
undetectable
5btdC-3m4pA:
1.4		 5btdA-3m4pA:
19.22
5btdB-3m4pA:
17.97
5btdC-3m4pA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTG_F_LFXF101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 3m4p ASPARAGINYL-TRNA
SYNTHETASE, PUTATIVE
(Entamoeba
histolytica) 		4 / 7 ALA A 300
ASP A 332
ARG A 328
GLY A 373
 None
 0.90A 5btgA-3m4pA:
undetectable
5btgC-3m4pA:
undetectable
5btgD-3m4pA:
undetectable		 5btgA-3m4pA:
19.22
5btgC-3m4pA:
19.22
5btgD-3m4pA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWZ_B_BEZB301_0
(14-3-3 PROTEIN
ZETA/DELTA)		 3m4p ASPARAGINYL-TRNA
SYNTHETASE, PUTATIVE
(Entamoeba
histolytica) 		3 / 3 MET A 330
GLN A 329
ARG A 328
 None
 1.06A 5ewzB-3m4pA:
undetectable		 5ewzB-3m4pA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M35_B_BEZB302_0
(14-3-3 PROTEIN
ZETA/DELTA)		 3m4p ASPARAGINYL-TRNA
SYNTHETASE, PUTATIVE
(Entamoeba
histolytica) 		3 / 3 MET A 330
GLN A 329
ARG A 328
 None
 1.09A 5m35B-3m4pA:
undetectable		 5m35B-3m4pA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M36_A_BEZA303_0
(14-3-3 PROTEIN
ZETA/DELTA)		 3m4p ASPARAGINYL-TRNA
SYNTHETASE, PUTATIVE
(Entamoeba
histolytica) 		3 / 3 MET A 330
GLN A 329
ARG A 328
 None
 1.08A 5m36A-3m4pA:
undetectable		 5m36A-3m4pA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1805_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 3m4p ASPARAGINYL-TRNA
SYNTHETASE, PUTATIVE
(Entamoeba
histolytica) 		4 / 7 PRO A 175
ILE A 173
SER A 225
THR A 202
 None
 0.81A 5vkqA-3m4pA:
undetectable
5vkqD-3m4pA:
undetectable		 5vkqA-3m4pA:
13.76
5vkqD-3m4pA:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRF_D_EVPD101_1
()		 3m4p ASPARAGINYL-TRNA
SYNTHETASE, PUTATIVE
(Entamoeba
histolytica) 		4 / 5 GLY A  54
ASP A  51
ARG A  50
GLN A  57
 None
 1.50A 5zrfB-3m4pA:
undetectable		 5zrfB-3m4pA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_B_8NUB3001_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		 3m4p ASPARAGINYL-TRNA
SYNTHETASE, PUTATIVE
(Entamoeba
histolytica) 		4 / 5 ILE A 341
PHE A 252
ASN A 168
TYR A 419
 None
 1.22A 6a93B-3m4pA:
undetectable		 6a93B-3m4pA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BNI_A_ADNA602_1
(LYSINE--TRNA LIGASE)		 3m4p ASPARAGINYL-TRNA
SYNTHETASE, PUTATIVE
(Entamoeba
histolytica) 		6 / 10 ARG A 227
GLU A 229
HIS A 236
GLY A 422
ARG A 425
ILE A 436
 4AD  A 500 (-3.1A)
4AD  A 500 (-4.2A)
4AD  A 500 (-4.5A)
4AD  A 500 (-3.7A)
4AD  A 500 (-3.8A)
None
 0.65A 6bniA-3m4pA:
30.2		 6bniA-3m4pA:
10.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BNI_A_ADNA602_1
(LYSINE--TRNA LIGASE)		 3m4p ASPARAGINYL-TRNA
SYNTHETASE, PUTATIVE
(Entamoeba
histolytica) 		6 / 10 GLU A 229
HIS A 236
GLU A 374
GLY A 422
ARG A 425
ILE A 436
 4AD  A 500 (-4.2A)
4AD  A 500 (-4.5A)
4AD  A 500 (-4.1A)
4AD  A 500 (-3.7A)
4AD  A 500 (-3.8A)
None
 0.81A 6bniA-3m4pA:
30.2		 6bniA-3m4pA:
10.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BNI_B_ADNB602_1
(LYSINE--TRNA LIGASE)		 3m4p ASPARAGINYL-TRNA
SYNTHETASE, PUTATIVE
(Entamoeba
histolytica) 		6 / 10 ARG A 227
GLU A 229
HIS A 236
GLY A 422
ARG A 425
ILE A 436
 4AD  A 500 (-3.1A)
4AD  A 500 (-4.2A)
4AD  A 500 (-4.5A)
4AD  A 500 (-3.7A)
4AD  A 500 (-3.8A)
None
 0.63A 6bniB-3m4pA:
30.2		 6bniB-3m4pA:
10.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BNI_B_ADNB602_1
(LYSINE--TRNA LIGASE)		 3m4p ASPARAGINYL-TRNA
SYNTHETASE, PUTATIVE
(Entamoeba
histolytica) 		6 / 10 GLU A 229
HIS A 236
GLU A 374
GLY A 422
ARG A 425
ILE A 436
 4AD  A 500 (-4.2A)
4AD  A 500 (-4.5A)
4AD  A 500 (-4.1A)
4AD  A 500 (-3.7A)
4AD  A 500 (-3.8A)
None
 0.79A 6bniB-3m4pA:
30.2		 6bniB-3m4pA:
10.20