SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3m4u'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ6_B_CAMB502_0
(CYTOCHROME P450-CAM)		 3m4u TYROSINE SPECIFIC
PROTEIN PHOSPHATASE,
PUTATIVE
(Trypanosoma
brucei) 		4 / 5 PHE A 106
TYR A 135
VAL A 189
VAL A  93
 None
 1.31A 1dz6B-3m4uA:
undetectable		 1dz6B-3m4uA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LWE_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 3m4u TYROSINE SPECIFIC
PROTEIN PHOSPHATASE,
PUTATIVE
(Trypanosoma
brucei) 		4 / 7 LEU A 298
VAL A 293
TYR A 284
GLY A 289
 None
 1.03A 1lweA-3m4uA:
undetectable		 1lweA-3m4uA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S1X_A_NVPA999_1
(REVERSE
TRANSCRIPTASE)		 3m4u TYROSINE SPECIFIC
PROTEIN PHOSPHATASE,
PUTATIVE
(Trypanosoma
brucei) 		4 / 8 LEU A 298
VAL A 293
TYR A 284
GLY A 289
 None
 1.03A 1s1xA-3m4uA:
undetectable		 1s1xA-3m4uA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_G_BEZG3385_0
(CES1 PROTEIN)		 3m4u TYROSINE SPECIFIC
PROTEIN PHOSPHATASE,
PUTATIVE
(Trypanosoma
brucei) 		3 / 3 SER A   6
VAL A 287
LEU A 291
 None
 0.75A 1yajG-3m4uA:
undetectable		 1yajG-3m4uA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLC_A_GLYA333_0
(CHOLOYLGLYCINE
HYDROLASE)		 3m4u TYROSINE SPECIFIC
PROTEIN PHOSPHATASE,
PUTATIVE
(Trypanosoma
brucei) 		3 / 3 ASN A  49
ASN A  80
ARG A 270
 None
 0.92A 2rlcA-3m4uA:
undetectable		 2rlcA-3m4uA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UR0_B_SVRB516_1
(RNA-DEPENDENT RNA
POLYMERASE)		 3m4u TYROSINE SPECIFIC
PROTEIN PHOSPHATASE,
PUTATIVE
(Trypanosoma
brucei) 		4 / 7 GLY A 232
ALA A 231
ALA A 132
ARG A  50
 PO4  A 307 (-3.2A)
PO4  A 307 (-3.5A)
None
None
 0.86A 3ur0B-3m4uA:
undetectable		 3ur0B-3m4uA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3N_A_MIYA2001_1
(TETX2 PROTEIN)		 3m4u TYROSINE SPECIFIC
PROTEIN PHOSPHATASE,
PUTATIVE
(Trypanosoma
brucei) 		5 / 11 GLN A 279
GLY A 234
PRO A 203
PHE A 209
GLY A 196
 None
PO4  A 307 (-3.7A)
None
None
None
 1.31A 3v3nA-3m4uA:
undetectable		 3v3nA-3m4uA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G10_A_ACTA301_0
(GLUTATHIONE
S-TRANSFERASE
HOMOLOG)		 3m4u TYROSINE SPECIFIC
PROTEIN PHOSPHATASE,
PUTATIVE
(Trypanosoma
brucei) 		4 / 6 PRO A  89
ILE A 225
TYR A 243
PHE A  92
 None
 1.14A 4g10A-3m4uA:
undetectable		 4g10A-3m4uA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JX1_E_CAME502_0
(CAMPHOR
5-MONOOXYGENASE)		 3m4u TYROSINE SPECIFIC
PROTEIN PHOSPHATASE,
PUTATIVE
(Trypanosoma
brucei) 		4 / 5 TYR A 284
THR A 255
PHE A   7
ILE A 262
 None
 1.05A 4jx1E-3m4uA:
undetectable		 4jx1E-3m4uA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_B_STRB601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 3m4u TYROSINE SPECIFIC
PROTEIN PHOSPHATASE,
PUTATIVE
(Trypanosoma
brucei) 		6 / 12 LEU A 239
ALA A  94
ILE A 283
GLY A 234
ILE A  84
VAL A 263
 None
None
None
PO4  A 307 (-3.7A)
None
None
 1.24A 4nkxB-3m4uA:
undetectable		 4nkxB-3m4uA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_B_STRB601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 3m4u TYROSINE SPECIFIC
PROTEIN PHOSPHATASE,
PUTATIVE
(Trypanosoma
brucei) 		6 / 12 LEU A 239
ILE A 283
GLY A 234
ALA A 265
ILE A  84
VAL A 263
 None
None
PO4  A 307 (-3.7A)
None
None
None
 1.47A 4nkxB-3m4uA:
undetectable		 4nkxB-3m4uA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3m4u TYROSINE SPECIFIC
PROTEIN PHOSPHATASE,
PUTATIVE
(Trypanosoma
brucei) 		4 / 5 ARG A 290
LEU A 246
LEU A 213
PHE A 209
 None
 1.16A 5x1fC-3m4uA:
undetectable
5x1fJ-3m4uA:
undetectable		 5x1fC-3m4uA:
22.98
5x1fJ-3m4uA:
11.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YCN_A_8LXA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3m4u TYROSINE SPECIFIC
PROTEIN PHOSPHATASE,
PUTATIVE
(Trypanosoma
brucei) 		5 / 12 LEU A  88
TYR A 194
LEU A 121
VAL A 227
ILE A 240
 None
 0.96A 5ycnA-3m4uA:
undetectable		 5ycnA-3m4uA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_B_ADNB501_2
(-)		 3m4u TYROSINE SPECIFIC
PROTEIN PHOSPHATASE,
PUTATIVE
(Trypanosoma
brucei) 		4 / 5 GLN A 268
THR A 258
HIS A 248
LEU A  86
 None
 1.20A 6gbnB-3m4uA:
undetectable		 6gbnB-3m4uA:
20.73