SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3m62'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ9_A_CAMA503_0
(CYTOCHROME P450-CAM)		 3m62 UBIQUITIN
CONJUGATION FACTOR
E4
(Saccharomyces
cerevisiae) 		4 / 8 TYR A 635
LEU A 539
VAL A 535
THR A 562
 None
 0.98A 1dz9A-3m62A:
undetectable		 1dz9A-3m62A:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IG3_A_VIBA502_1
(THIAMIN
PYROPHOSPHOKINASE)		 3m62 UBIQUITIN
CONJUGATION FACTOR
E4
(Saccharomyces
cerevisiae) 		4 / 8 LEU A 662
SER A 666
GLN A 816
THR A 761
 None
 0.90A 1ig3A-3m62A:
undetectable
1ig3B-3m62A:
undetectable		 1ig3A-3m62A:
14.15
1ig3B-3m62A:
14.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1O76_B_CAMB1420_0
(CYTOCHROME P450-CAM)		 3m62 UBIQUITIN
CONJUGATION FACTOR
E4
(Saccharomyces
cerevisiae) 		4 / 8 TYR A 635
LEU A 539
VAL A 535
THR A 562
 None
 1.01A 1o76B-3m62A:
undetectable		 1o76B-3m62A:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QVT_A_PRLA311_0
(TRANSCRIPTIONAL
REGULATOR QACR)		 3m62 UBIQUITIN
CONJUGATION FACTOR
E4
(Saccharomyces
cerevisiae) 		4 / 8 LEU A 221
GLU A 212
THR A 400
ILE A 315
 None
 1.15A 1qvtA-3m62A:
2.0		 1qvtA-3m62A:
11.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SKX_A_RFPA1_2
(ORPHAN NUCLEAR
RECEPTOR PXR)		 3m62 UBIQUITIN
CONJUGATION FACTOR
E4
(Saccharomyces
cerevisiae) 		4 / 5 PHE A 211
LEU A 388
MET A 312
LEU A 295
 None
 1.38A 1skxA-3m62A:
undetectable		 1skxA-3m62A:
14.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T9W_A_NFNA6002_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 3m62 UBIQUITIN
CONJUGATION FACTOR
E4
(Saccharomyces
cerevisiae) 		4 / 7 ALA A 512
ARG A 356
ASN A 358
GLU A 363
 None
 1.36A 1t9wA-3m62A:
2.6		 1t9wA-3m62A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TD7_A_NFLA2001_1
(PHOSPHOLIPASE A2
ISOFORM 3)		 3m62 UBIQUITIN
CONJUGATION FACTOR
E4
(Saccharomyces
cerevisiae) 		5 / 9 LEU A 585
ILE A 549
GLY A 556
CYH A 474
PHE A 470
 None
 1.24A 1td7A-3m62A:
undetectable		 1td7A-3m62A:
8.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UYU_A_CAMA1416_0
(CYTOCHROME P450-CAM)		 3m62 UBIQUITIN
CONJUGATION FACTOR
E4
(Saccharomyces
cerevisiae) 		4 / 8 TYR A 635
LEU A 539
VAL A 535
THR A 562
 None
 1.03A 1uyuA-3m62A:
undetectable		 1uyuA-3m62A:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UYU_B_CAMB1416_0
(CYTOCHROME P450-CAM)		 3m62 UBIQUITIN
CONJUGATION FACTOR
E4
(Saccharomyces
cerevisiae) 		4 / 8 TYR A 635
LEU A 539
VAL A 535
THR A 562
 None
 1.07A 1uyuB-3m62A:
undetectable		 1uyuB-3m62A:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AXN_A_EDTA737_0
(6-PHOSPHOFRUCTO-2-KI
NASE/FRUCTOSE-2,6-BI
PHOSPHATASE 3
(6PF-2-K/FRU-
2,6-P2ASE
BRAIN/PLACENTA-TYPE
ISOZYME) (IPFK-2)
[INCLUDES: 6-
PHOSPHOFRUCTO-2-KINA
SE (EC 2.7.1.105)
FRUCTOSE-2,6-BISPHO
SPHATASE (EC
3.1.3.46)])		 3m62 UBIQUITIN
CONJUGATION FACTOR
E4
(Saccharomyces
cerevisiae) 		5 / 12 PRO A 491
GLY A 556
ARG A 554
THR A 478
TYR A 331
 1PE  A 962 ( 4.5A)
None
None
None
1PE  A 962 (-4.7A)
 0.86A 2axnA-3m62A:
undetectable		 2axnA-3m62A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXF_A_DZPA2001_1
(SERUM ALBUMIN)		 3m62 UBIQUITIN
CONJUGATION FACTOR
E4
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 806
TYR A 810
VAL A 780
CYH A 784
LEU A 834
 None
 1.25A 2bxfA-3m62A:
undetectable		 2bxfA-3m62A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CIZ_A_ACTA1320_0
(CHLOROPEROXIDASE)		 3m62 UBIQUITIN
CONJUGATION FACTOR
E4
(Saccharomyces
cerevisiae) 		4 / 6 ALA A 861
ILE A 820
VAL A 823
PHE A 830
 None
 0.84A 2cizA-3m62A:
undetectable		 2cizA-3m62A:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_D_SNLD4001_1
(MINERALOCORTICOID
RECEPTOR)		 3m62 UBIQUITIN
CONJUGATION FACTOR
E4
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 802
LEU A 842
ALA A 838
MET A 745
LEU A 772
 None
 1.21A 2oaxD-3m62A:
undetectable		 2oaxD-3m62A:
13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_E_SNLE5001_1
(MINERALOCORTICOID
RECEPTOR)		 3m62 UBIQUITIN
CONJUGATION FACTOR
E4
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 802
LEU A 842
ALA A 838
MET A 745
LEU A 772
 None
 1.29A 2oaxE-3m62A:
undetectable		 2oaxE-3m62A:
13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_A_CHDA702_0
(FERROCHELATASE)		 3m62 UBIQUITIN
CONJUGATION FACTOR
E4
(Saccharomyces
cerevisiae) 		3 / 3 LEU A 900
PRO A 901
ARG A 926
 None
 0.63A 2qd5A-3m62A:
undetectable		 2qd5A-3m62A:
15.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDM_B_AGGB1462_1
(INTEGRIN ALPHA-IIB
INTEGRIN BETA-3)		 3m62 UBIQUITIN
CONJUGATION FACTOR
E4
(Saccharomyces
cerevisiae) 		5 / 12 PHE A 686
LEU A 692
SER A 645
ARG A 641
ALA A 741
 None
 1.36A 2vdmA-3m62A:
undetectable
2vdmB-3m62A:
undetectable		 2vdmA-3m62A:
18.93
2vdmB-3m62A:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2N_A_X2NA1480_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 3m62 UBIQUITIN
CONJUGATION FACTOR
E4
(Saccharomyces
cerevisiae) 		5 / 12 PHE A 860
TYR A 810
ALA A 758
ALA A 864
ALA A 824
 None
 1.11A 2x2nA-3m62A:
1.3		 2x2nA-3m62A:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2N_B_X2NB1479_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 3m62 UBIQUITIN
CONJUGATION FACTOR
E4
(Saccharomyces
cerevisiae) 		5 / 12 PHE A 860
TYR A 810
ALA A 758
ALA A 864
ALA A 824
 None
 1.08A 2x2nB-3m62A:
1.3		 2x2nB-3m62A:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YDO_A_ADNA400_1
(ADENOSINE RECEPTOR
A2A)		 3m62 UBIQUITIN
CONJUGATION FACTOR
E4
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 397
PHE A 460
GLU A 404
SER A 224
HIS A 257
 None
 1.45A 2ydoA-3m62A:
undetectable		 2ydoA-3m62A:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGO_A_PCFA1213_0
(WNT INHIBITORY
FACTOR 1)		 3m62 UBIQUITIN
CONJUGATION FACTOR
E4
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 351
ILE A 349
ILE A 337
PHE A 342
VAL A 530
 None
 1.08A 2ygoA-3m62A:
undetectable		 2ygoA-3m62A:
10.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZAX_A_CAMA422_0
(CYTOCHROME P450-CAM)		 3m62 UBIQUITIN
CONJUGATION FACTOR
E4
(Saccharomyces
cerevisiae) 		4 / 7 TYR A 635
LEU A 539
VAL A 535
THR A 562
 None
 1.05A 2zaxA-3m62A:
undetectable		 2zaxA-3m62A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FWG_B_CAMB420_0
(CAMPHOR
5-MONOOXYGENASE)		 3m62 UBIQUITIN
CONJUGATION FACTOR
E4
(Saccharomyces
cerevisiae) 		4 / 7 TYR A 635
LEU A 539
VAL A 535
THR A 562
 None
 1.02A 3fwgB-3m62A:
undetectable		 3fwgB-3m62A:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FWI_A_CAMA420_0
(CAMPHOR
5-MONOOXYGENASE)		 3m62 UBIQUITIN
CONJUGATION FACTOR
E4
(Saccharomyces
cerevisiae) 		4 / 7 TYR A 635
LEU A 539
VAL A 535
THR A 562
 None
 1.04A 3fwiA-3m62A:
undetectable		 3fwiA-3m62A:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H5G_A_LEIA16_0
(COIL SER L16D-PEN)		 3m62 UBIQUITIN
CONJUGATION FACTOR
E4
(Saccharomyces
cerevisiae) 		4 / 6 LEU A 648
GLU A 649
LYS A 743
LEU A 747
 None
 0.93A 3h5gA-3m62A:
undetectable
3h5gC-3m62A:
undetectable		 3h5gA-3m62A:
2.82
3h5gC-3m62A:
2.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LOQ_A_ACTA277_0
(UNIVERSAL STRESS
PROTEIN)		 3m62 UBIQUITIN
CONJUGATION FACTOR
E4
(Saccharomyces
cerevisiae) 		3 / 3 ASP A 826
SER A 770
ARG A 828
 None
 1.01A 3loqA-3m62A:
undetectable		 3loqA-3m62A:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZW_A_KKKA413_1
(FLAVOHEMOGLOBIN)		 3m62 UBIQUITIN
CONJUGATION FACTOR
E4
(Saccharomyces
cerevisiae) 		4 / 8 ILE A 418
GLN A 438
ALA A 445
LEU A 446
 None
 0.86A 3ozwA-3m62A:
undetectable		 3ozwA-3m62A:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S79_A_ASDA601_1
(CYTOCHROME P450 19A1)		 3m62 UBIQUITIN
CONJUGATION FACTOR
E4
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 841
ALA A 838
THR A 807
LEU A 684
LEU A 802
 None
 1.27A 3s79A-3m62A:
undetectable		 3s79A-3m62A:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_E_9PLE1_1
(CYTOCHROME P450 2A13)		 3m62 UBIQUITIN
CONJUGATION FACTOR
E4
(Saccharomyces
cerevisiae) 		4 / 8 PHE A 194
PHE A 181
ASN A 149
PHE A 152
 None
 1.10A 3t3sE-3m62A:
undetectable		 3t3sE-3m62A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA504_1
(CYTOCHROME P450 2B4)		 3m62 UBIQUITIN
CONJUGATION FACTOR
E4
(Saccharomyces
cerevisiae) 		5 / 9 LEU A  60
LEU A  47
ILE A  10
ILE A   4
GLU A  51
 None
 1.22A 3tmzA-3m62A:
undetectable		 3tmzA-3m62A:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DUB_B_LDPB501_1
(CYTOCHROME P450 BM3
VARIANT 9D7)		 3m62 UBIQUITIN
CONJUGATION FACTOR
E4
(Saccharomyces
cerevisiae) 		5 / 6 PHE A 472
ALA A 476
GLY A 533
LEU A 390
VAL A 530
 None
 1.45A 4dubB-3m62A:
undetectable		 4dubB-3m62A:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ECK_A_FOLA703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3m62 UBIQUITIN
CONJUGATION FACTOR
E4
(Saccharomyces
cerevisiae) 		5 / 12 ALA A 476
LEU A 393
PHE A 558
LEU A 584
VAL A 587
 None
 1.25A 4eckA-3m62A:
undetectable		 4eckA-3m62A:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KMU_C_RFPC1401_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 3m62 UBIQUITIN
CONJUGATION FACTOR
E4
(Saccharomyces
cerevisiae) 		5 / 12 ASP A 203
LEU A 145
PRO A 153
ASN A 149
ILE A 197
 None
 1.43A 4kmuC-3m62A:
2.9		 4kmuC-3m62A:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM4_B_8PRB603_2
(TRANSPORTER)		 3m62 UBIQUITIN
CONJUGATION FACTOR
E4
(Saccharomyces
cerevisiae) 		3 / 3 SER A 278
MET A 282
ASP A 198
 None
 0.92A 4mm4B-3m62A:
undetectable		 4mm4B-3m62A:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y03_B_SALB801_1
(PROTEIN POLYBROMO-1)		 3m62 UBIQUITIN
CONJUGATION FACTOR
E4
(Saccharomyces
cerevisiae) 		4 / 5 LEU A 319
TYR A 392
ALA A 287
ILE A 349
 None
 0.87A 4y03B-3m62A:
undetectable		 4y03B-3m62A:
9.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_C_HISC302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 3m62 UBIQUITIN
CONJUGATION FACTOR
E4
(Saccharomyces
cerevisiae) 		5 / 10 GLY A 588
VAL A 587
LEU A 555
SER A 542
LEU A 539
 None
 1.36A 4yb6C-3m62A:
undetectable
4yb6F-3m62A:
undetectable		 4yb6C-3m62A:
15.46
4yb6F-3m62A:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_E_HISE302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 3m62 UBIQUITIN
CONJUGATION FACTOR
E4
(Saccharomyces
cerevisiae) 		5 / 10 LEU A 555
SER A 542
LEU A 539
GLY A 588
VAL A 587
 None
 1.35A 4yb6D-3m62A:
undetectable
4yb6E-3m62A:
undetectable		 4yb6D-3m62A:
15.46
4yb6E-3m62A:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z90_F_4LEF401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 3m62 UBIQUITIN
CONJUGATION FACTOR
E4
(Saccharomyces
cerevisiae) 		4 / 8 LEU A 916
LEU A 900
THR A 921
LEU A 929
 None
 0.77A 4z90F-3m62A:
4.6
4z90G-3m62A:
3.8
4z90H-3m62A:
4.6
4z90I-3m62A:
4.5
4z90J-3m62A:
4.6		 4z90F-3m62A:
16.38
4z90G-3m62A:
16.38
4z90H-3m62A:
16.38
4z90I-3m62A:
16.38
4z90J-3m62A:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZN7_A_DESA601_1
(ESTROGEN RECEPTOR)		 3m62 UBIQUITIN
CONJUGATION FACTOR
E4
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 834
ALA A 838
LEU A 806
LEU A 803
LEU A 857
 None
 0.78A 4zn7A-3m62A:
undetectable		 4zn7A-3m62A:
13.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZUD_A_OLMA1201_1
(CHIMERA PROTEIN OF
SOLUBLE CYTOCHROME
B562 AND TYPE-1
ANGIOTENSIN II
RECEPTOR)		 3m62 UBIQUITIN
CONJUGATION FACTOR
E4
(Saccharomyces
cerevisiae) 		5 / 9 PHE A 490
SER A 477
LEU A 480
ARG A 554
ILE A 334
 1PE  A 962 ( 4.4A)
None
None
None
None
 1.47A 4zudA-3m62A:
2.7		 4zudA-3m62A:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3m62 UBIQUITIN
CONJUGATION FACTOR
E4
(Saccharomyces
cerevisiae) 		4 / 7 ILE A 337
PHE A 326
THR A 391
LEU A 390
 None
 0.91A 5b1bN-3m62A:
3.6
5b1bW-3m62A:
undetectable		 5b1bN-3m62A:
18.07
5b1bW-3m62A:
4.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3m62 UBIQUITIN
CONJUGATION FACTOR
E4
(Saccharomyces
cerevisiae) 		4 / 7 ILE A 337
PHE A 326
THR A 391
LEU A 390
 None
 0.92A 5b3sN-3m62A:
3.0
5b3sW-3m62A:
undetectable		 5b3sN-3m62A:
18.07
5b3sW-3m62A:
4.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BPH_C_ACTC403_0
(D-ALANINE--D-ALANINE
LIGASE)		 3m62 UBIQUITIN
CONJUGATION FACTOR
E4
(Saccharomyces
cerevisiae) 		4 / 4 TYR A 368
GLY A 353
SER A 352
LEU A 351
 None
 1.34A 5bphC-3m62A:
undetectable		 5bphC-3m62A:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EAJ_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 3m62 UBIQUITIN
CONJUGATION FACTOR
E4
(Saccharomyces
cerevisiae) 		5 / 12 PHE A 924
THR A 911
ILE A 912
LEU A 900
PRO A 901
 None
 1.06A 5eajB-3m62A:
undetectable		 5eajB-3m62A:
10.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHZ_B_REAB602_1
(ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3)		 3m62 UBIQUITIN
CONJUGATION FACTOR
E4
(Saccharomyces
cerevisiae) 		5 / 9 ILE A  95
GLY A  98
GLN A  88
LEU A  43
LEU A  47
 None
 1.17A 5fhzB-3m62A:
undetectable		 5fhzB-3m62A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHZ_C_REAC602_1
(ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3)		 3m62 UBIQUITIN
CONJUGATION FACTOR
E4
(Saccharomyces
cerevisiae) 		5 / 10 ILE A  95
GLY A  98
GLN A  88
LEU A  43
LEU A  47
 None
 1.12A 5fhzC-3m62A:
undetectable		 5fhzC-3m62A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GSN_A_MMZA503_1
(FLAVIN-CONTAINING
MONOOXYGENASE)		 3m62 UBIQUITIN
CONJUGATION FACTOR
E4
(Saccharomyces
cerevisiae) 		3 / 3 ASN A 694
SER A 737
SER A 736
 None
 0.63A 5gsnA-3m62A:
undetectable		 5gsnA-3m62A:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IL1_A_SAMA601_0
(METTL3)		 3m62 UBIQUITIN
CONJUGATION FACTOR
E4
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 120
LEU A 102
GLU A  58
PHE A  57
GLY A 119
 None
 1.25A 5il1A-3m62A:
undetectable		 5il1A-3m62A:
11.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3m62 UBIQUITIN
CONJUGATION FACTOR
E4
(Saccharomyces
cerevisiae) 		4 / 5 LEU A 618
PHE A 621
LEU A 614
PHE A 604
 None
 1.24A 5iy5P-3m62A:
2.1
5iy5W-3m62A:
undetectable		 5iy5P-3m62A:
12.44
5iy5W-3m62A:
4.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K7U_A_SAMA601_0
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)		 3m62 UBIQUITIN
CONJUGATION FACTOR
E4
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 120
LEU A 102
GLU A  58
PHE A  57
GLY A 119
 None
 1.27A 5k7uA-3m62A:
undetectable		 5k7uA-3m62A:
12.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVS_B_ADNB401_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 3m62 UBIQUITIN
CONJUGATION FACTOR
E4
(Saccharomyces
cerevisiae) 		4 / 8 ASP A 636
PHE A 638
ASN A 682
PHE A 686
 None
 0.96A 5mvsB-3m62A:
undetectable		 5mvsB-3m62A:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0O_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 3m62 UBIQUITIN
CONJUGATION FACTOR
E4
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 473
PHE A 387
ALA A 476
PHE A 386
VAL A 320
 None
 1.12A 5n0oB-3m62A:
undetectable		 5n0oB-3m62A:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUD_A_ERMA2001_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)		 3m62 UBIQUITIN
CONJUGATION FACTOR
E4
(Saccharomyces
cerevisiae) 		5 / 12 VAL A 124
ALA A 191
PHE A 152
LEU A 155
VAL A 151
 None
 1.12A 5tudA-3m62A:
3.3		 5tudA-3m62A:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3m62 UBIQUITIN
CONJUGATION FACTOR
E4
(Saccharomyces
cerevisiae) 		4 / 5 LEU A 618
PHE A 621
LEU A 614
PHE A 604
 None
 1.18A 5x1fC-3m62A:
3.1
5x1fJ-3m62A:
undetectable		 5x1fC-3m62A:
12.63
5x1fJ-3m62A:
4.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_C_CHDC308_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT VIIA-HEART)		 3m62 UBIQUITIN
CONJUGATION FACTOR
E4
(Saccharomyces
cerevisiae) 		4 / 5 LEU A 618
PHE A 621
LEU A 614
PHE A 604
 None
 1.24A 5xdxC-3m62A:
3.1
5xdxJ-3m62A:
undetectable		 5xdxC-3m62A:
12.54
5xdxJ-3m62A:
4.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_D_ADND502_1
(ADENOSYLHOMOCYSTEINA
SE)		 3m62 UBIQUITIN
CONJUGATION FACTOR
E4
(Saccharomyces
cerevisiae) 		3 / 3 LEU A 452
ASN A 169
LEU A 253
 None
 0.46A 6exiD-3m62A:
undetectable		 6exiD-3m62A:
6.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MA7_A_TPFA602_0
(CYTOCHROME P450 3A4)		 3m62 UBIQUITIN
CONJUGATION FACTOR
E4
(Saccharomyces
cerevisiae) 		4 / 7 ALA A 150
THR A 154
ILE A 114
ALA A 112
 None
 0.99A 6ma7A-3m62A:
undetectable		 6ma7A-3m62A:
6.15